Insulin resistance, a key metabolic disturbance of type 2 diabetes and obesity, has been associated with reduced lipid oxidation rates [...]
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So far bastien has created 58 blog entries.
An APOA5 3′ UTR Variant Associated with Plasma Triglycerides Triggers APOA5 Downregulation by Creating a Functional miR-485-5p Binding Site.
APOA5 is a major actor of triglyceride rich lipoproteins (TGRL) metabolism, activating lipoprotein lipase activity and regulating TGRL hepatic clearance. [...]
Low-dose food contaminants trigger sex-specific, hepatic metabolic changes in the progeny of obese mice
Environmental contaminants are suspected to be involved in the epidemic incidence of metabolic disorders, food ingestion being a primarily route [...]
Anti-aggregatory properties of in vivo oxidized HDL: evidence from patients with abetalipoproteinemia
Many studies have shown that high-density lipoproteins (HDL) possess anti-atherogenic properties, including antioxidant and anti-thrombotic properties. There are few studies [...]
Modulating absorption and postprandial handling of dietary fatty acids by structuring fat in the meal: a randomized cross-over clinical trial
Prolonged postprandial hypertriglyceridemia is a potential risk factor for cardiovascular diseases. This is also associated in obese people with a [...]
Visceral Fat Accumulation During Lipid Overfeeding Is Related to Subcutaneous Adipose Tissue Characteristics in Healthy Men
The mechanisms governing the orientation of excess lipids toward ectopic sites, contributing to visceral adipose depots and insulin resistance are [...]
The mechanisms underlying the insulin resistance that frequently accompanies chronic kidney disease (CKD) are poorly understood, but the retention of [...]
GPIHBP1 C89F neomutation and hydrophobic C-terminal domain G175R mutation in two pedigrees with severe hyperchylomicronemia
GPIHBP1 is a new endothelial binding site for lipoprotein lipase (LPL). We have identified two new missense mutations of the [...]
Characterization of the initial phase of subcutaneous adipose tissue remodeling and development during of weight gain in healthy subjects
We used experimental overfeeding as a unique situation to decipher the early processes occurring in adipose tissue during weight gain. [...]
Phospholipase D regulates myogenic differentiation through the activation of both mTORC1 and mTORC2 complexes
Phospholipase D (PLD) is known to be involved in myogenesis, but its mechanism of action remains unclear. We thus investigated [...]