Equipe 1 : « Adaptations Nutritionnelles, Environnement et Diabètes »

equipe1

La réponse appropriée aux modifications de notre environnement est essentielle au maintien de l’homéostasie. A tous les stades de la vie, depuis l’embryon jusqu’à un très grand âge, nous sommes soumis à des changements, transitoires ou chroniques, de notre mode de vie, de notre alimentation et exposé à de nombreuses substances toxiques présentes dans notre environnement. La capacité de s’adapter à ces changements conditionne en grande partie la santé et la durée de vie. Notre hypothèse est que des anomalies dans les mécanismes d’adaptation, en ne permettant pas une réponse appropriée à l’environnement, contribueraient au développement de l’obésité, du diabète de type 2 et de leurs complications.

Les principaux objectifs de l’équipe 1 de laboratoire CarMeN sont de comprendre les mécanismes impliqués dans la réponse physiologique aux stress environnementaux chez l’homme, afin d’identifier des défauts potentiels dans ces processus chez les patients diabétiques et chez les sujets obèses, et de développer de nouvelles stratégies de lutte contre ces maladies métaboliques et nutritionnelles.

Tous nos projets combinent des approches complémentaires de recherche clinique, des études sur modèles animaux et une recherche expérimentale in vitro. Cette recherche transversale est possible grâce à l’association efficace de chercheurs et enseignant-chercheurs spécialistes en biochimie, en biologie cellulaire et moléculaire, en immunologie et en physiologie avec des cliniciens de la diabétologie et de la nutrition, du métabolisme  et de la néphrologie.

L’équipe 1 est principalement localisée dans les locaux de la Faculté de Médecine Lyon-Sud (plan d’accès), et le service de biochime de l’Hôpital Lyon-Sud, à proximité immédiate du Centre de Recherche en Nutrition Humaine – Rhône-Alpes . Une partie de l’équipe travaille dans les locaux de l’IMBL (plan d’accès) sur la campus de la Doua à INSA de Lyon.

Thématique générale de l’Equipe 1

Les changements de notre environnement nutritionnel sont en partie responsables de « l’épidémie » actuelle de surpoids, d’obésité et de diabète.

Les objectifs principaux de nos projets de recherche sont 1) de comprendre, les mécanismes moléculaires de la réponse et de l’adaptation aux changements de l’environnement nutritionnel et 2) d’identifier quelles sont les anomalies dans ces processus qui pourraient conduire aux maladies de la nutrition. Nous avons choisi d’aborder ces questions à partir de situations expérimentales susceptibles de représenter les conditions de vie réelle impliquées dans le développement des maladies nutritionnelles et métaboliques. Sur la base des avancées significatives réalisées au cours des dernières années, notre stratégie repose sur 5 programmes complémentaires de recherche:

1) « Adaptation métabolique des tissu adipeux au cours de la suralimention » pour comprendre le remodelage des dépôts de tissu adipeux pendant la prise de poids et pour proposer des stratégies nouvelles pour lutter contre l’obésité et prévenir ses complications

2 ) « Cellules souches adipocytaires dans les tissus adipeux sains et pathologiques » pour comprendre les mécanismes à l’origine des altérations fonctionnelles et de l’inflammation du tissu adipeux qui sont initiatrices des complications de  l’obésité

3)  » Impact des polluants environnementaux dans les maladies métaboliques » pour démontrer la contribution et les mécanismes d’action des polluants dans l’initiation ou l’amplification des maladies métaboliques

4) « Adaptation métabolique dans la maladie rénale chronique » pour définir les déterminants des complications métaboliques, en particulier la résistance à l’insuline, dans la maladie rénale chronique et proposer de nouveaux traitements;

5) « Les probiotiques pour lutter contre les maladies métaboliques »  afin de démontrer que des souches bactériennes sélectionnées peuvent être de puissants agents pour traiter les patients obèses et diabétiques

Diapositive1

Principales méthodologies et outils

Les études nutritionnelles chez l’homme (réalisées au Centre de Recherche en Nutrition Humaine, CRNH-RA) / La mesure de la sensibilité à l’insuline (clamp hyperinsulinémique) / La biobanque de tissus humains (muscle squelettique et tissu adipeux) / Les modèles animaux (souris) / La culture cellulaire (cellules souches, adipocytes, cellules musculaires) / Les approches de génomique et épigénétique (puces à ADN, RT-PCR en temps réel) / L’étude de la signalisation intracellulaire (insuline) / La mesure de la taille des adipocytes / L ‘immunohistologie / La manipulation génique in vitro (adenovirus, ShRNA) / Les tests fonctionnels immunologiques (réponses autologue/allogénique, ELISA, cytométrie en flux)

Axe 1 : Adaptation métabolique des tissus adipeux au cours de la suralimentation

Un apport calorique excessif par rapport aux dépenses énergétiques est une des caractéristiques du mode de vie moderne, contequipe1_fig3ribuant de façon majeure au développement de l’obésité. Les mécanismes qui régulent les réorientations métaboliques chez l’homme lors de la surnutrition (stockage ou catabolisme des calories excédentaires, régulation de l’expansion du tissu adipeux, stockage ectopique des graisses) sont très mal connus. Ils sont en général abordés par des études de perte de poids, qui ne représentent pas la réalité du développement de l’obésité. En collaboration avec le CRNH-RA, nous développons un programme de recherche ambitieux pour caractériser ces mécanismes en utilisant des protocoles de suralimentation chez l’homme et chez l’animal.

Dans les études cliniques, des volontaires sont soumis à différents protocoles de suralimentation au cours desquels ils consomment environ 30% d’excédent calorique chaque jour pendant plusieurs semaines. Une analyse détaillée des modifications biologiques, métaboliques et anthropométriques est effectuée tout au long des protocoles. Nous testons différents types de suppléments caloriques (lipides, fructose ou « junk food »), mais également de nouvelles stratégies pour prévenir les effets délétères de la suralimentation (polyphénols, probiotiques). Des résultats importants ont déjà été obtenus ces dernières années, nous permettant de comprendre les mécanismes moléculaires de la répartition des substrats énergétiques dans le muscle squelettique ainsi que les premières étapes du développement du tissu adipeux quand les sujets prennent du poids (Seyssel et al, JCEM, 2014; Alligier et al JCEM, 2012).

De façon intéressante, certains sujets présentent une orientation préférentielle du stockage des lipides dans le tissu adipeux viscéral et d’autres dépôts ectopiques tels que le foie et le muscle. Cela suggère que ces sujets présentent probablement un risque plus élevé pour le syndrome métabolique. Nous étudions actuellement plus en détail ces sujets avec l’objectif d’identifier de nouveaux biomarqueurs de risque en utilisant des approches transcriptomiques du tissu adipeux et du muscle squelettique et une approche métabolomique dans le sang et l’urine. Parallèlement aux études cliniques, les mécanismes de l’accumulation de graisse et les fonctions des adipocytes sont étudiés in vitro à l’aide d’adipocytes humains en culture primaire.

Axe 2 : Cellules souches adipocytaires dans les tissus adipeux sain et pathologique

Les cellules souches mésenchymateuses, présentes en grand nombre dans le tissu adipeux (Adipose Stem Cells, ASC), ont non seulement la capacité de se différencier en adipocytes, mais possèdent aussi de nombreuses fonctions régulatrices notamment vis à vis des cellules immunes. Nous explorons la contribution de ces cellules au fonctionnement du tissu adipeux sain et à son évolution pathologique au travers de plusieurs axes de recherche.

Un de ces axes de recherche (A. El Jaafari et L. Pirola) vise à mieux comprendre le rôle de  l’inflammation dans la pathogénicité du tissu adipeux. Alors que la présence des macrophages dans le tissu adipeux a été montrée comme contribuant à l’inflammation de bas grade associée à l’obésité, nous avons récemment identifié 2 nouveaux acteurs dans ce processus: les cellules souches mésenchymateuses dérivées de tissu adipeux (ASC) et les lymphocytes Th17 (El Jaafari et al, Diabetes, 2015). Nous avons démontré que les ASC préparées à partir du tissu adipeux des personnes obèses (mais pas à partir de donneurs sains) peuvent augmenter la sécrétion d’IL-17A et d’IL-1beta par les cellules mononuclées du sang. Ces cytokines inhibent en retour l’adipogénèse et diminue la réponse à l’insuline des adipocytes. Nous cherchons maintenant à identifier les mécanismes en cause, en particulier les molécules impliquées dans l’interaction cellulaire entre ASC et lymphocytes Th17, qui pourraient représenter des cibles nouvelles pour combattre l’inflammation dans l’obésité.

Un autre projet de recherche, développé par A. Mey, vise à comprendre l’origine des différences fonctionnelles entre les dépôts de tissu adipeux et leurs contributions dans l’obésité. Elle s’intéresse pour cela aux spécificités moléculaires et biologiques des cellules souches mésenchymateuses (ASC) qui sont à l’origine développementale de ces dépôts et qui restent présentes dans les dépôts à l’âge adulte. Afin de comprendre comment l’environnement nutritionnel impacte les propriétés des ASC aux différents âges de la vie nous avons développé l’isolement et la culture de ces cellules à partir de différents dépôts de tissu adipeux chez la souris et l’homme.

Une des propriétés intéressantes des ASC est leur possibilité, en tant que cellules souches, de se différencier en différents types cellulaires. Nous avons mis au point un protocole pour générer des cellules bêta-pancréatiques à partir des ASC humaines. Nous allons maintenant utiliser ces cellules pour étudier l’impact de l’inflammation médiée par les cellules souches sur les cellules bêta afin de mieux comprendre les mécanismes conduisant à leur dysfonctionnement dans le diabète de type 2. Nous espérons également optimiser la production de cellules bêta à partir d’ASC pour proposer à l’avenir ces cellules comme outils thérapeutiques. Ceci sera réalisé par A. El Jaafari, en collaboration avec les membres de l’équipe 3 (A-M Madec, C. Thivolet) et de l’Unité de thérapie cellulaire des hôpitaux de Lyon, qui ont récemment rejoint l’équipe.

 

Axe 3 : Impact des polluants dans les maladies métaboliques

En plus de la génétique, de l’excès de calories et du manque d’activité physique, il est maintenant clairement démontré que les polluants environnementaux, en particulier ceux qui possèdent des activités de perturbateurs endocriniens et qui agissent à très faible dose, contribuent à l’épidémie de maladies métaboliques. Plusieurs études épidémiologiques ont montré une corrélation significative entre les critères du syndrome métabolique et la présence dans le sang ou dans l’urine de polluants ou de leurs métabolites. En outre, des études expérimentales chez la souris, y compris les travaux de notre équipe (Naville et al, FASEB J 2013; PlosOne, 2015; Ruzzin et al, EHP 2011) ont établi un lien de causalité entre l’exposition aux produits chimiques et les dysfonctionnements métaboliques liés à l’obésité, tel que la résistance à l’insuline.

D. Naville et B. Le Magueresse dans l’équipe, ont développé un modèle d’exposition de souris à un cocktail de polluants (dioxine, PCB153, DEHP et BPA) à doses très faibles, et ajoutés à une alimentation enrichies en saccharose et lipides aux mères puis à leur descendance. Ce protocole nous permet d’étudier l’impact d’un mélange de polluants à doses environnementales sur les paramètres biologiques, la masse grasse, la tolérance au glucose et la sensibilité à l’insuline dans la souris et sur sa descendance. Afin de comprendre l’origine moléculaire des altérations métaboliques, une approche moléculaire gène-candidat ou globale de type transcriptomique est développée.

En parallèle, nous explorons le phénotype des souris PXR KO en collaboration avec le groupe de J. Ruzzin, Université de Bergen, Norvège et nous utilisons divers modèles cellulaires in vitro. Enfin, nous avons émis l’hypothèse que des variations de microbiote intestinal pourraient modifier la façon dont les individus métabolisent et répondent aux polluants. Nous allons donc tester si des modifications du microbiote induites par l’utilisation de probiotiques pourraient protéger contre  les effets délétères des polluants (cf. Axe 4).

 

Axe 4 : Adaptation métabolique dans la maladie rénale chronique

L’insuffisance rénale chronique (IRC) est fréquemment associée à une résistance périphérique à l’insuline, qui est un important facteur de risque cardiovasculaire. Cependant, les raisons pour lesquelles les patients insuffisants rénaux développent cette résistance à l’insuline, même en l’absence de surpoids ou d’obésité, sont en grande partie inconnues.

D. Fouque et Ch. Soulage dans l’équipe ont récemment démontré que l’accumulation de toxines urémiques, tels que le p-crésol, pourrait être un facteur clé pour le développement de la résistance à l’insuline dans la maladie rénale au stade terminal (J Amer Soc Nephrol, 2013). En utilisant un modèle expérimental d’ IRC chez la souris, nous tentons actuellement d’étendre ce concept à d’autres toxines urémiques, comme indoxyle sulfate, et essayons de définir leurs mécanismes d’action, en mettant l’accent sur l’activation des récepteurs nucléaires, tels que le récepteur AhR (qui est aussi le récepteurdes dioxines). Les mécanismes sous-jacents au développement de la résistance à l’insuline sont aussi étudiés in vitro en utilisant des adipocytes et des cellules musculaires en culture incubées avec des toxines urémiques. L’identification des voies de signalisation contribuant aux effets délétères de ces composés et le rôle potentiel d’AhR seront étudiés en détail dans ces systèmes in vitro. Nous allons ensuite vérifier la pertinence de ces résultats dans notre cohorte de patients atteints de néphropathie chronique. Le rôle de la flore intestinale sera également étudié dans le but d’élaborer des stratégies pro / prébiotiques pour moduler la production de toxines urémiques.
Un autre projet de recherche porte sur l’étude de l’impact de la dialyse péritonéale sur le développement et les fonctions du tissu adipeux blanc intra-abdominal, en utilisant un modèle original de dialyse péritonéale chez la souris (en cours de développement dans le laboratoire). La pertinence de ce modèle pré-clinique sera évaluée dans les biopsies de tissu adipeux sous-cutané et intra-abdominal prélevées chez des patients traités par dialyse péritonéale. Ces échantillons biologiques permettront d’analyser les effets de la dialyse sur la taille des adipocytes, l’histologie du tissu (infiltration de cellules immunitaires, fibrose), les fonctions des adipocytes et la sécrétion adipokines.

Axe 5 : Utilisation de probiotiques pour lutter contre les maladies métaboliques

L’utilisation des probiotiques dans le but de moduler la glycémie et donc d’améliorer le diabète a été envisagée depuis longtemps, en particulier en tant que supplément nutritionnel, et la découverte du rôle critique de microbiote intestinal dans les maladies métaboliques a fortement stimulé la recherche dans ce domaine. L’obésité et le diabète de type 2 sont en effet associés à une perturbation de la composition et du fonctionnement du microbiote intestinal (appelé dysbiose), caractérisée globalement par le changement dans le rapport entre Firmicutes (Gram-positif) et Bacteroidetes (Gram négatif). En outre, il a été démontré récemment que le microbiote intestinal joue certainement un rôle essentiel dans la pathogénie de ces maladies.

Plusieurs souches bactériennes, utilisées comme probiotiques, ont montré récemment des actions bénéfiques sur la tolérance au glucose et la sensibilité à l’insuline chez les souris. Cependant, les effets sont moins importants chez l’homme et leurs mécanismes d’action ne sont pas encore bien compris. Notre objectif est donc d’identifier des souches bactériennes d’intérêt, possédant des effets bénéfiques forts pour la santé humaine, et de les proposer en tant que nouveaux probiotiques pour la prévention et/ou le traitement des maladies métaboliques.
Pour identifier ces nouvelles souches, nous travaillons en étroite collaboration avec l’équipe de F. Leulier à l’IGFL (un leader dans le domaine des interactions hôte-bactéries chez la drosophile  qui a mis au point une méthode innovante pour qualifier les souches de Lactobacillus avec des propriétés anti-diabétiques (brevet déposé en février 2016).

Nous avons récemment utilisé ensemble une variante de ce système de sélection pour démontrer pour la première fois le rôle critique du microbiote et d’une des souches de L.plantarum sélectionnées dans la croissance juvéniles (Schwarzer et al. Science 2016). Nous sommes actuellement en train de qualifier des  souches pertinentes pour leurs propriétés anti-diabétiques, qui sont tout d’abord tester chez les souris diabétiques, avant leur évaluation chez les patients. En parallèle, comme indiqué dans les axes 2 et 3 ci-dessus, les souches bactériennes avec des propriétés probiotiques sont aussi évalués pour leur potentiel à contrer les effets toxiques d’un cocktail de polluants chez les souris exposées et à contrôler la production de toxines urémiques dans un modèle de souris avec insuffisance rénale chronique.

2017

  1. Benoit B, Meugnier E, Castelli M, Chanon S, Vieille-Marchiset A, Durand C, Bendridi N, Pesenti S, Monternier PA, Durieux AC, Freyssenet D, Rieusset J, Lefai E, Vidal H, Ruzzin J.(2017) Fibroblast growth factor 19 regulates skeletal muscle mass and ameliorates muscle wasting in mice. Nat Med 23; 990-996
  2. Betry, C., Disse, E., Chambrier, C., Barnoud, D., Gelas, P., Baubet, S., Laville, M., Pelascini, E. and Robert, M. (2017) Need for Intensive Nutrition Care After Bariatric Surgery. JPEN J Parenter Enteral Nutr. 41; 258-262.
  3. Blond E, Disse E, Cuerq C, Drai J, Valette PJ, Laville M, Thivolet C, Simon C, Caussy C.(2017) EASL-EASD-EASO clinical practice guidelines for the management of non-alcoholic fatty liver disease in severely obese people: do they lead to over-referral? Diabetologia 60; 1218-1222
  4. Bischoff, S. C., Boirie, Y., Cederholm, T., Chourdakis, M., Cuerda, C., Delzenne, N. M., Deutz, N. E., Fouque, D., Genton, L., Gil, C., Koletzko, B., Leon-Sanz, M., Shamir, R., Singer, J., Singer, P., Stroebele-Benschop, N., Thorell, A., Weimann, A. and Barazzoni, R. (2017) Towards a multidisciplinary approach to understand and manage obesity and related diseases. Clin Nutr. 36; 917-938.
  5. Boksebeld, M., Kilin, V., Geloen, A., Ceccone, G., Jaffal, A., Schmidt, C., Alekseev, S., Lysenko, V., Wolf, J. P., Bonacina, L., Souteyrand, E., Chevolot, Y. and Monnier, V. (2017) Folate-modified silicon carbide nanoparticles as multiphoton imaging nanoprobes for cancer-cellspecific labeling. Rsc Advances. 7; 27361-27369.
  6. Chriett, S., Zerzaihi, O., Vidal, H. and Pirola, L. (2017) The histone deacetylase inhibitor sodium butyrate improves insulin signalling in palmitate-induced insulin resistance in L6 rat muscle cells through epigenetically-mediated up-regulation of Irs1. Mol Cell Endocrinol. 439; 224-232.
  7. Coffin, B., Maunoury, V., Pattou, F., Hebuterne, X., Schneider, S., Coupaye, M., Ledoux, S., Iglicki, F., Mion, F., Robert, M., Disse, E., Escourrou, J., Tuyeras, G., Le Roux, Y., Arvieux, C., Pouderoux, P., Huten, N., Alfaiate, T., Hajage, D. and Msika, S. (2017) Impact of Intragastric Balloon Before Laparoscopic Gastric Bypass on Patients with Super Obesity: a Randomized Multicenter Study. Obes Surg. 27; 902-909.
  8. de Brito Alves JL, Toscano AE, da Costa-Silva JH, Vidal H, Leandro CG, Pirola L. (2017)Transcriptional response of skeletal muscle to a low protein perinatal diet in rat offspring at different ages: The role of key enzymes of glucose-fatty acid oxidation. J Nutr Biochem 41; 117-123
  9. Disse, E., Pasquer, A., Pelascini, E., Valette, P. J., Betry, C., Laville, M., Gouillat, C. and Robert, M. (2017) Dilatation of Sleeve Gastrectomy: Myth or Reality? Obes Surg. 27; 30-37.
  10. Donadio-Andrei, S., Chikh, K., Heuclin, C., Kuczewski, E., Charrie, A., Gauchez, A. S. and Ronin, C. (2017) Variability among TSH Measurements Can Be Reduced by Combining a Glycoengineered Calibrator to Epitope-Defined Immunoassays. European Thyroid Journal. 6; 3-11.
  11. Dupuis, M., Kuczewski, E., Villeneuve, L., Bin-Dorel, S., Haine, M., Falandry, C., Gilbert, T., Passot, G., Glehen, O. and Bonnefoy, M. (2017) Age Nutrition Chirurgie (ANC) study: impact of a geriatric intervention on the screening and management of undernutrition in elderly patients operated on for colon cancer, a stepped wedge controlled trial BMC Geriatrics 17; 9
  12. Elisha, B., Disse, E., Chabot, K., Taleb, N., Prud’homme, D., Bernard, S., Rabasa-Lhoret, R. and Bastard, J. P. (2017) Relative contribution of muscle and liver insulin resistance to dysglycemia in postmenopausal overweight and obese women: A MONET group study. Ann Endocrinol (Paris). 78; 1-8.
  13. El Kharbili M, Robert C, Witkowski T, Danty-Berger E, Barbollat-Boutrand L, Masse I, Gadot N, de la Fouchardière A, McDonald PC, Dedhar S, Le Naour F, Degoul F, Berthier-Vergnes O. (2017)Tetraspanin 8 is a novel regulator of ILK-driven _1 integrin adhesion and signaling in invasive melanoma cells. Oncotarget 8; 17140
  14. Florens, N., Lemoine, S., Pelletier, C. C., Rabeyrin, M., Juillard, L. and Soulage, C. O. (2017) Adenine Rich Diet Is Not a Surrogate of 5/6 Nephrectomy in Rabbits. Nephron. 135; 307-314.
  15. Frin, A. C., Filippi, J., Boschetti, G., Flourie, B., Drai, J., Ferrari, P., Hebuterne, X. and Nancey, S. (2017) Accuracies of fecal calprotectin, lactoferrin, M2-pyruvate kinase, neopterin and zonulin to predict the response to infliximab in ulcerative colitis. Dig Liver Dis. 49; 11-16.
  16. Girard, R., Metereau, E., Thomas, J., Pugeat, M., Qu, C. and Dreher, J. C. (2017) Hormone therapy at early post-menopause increases cognitive control-related prefrontal activity. Scientific Reports. 7; 11.
  17. Jenkins, B. J., Seyssel, K., Chiu, S., Pan, P. H., Lin, S. Y., Stanley, E., Ament, Z., West, J. A., Summerhill, K., Griffin, J. L., Vetter, W., Autio, K. J., Hiltunen, K., Hazebrouck, S., Stepankova, R., Chen, C. J., Alligier, M., Laville, M., Moore, M., Kraft, G., Cherrington, A., King, S., Krauss, R. M., de Schryver, E., Van Veldhoven, P. P., Ronis, M. and Koulman, A. (2017) Odd Chain Fatty Acids; New Insights of the Relationship Between the Gut Microbiota, Dietary Intake, Biosynthesis and Glucose Intolerance. Scientific Reports 7; 8.
  18. Labaronne E, Pinteur C, Vega N, Pesenti S, Julien B, Meugnier-Fouilloux E, Vidal H, Naville D, Le Magueresse-Battistoni B. (2017) Low-dose pollutant mixture triggers metabolic disturbances in female mice leading to common and specific features as compared to a high-fat diet. J Nutr Biochem 45, 83-93
  19. Laforest, S., Michaud, A., Paris, G., Pelletier, M., Vidal, H., Geloen, A. and Tchernof, A. (2017) Comparative analysis of three human adipocyte size measurement methods and their relevance for cardiometabolic risk. Obesity 9. 25; 122-131.
  20. 20. Lecomte, M., Couedelo, L., Meugnier, E., Loizon, E., Plaisancie, P., Durand, A., Geloen, A., Joffre, F., Vaysse, C., Michalski, M. C. and Laugerette, F. (2017) Soybean polar lipids differently impact adipose tissue inflammation and the endotoxin transporters LBP and sCD14 in flaxseed vs. palm oil-rich diets. Journal of Nutritional Biochemistry. 43; 116-124.
  21. Le Magueresse-Battistoni B, Labaronne E, Vidal H, Naville D.(2017) Endocrine disrupting chemicals in mixture and obesity, diabetes and related metabolic disorders. World J Biol Chem 8108-119
  22. le Roux CW, Astrup A, Fujioka K, Greenway F, Lau DCW, Van Gaal L, Ortiz RV, Wilding JPH, Skjøth TV, Manning LS, Pi-Sunyer X; SCALE Obesity Prediabetes NN8022-1839 Study Group (Laville M). (2017) 3 years of liraglutide versus placebo for type 2 diabetes risk reduction and weight management in individuals with prediabetes: a randomised, double-blind trial. Lancet 389; 1399-140
  23.  Marçais C, Maucort-Boulch D, Drai J, Dantony E, Carlier MC, Blond E, Genet L, Kuentz F, Lataillade D, Legrand E, Moreau-Gaudry X, Jean G, Fouque D; ARNOGENE project. (2017) Circulating Klotho associates with cardiovascular morbidity and mortality during hemodialysis. J Clin Endocrinol Metab
  24. Soulere, L. and Soulage, C. O. (2017) Exploring docking methods for virtual screening: application to the identification of neuraminidase and Ftsz potential inhibitors. Molecular Simulation. 43; 656-663.
  25. van Beek, A. P., Emous, M., Laville, M. and Tack, J. (2017) Dumping syndrome after esophageal, gastric or bariatric surgery: pathophysiology, diagnosis, and management. Obes Rev. 18; 68-85.
  26. Vervloet, M. G., Sezer, S., Massy, Z. A., Johansson, L., Cozzolino, M., Fouque, D., Disease-Mineral, E.-E. W. G. o. C. K., Bone, D. and the European Renal Nutrition Working, G. (2017) The role of phosphate in kidney disease. Nat Rev Nephrol. 13; 27-38.
  27. Viel, S., Besson, L., Charrier, E., Marcais, A., Disse, E., Bienvenu, J., Walzer, T. and Dumontet, C. (2017) Alteration of Natural Killer cell phenotype and function in obese individuals. Clin Immunol. 177; 12-17.
  28. Vinoy S, Meynier A, Goux A, Jourdan-Salloum N, Normand S, Rabasa-Lhoret R, Brack O, Nazare JA, Péronnet F, Laville M. (2017)The Effect of a Breakfast Rich in Slowly Digestible Starch on Glucose Metabolism: A Statistical Meta-Analysis of Randomized Controlled Trials. Nutrients.                           
  29. Vors, C., Drai, J., Pineau, G., Laville, M., Vidal, H., Laugerette, F. and Michalski, M. C. (2017) Emulsifying dietary fat modulates postprandial endotoxemia associated with chylomicronemia in obese men: a pilot randomized crossover study. Lipids in Health and Disease. 16; 6.
  30. Wojtala, M., Pirola, L. and Balcerczyk, A. (2017) Modulation of the vascular endothelium functioning by dietary components, the role of epigenetics. Biofactors. 43; 5-16.
  31. Yan, X. B., Ramos, R., Hoibian, E., Soulage, C., Alcouffe, P., Ganachaud, F. and Bernard, J. (2017) Nanoprecipitation of PHPMA (Co)Polymers into Nanocapsules Displaying Tunable Compositions, Dimensions, and Surface Properties. Acs Macro Letters. 6; 447-451.
  32. Chehimi M, Vidal H, Eljaafari A. Pathogenic Role of IL-17-Producing Immune Cells in Obesity, and Related Inflammatory Diseases (2017) J Clin Med. 2017 Jul 14;6(7). pii: E68. doi: 10.3390/jcm6070068. Review.

 

2016

  1. Alexandre J, Ray-Coquard I, Selle F, Floquet A, Cottu P, Weber B, Falandry C, Lebrun D, Pujade-Lauraine E; GINECO-Group.. Clinical presentation and sensitivity to platinum-based chemotherapy (CT) of mucinous advanced epithelial ovarian carcinoma (M-AEOC): The GINECO-Group experience. J Clin Oncol. 2009 May 20;27(15_suppl):5572.
  1. Balcerczyk, A., Rybaczek, D., Wojtala, M., Pirola, L., Okabe, J. and El-Osta, A. (2016) Pharmacological inhibition of arginine and lysine methyltransferases induces nuclear abnormalities and suppresses angiogenesis in human endothelial cells Biochemical Pharmacology 121 18-32
  1. Betry, C., Disse, E., Chambrier, C., Barnoud, D., Gelas, P., Baubet, S., Laville, M., Pelascini, E. and Robert, M. (2016) Need for Intensive Nutrition Care After Bariatric Surgery: Is Mini Gastric Bypass at Fault? JPENJ Parenter Enteral Nutr doi:10.1177/0148607116637935
  1. Bischoff, S. C., Boirie, Y., Cederholm, T., Chourdakis, M., Cuerda, C., Delzenne, N. M., Deutz, N. E., Fouque, D., Genton, L., Gil, C., Koletzko, B., Leon-Sanz, M., Shamir, R., Singer, J., Singer, P., Stroebele-Benschop, N., Thorell, A., Weimann, A. and Barazzoni, R. (2016) Towards a multidisciplinary approach to understand and manage obesity and related diseases Clinical Nutrition doi: 10.1016/j.clnu.2016.11.007
  1. Borges, N. A., Barros, A. F., Nakao, L. S., Dolenga, C. J., Fouque, D. and Mafra, D. (2016) Protein-Bound Uremic Toxins from Gut Microbiota and Inflammatory Markers in Chronic Kidney Disease Journal of Renal Nutrition 26 396-400
  1. Capel, F., Cheraiti, N., Acquaviva, C., Henique, C., Bertrand-Michel, J., Vianey-Saban, C., Prip-Buus, C. and Morio, B. (2016) Oleate dose-dependently regulates palmitate metabolism and insulin signaling in C2C12 myotubes Biochimica et Biophysica Acta 1861 2000-2010
  1. Casteras, S., Abdul-Wahed, A., Soty, M., Vulin, F., Guillou, H., Campana, M., Le Stunff, H., Pirola, L., Rajas, F., Mithieux, G. and Gautier-Stein, A. (2016) The suppression of hepatic glucose production improves metabolism and insulin sensitivity in subcutaneous adipose tissue in mice Diabetologia 59 2645-2653
  1. Charpiat, B., Derfoufi, S., Larger, M., Janoly-Dumenil, A., Mouchoux, C., Allenet, B., Tod, M., Grassin, J., Boulieu, R., Catala, O., Bedouch, P., Goudable, J. and Vinciguerra, C. (2016) Identification of knowledge deficits of pharmacy students at the beginning of the fifth year of pharmacy practice experience: Proposals to change the content of academic programs Annales Pharmaceutiques Francaises 74 404-12
  1. Chauveau, P., Moreau, K., Lasseur, C., Fouque, D., Combe, C. and Aparicio, M. (2016) Sarcopenia or uremic myopathy in CKD patients Néphrologie & Thérapeutique 12 71-5
  1. Chastin SF, De Craemer M, Lien N, Bernaards C, Buck C, Oppert JM, Nazare JA, Lakerveld J, O’Donoghue G, Holdsworth M, Owen N, Brug J, Cardon G; DEDIPAC consortium, expert working group and consensus panel.. The SOS-framework (Systems of Sedentary behaviours): an international transdisciplinary consensus framework for the study of determinants, research priorities and policy on sedentary behaviour across the life course: a DEDIPAC-study. Int J Behav Nutr Phys Act. 2016 Jul 15;13:83.
  1. Chehimi, M., Robert, M., Bechwaty, M. E., Vial, G., Rieusset, J., Vidal, H., Pirola, L. and Eljaafari, A. (2016) Adipocytes, like their progenitors, contribute to inflammation of adipose tissues through promotion of Th-17 cells and activation of monocytes, in obese subjects Adipocyte 5 275-82
  1. Chriett, S., Le Huerou-Luron, I., Vidal, H. and Pirola, L. (2016) Dysregulation of sirtuins and key metabolic genes in skeletal muscle of pigs with spontaneous intrauterine growth restriction is associated with alterations of circulating IGF-1 General and Comparative Endocrinology 232 76-85
  1. Coffin, B., Maunoury, V., Pattou, F., Hebuterne, X., Schneider, S., Coupaye, M., Ledoux, S., Iglicki, F., Mion, F., Robert, M., Disse, E., Escourrou, J., Tuyeras, G., Le Roux, Y., Arvieux, C., Pouderoux, P., Huten, N., Alfaiate, T., Hajage, D. and Msika, S. (2016) Impact of Intragastric Balloon Before Laparoscopic Gastric Bypass on Patients with Super Obesity: a Randomized Multicenter Study Obesity Surgery doi: 10.1007/s11695-016-2383-x
  1. Condello G, Ling FC, Bianco A, Chastin S, Cardon G, Ciarapica D, Conte D, Cortis C, De Craemer M, Di Blasio A, Gjaka M, Hansen S, Holdsworth M, Iacoviello L, Izzicupo P, Jaeschke L, Leone L, Manoni L, Menescardi C, Migliaccio S, Nazare JA, Perchoux C, Pesce C, Pierik F, Pischon T, Polito A, Puggina A, Sannella A, Schlicht W, Schulz H, Simon C, Steinbrecher A, MacDonncha C, Capranica L; DEDIPAC consortium.. Using concept mapping in the development of the EU-PAD framework (EUropean-Physical Activity Determinants across the life course): a DEDIPAC-study. BMC Public Health. 2016 Nov 9;16(1):1145.
  1. Confavreux, C. B., Casey, R., Varennes, A., Goudable, J., Chapurlat, R. D. and Szulc, P. (2016) Has sclerostin a true endocrine metabolic action complementary to osteocalcin in older men? Osteoporosis International 27 2301-9
  1. Courand, P. Y., Lesiuk, C., Milon, H., Defforges, A., Fouque, D., Harbaoui, B. and Lantelme, P. (2016) Association Between Protein Intake and Mortality in Hypertensive Patients Without Chronic Kidney Disease in the OLD-HTA Cohort Hypertension 67 1142-9
  1. Cuerq, C., Restier, L., Drai, J., Blond, E., Roux, A., Charriere, S., Michalski, M. C., Di Filippo, M., Levy, E., Lachaux, A. and Peretti, N. (2016) Establishment of reference values of alpha-tocopherol in plasma, red blood cells and adipose tissue in healthy children to improve the management of chylomicron retention disease, a rare genetic hypocholesterolemia Orphanet Journal of Rare Diseases 11 114
  1. Dalko E, Tchitchek N, Pays L, Herbert F, Cazenave PA, Ravindran B, Sharma S, Nataf S, Das B, Pied S. Erythropoietin Levels Increase during Cerebral Malaria and Correlate with Heme, Interleukin-10 and Tumor Necrosis Factor-Alpha in India. PLoS One. 2016 Jul 21;11(7):e0158420.
  1. de Brito Alves, J. L., de Oliveira, J. M., Ferreira, D. J., Barros, M. A., Nogueira, V. O., Alves, D. S., Vidal, H., Leandro, C. G., Lagranha, C. J., Pirola, L. and da Costa-Silva, J. H. (2016) Maternal protein restriction induced-hypertension is associated to oxidative disruption at transcriptional and functional levels in the medulla oblongata Clinical and Experimental Pharmacology and Physiology 43 1177-1184
  1. de Brito Alves, J. L., de Sousa, V. P., Cavalcanti Neto, M. P., Magnani, M., Braga, V. A., da Costa-Silva, J. H., Leandro, C. G., Vidal, H. and Pirola, L. (2016) New Insights on the Use of Dietary Polyphenols or Probiotics for the Management of Arterial Hypertension Frontiers in Physiology 7 448
  1. Devaux S, Cizkova D, Quanico J, Franck J, Nataf S, Pays L, Hauberg-Lotte L, Maass P, Kobarg JH, Kobeissy F, Mériaux C, Wisztorski M, Slovinska L, Blasko J, Cigankova V, Fournier I, Salzet M. Proteomic Analysis of the Spatio-temporal Based Molecular Kinetics of Acute Spinal Cord Injury Identifies a Time- and Segment-specific Window for Effective Tissue Repair. Mol Cell Proteomics. 2016 Aug;15(8):2641-70
  1. Di Cataldo, V., Geloen, A., Langlois, J. B., Chauveau, F., Theze, B., Hubert, V., Wiart, M., Chirico, E. N., Rieusset, J., Vidal, H., Pialoux, V. and Canet-Soulas, E. (2016) Exercise Does Not Protect against Peripheral and Central Effects of a High Cholesterol Diet Given Ad libitum in Old ApoE-/- Mice Frontiers in Physiology 7 453
  1. Disse, E., Pasquer, A., Pelascini, E., Valette, P. J., Betry, C., Laville, M., Gouillat, C. and Robert, M. (2016) Dilatation of Sleeve Gastrectomy: Myth or Reality? Obesity Surgery doi: 10.1007/s11695-016-2261-6
  1. Egli, L., Lecoultre, V., Cros, J., Rosset, R., Marques, A. S., Schneiter, P., Hodson, L., Gabert, L., Laville, M. and Tappy, L. (2016) Exercise performed immediately after fructose ingestion enhances fructose oxidation and suppresses fructose storage The American Journal of Clinical Nutrition 103 348-55
  1. Elisha, B., Disse, E., Chabot, K., Taleb, N., Prud’homme, D., Bernard, S., Rabasa-Lhoret, R. and Bastard, J. P. (2016) Relative contribution of muscle and liver insulin resistance to dysglycemia in postmenopausal overweight and obese women: A MONET group study Annales d’ Endocrinologie (Paris) doi: 10.1016/j.ando.2016.10.00
  1. Farage, N. E., Stockler-Pinto, M. B., Leal, V. O., Cardozo, L. L., Carraro-Eduardo, J. C., Fouque, D. and Mafra, D. (2016) NF-kappaB expression and its association with nutritional status in hemodialysis patients International Urology and Nephrology 48 2089-2094
  1. Fossard, G., Blond, E., Balsat, M., Morisset, S., Giraudier, S., Escoffre-Barbe, M., Labussiere-Wallet, H., Heiblig, M., Bert, A., Etienne, M., Drai, J., Sobh, M., Redonnet-Vernhet, I., Lega, J. C., Mahon, F. X., Etienne, G. and Nicolini, F. E. (2016) Hyperhomocysteinemia and high doses of nilotinib favor cardiovascular events in chronic phase Chronic Myelogenous Leukemia patients Haematologica 101 e86-90
  1. Fouque, D., Chen, J., Chen, W., Garneata, L., Hwang, S. J., Kalantar-Zadeh, K., Kopple, J. D., Mitch, W. E., Piccoli, G., Teplan, V. and Chauveau, P. (2016) Adherence to ketoacids/essential amino acids-supplemented low protein diets and new indications for patients with chronic kidney disease BMC Nephrology 17 63
  1. Frin, A. C., Filippi, J., Boschetti, G., Flourie, B., Drai, J., Ferrari, P., Hebuterne, X. and Nancey, S. (2016) Accuracies of fecal calprotectin, lactoferrin, M2-pyruvate kinase, neopterin and zonulin to predict the response to infliximab in ulcerative colitis Digestive and Liver Diseasedoi.org/10.1016/j.dld.2016.09.001
  1. Garattini, S., Jakobsen, J. C., Wetterslev, J., Bertele, V., Banzi, R., Rath, A., Neugebauer, E. A., Laville, M., Masson, Y., Hivert, V., Eikermann, M., Aydin, B., Ngwabyt, S., Martinho, C., Gerardi, C., Szmigielski, C. A., Demotes-Mainard, J. and Gluud, C. (2016) Evidence-based clinical practice: Overview of threats to the validity of evidence and how to minimise them European Journal of Internal Medicine 32 13-21
  1. Gastebois, C., Villars, C., Drai, J., Canet-Soulas, E., Blanc, S., Bergouignan, A., Lefai, E. and Simon, C. (2016) Effects of training and detraining on adiponectin plasma concentration and muscle sensitivity in lean and overweight men European Journal of Applied Physiology 116 2135-2144
  1. Geloen, A. and Quintin, L. (2016) Reverse Physiology, i.e., Cellular Versus Integrative Versus Comparative Physiology? alpha-2 Agonists and Septic Shock Critical Care Medicine 44 e238-9
  1. Hachem, M., Geloen, A., Van, A. L., Foumaux, B., Fenart, L., Gosselet, F., Da Silva, P., Breton, G., Lagarde, M., Picq, M. and Bernoud-Hubac, N. (2016) Efficient Docosahexaenoic Acid Uptake by the Brain from a Structured Phospholipid Molecular Neurobiology 53 3205-15
  1. Hage, V., Pelletier, S. and Fouque, D. (2016) No apparent link between serum Klotho and phosphate in human chronic kidney disease Kidney International 89 1399-400
  1. Hannedouche, T., Roth, H., Krummel, T., London, G. M., Jean, G., Bouchet, J. L., Drueke, T. B. and Fouque, D. (2016) Multiphasic effects of blood pressure on survival in hemodialysis patients Kidney International 90 674-84
  1. Jalabert, A., Vial, G., Guay, C., Wiklander, O. P., Nordin, J. Z., Aswad, H., Forterre, A., Meugnier, E., Pesenti, S., Regazzi, R., Danty-Berger, E., Ducreux, S., Vidal, H., El-Andaloussi, S., Rieusset, J. and Rome, S. (2016) Exosome-like vesicles released from lipid-induced insulin-resistant muscles modulate gene expression and proliferation of beta recipient cells in mice Diabetologia 59 1049-58
  1. Junien, C., Panchenko, P., Fneich, S., Pirola, L., Chriett, S., Amarger, V., Kaeffer, B., Parnet, P., Torrisani, J., Bolanos Jimenez, F., Jammes, H. and Gabory, A. (2016) Epigenetics in transgenerational responses to environmental impacts : from facts and gaps Médecine Sciences 32 35-44
  1. Junien, C., Panchenko, P., Pirola, L., Amarger, V., Kaeffer, B., Parnet, P., Torrisani, J., Bolanos Jimenez, F., Jammes, H. and Gabory, A. (2016) The new paradigm of the developmental origin of health and diseases (DOHaD) – Epigenetics and environment: evidence and missing links Médecine Sciences 32 27-34
  1. Kervella, D., Lemoine, S., Sens, F., Dubourg, L., Sebbag, L., Guebre-Egziabher, F., Bonnefoy, E. and Juillard, L. (2016) Cystatin C Versus Creatinine for GFR Estimation in CKD Due to Heart Failure American Journal of Kidney Diseases doi: 10.1053/j.ajkd.2016.09.016
  1. Laforest, S., Michaud, A., Paris, G., Pelletier, M., Vidal, H., Geloen, A. and Tchernof, A. (2016) Comparative analysis of three human adipocyte size measurement methods and their relevance for cardiometabolic risk Obesity (Silver Spring) doi: 10.1002/oby.21697
  1. Le Magueresse-Battistoni, B., Vidal, H. and Naville, D. (2016) Impact of in utero exposure to pollutants on metabolic health in adults Médecine Sciences 32 51-6
  1. Lecomte, M., Couedelo, L., Meugnier, E., Plaisancie, P., Letisse, M., Benoit, B., Gabert, L., Penhoat, A., Durand, A., Pineau, G., Joffre, F., Geloen, A., Vaysse, C., Laugerette, F. and Michalski, M. C. (2016) Dietary emulsifiers from milk and soybean differently impact adiposity and inflammation in association with modulation of colonic goblet cells in high-fat fed mice Molecular Nutrition & Food Research 60 609-20
  1. Le Saux O, Falandry C, Gan HK, You B, Freyer G, Péron J. Inclusion of elderly patients in oncology clinical trials. Ann Oncol. 2016 Sep;27(9):1799-804
  1. Liminet, C., Vouillarmet, J., Chikh, K. and Disse, E. (2016) Antibody-Mediated Insulin Resistance: When Insulin and Insulin Receptor Act as Autoantigens in Humans Canadian Journal of Diabetes 40 462-465
  1. Lips, L., de Roij van Zuijdewijn, C. L., Ter Wee, P. M., Bots, M. L., Blankestijn, P. J., van den Dorpel, M. A., Fouque, D., de Jongh, R., Pelletier, S., Vervloet, M. G., Nube, M. J. and Grooteman, M. P. (2016) Serum sclerostin: relation with mortality and impact of hemodiafiltration Nephrology Dialysis Transplantation doi:10.1093/ndt/gfw246
  1. Makino, A., Hullin-Matsuda, F., Murate, M., Abe, M., Tomishige, N., Fukuda, M., Yamashita, S., Fujimoto, T., Vidal, H., Lagarde, M., Delton, I. and Kobayashi, T. (2016) Acute accumulation of free cholesterol induces the degradation of perilipin 2 and Rab18-dependent fusion of ER and lipid droplets in cultured human hepatocytes Molecular Biology of the Cell 27 3293-3304
  1. Marinho, S. M., Mafra, D., Pelletier, S., Hage, V., Teuma, C., Laville, M., Carraro Eduardo, J. C. and Fouque, D. (2016) In Hemodialysis Patients, Intradialytic Resistance Exercise Improves Osteoblast Function: A Pilot Study Journal of Renal Nutrition 26 341-5
  1. Martinez-Martinez, E., Calvier, L., Rossignol, P., Rousseau, E., Fernandez-Celis, A., Jurado-Lopez, R., Laville, M., Cachofeiro, V. and Lopez-Andres, N. (2016) Galectin-3 inhibition prevents adipose tissue remodelling in obesity International Journal of Obesity 40 1034-8
  1. Mastino, D., Robert, M., Betry, C., Laville, M., Gouillat, C. and Disse, E. (2016) Bariatric Surgery Outcomes in Sarcopenic Obesity Obesity Surgery 26 2355-62
  1. Mensah K, Maire A, Oppert JM, Dugas J, Charreire H, Weber C, Simon C, Nazare JA; ACTI-Cités consortium.. Assessment of sedentary behaviors and transport-related activities by questionnaire: a validation study. BMC Public Health. 2016 Aug 9;16:753.
  1. Merle, E., Roth, H., London, G. M., Jean, G., Hannedouche, T., Bouchet, J. L., Drueke, T., Fouque, D., Daugas, E., French, C. and Phosphate, O. (2016) Low parathyroid hormone status induced by high dialysate calcium is an independent risk factor for cardiovascular death in hemodialysis patients Kidney International 89 666-74
  1. Michaud, A., Laforest, S., Pelletier, M., Nadeau, M., Simard, S., Daris, M., Leboeuf, M., Vidal, H., Geloen, A. and Tchernof, A. (2016) Abdominal adipocyte populations in women with visceral obesity Euroean Journal of Endocrinology 174 227-39
  1. Mirabel-Chambaud, E., N’Guyen, M., Valdeyron, M. L., Quessada, T., Goudable, J., Loras-Duclaux, I., Marotte, S., Heissat, S., Restier, L., Lachaux, A. and Peretti, N. (2016) Dramatic increase of central venous catheter-related infections associated with a high turnover of the nursing team Clinical Nutrition 35 446-52
  1. Nataf S. Clonal selection versus clonal cooperation: the integrated perception of immune objects. F1000Res. 2016 Sep 5;5:2226.
  1. O’Donoghue, G., Perchoux, C., Mensah, K., Lakerveld, J., van der Ploeg, H., Bernaards, C., Chastin, S. F., Simon, C., O’Gorman, D., Nazare, J. A. and consortium, D. (2016) A systematic review of correlates of sedentary behaviour in adults aged 18-65 years: a socio-ecological approach BMC Public Health 16 163
  1. Papastathi, C., Disse, E., Berthiller, J., Laville, M., Gouillat, C. and Robert, M. (2016) Impact of Pregnancy on Weight Loss and Quality of Life Following Gastric Banding Obesity Surgery 26 1843-50
  1. Pasian, C., Azar, R. and Fouque, D. (2016) [Wasting in chronic kidney disease: Refeeding techniques and artificial nutrition practices] Néphrologie & Thérapeutique 12 496-502
  1. Pelascini, E., Disse, E., Pasquer, A., Poncet, G., Gouillat, C. and Robert, M. (2016) Should we wait for metabolic complications before operating on obese patients? Gastric bypass outcomes in metabolically healthy obese individuals Surgery for Obesity and Related Diseases 12 49-56
  1. Pelletier, S., Roth, H., Bouchet, J. L., Drueke, T. B., Hannedouche, T., Jean, G., London, G. and Fouque, D. (2016) Changes in mineral and bone disorder management in a French cohort of hemodialysis patients between 2008 and 2012: The National Bone and Mineral Metabolism observatory (Photo-Graphe 2 and 3) Néphrologie & Thérapeutique 12 171-7
  1. Pippias, M., Jager, K. J., Kramer, A., Leivestad, T., Sanchez, M. B., Caskey, F. J., Collart, F., Couchoud, C., Dekker, F. W., Finne, P., Fouque, D., Heaf, J. G., Hemmelder, M. H., Kramar, R., De Meester, J., Noordzij, M., Palsson, R., Pascual, J., Zurriaga, O., Wanner, C. and Stel, V. S. (2016) The changing trends and outcomes in renal replacement therapy: data from the ERA-EDTA Registry Nephrology Dialysis Transplantation 31 831-41
  1. Rieusset, J., Fauconnier, J., Paillard, M., Belaidi, E., Tubbs, E., Chauvin, M. A., Durand, A., Bravard, A., Teixeira, G., Bartosch, B., Michelet, M., Theurey, P., Vial, G., Demion, M., Blond, E., Zoulim, F., Gomez, L., Vidal, H., Lacampagne, A. and Ovize, M. (2016) Disruption of calcium transfer from ER to mitochondria links alterations of mitochondria-associated ER membrane integrity to hepatic insulin resistance Diabetologia 59 614-23
  1. Robert, M., Pasquer, A., Pelascini, E., Valette, P. J., Gouillat, C. and Disse, E. (2016) Impact of sleeve gastrectomy volumes on weight loss results: a prospective study Surgery for Obesity Related Diseases 12 1286-1291
  1. Rodrigues MJ, Zapardiel I, Frélaut M, Brain E, Falandry C. A call for specific geriatric data on cervical cancers. Future Oncol. 2016 May;12(9):1101-4.
  1. Saldanha, J. F., Yi, D., Stockler-Pinto, M. B., Soula, H. A., Chambert, S., Fouque, D., Mafra, D. and Soulage, C. O. (2016) Determination of the binding properties of the uremic toxin phenylacetic acid to human serum albumin Biochimie 125 53-8
  1. Schwarzer, M., Makki, K., Storelli, G., Machuca-Gayet, I., Srutkova, D., Hermanova, P., Martino, M. E., Balmand, S., Hudcovic, T., Heddi, A., Rieusset, J., Kozakova, H., Vidal, H. and Leulier, F. (2016) Lactobacillus plantarum strain maintains growth of infant mice during chronic undernutrition Science 351 854-7
  1. Seyssel, K., Allirot, X., Nazare, J. A., Roth, H., Blond, E., Charrie, A., Mialon, A., Drai, J., Laville, M. and Disse, E. (2016) Plasma acyl-ghrelin increases after meal initiation: a new insight European Journal of Clinical Nutrition 70 790-4
  1. Seyssel, K., Meugnier, E., Le, K. A., Durand, C., Disse, E., Blond, E., Pays, L., Nataf, S., Brozek, J., Vidal, H., Tappy, L. and Laville, M. (2016) Fructose overfeeding in first-degree relatives of type 2 diabetic patients impacts energy metabolism and mitochondrial functions in skeletal muscle Molecular Nutrition & Food Research 60 2691-2699
  1. Souberbielle, J. C., Deschenes, G., Fouque, D., Groussin, L., Guggenbuhl, P., Jean, G., Linglart, A. and Thomas, T. (2016) Recommendations for the measurement of blood 25-OH vitamin D Annales de Biologie Cliniques (Paris) 74 7-19
  1. Stengel, B., Combe, C., Jacquelinet, C., Briancon, S., Fouque, D., Laville, M., Frimat, L., Pascal, C., Herpe, Y. E., Morel, P., Deleuze, J. F., Schanstra, J. P., Pisoni, R. L., Robinson, B. M. and Massy, Z. A. (2016) [The French Chronic Kidney Disease-Renal Epidemiology and Information Network (CKD-REIN) cohort study: To better understand chronic kidney disease] Néphrologie & Thérapeutique 12 Suppl 1 S49-56
  1. Stockler-Pinto, M. B., Saldanha, J. F., Yi, D., Mafra, D., Fouque, D. and Soulage, C. O. (2016) The uremic toxin indoxyl sulfate exacerbates reactive oxygen species production and inflammation in 3T3-L1 adipose cells Free Radical Research 50 337-44
  1. Surowska, A., De Giorgi, S., Theytaz, F., Campos, V., Hodson, L., Stefanoni, N., Rey, V., Schneiter, P., Laville, M., Giusti, V., Gabert, L. and Tappy, L. (2016) Effects of roux-en-Y gastric bypass surgery on postprandial fructose metabolism Obesity (Silver Spring) 24 589-96
  1. Szulc, P., Amri, E. Z., Varennes, A., Panaia-Ferrari, P., Fontas, E., Goudable, J., Chapurlat, R. and Breuil, V. (2016) High serum oxytocin is associated with metabolic syndrome in older men – The MINOS study Diabetes Research and Clinical Practice 122 17-27
  1. Teuma, C., Perier-Muzet, M., Pelletier, S., Nouvier, M., Amini-Adl, M., Dijoud, F., Duru, G., Thomas, L., Fouque, D., Laville, M. and Dalle, S. (2016) New insights into renal toxicity of the B-RAF inhibitor, vemurafenib, in patients with metastatic melanoma Cancer Chemotherapy and Pharmacology 78 419-26
  1. Theurey, P., Tubbs, E., Vial, G., Jacquemetton, J., Bendridi, N., Chauvin, M. A., Alam, M. R., Le Romancer, M., Vidal, H. and Rieusset, J. (2016) Mitochondria-associated endoplasmic reticulum membranes allow adaptation of mitochondrial metabolism to glucose availability in the liver Journal of Molecular Cell Biology 8 129-43
  1. Tinquaut F, Freyer G, Chauvin F, Gane N, Pujade-Lauraine E, Falandry C. Prognostic factors for overall survival in elderly patients with advanced ovarian cancer treated with chemotherapy: Results of a pooled analysis of three GINECO phase II trials. Gynecol Oncol. 2016 Oct;143(1):22-6
  1. Vanholder, R., Fouque, D., Glorieux, G., Heine, G. H., Kanbay, M., Mallamaci, F., Massy, Z. A., Ortiz, A., Rossignol, P., Wiecek, A., Zoccali, C., London, G. M., European Renal Association European, D., Transplant Association European, R. and Cardiovascular Medicine working, g. (2016) Clinical management of the uraemic syndrome in chronic kidney disease Lancet Diabetes Endocrinology 4 360-73
  1. Vervloet, M. G., Sezer, S., Massy, Z. A., Johansson, L., Cozzolino, M. and Fouque, D. (2016) The role of phosphate in kidney disease Nature Reviews Nephrology 2017 13:27-38
  1. Viel, S., Besson, L., Charrier, E., Marcais, A., Disse, E., Bienvenu, J., Walzer, T. and Dumontet, C. (2016) Alteration of Natural Killer cell phenotype and function in obese individuals Clinical Immunology doi:10.1016/j.clim.2016.01.007
  1. Villain, C., Fouque, D., Genet, L., Jean, G., Kuentz, F., Lataillade, D., Legrand, E., Moreau-Gaudry, X. and Ecochard, R. (2016) Prognostic Value of Serum Albumin Changes Over Time in Elderly Adults Undergoing Hemodialysis Journal of the American Geriatrics Society 64 1353-4
  1. Vinoy, S., Laville, M. and Feskens, E. J. (2016) Slow-release carbohydrates: growing evidence on metabolic responses and public health interest. Summary of the symposium held at the 12th European Nutrition Conference (FENS 2015) Food Nutrition Research 60 31662
  1. Vouillarmet, J. and Laville, M. (2016) A Case of Familial Partial Lipodystrophy: From Clinical Phenotype to Genetics Canadian Journal of Diabetes 40 376-37
  1. Wojtala, M., Pirola, L. and Balcerczyk, A. (2016) Modulation of the vascular endothelium functioning by dietary components, the role of epigenetics Biofactors doi: 10.1002/biof.1306

2015

1. Bastard, J. P., Rabasa-Lhoret, R., Laville, M., and Disse, E. (2015) Surrogate measures of insulin sensitivity vs the hyperinsulinaemic-euglycaemic clamp: a meta-analysis. Are there not some surrogate indexes lost in this story? Diabetologia. 58, 414-415

2. Benoit, B., Laugerette, F., Plaisancie, P., Geloen, A., Bodennec, J., Estienne, M., Pineau, G., Bernalier-Donadille, A., Vidal, H., and Michalski, M. C. (2015) Increasing fat content from 20 to 45 wt% in a complex diet induces lower endotoxemia in parallel with an increased number of intestinal goblet cells in mice. Nutrition Research. 35, 346-356

3. Berger, E., Heraud, S., Mojallal, A., Lequeux, C., Weiss-Gayet, M., Damour, O., and Geloen, A. (2015) Pathways commonly dysregulated in mouse and human obese adipose tissue: FAT/CD36 modulates differentiation and lipogenesis. Adipocyte. 4, 161-180

4. Berger, E., Vega, N., Weiss-Gayet, M., and Geloen, A. (2015) Gene Network Analysis of Glucose Linked Signaling Pathways and Their Role in Human Hepatocellular Carcinoma Cell Growth and Survival in HuH7 and HepG2 Cell Lines. BioMed Research International. 2015, 821761

5. Betry, C., Challan-Belval, M. A., Bernard, A., Charrie, A., Drai, J., Laville, M., Thivolet, C., and Disse, E. (2015) Increased TSH in obesity: Evidence for a BMI-independent association with leptin. Diabetes & Metabolism. 41, 248-251

6. Blond, E., Goudable, J., and Laville, M. (2015) Nonalcoholic Fatty liver disease and hyperuricemia: a close relation with hepatic insulin resistance after nicotinic Acid treatment? Hormone and Metabolic Research. 47, 546-547

7. Boschetti, G., Garnero, P., Moussata, D., Cuerq, C., Preaudat, C., Duclaux-Loras, R., Mialon, A., Drai, J., Flourie, B., and Nancey, S. (2015) Accuracies of serum and fecal S100 proteins (calprotectin and calgranulin C) to predict the response to TNF antagonists in patients with Crohn’s disease. Inflammatory Bowel Diseases. 21, 331-336

8. Boschetti, G., Laidet, M., Moussata, D., Stefanescu, C., Roblin, X., Phelip, G., Cotte, E., Passot, G., Francois, Y., Drai, J., Del Tedesco, E., Bouhnik, Y., Flourie, B., and Nancey, S. (2015) Levels of Fecal Calprotectin Are Associated With the Severity of Postoperative Endoscopic Recurrence in Asymptomatic Patients With Crohn’s Disease. The American Journal of Gastroenterology. 110, 865-872

9. Capel, F., Acquaviva, C., Pitois, E., Laillet, B., Rigaudiere, J. P., Jouve, C., Pouyet, C., Gladine, C., Comte, B., Vianey Saban, C., and Morio, B. (2015) DHA at nutritional doses restores insulin sensitivity in skeletal muscle by preventing lipotoxicity and inflammation. The Journal of Nutritional Biochemistry. 26, 949-959

10. Chevalier, N., Brucker-Davis, F., Lahlou, N., Coquillard, P., Pugeat, M., Pacini, P., Panaia-Ferrari, P., Wagner-Mahler, K., and Fenichel, P. (2015) A negative correlation between insulin-like peptide 3 and bisphenol A in human cord blood suggests an effect of endocrine disruptors on testicular descent during fetal development. Human Reproduction. 30, 447-453

11. Chriett, S., and Pirola, L. (2015) Essential roles of four-carbon backbone chemicals in the control of metabolism. World Journal of Biological Chemistry. 6, 223-230

12. Croze, M. L., Geloen, A., and Soulage, C. O. (2015) Abnormalities in myo-inositol metabolism associated with type 2 diabetes in mice fed a high-fat diet: benefits of a dietary myo-inositol supplementation. The British Journal of Nutrition. 113, 1862-1875

13. Cuerq, C., Peretti, N., Chikh, K., Mialon, A., Guillaumont, M., Drai, J., and Blond, E. (2015) Overview of the in vitro stability of commonly measured vitamins and carotenoids in whole blood. Annals of Clinical Biochemistry. 52, 259-269

14. Eljaafari, A., Robert, M., Chehimi, M., Chanon, S., Durand, C., Vial, G., Bendridi, N., Madec, A. M., Disse, E., Laville, M., Rieusset, J., Lefai, E., Vidal, H., and Pirola, L. (2015) Adipose Tissue-Derived Stem Cells From Obese Subjects Contribute to Inflammation and Reduced Insulin Response in Adipocytes Through Differential Regulation of the Th1/Th17 Balance and Monocyte Activation. Diabetes. 64, 2477-2488

15. Hachem, M., Geloen, A., Van, A. L., Foumaux, B., Fenart, L., Gosselet, F., Da Silva, P., Breton, G., Lagarde, M., Picq, M., and Bernoud-Hubac, N. (2015) Efficient Docosahexaenoic Acid Uptake by the Brain from a Structured Phospholipid. Molecular neurobiology.

16. Heinrich-Balard, L., Zeinyeh, W., Dechaud, H., Rivory, P., Roux, A., Pugeat, M., and Cohen, R. (2015) Inverse relationship between hSHBG affinity for testosterone and hSHBG concentration revealed by surface plasmon resonance. Molecular and cellular endocrinology. 399, 201-207

17. Honnorat, D., Disse, E., Millot, L., Mathiotte, E., Claret, M., Charrie, A., Drai, J., Garnier, L., Maurice, C., Durand, E., Simon, C., Dupuis, O., and Thivolet, C. (2015) Are third-trimester adipokines associated with higher metabolic risk among women with gestational diabetes? Diabetes & Metabolism. 41, 393-400

18. Huvenne, H., Le Beyec, J., Pepin, D., Alili, R., Kherchiche, P. P., Jeannic, E., Frelut, M. L., Lacorte, J. M., Nicolino, M., Viard, A., Laville, M., Ledoux, S., Tounian, P., Poitou, C., Dubern, B., and Clement, K. (2015) Seven novel deleterious LEPR mutations found in early-onset obesity: a DeltaExon6-8 shared by subjects from Reunion Island, France, suggests a founder effect. The Journal of Clinical Endocrinology and Metabolism. 100, E757-766

19. Koppe, L., Mafra, D., and Fouque, D. (2015) Probiotics and chronic kidney disease. Kidney international. 88, 958-966

20. Le Guen, M., Chate, V., Hininger-Favier, I., Laillet, B., Morio, B., Pieroni, G., Schlattner, U., Pison, C., and Dubouchaud, H. (2016) A 9-wk docosahexaenoic acid-enriched supplementation improves endurance exercise capacity and skeletal muscle mitochondrial function in adult rats. Am J Physiol Endocrinol Metab. 310, E213-224

21. Lecomte, M., Couedelo, L., Meugnier, E., Plaisancie, P., Letisse, M., Benoit, B., Gabert, L., Penhoat, A., Durand, A., Pineau, G., Joffre, F., Geloen, A., Vaysse, C., Laugerette, F., and Michalski, M. C. (2016) Dietary emulsifiers from milk and soybean differently impact adiposity and inflammation in association with modulation of colonic goblet cells in high-fat fed mice. Molecular nutrition & food research. 60, 609-620

22. Mafra, D., and Fouque, D. (2015) Gut microbiota and inflammation in chronic kidney disease patients. Clin Kidney J. 8, 332-334

23. Millon, A., Sigovan, M., Boussel, L., Mathevet, J. L., Louzier, V., Paquet, C., Geloen, A., Provost, N., Majd, Z., Patsouris, D., Serusclat, A., and Canet-Soulas, E. (2015) Low WSS Induces Intimal Thickening, while Large WSS Variation and Inflammation Induce Medial Thinning, in an Animal Model of Atherosclerosis. PLoS One. 10, e0141880

24. Naville, D., Labaronne, E., Vega, N., Pinteur, C., Canet-Soulas, E., Vidal, H., and Le Magueresse-Battistoni, B. (2015) Metabolic outcome of female mice exposed to a mixture of low-dose pollutants in a diet-induced obesity model. PLoS One. 10, e0124015

25. Papastathi, C., Disse, E., Berthiller, J., Laville, M., Gouillat, C., and Robert, M. (2015) Impact of Pregnancy on Weight Loss and Quality of Life Following Gastric Banding. Obesity surgery.
26. Perez, E. C., Elie, J. E., Boucaud, I. C., Crouchet, T., Soulage, C. O., Soula, H. A., Theunissen, F. E., and Vignal, C. (2015) Physiological resonance between mates through calls as possible evidence of empathic processes in songbirds. Hormones and Behavior. 75, 130-141

27. Perrin, L., Loizides-Mangold, U., Skarupelova, S., Pulimeno, P., Chanon, S., Robert, M., Bouzakri, K., Modoux, C., Roux-Lombard, P., Vidal, H., Lefai, E., and Dibner, C. (2015) Human skeletal myotubes display a cell-autonomous circadian clock implicated in basal myokine secretion. Molecular metabolism. 4, 834-845

28. Revel, F., Gilbert, T., Roche, S., Drai, J., Blond, E., Ecochard, R., and Bonnefoy, M. (2015) Influence of oxidative stress biomarkers on cognitive decline. Journal of Alzheimer’s disease. 45, 553-560

29. Rieusset, J., Fauconnier, J., Paillard, M., Belaidi, E., Tubbs, E., Chauvin, M. A., Durand, A., Bravard, A., Teixeira, G., Bartosch, B., Michelet, M., Theurey, P., Vial, G., Demion, M., Blond, E., Zoulim, F., Gomez, L., Vidal, H., Lacampagne, A., and Ovize, M. (2016) Disruption of calcium transfer from ER to mitochondria links alterations of mitochondria-associated ER membrane integrity to hepatic insulin resistance. Diabetologia. 59, 614-623

30. Robert, M., Pechoux, A., Marion, D., Laville, M., Gouillat, C., and Disse, E. (2015) Relevance of Roux-en-Y gastric bypass volumetry using 3-dimensional gastric computed tomography with gas to predict weight loss at 1 year. Surgery for obesity and related diseases. 11, 26-31

31. Rossignol, P., Massy, Z. A., Azizi, M., Bakris, G., Ritz, E., Covic, A., Goldsmith, D., Heine, G. H., Jager, K. J., Kanbay, M., Mallamaci, F., Ortiz, A., Vanholder, R., Wiecek, A., Zoccali, C., London, G. M., Stengel, B., Fouque, D., group, Era-Edta Eureca- m working, Red de Investigacion Renal, network, Cardiovascular, and Renal Clinical Trialists, network (2015) The double challenge of resistant hypertension and chronic kidney disease. Lancet. 386, 1588-1598

32. Salvatore, G., Bernoud-Hubac, N., Bissay, N., Debard, C., Daira, P., Meugnier, E., Proamer, F., Hanau, D., Vidal, H., Arico, M., Delprat, C., and Mahtouk, K. (2015) Human monocyte-derived dendritic cells turn into foamy dendritic cells with IL-17A. Journal of lipid research. 56, 1110-1122

33. Soula, H. A., Geloen, A., and Soulage, C. O. (2015) Model of adipose tissue cellularity dynamics during food restriction. Journal of theoretical biology. 364, 189-196

34. Steiber, A. L., Leon, J. B., Hand, R. K., Murphy, W. J., Fouque, D., Parrott, J. S., Kalantar-Zadeh, K., and Cuppari, L. (2015) Using a web-based nutrition algorithm in hemodialysis patients. Journal of renal nutrition. 25, 6-16

35. Vella, R. E., Pillon, N. J., Zarrouki, B., Croze, M. L., Koppe, L., Guichardant, M., Pesenti, S., Chauvin, M. A., Rieusset, J., Geloen, A., and Soulage, C. O. (2015) Ozone exposure triggers insulin resistance through muscle c-Jun N-terminal kinase activation. Diabetes. 64, 1011-1024

36. Vericel, E., Colas, R., Calzada, C., Le, Q. H., Feugier, N., Cugnet, C., Vidal, H., Laville, M., Moulin, P., and Lagarde, M. (2015) Moderate oral supplementation with docosahexaenoic acid improves platelet function and oxidative stress in type 2 diabetic patients. Thrombosis and haemostasis. 114, 289-296

37. Vial, G., Chauvin, M. A., Bendridi, N., Durand, A., Meugnier, E., Madec, A. M., Bernoud-Hubac, N., Pais de Barros, J. P., Fontaine, E., Acquaviva, C., Hallakou-Bozec, S., Bolze, S., Vidal, H., and Rieusset, J. (2015) Imeglimin normalizes glucose tolerance and insulin sensitivity and improves mitochondrial function in liver of a high-fat, high-sucrose diet mice model. Diabetes. 64, 2254-2264

38. Villain, C., Ecochard, R., Genet, L., Jean, G., Kuentz, F., Lataillade, D., Legrand, E., Moreau-Gaudry, X., and Fouque, D. (2015) Impact of BMI Variations on Survival in Elderly Hemodialysis Patients. Journal of renal nutrition. 25, 488-493

39. Vogelzang, J. L., van Stralen, K. J., Noordzij, M., Diez, J. A., Carrero, J. J., Couchoud, C., Dekker, F. W., Finne, P., Fouque, D., Heaf, J. G., Hoitsma, A., Leivestad, T., de Meester, J., Metcalfe, W., Palsson, R., Postorino, M., Ravani, P., Vanholder, R., Wallner, M., Wanner, C., Groothoff, J. W., and Jager, K. J. (2015) Mortality from infections and malignancies in patients treated with renal replacement therapy: data from the ERA-EDTA registry. Nephrology, dialysis, transplantation. 30, 1028-1037

40. Vors, C., Drai, J., Gabert, L., Pineau, G., Laville, M., Vidal, H., Guichard, E., Michalski, M. C., and Feron, G. (2015) Salivary composition in obese vs normal-weight subjects: towards a role in postprandial lipid metabolism? International Journal of Obesity. 39, 1425-1428

41. Vors, C., Pineau, G., Drai, J., Meugnier, E., Pesenti, S., Laville, M., Laugerette, F., Malpuech-Brugere, C., Vidal, H., and Michalski, M. C. (2015) Postprandial Endotoxemia Linked With Chylomicrons and Lipopolysaccharides Handling in Obese Versus Lean Men: A Lipid Dose-Effect Trial. The Journal of Clinical Endocrinology and Metabolism. 100, 3427-3435

2014

1. Allirot, X., Seyssel, K., Saulais, L., Roth, H., Charrie, A., Drai, J., Goudable, J., Blond, E., Disse, E., and Laville, M. (2014) Effects of a breakfast spread out over time on the food intake at lunch and the hormonal responses in obese men. Physiology & behavior. 127, 37-44

2. Bacchetta, J., Pelletier, S., Jean, G., and Fouque, D. (2014) Immune, metabolic and epidemiological aspects of vitamin D in chronic kidney disease and transplant patients. Clinical biochemistry.

3. Benoit, B., Plaisancie, P., Geloen, A., Estienne, M., Debard, C., Meugnier, E., Loizon, E., Daira, P., Bodennec, J., Cousin, O., Vidal, H., Laugerette, F., and Michalski, M. C. (2014) Pasture v. standard dairy cream in high-fat diet-fed mice: improved metabolic outcomes and stronger intestinal barrier. The British journal of nutrition. 1-16

4. Bessa, B., de Oliveira Leal, V., Moraes, C., Barboza, J., Fouque, D., and Mafra, D. (2014) Resistance Training in Hemodialysis Patients: A Review. Rehabilitation nursing : the official journal of the Association of Rehabilitation Nurses.

5. Blanc, S., Ruggiero, F., Birot, A. M., Acloque, H., Decimo, D., Lerat, E., Ohlmann, T., Samarut, J., and Mey, A. (2014) Subcellular localization of ENS-1/ERNI in chick embryonic stem cells. PloS one. 9, e92039

6. Blond, E., Rieusset, J., Alligier, M., Lambert-Porcheron, S., Bendridi, N., Gabert, L., Chetiveaux, M., Debard, C., Chauvin, M. A., Normand, S., Roth, H., de Gouville, A. C., Krempf, M., Vidal, H., Goudable, J., and Laville, M. (2014) Nicotinic Acid effects on insulin sensitivity and hepatic lipid metabolism: an in vivo to in vitro study. Hormone and metabolic research. 46, 390-396

7. Boirie, Y., Morio, B., Caumon, E., and Cano, N. J. (2014) Nutrition and protein energy homeostasis in elderly. Mechanisms of ageing and development. 136-137, 76-84

8. Borges, N., Moraes, C., Barros, A. F., Carraro-Eduardo, J. C., Fouque, D., and Mafra, D. (2014) Acyl-ghrelin and obestatin plasma levels in different stages of chronic kidney disease. Journal of renal nutrition. 24, 100-104

9. Bravard, A., Vial, G., Chauvin, M. A., Rouille, Y., Bailleul, B., Vidal, H., and Rieusset, J. (2014) FTO contributes to hepatic metabolism regulation through regulation of leptin action and STAT3 signalling in liver. Cell communication and signaling : CCS. 12, 4

10. Conway, G. S., Dewailly, D., Diamanti-Kandarakis, E., Escobar Morreale, H., Franks, S., Gambineri, A., Kelestimur, F., Macut, D., Micic, D., Pasquali, R., Pfeifer, M., Pignatelli, D., Pugeat, M., and Yildiz, B. (2014) The Polycystic Ovary Syndrome: an Endocrinological Perspective from the European Society of Endocrinology. European journal of endocrinology / European Federation of Endocrine Societies.

11. Disse, E., Pasquer, A., Espalieu, P., Poncet, G., Gouillat, C., and Robert, M. (2014) Greater Weight Loss with the Omega Loop Bypass Compared to the Roux-en-Y Gastric Bypass: a Comparative Study. Obesity surgery.

12. Eyenga, P., Roussel, D., Morel, J., Rey, B., Romestaing, C., Teulier, L., Sheu, S. S., Goudable, J., Negrier, C., and Viale, J. P. (2014) Early septic shock induces loss of oxidative phosphorylation yield plasticity in liver mitochondria. Journal of physiology and biochemistry. 70, 285-296

13. Fluck, R. J., Fouque, D., and Lockridge, R. S., Jr. (2014) Nephrologists’ perspectives on dialysis treatment: results of an international survey. BMC nephrology. 15, 16

14. Fontas, M., Poulain, J. P., Souquet, P. J., Laville, M., Giboreau, A., Bensafi, M., and Mazieres, J. (2014) [Socio-anthropological perspective of the under nutrition care of cancer patients]. Bulletin du cancer. 101, 258-265

15. Forterre, A., Jalabert, A., Chikh, K., Pesenti, S., Euthine, V., Granjon, A., Errazuriz, E., Lefai, E., Vidal, H., and Rome, S. (2014) Myotube-derived exosomal miRNAs downregulate Sirtuin1 in myoblasts during muscle cell differentiation. Cell Cycle. 13, 78-89

16. Fouque, D., Cruz Casal, M., Lindley, E., Rogers, S., Pancirova, J., Kernc, J., and Copley, J. B. (2014) Dietary trends and management of hyperphosphatemia among patients with chronic kidney disease: an international survey of renal care professionals. Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation. 24, 110-115

17. Gadea, E., Thivat, E., Paulon, R., Mishellany, F., Gimbergues, P., Capel, F., Mosoni, L., Merlin, C., Lombes, M., Morio, B., and Durando, X. (2014) Hibernoma: a clinical model for exploring the role of brown adipose tissue in the regulation of body weight? The Journal of clinical endocrinology and metabolism. 99, 1-6

18. Hage, V., Pelletier, S., Dubourg, L., Drai, J., Cuerq, C., Lemoine, S., Hadj-Aissa, A., Laville, M., Fouque,… and Park, C. W. (2014) Uremic toxicity. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association – European Renal Association. 29 Suppl 3, iii19-iii20

19. Harmel, E., Grenier, E., Bendjoudi Ouadda, A., El Chebly, M., Ziv, E., Beaulieu, J. F., Sane, A., Spahis, S., Laville, M., and Levy, E. (2014) AMPK in the small intestine in normal and pathophysiological conditions. Endocrinology. 155, 873-888

20. Koppe, L., and Fouque, D. (2014) Nutrition: Intradialytic oral nutrition–the ultimate conviction. Nature reviews. Nephrology. 10, 11-12

21. Laugerette, F., Alligier, M., Bastard, J. P., Drai, J., Chanseaume, E., Lambert-Porcheron, S., Laville, M., Morio, B., Vidal, H., and Michalski, M. C. (2014) Overfeeding increases postprandial endotoxemia in men: Inflammatory outcome may depend on LPS transporters LBP and sCD14. Molecular nutrition & food research.

22. Lemoine, S., Guebre-Egziabher, F., Sens, F., Nguyen-Tu, M. S., Juillard, L., Dubourg, L., and Hadj-Aissa, A. (2014) Accuracy of GFR Estimation in Obese Patients. Clinical journal of the American Society of Nephrology : CJASN. 9, 720-727

23. Manfo, F. P., Nantia, E. A., Dechaud, H., Tchana, A. N., Zabot, M. T., Pugeat, M., and Moundipa, P. F. (2014) Protective effect of Basella alba and Carpolobia alba extracts against maneb-induced male infertility. Pharmaceutical biology. 52, 97-104

24. Mourmoura, E., Chate, V., Couturier, K., Laillet, B., Vial, G., Rigaudiere, J. P., Morio, B., Malpuech-Brugere, C., Azarnoush, K., and Demaison, L. (2014) Body adiposity dictates different mechanisms of increased coronary reactivity related to improved in vivo cardiac function. Cardiovascular diabetology. 13, 54

25. Nagler, E. V., Webster, A. C., Bolignano, D., Haller, M. C., Nistor, I., van der Veer, S. N., Fouque, D., and Van Biesen, W. (2014) European Renal Best Practice (ERBP) Guideline development methodology: towards the best possible guidelines. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association – European Renal Association. 29, 731-738

26. Pirola, L. (2014) The DCCT/EDIC study: epigenetic clues after three decades. Diabetes. 63, 1460-1462

27. Robert, M., Pasquer, A., Espalieu, P., Laville, M., Gouillat, C., and Disse, E. (2014) Gastric Bypass for Obesity in the Elderly: Is It as Appropriate as for Young and Middle-Aged Populations? Obesity surgery.

28. Sala, D., Ivanova, S., Plana, N., Ribas, V., Duran, J., Bach, D., Turkseven, S., Laville, M., Vidal, H., Karczewska-Kupczewska, M., Kowalska, I., Straczkowski, M., Testar, X., Palacin, M., Sandri, M., Serrano, A. L., and Zorzano, A. (2014) Autophagy-regulating TP53INP2 mediates muscle wasting and is repressed in diabetes. The Journal of clinical investigation. 124, 1914-1927

29. Seyssel, K., Alligier, M., Meugnier, E., Chanseaume, E., Loizon, E., Canto, C., Disse, E., Lambert-Porcheron, S., Brozek, J., Blond, E., Rieusset, J., Morio, B., Laville, M., and Vidal, H. (2014) Regulation of Energy Metabolism and Mitochondrial Function in Skeletal Muscle during Lipid Overfeeding in Healthy Men. The Journal of clinical endocrinology and metabolism. jc20134379

30. Souberbielle, J. C., Benhamou, C. L., ….Fouque, D., and Thomas, T. (2014) [HAS report on vitamin D measurement: don’t go from an extreme situation to another as extreme situation]. Presse Med. 43, 5-8

31. Soula, H., Care, B., Beslon, G., and Berry, H. (2014) Reply to the Comment by V. P. Shkilev on « Anomalous versus Slowed-Down Brownian Diffusion in the Ligand-Binding Equilibrium ». Biophysical journal. 106, 2544-2546

32. Stark, R., Guebre-Egziabher, F., Zhao, X., Feriod, C., Dong, J., Alves, T. C., Ioja, S., Pongratz, R. L., Bhanot, S., Roden, M., Cline, G. W., Shulman, G. I., and Kibbey, R. G. (2014) A role for mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) in the regulation of hepatic gluconeogenesis. The Journal of biological chemistry. 289, 7257-7263

33. Stockler-Pinto, M. B., Fouque, D., Soulage, C. O., Croze, M., and Mafra, D. (2014) Indoxyl Sulfate and p-Cresyl Sulfate in Chronic Kidney Disease. Could These Toxins Modulate the Antioxidant Nrf2-Keap1 Pathway? Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation.

34. Thivel, D., Aucouturier, J., Metz, L., Morio, B., and Duche, P. (2014) Is there spontaneous energy expenditure compensation in response to intensive exercise in obese youth? Pediatric obesity. 9, 147-154

35. Thivel, D., Duche, P., and Morio, B. (2014) Post-exercise energy load and activities may affect subsequent ad libitum energy intake. Int J Obes (Lond). 38, 750

36. Thivel, D., Metz, L., Julien, A., Morio, B., and Duche, P. (2014) Obese but not lean adolescents spontaneously decrease energy intake after intensive exercise. Physiology & behavior. 123, 41-46

37. Tubbs, E., Theurey, P., Vial, G., Bendridi, N., Bravard, A., Chauvin, M. A., Ji-Cao, J., Zoulim, F., Bartosch, B., Ovize, M., Vidal, H., and Rieusset, J. (2014) Mitochondria-Associated Endoplasmic Reticulum Membrane (MAM) Integrity Is Required for Insulin Signaling and Is Implicated in Hepatic Insulin Resistance. Diabetes.

38. Verbeke, F., Lindley, E., Van Bortel, L., Vanholder, R., London, G., Cochat, P., Wiecek, A., Fouque, D., and Van Biesen, W. (2014) A European Renal Best Practice (ERBP) position statement on the Kidney Disease: Improving Global Outcomes (KDIGO) clinical practice guideline for the management of blood pressure in non-dialysis-dependent chronic kidney disease: an endorsement with some caveats for real-life application. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association – European Renal Association. 29, 490-496

39. Zerzaihi, O., Chriett, S., Vidal, H., and Pirola, L. (2014) Insulin-dependent transcriptional control in L6 rat myotubes is associated with modulation of histone acetylation and accumulation of the histone variant H2A.Z in the proximity of the transcriptional start site. Biochemistry and cell biology = Biochimie et biologie cellulaire. 92, 61-67

2013

1. Agin, A., Charrie, A., Chikh, K., Tabarin, A., and Vezzosi, D. (2013) Fast test: clinical practice and interpretation. Annales d’endocrinologie. 74, 174-184

2. Alligier, M., Gabert, L., Meugnier, E., Lambert-Porcheron, S., Chanseaume, E., Pilleul, F., Debard, C., Sauvinet, V., Morio, B., Vidal-Puig, A., Vidal, H., and Laville, M. (2013) Visceral fat accumulation during lipid overfeeding is related to subcutaneous adipose tissue characteristics in healthy men. The Journal of clinical endocrinology and metabolism. 98, 802-810

3. Allirot, X., Saulais, L., Seyssel, K., Graeppi-Dulac, J., Roth, H., Charrie, A., Drai, J., Goudable, J., Blond, E., Disse, E., and Laville, M. (2013) An isocaloric increase of eating episodes in the morning contributes to decrease energy intake at lunch in lean men. Physiology & behavior. 110-111, 169-178

4. Almaiman, H., Serre, J. E., Abid, N., Fouque, D., and Martin, X. (2013) [A mini-invasive approach to renal autotransplantation in the management of loin pain hematuria syndrome]. Progres en urologie : journal de l’Association francaise d’urologie et de la Societe francaise d’urologie. 23, 389-393

5. Aparicio, M., Bellizzi, V., Chauveau, P., Cupisti, A., Ecder, T., Fouque, D., Garneata, L., Lin, S., Mitch, W., Teplan, V., Yu, X., and Zakar, G. (2013) Do ketoanalogues still have a role in delaying dialysis initiation in CKD predialysis patients? Seminars in dialysis. 26, 714-719

6. Awada, M., Meynier, A., Soulage, C. O., Hadji, L., Geloen, A., Viau, M., Ribourg, L., Benoit, B., Debard, C., Guichardant, M., Lagarde, M., Genot, C., and Michalski, M. C. (2013) n-3 PUFA added to high-fat diets affect differently adiposity and inflammation when carried by phospholipids or triacylglycerols in mice. Nutrition & metabolism. 10, 23

7. Baldi, S., Bonnet, F., Laville, M., Morgantini, C., Monti, L., Hojlund, K., Ferrannini, E., and Natali, A. (2013) Influence of apolipoproteins on the association between lipids and insulin sensitivity: a cross-sectional analysis of the RISC Study. Diabetes care. 36, 4125-4131

8. Batisse-Lignier, M., Rieu, I., Guillet, C., Pujos, E., Morio, B., Lemaire, J. J., Durif, F., and Boirie, Y. (2013) Deep brain stimulation of the subthalamic nucleus regulates postabsorptive glucose metabolism in patients with Parkinson’s disease. The Journal of clinical endocrinology and metabolism. 98, E1050-1054

9. Benoit, B., Plaisancie, P., Awada, M., Geloen, A., Estienne, M., Capel, F., Malpuech-Brugere, C., Debard, C., Pesenti, S., Morio, B., Vidal, H., Rieusset, J., and Michalski, M. C. (2013) High-fat diet action on adiposity, inflammation, and insulin sensitivity depends on the control low-fat diet. Nutr Res. 33, 952-960

10. Bergouignan, A., Momken, I., Lefai, E., Antoun, E., Schoeller, D. A., Platat, C., Chery, I., Zahariev, A., Vidal, H., Gabert, L., Normand, S., Freyssenet, D., Laville, M., Simon, C., and Blanc, S. (2013) Activity energy expenditure is a major determinant of dietary fat oxidation and trafficking, but the deleterious effect of detraining is more marked than the beneficial effect of training at current recommendations. The American journal of clinical nutrition. 98, 648-658

11. Bonnet, F., Roussel, R., Natali, A., Cauchi, S., Petrie, J., Laville, M., Yengo, L., Froguel, P., Lange, C., Lantieri, O., Marre, M., Balkau, B., and Ferrannini, E. (2013) Parental history of type 2 diabetes, TCF7L2 variant and lower insulin secretion are associated with incident hypertension. Data from the DESIR and RISC cohorts. Diabetologia. 56, 2414-2423

12. Bourgault, M., Grimbert, P., Verret, C., Pourrat, J., Herody, M., Halimi, J. M., Karras, A., Amoura, Z., Jourde-Chiche, N., Izzedine, H., Francois, H., Boffa, J. J., Hummel, A., Bernadet-Monrozies, P., Fouque, D., Canoui-Poitrine, F., Lang, P., Daugas, E., and Audard, V. (2013) Acute renal infarction: a case series. Clinical journal of the American Society of Nephrology : CJASN. 8, 392-398

13. Bravard, A., Veilleux, A., Disse, E., Laville, M., Vidal, H., Tchernof, A., and Rieusset, J. (2013) The expression of FTO in human adipose tissue is influenced by fat depot, adiposity, and insulin sensitivity. Obesity (Silver Spring). 21, 1165-1173

14. Calzada, C., Vericel, E., Colas, R., Guillot, N., El Khoury, G., Drai, J., Sassolas, A., Peretti, N., Ponsin, G., Lagarde, M., and Moulin, P. (2013) Inhibitory effects of in vivo oxidized high-density lipoproteins on platelet aggregation: evidence from patients with abetalipoproteinemia. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 27, 2855-2861

15. Cantley, J. L., Yoshimura, T., Camporez, J. P., Zhang, D., Jornayvaz, F. R., Kumashiro, N., Guebre-Egziabher, F., Jurczak, M. J., Kahn, M., Guigni, B. A., Serr, J., Hankin, J., Murphy, R. C., Cline, G. W., Bhanot, S., Manchem, V. P., Brown, J. M., Samuel, V. T., and Shulman, G. I. (2013) CGI-58 knockdown sequesters diacylglycerols in lipid droplets/ER-preventing diacylglycerol-mediated hepatic insulin resistance. Proceedings of the National Academy of Sciences of the United States of America. 110, 1869-1874

16. Care, B. R., and Soula, H. A. (2013) Receptor clustering affects signal transduction at the membrane level in the reaction-limited regime. Physical review. E, Statistical, nonlinear, and soft matter physics. 87, 012720

17. Cariou, B., Hanf, R., Lambert-Porcheron, S., Zair, Y., Sauvinet, V., Noel, B., Flet, L., Vidal, H., Staels, B., and Laville, M. (2013) Dual peroxisome proliferator-activated receptor alpha/delta agonist GFT505 improves hepatic and peripheral insulin sensitivity in abdominally obese subjects. Diabetes care. 36, 2923-2930

18. Carobbio, S., Hagen, R. M., Lelliott, C. J., Slawik, M., Medina-Gomez, G., Tan, C. Y., Sicard, A., Atherton, H. J., Barbarroja, N., Bjursell, M., Bohlooly, Y. M., Virtue, S., Tuthill, A., Lefai, E., Laville, M., Wu, T., Considine, R. V., Vidal, H., Langin, D., Oresic, M., Tinahones, F. J., Fernandez-Real, J. M., Griffin, J. L., Sethi, J. K., Lopez, M., and Vidal-Puig, A. (2013) Adaptive changes of the Insig1/SREBP1/SCD1 set point help adipose tissue to cope with increased storage demands of obesity. Diabetes. 62, 3697-3708

19. Chauveau, P., Combe, C., Fouque, D., and Aparicio, M. (2013) Vegetarianism: advantages and drawbacks in patients with chronic kidney diseases. Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation. 23, 399-405

20. Chauveau, P., Fouque, D., Combe, C., and Aparicio, M. (2013) [Evolution of the diet from the paleolithic to today: progress or regress?]. Nephrologie & therapeutique. 9, 202-208

21. Confavreux, C. B., Szulc, P., Casey, R., Boutroy, S., Varennes, A., Vilayphiou, N., Goudable, J., and Chapurlat, R. D. (2013) Higher serum osteocalcin is associated with lower abdominal aortic calcification progression and longer 10-year survival in elderly men of the MINOS cohort. The Journal of clinical endocrinology and metabolism. 98, 1084-1092

22. Croze, M. L., and Soulage, C. O. (2013) Potential role and therapeutic interests of myo-inositol in metabolic diseases. Biochimie. 95, 1811-1827

23. Croze, M. L., Vella, R. E., Pillon, N. J., Soula, H. A., Hadji, L., Guichardant, M., and Soulage, C. O. (2013) Chronic treatment with myo-inositol reduces white adipose tissue accretion and improves insulin sensitivity in female mice. The Journal of nutritional biochemistry. 24, 457-466

24. Disse, E., Graeppi-Dulac, J., Joncour-Mills, G., Dupuis, O., and Thivolet, C. (2013) Heterogeneity of pregnancy outcomes and risk of LGA neonates in Caucasian females according to IADPSG criteria for gestational diabetes mellitus. Diabetes & metabolism. 39, 132-138

25. Ducher, M., Kalbacher, E., Combarnous, F., Finaz de Vilaine, J., McGregor, B., Fouque, D., and Fauvel, J. P. (2013) Comparison of a Bayesian network with a logistic regression model to forecast IgA nephropathy. BioMed research international. 2013, 686150

26. Eljaafari, A., Yuruker, O., Ferrand, C., Farre, A., Addey, C., Tartelin, M. L., Thomas, X., Tiberghien, P., Simpson, E., Rigal, D., and Scott, D. (2013) Isolation of human CD4/CD8 double-positive, graft-versus-host disease-protective, minor histocompatibility antigen-specific regulatory T cells and of a novel HLA-DR7-restricted HY-specific CD4 clone. J Immunol. 190, 184-194

27. Faure, C., Morio, B., Chafey, P., Le Plenier, S., Noirez, P., Randrianarison-Huetz, V., Cynober, L., Aussel, C., and Moinard, C. (2013) Citrulline enhances myofibrillar constituents expression of skeletal muscle and induces a switch in muscle energy metabolism in malnourished aged rats. Proteomics. 13, 2191-2201

28. Forterre, A., Jalabert, A., Chikh, K., Pesenti, S., Euthine, V., Granjon, A., Errazuriz, E., Lefai, E., Vidal, H., and Rome, S. (2013) Myotube-derived exosomal miRNAs downregulate Sirtuin1 in myoblasts during muscle cell differentiation. Cell Cycle. 13

29. Fouque, D. (2013) The phosphorus-proteinuria interaction in chronic kidney disease. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association – European Renal Association. 28, 493-495

30. Fouque, D., and Guebre-Egziabher, F. (2013) To supplement or not: that is the question. Clinical journal of the American Society of Nephrology : CJASN. 8, 8-9

31. Fouque, D., Roth, H., Pelletier, S., London, G. M., Hannedouche, T., Jean, G., Bouchet, J. L., and Drueke, T. (2013) Control of mineral metabolism and bone disease in haemodialysis patients: which optimal targets? Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association – European Renal Association. 28, 360-367

32. Gadea, E., Thivat, E., Wang-Lopez, Q., Viala, M., Paulon, R., Planchat, E., Chadeyras, J. B., Merlin, C., Coudert, B., Bignon, Y. J., Morio, B., and Durando, X. (2013) [Poor prognostic value of weight change during chemotherapy in non-metastatic breast cancer patients: causes, mechanisms involved and preventive strategies]. Bulletin du cancer. 100, 865-870

33. Geloen, A., Chapelier, K., Cividjian, A., Dantony, E., Rabilloud, M., May, C. N., and Quintin, L. (2013) Clonidine and dexmedetomidine increase the pressor response to norepinephrine in experimental sepsis: a pilot study. Critical care medicine. 41, e431-438

34. Girerd, N., Scridon, A., Bessiere, F., Chauveau, S., Geloen, A., Boussel, L., Morel, E., and Chevalier, P. (2013) Periatrial epicardial fat is associated with markers of endothelial dysfunction in patients with atrial fibrillation. PloS one. 8, e77167

35. Golay, A., Brock, E., Gabriel, R., Konrad, T., Lalic, N., Laville, M., Mingrone, G., Petrie, J., Phan, T. M., Pietilainen, K. H., and Anderwald, C. H. (2013) Taking small steps towards targets – perspectives for clinical practice in diabetes, cardiometabolic disorders and beyond. International journal of clinical practice. 67, 322-332

36. Goudable, J. (2013) [SFBC objective for 2013]. Annales de biologie clinique. 71, 4

37. Goudable, J., Beaudeux, J. L., and Legrand, A. (2013) [Guidelines for Accreditation of medical laboratories – Volume 3. Editorial]. Annales de biologie clinique. 71 Spec No 1, V-VI

38. Guebre-Egziabher, F., Alix, P. M., Koppe, L., Pelletier, C. C., Kalbacher, E., Fouque, D., and Soulage, C. O. (2013) Ectopic lipid accumulation: A potential cause for metabolic disturbances and a contributor to the alteration of kidney function. Biochimie. 95, 1971-1979

39. Guebre-Egziabher, F., Debard, C., Drai, J., Denis, L., Pesenti, S., Bienvenu, J., Vidal, H., Laville, M., and Fouque, D. (2013) Differential dose effect of fish oil on inflammation and adipose tissue gene expression in chronic kidney disease patients. Nutrition. 29, 730-736

40. Haynes, V., Connor, T., Tchernof, A., Vidal, H., and Dubois, S. (2013) Metallothionein 2a gene expression is increased in subcutaneous adipose tissue of type 2 diabetic patients. Molecular genetics and metabolism. 108, 90-94

41. Hokayem, M., Blond, E., Vidal, H., Lambert, K., Meugnier, E., Feillet-Coudray, C., Coudray, C., Pesenti, S., Luyton, C., Lambert-Porcheron, S., Sauvinet, V., Fedou, C., Brun, J. F., Rieusset, J., Bisbal, C., Sultan, A., Mercier, J., Goudable, J., Dupuy, A. M., Cristol, J. P., Laville, M., and Avignon, A. (2013) Grape polyphenols prevent fructose-induced oxidative stress and insulin resistance in first-degree relatives of type 2 diabetic patients. Diabetes care. 36, 1454-1461

42. Ikizler, T. A., Cano, N. J., Franch, H., Fouque, D., Himmelfarb, J., Kalantar-Zadeh, K., Kuhlmann, M. K., Stenvinkel, P., TerWee, P., Teta, D., Wang, A. Y., and Wanner, C. (2013) Prevention and treatment of protein energy wasting in chronic kidney disease patients: a consensus statement by the International Society of Renal Nutrition and Metabolism. Kidney international. 84, 1096-1107

43. Jaafar, R., De Larichaudy, J., Chanon, S., Euthine, V., Durand, C., Naro, F., Bertolino, P., Vidal, H., Lefai, E., and Nemoz, G. (2013) Phospholipase D regulates the size of skeletal muscle cells through the activation of mTOR signaling. Cell communication and signaling : CCS. 11, 55

44. Jean, G., Lataillade, D., Genet, L., Legrand, E., Kuentz, F., Moreau-Gaudry, X., and Fouque, D. (2013) [Higher dialysate calcium is not associated with mortality in hemodialysis patients: results from the French ARNOS study]. Nephrologie & therapeutique. 9, 103-107

45. Joussain, P., Giboreau, A., Fontas, M., Laville, M., Hummel, T., Souquet, P. J., and Bensafi, M. (2013) Cisplatin chemotherapy induces odor perception changes in bronchial cancer patients. Lung Cancer. 82, 168-170

46. Koppe, L., Arkouche, W., and Fouque, D. (2013) Which optimal protein intake in maintenance dialysis patients? Journal of human nutrition and dietetics : the official journal of the British Dietetic Association. 26, 313-314

47. Koppe, L., Pelletier, C. C., Alix, P. M., Kalbacher, E., Fouque, D., Soulage, C. O., and Guebre-Egziabher, F. (2013) Insulin resistance in chronic kidney disease: new lessons from experimental models. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association – European Renal Association.

48. Koppe, L., Pillon, N. J., Vella, R. E., Croze, M. L., Pelletier, C. C., Chambert, S., Massy, Z., Glorieux, G., Vanholder, R., Dugenet, Y., Soula, H. A., Fouque, D., and Soulage, C. O. (2013) p-Cresyl sulfate promotes insulin resistance associated with CKD. Journal of the American Society of Nephrology : JASN. 24, 88-99

49. Koraichi, F., Inoubli, L., Lakhdari, N., Meunier, L., Vega, A., Mauduit, C., Benahmed, M., Prouillac, C., and Lecoeur, S. (2013) Neonatal exposure to zearalenone induces long term modulation of ABC transporter expression in testis. Toxicology. 310, 29-38

50. Kumashiro, N., Beddow, S. A., Vatner, D. F., Majumdar, S. K., Cantley, J. L., Guebre-Egziabher, F., Fat, I., Guigni, B., Jurczak, M. J., Birkenfeld, A. L., Kahn, M., Perler, B. K., Puchowicz, M. A., Manchem, V. P., Bhanot, S., Still, C. D., Gerhard, G. S., Petersen, K. F., Cline, G. W., Shulman, G. I., and Samuel, V. T. (2013) Targeting pyruvate carboxylase reduces gluconeogenesis and adiposity and improves insulin resistance. Diabetes. 62, 2183-2194

51. Kumashiro, N., Yoshimura, T., Cantley, J. L., Majumdar, S. K., Guebre-Egziabher, F., Kursawe, R., Vatner, D. F., Fat, I., Kahn, M., Erion, D. M., Zhang, X. M., Zhang, D., Manchem, V. P., Bhanot, S., Gerhard, G. S., Petersen, K. F., Cline, G. W., Samuel, V. T., and Shulman, G. I. (2013) Role of patatin-like phospholipase domain-containing 3 on lipid-induced hepatic steatosis and insulin resistance in rats. Hepatology. 57, 1763-1772

52. Lahjibi, E., Heude, B., Dekker, J. M., Hojlund, K., Laville, M., Nolan, J., Oppert, J. M., and Balkau, B. (2013) Impact of objectively measured sedentary behaviour on changes in insulin resistance and secretion over 3 years in the RISC study: interaction with weight gain. Diabetes & metabolism. 39, 217-225

53. Laville, M., Vors, C., Nazare, J. A., and Michalski, M. C. (2013) [Importance of the postprandial phase in human health]. Bulletin de l’Academie nationale de medecine. 197, 65-77; discussion 77-68

54. Le Beyec, J., Cugnet-Anceau, C., Pepin, D., Alili, R., Cotillard, A., Lacorte, J. M., Basdevant, A., Laville, M., and Clement, K. (2013) Homozygous leptin receptor mutation due to uniparental disomy of chromosome 1: response to bariatric surgery. The Journal of clinical endocrinology and metabolism. 98, E397-402

55. Lefils-Lacourtablaise, J., Socorro, M., Geloen, A., Daira, P., Debard, C., Loizon, E., Guichardant, M., Dominguez, Z., Vidal, H., Lagarde, M., and Bernoud-Hubac, N. (2013) The eicosapentaenoic acid metabolite 15-deoxy-delta(12,14)-prostaglandin J3 increases adiponectin secretion by adipocytes partly via a PPARgamma-dependent mechanism. PloS one. 8, e63997

56. Legendre, C. M., Licht, C., Muus, P., Greenbaum, L. A., Babu, S., Bedrosian, C., Bingham, C., Cohen, D. J., Delmas, Y., Douglas, K., Eitner, F., Feldkamp, T., Fouque, D., Furman, R. R., Gaber, O., Herthelius, M., Hourmant, M., Karpman, D., Lebranchu, Y., Mariat, C., Menne, J., Moulin, B., Nurnberger, J., Ogawa, M., Remuzzi, G., Richard, T., Sberro-Soussan, R., Severino, B., Sheerin, N. S., Trivelli, A., Zimmerhackl, L. B., Goodship, T., and Loirat, C. (2013) Terminal complement inhibitor eculizumab in atypical hemolytic-uremic syndrome. The New England journal of medicine. 368, 2169-2181

57. Mafra, D., Barros, A. F., and Fouque, D. (2013) Dietary protein metabolism by gut microbiota and its consequences for chronic kidney disease patients. Future microbiology. 8, 1317-1323

58. Moreno-Navarrete, J. M., Escote, X., Ortega, F., Serino, M., Campbell, M., Michalski, M. C., Laville, M., Xifra, G., Luche, E., Domingo, P., Sabater, M., Pardo, G., Waget, A., Salvador, J., Giralt, M., Rodriguez-Hermosa, J. I., Camps, M., Kolditz, C. I., Viguerie, N., Galitzky, J., Decaunes, P., Ricart, W., Fruhbeck, G., Villarroya, F., Mingrone, G., Langin, D., Zorzano, A., Vidal, H., Vendrell, J., Burcelin, R., Vidal-Puig, A., and Fernandez-Real, J. M. (2013) A role for adipocyte-derived lipopolysaccharide-binding protein in inflammation- and obesity-associated adipose tissue dysfunction. Diabetologia. 56, 2524-2537

59. Mourmoura, E., Vial, G., Laillet, B., Rigaudiere, J. P., Hininger-Favier, I., Dubouchaud, H., Morio, B., and Demaison, L. (2013) Preserved endothelium-dependent dilatation of the coronary microvasculature at the early phase of diabetes mellitus despite the increased oxidative stress and depressed cardiac mechanical function ex vivo. Cardiovascular diabetology. 12, 49

60. Nancey, S., Boschetti, G., Moussata, D., Cotte, E., Peyras, J., Cuerq, C., Haybrard, J., Charlois, A. L., Mialon, A., Chauvenet, M., Stroeymeyt, K., Kaiserlian, D., Drai, J., and Flourie, B. (2013) Neopterin is a novel reliable fecal marker as accurate as calprotectin for predicting endoscopic disease activity in patients with inflammatory bowel diseases. Inflammatory bowel diseases. 19, 1043-1052

61. Naville, D., Pinteur, C., Vega, N., Menade, Y., Vigier, M., Le Bourdais, A., Labaronne, E., Debard, C., Luquain-Costaz, C., Begeot, M., Vidal, H., and Le Magueresse-Battistoni, B. (2013) Low-dose food contaminants trigger sex-specific, hepatic metabolic changes in the progeny of obese mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 27, 3860-3870

62. Pataky, Z., Golay, A., Laville, M., Disse, E., Mitrakou, A., Guidone, C., Gabriel, R., and Bobbioni-Harsch, E. (2013) Fasting insulin at baseline influences the number of cardiometabolic risk factors and R-R interval at 3years in a healthy population: the RISC Study. Diabetes & metabolism. 39, 330-336

63. Pelletier, C. C., Koppe, L., Croze, M. L., Kalbacher, E., Vella, R. E., Guebre-Egziabher, F., Geloen, A., Badet, L., Fouque, D., and Soulage, C. O. (2013) White adipose tissue overproduces the lipid-mobilizing factor zinc alpha2-glycoprotein in chronic kidney disease. Kidney international. 83, 878-886

64. Pelletier, S., Dubourg, L., Carlier, M. C., Hadj-Aissa, A., and Fouque, D. (2013) The relation between renal function and serum sclerostin in adult patients with CKD. Clinical journal of the American Society of Nephrology : CJASN. 8, 819-823

65. Pina, G., Dubois, S., Murat, A., Berger, N., Niccoli, P., Peix, J. L., Cohen, R., Guillausseau, C., Charrie, A., Chabre, O., Cornu, C., Borson-Chazot, F., and Rohmer, V. (2013) Is basal ultrasensitive measurement of calcitonin capable of substituting for the pentagastrin-stimulation test? Clinical endocrinology. 78, 358-364

66. Robert, M., Ferrand-Gaillard, C., Disse, E., Espalieu, P., Simon, C., Laville, M., Gouillat, C., and Thivolet, C. (2013) Predictive factors of type 2 diabetes remission 1 year after bariatric surgery: impact of surgical techniques. Obesity surgery. 23, 770-775

67. Robert, M., Pelascini, E., Disse, E., Espalieu, P., Poncet, G., Laville, M., and Gouillat, C. (2013) Preoperative fat-free mass: a predictive factor of weight loss after gastric bypass. Obesity surgery. 23, 446-455

68. Rouffet, D., Villars, C., Fissoune, R., Sappey-Marinier, D., Laville, M., Ibarrola, D., Sothier, M., Monnet, M. F., Ovize, M., Bonnefoy, M., Boesch, C., and Canet-Soulas, E. (2013) Intramyocellular lipid variations in active older men: relationship with aerobic fitness. Acta Physiol (Oxf). 207, 516-523

69. Salinari, S., Debard, C., Bertuzzi, A., Durand, C., Zimmet, P., Vidal, H., and Mingrone, G. (2013) Jejunal proteins secreted by db/db mice or insulin-resistant humans impair the insulin signaling and determine insulin resistance. PloS one. 8, e56258

70. Serdiuk, T., Lysenko, V., Mognetti, B., Skryshevsky, V., and Geloen, A. (2013) Impact of cell division on intracellular uptake and nuclear targeting with fluorescent SiC-based nanoparticles. Journal of biophotonics. 6, 291-297

71. Soula, H., Care, B., Beslon, G., and Berry, H. (2013) Anomalous versus slowed-down Brownian diffusion in the ligand-binding equilibrium. Biophysical journal. 105, 2064-2073

72. Soula, H. A., Julienne, H., Soulage, C. O., and Geloen, A. (2013) Modelling adipocytes size distribution. Journal of theoretical biology. 332, 89-95

73. Soulage, C. O., Koppe, L., and Fouque, D. (2013) Protein-bound uremic toxins…new targets to prevent insulin resistance and dysmetabolism in patients with chronic kidney disease. Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation. 23, 464-466

74. Stengel, B., Combe, C., Jacquelinet, C., Briancon, S., Fouque, D., Laville, M., Frimat, L., Pascal, C., Herpe, Y. E., Deleuze, J. F., Schanstra, J., Pisoni, R. L., Robinson, B. M., and Massy, Z. A. (2013) The French Chronic Kidney Disease-Renal Epidemiology and Information Network (CKD-REIN) cohort study. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association – European Renal Association.

75. Thauvin-Robinet, C., Auclair, M., Duplomb, L., Caron-Debarle, M., Avila, M., St-Onge, J., Le Merrer, M., Le Luyer, B., Heron, D., Mathieu-Dramard, M., Bitoun, P., Petit, J. M., Odent, S., Amiel, J., Picot, D., Carmignac, V., Thevenon, J., Callier, P., Laville, M., Reznik, Y., Fagour, C., Nunes, M. L., Capeau, J., Lascols, O., Huet, F., Faivre, L., Vigouroux, C., and Riviere, J. B. (2013) PIK3R1 Mutations Cause Syndromic Insulin Resistance with Lipoatrophy. American journal of human genetics (In press).

76. Thivel, D., Brakonieki, K., Duche, P., Morio, B., Boirie, Y., and Laferrere, B. (2013) Surgical weight loss: impact on energy expenditure. Obesity surgery. 23, 255-266

77. Thivel, D., Duche, P., and Morio, B. (2013) Energy balance in youth: an ‘inter-dynamic’ concept? The British journal of nutrition. 109, 581-582

78. Thivel, D., Metz, L., Aucouturier, J., Brakoniecki, K., Duche, P., and Morio, B. (2013) The effects of imposed sedentary behavior and exercise on energy intake in adolescents with obesity. Journal of developmental and behavioral pediatrics : JDBP. 34, 616-622

79. Tian, S., Mioche, L., Denis, J. B., and Morio, B. (2013) A multivariate model for predicting segmental body composition. The British journal of nutrition. 110, 2260-2270

80. Van Biesen, W., van der Veer, S. N., Jager, K. J., Fouque, D., Wanner, C., and Vanholder, R. (2013) What guidelines should or should not be: implications for guideline production. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association – European Renal Association. 28, 1980-1984

81. Vinoy, S., Normand, S., Meynier, A., Sothier, M., Louche-Pelissier, C., Peyrat, J., Maitrepierre, C., Nazare, J. A., Brand-Miller, J., and Laville, M. (2013) Cereal processing influences postprandial glucose metabolism as well as the GI effect. Journal of the American College of Nutrition. 32, 79-91

82. Vors, C., Pineau, G., Gabert, L., Drai, J., Louche-Pelissier, C., Defoort, C., Lairon, D., Desage, M., Danthine, S., Lambert-Porcheron, S., Vidal, H., Laville, M., and Michalski, M. C. (2013) Modulating absorption and postprandial handling of dietary fatty acids by structuring fat in the meal: a randomized crossover clinical trial. The American journal of clinical nutrition. 97, 23-36

83. Zitt, E., Fouque, D., Jacobson, S. H., Malberti, F., Ryba, M., Urena, P., Rix, M., Dehmel, B., Manamley, N., and Vervloet, M. (2013) Serum phosphorus reduction in dialysis patients treated with cinacalcet for secondary hyperparathyroidism results mainly from parathyroid hormone reduction. Clinical kidney journal. 6, 287-294