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About bastien

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So far bastien has created 55 blog entries.

An APOA5 3′ UTR Variant Associated with Plasma Triglycerides Triggers APOA5 Downregulation by Creating a Functional miR-485-5p Binding Site.

juillet 2015|

APOA5 is a major actor of triglyceride rich lipoproteins (TGRL) metabolism, activating lipoprotein lipase activity and regulating TGRL hepatic clearance. [...]

Low-dose food contaminants trigger sex-specific, hepatic metabolic changes in the progeny of obese mice

juillet 2015|

Environmental contaminants are suspected to be involved in the epidemic incidence of metabolic disorders, food ingestion being a primarily route [...]

Anti-aggregatory properties of in vivo oxidized HDL: evidence from patients with abetalipoproteinemia

juillet 2015|

Many studies have shown that high-density lipoproteins (HDL) possess anti-atherogenic properties, including antioxidant and anti-thrombotic properties. There are few studies [...]

Modulating absorption and postprandial handling of dietary fatty acids by structuring fat in the meal: a randomized cross-over clinical trial

juillet 2015|

Prolonged postprandial hypertriglyceridemia is a potential risk factor for cardiovascular diseases. This is also associated in obese people with a [...]

Visceral Fat Accumulation During Lipid Overfeeding Is Related to Subcutaneous Adipose Tissue Characteristics in Healthy Men

juillet 2015|

The mechanisms governing the orientation of excess lipids toward ectopic sites, contributing to visceral adipose depots and insulin resistance are [...]

p-Cresyl Sulfate Promotes Insulin Resistance Associated with chronic kidney disease

juillet 2015|

The mechanisms underlying the insulin resistance that frequently accompanies chronic kidney disease (CKD) are poorly understood, but the retention of [...]

GPIHBP1 C89F neomutation and hydrophobic C-terminal domain G175R mutation in two pedigrees with severe hyperchylomicronemia

juillet 2015|

GPIHBP1 is a new endothelial binding site for lipoprotein lipase (LPL). We have identified two new missense mutations of the [...]

Characterization of the initial phase of subcutaneous adipose tissue remodeling and development during of weight gain in healthy subjects

juillet 2015|

We used experimental overfeeding as a unique situation to decipher the early processes occurring in adipose tissue during weight gain. [...]

Phospholipase D regulates myogenic differentiation through the activation of both mTORC1 and mTORC2 complexes

juillet 2015|

Phospholipase D (PLD) is known to be involved in myogenesis, but its mechanism of action remains unclear. We thus investigated [...]

Identification and characterization of Poxytrins, a novel class of oxygenated products from omega 3 polyunsaturated fatty acids

juillet 2015|

Docosahexaenoic acid (DHA), an important component of marine lipids, exhibits anti-inflammatory activity related to some of its oxygenated metabolites, such [...]