About bastien

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So far bastien has created 57 blog entries.

MicroARN et épigénétique

août 2015|

Ozone Exposure Triggers Insulin Resistance Through Muscle c-Jun N-terminal Kinases (JNKs) Activation

juillet 2015|

A growing body of evidence suggests that exposure to traffic-related air pollution is a risk factor for type 2 diabetes. [...]

Exosomes released from cells can transfer both functional proteins and RNAs between cells

juillet 2015|

In this study we tested the hypothesis that muscle cells might transmit specific signals during lipid-induced insulin resistance through the [...]

Mitochondria-Associated Endoplasmic Reticulum Membrane (MAM) Integrity Is Required for Insulin Signaling and Is Implicated in Hepatic Insulin Resistance

juillet 2015|

Mitochondria-associated endoplasmic reticulum (ER) membranes (MAM) are functional domains between both organelles involved in Ca2+ exchange, through the voltage-dependent anion [...]

Grape Polyphenols Prevent Fructose-Induced Oxidative Stress and Insulin Resistance in First-Degree Relatives of Type 2 Diabetic Patients

juillet 2015|

High consumption of fructose is generally associated with oxidative stress and insulin resistance and based on rodent studies, polyphenols have [...]

LDL from obese patients with the metabolic syndrome show increased lipid peroxidation and activate platelets

juillet 2015|

The metabolic syndrome is associated with an increased risk of developing type 2 diabetes and cardiovascular diseases. Platelet hyperactivation and [...]

High expression of FTO in the skeletal muscle of type 2 diabetic patients may contribute to metabolic abnormalities and insulin resistance

juillet 2015|

This study demonstrates increased FTO expression in skeletal muscle from type 2 diabetic patients, which can be normalized by thiazolidinedione [...]

A Novel Hypomorphic PDX1 Mutation Responsible for Permanent Neonatal Diabetes With Subclinical Exocrine Deficiency

juillet 2015|

We found a novel mutation in the pancreatic and duodenal homeobox 1 gene (PDX1, IPF1), which segregated with diabetes in [...]

MicroRNAs contribute to the transcriptional action of insulin in human skeletal muscle

juillet 2015|

MicroRNAs represent a large class of evolutionary conserved RNAs of 21 to 22 nt which act as negative regulators of [...]

Mitochondrial dysfunction is not the initial cause of insulin resistance in skeletal muscle

juillet 2015|

Insulin resistance, a key metabolic disturbance of type 2 diabetes and obesity, has been associated with reduced lipid oxidation rates [...]