Equipe 2 : “Régulation of Muscle Mass and Metabolic Disorders”
CarMeN’ Team 2 gathers scientists and clinicians to work on the regulation of muscle mass and muscle homeostasis in relation to energetic disorders and metabolic diseases, such as obesity and diabetes. We are working on the hypothesis that muscle tissue response to environmental and lifestyle changes (e.g. sedentary behavior, physical activity and nutrition) impacts health status (obesity, insulin resistance, type 2 diabetes as well other factors involved in the development of cardiovascular risk).
Our research strategies focus on:
- Identification of the events sequence and the signals that link sedentary behavior with muscle dysfunction and affect health, using a top-down approach from whole-body level to molecular pathways (real-life phenotyping, novel imaging methodologies, stable isotope metabolic measurement, micro-biopsies for tissue investigations, genomic and histology analyses) –
Principal Investigator: Chantal SIMON (PU-PH)
- Characterization of the role of extracellular vesicles released from skeletal muscle in inter-organ cross talks and in muscle physiology (exosomes, exosomal miRNAs, and use of circulating miRNAs as biomarkers of whole-body homeostasis)-
Principal Investigator: Sophie ROME (DR INRA)
Ongoing Research projects
- In vivo modulation of sedentary behavior and physical activity to study muscle homeostasis and metabolic health outcomes (PI: Chantal SIMON)
Several exploratory and interventional research studies are already developed or will be programmed, both in humans and in animal models, to investigate the role of skeletal muscle tissue in the energetic and metabolic adaptation to physical inactivity and sedentary behavior.
These programs benefit from all the expertise and facilities that have been developed by/or in collaboration with our team (real-life phenotyping, novel imaging methodologies, stable isotope metabolic measurement, micro-biopsies for tissue investigations, genomic and histology facilities), which allow to investigate the consequences of physical activity and sedentariness modulation from whole-body level to cell biology.
1.a) Projects in humans
In human we use two main approaches to study energetic and metabolic adaptations to physical inactivity, and to test different counter-measures (physical activity protocols or nutritional): 1) free-living observational and interventional studies in various groups of normal subjects with contrasted fat mass phenotypes or in patients (e.g. obese, insulin-resistant and diabetic patients); 2) extreme conditions, e.g. terrestrial models of physiological changes in human spaceflights such as prolonged (up to 3 months) bed-rest studies with a six-degree head-down tilt to simulate weightless.
Exercise training improves fat metabolism in sedentary overweight men, but does not restore lean metabolic phenotype. In the LIPOX study, we showed that 2 months of exercise training at 50% VO2peak (according to current guidelines) improved aerobic fitness, insulin sensitivity and fat oxidation (measured by [d31]palmitate and [1-(13)C]oleate mixed in standard meals). This latter was explained by a coordinated response at the muscle level enhancing fat uptake, acylation and oxidation rather than by changes in dietary fat trafficking. However, the training did not restore the lean metabolic phenotype in overweight adults, likely due to a spontaneous reduction in non-training activity related energy expenditure (accelerometry and doubly labeled water) that partially compensated the training effects. These data support the crucial role of all the physical activity components, including those of low intensity, for fat and energetic balance (E.Lefai et al, Int. J. Obes. 2017).
A nutrient cocktail as an antidote to sedentary behavior. In the COCKTAIL study, we examined the capacity of a nutrient cocktail with anti-inflammatory and anti-oxidant properties to prevent the expected metabolic alterations of induced physical inactivity and sedentary behaviour. Healthy trained men were randomly divided into a control group (no supplementation) and a cocktail group for a 20-day free-living intervention during which they stopped exercise, decreased their daily steps and were submitted to a 10-day fructose overfeeding. We showed that the nutrient cocktail prevented the alterations in lipid metabolism including de novo lipogenesis (measured by means of labelled fructose), the decrease in type-IIa muscle fiber cross-sectional area, the increase in protein ubiquitination content, and improved the circulating anti-oxidant capacity, while it did not prevent the decrease in insulin sensitivity and its muscular correlates (Damiot A. et al, J.Appl.Physiol.2018).
Bed-Rest Studies (supported by CNES and ESA, the French and European Spatial Agencies). Using a mid-term bed-rest protocol with showed that 21 days of severe physical inactivity, with or without whey protein supplementation, decreased the ability to switch from fat to carbohydrate oxidation when transitioning from fasted to fed states (i.e. metabolic inflexibility), anti-oxidant capacity, fat-free mass, and muscle insulin sensitivity along with greater fat deposition in muscle. Importantly, physical inactivity triggered metabolic inflexibility, even if energy balance was maintained. These data support the role of physical inactivity in metabolic inflexibility, and we further showed that muscle alterations and metabolic inflexibility preceded systemic glucose intolerance (F.Rudwill, J.Clin.Endocrinol. Metab., 2018).
The long-term bed-rest (60-days) conducted in Toulouse in 2017 (ESA AO13-BR CNES 2015-2018) will allow us to better delineate the mechanisms and the temporal sequence of events by which severe and prolonged sedentary behavior in humans leads to ectopic fat storage and insulin resistance. We will also test if the preventive effects of the nutrient cocktail observed in the free-living COCKTAIL study are maintained during a more severe and longer physical inactivity period.
TRANSITION, an ongoing longitudinal study of the Fulani people, an ancestral population of nomad pastoralists living in the Ferlo, a Sahelian region in northern Senegal, aims to better understand the respective role of biological and environmental factors on body weight regulation, a question that remains one of the most debated research topics. During the last decades, part of the Fulanis progressively sedentarised in small cities around boreholes built to facilitate access to water, while others remained in camps spread across the savanna, some being more than 30 km of walking distance from water. The recent coordinated construction of the Great Green Wall is expected to further amplify this ecological transition in the next few years and thus offers an exceptional opportunity to track in real-time the behavioral, social and biological changes induced by an epidemiological transition. In collaboration with the OHMi Tessékéré (Sénégal) and the IPHC (Strasbourg), we will follow 400 Fulanis facing different anthropo-socio-ecological constraints to dissect the respective role of diet, physical activity and lifestyles on long-term regulation of adiposity and biomarkers of health.
1.b) Projects in animals
Hibernatus: Hibernating bear has developed specific adaptations to preserve its skeletal muscle tissue during extended periods of disuse and starvation, two conditions that are known to trigger immediate and massive muscle atrophy in humans and laboratory rodent models. The bear’s ability to muscle functionality contrasts dramatically with the wealth of studies demonstrating the generallossof skeletal muscle mass and strength that is generally observed in response to inactivity.
Within a large collaborative European program, our team is focusing on the identification of specific compounds in winter bear serum, able to positively regulate muscle homeostasis. For this purpose, serum from bears collected in summer (non-hibernating) or in winter (hibernating) is tested for their ability to modify the protein balance, the metabolism and the phenotype of cultured muscle cells (Giroud S. et al, Scient. Rep., in press; Chanon S., J Vis Exp 2017). This work is presently developed by E. Lefai in his new laboratory in Clermont-Ferrand, in collaboration with our team.
- Role of extracellular vesicles released from skeletal muscle and the other insulin-sensitive tissues (PI: Sophie Rome)
2.a) Extracellular vesicles and inter-organ cross talk.
Long distance transmission of signals between tissues is commonly believed to be associated to protein-based signaling systems as hormones and cytokines. In this context, skeletal muscle (SkM)-secreted proteins have been shown to play an important role in intercellular communications. Recently, we have demonstrated that muscle cells release membranous bioactive extracellular vesicles (EVs) (exosomes, macroparticles and apoptotic bodies) which transfer both proteins and functional miRNAs between cells resulting in the regulation of specific signalling pathways in recipient cells (Forterre et al. 2014a/b, Aswad et al. 2016). We have also found that insulin-resistance induced by lipid-enriched diet, was associated with an increase in SkM-released EVs that were able to transfer the deleterious effects of palmitate between muscle cells (Aswad et al. 2014). Finally, we have provided a proof-of-concept that SkM-released EVs transmit signals to the pancreas during the development of insulin-resistance (Jalabert et al. 2015).
Ongoing projects :
-Relationship between insulin-resistance and multivesicular body formation ?
-Relationship between multivesicular body formation and insulin-signaling ?
-Characterisation of the subpopulations of extracellular vesicles released from muscle cells
-Creation of the French Society for extra cellular vesicles
2.b) Extracellular vesicles and miRNAs as biomarkers of whole body homeostasis
It has become clear that sedentary behaviour and obesity have multiple known, and likely unknown, physiological impacts which are not easily addressed by single-gene, protein or metabolite approaches. Therefore, a combination of all genomic-based data may be necessary to detect the full metabolic consequences of sedentary behavior and associated diseases, or to monitor the impact of lifestyle interventions. Circulating miRNA concentration are good biomarkers for cancers, neurological disorders and metabolic diseases and thus we have tested whether they could reflect either the early phases of metabolic stress or the development of metabolic syndrome associated with physical inactivity or obesity.
Ongoing projects :
-Quantification of circulating miRNAs during lifestyle interventions
-Determination of the most relevant biofluid for miRNA profiling in diabetic subjects
-Role of circulating miRNA in the developpement of obesity-associated complications
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|Responsables de l’Equipe 2|
Membres de l’Equipe 2
- Chanon, S., B. Chazarin, B. Toubhans, C. Durand, I. Chery, M. Robert, A. Vieille-Marchiset, J. E. Swenson, A. Zedrosser, A. L. Evans, S. Brunberg, J. M. Arnemo, G. Gauquelin-Koch, K. B. Storey, C. Simon, S. Blanc, F. Bertile and E. Lefai (2018) Proteolysis inhibition by hibernating bear serum leads to increased protein content in human muscle cells. Scientific Reports. 8, 10.1038/s41598-018-23891-5
- Dadet, S., A. Mulliez, G. Ducher, J. Bohatier, M. Bonnefoy, B. Lesourd and Y. Boirie (2018) A new marker for nutritional assessment in acute care geriatric units: The phase angle measured by bioelectrical impedance analysis. Experimental Gerontology. 111, 10.1016/j.exger.2018.07.003
- De Craemer, M., S. Chastin, W. Ahrens, C. Bernaards, J. Brug, C. Buck, G. Cardon, L. Capranica, P. Dargent-Molina, S. De Lepeleere, B. Hoffmann, A. Kennedy, J. Lakerveld, N. Lien, F. Ling, A. Loyen, C. MacDonncha, J. A. Nazare, G. O’Donoghue, D. O’Gorman, C. Perchoux, I. Pigeot, C. Simon, A. S. Mueller-Stierlin, H. van der Ploeg, J. Van Cauwenberg and J. M. Oppert (2018) Data on Determinants Are Needed to Curb the Sedentary Epidemic in Europe. Lessons Learnt from the DEDIPAC European Knowledge Hub. International Journal of Environmental Research and Public Health. 15, 10.3390/ijerph15071406
- De Jong, N. P., I. Debache, Z. X. Pan, M. Garnotel, K. Lyden, C. Sueur, C. Simon, D. H. Bessesen and A. Bergouignan (2018) Breaking up Sedentary Time in Overweight/Obese Adults on Work Days and Non-Work Days: Results from a Feasibility Study. International Journal of Environmental Research and Public Health. 15, 10.3390/ijerph15112566
- Disse, E., S. Ledoux, C. Betry, C. Caussy, C. Maitrepierre, M. Coupaye, M. Laville and C. Simon (2018) An artificial neural network to predict resting energy expenditure in obesity. Clinical Nutrition. 37, 10.1016/j.clnu.2017.07.017
- Feuillet, T., H. Commenges, M. Menai, P. Salze, C. Perchoux, R. Reuillon, E. Kesse-Guyot, C. Enaux, J. A. Nazare, S. Hercberg, C. Simon, H. Charreire and J. M. Oppert (2018) A massive geographically weighted regression model of walking-environment relationships. Journal of Transport Geography. 68, 10.1016/j.jtrangeo.2018.03.002
- Garnotel, M., T. Bastian, H. M. Romero-Ugalde, A. Maire, J. Dugas, A. Zahariev, M. Doron, P. Jallon, G. Charpentier, S. Franc, S. Blanc, S. Bonnet and C. Simon (2018) Prior automatic posture and activity identification improves physical activity energy expenditure prediction from hip-worn triaxial accelerometry. Journal of Applied Physiology. 124, 10.1152/japplphysiol.00556.2017
- Gignoux, B., M. C. Blanchet, T. Lanz, A. Vulliez, M. Saffarini, H. Bothorel, M. Robert and V. Frering (2018) Should ambulatory appendectomy become the standard treatment for acute appendicitis? World Journal of Emergency Surgery. 13, 10.1186/s13017-018-0191-4
- Gilbert, T., S. Roche, E. Blond, J. Y. Bar, J. Drai, C. Cuerq, M. Haution-Bitker, R. Ecochard and M. Bonnefoy (2018) Association between Peripheral Leptin and Adiponectin Levels and Cognitive Decline in Patients with Neurocognitive Disorders >= 65 Years. Journal of Alzheimers Disease. 66, 10.3233/jad-180533
- Giroud, S., A. L. Evans, I. Chery, F. Bertile, G. Tascher, J. Bertrand-Michel, G. Gauquelin-Koch, J. M. Arnemo, J. E. Swenson, E. Lefai, S. Blanc and C. Simon (2018) Seasonal changes in eicosanoid metabolism in the brown bear. Science of Nature. 105, 10.1007/s00114-018-1583-8
- Giroux, V., S. Saidj, C. Simon, M. Laville, B. Segrestin and M. E. Mathieu (2018) Physical activity, energy expenditure and sedentary parameters in overfeeding studies – a systematic review. Bmc Public Health. 18, 10.1186/s12889-018-5801-2
- Guay, C., J. K. Kruit, S. Rome, V. Menoud, N. L. Mulder, A. Jurdzinski, F. Mancarella, G. Sebastiani, A. Donda, B. J. Gonzalez, C. Jandus, K. Bouzakri, M. Pinget, C. Boitard, P. Romero, F. Dotta and R. Regazzi (2018) Lymphocyte-Derived Exosomal MicroRNAs Promote Pancreatic beta Cell Death and May Contribute to Type 1 Diabetes Development. Cell Metab. 1016/j.cmet.2018.09.011
- Haution-Bitker, M., T. Gilbert, A. Vignoles, C. Lecardonnel, S. Watelet, E. Blond, J. Drai and M. Bonnefoy (2018) Associations between Plasmatic Polyunsaturated Fatty Acids Concentrations and Cognitive Status and Decline in Neurocognitive Disorders. Journal of Nutrition Health & Aging. 22, 10.1007/s12603-018-1010-z
- Hermant, X., C. Delay, A. Flaig, J. Luque-Bedregal, G. Briand, M. A. Bout, D. Cottel, A. Wagner, D. Arveiler, C. Simon, J. Ferrieres, J. B. Ruidavets, B. Laillet, P. Amouyel, J. Dallongeville, A. Meirhaeghe and J. Dumont (2018) Identification of a functional FADS1 3 ‘ UTR variant associated with erythrocyte n-6 polyunsaturated fatty acids levels. Journal of Clinical Lipidology. 12, 10.1016/j.jacl.2018.07.012
- Iceta, S., E. Disse and M. Robert (2018) Are we really assessing safety and efficacy of bariatric surgery in patients suffering from bipolar disorder? Surgery for Obesity and Related Diseases. 14, 10.1016/j.soard.2018.01.037
- Lippai, D., A. Lupu, F. Rostain, J. Rivory, M. Robert, T. Ponchon and M. Pioche (2018) Endoscopic ultrasound-guided detection and internal drainage of a closed gastro-cutaneous fistula after bariatric surgery. 50, 10.1055/a-0631-8479
- Menai, M., H. Charreire, P. Galan, C. Simon, J. A. Nazare, C. Perchoux, C. Weber, C. Enaux, S. Hercberg, LeopoldFezeu and J. M. Oppert (2018) Differential Associations of Walking and Cycling with Body Weight, Body Fat and Fat Distribution – the ACTI-Cites Project. Obesity Facts. 11, 10.1159/000488532
- O’Donoghue, G., A. Kennedy, A. Puggina, K. Aleksovska, C. Buck, C. Burns, G. Cardon, A. Carlin, D. Ciarapica, M. Colotto, G. Condello, T. Coppinger, C. Cortis, S. D’Haese, M. De Craemer, A. Di Blasio, S. Hansen, L. Iacoviello, J. Issartel, P. Izzicupo, L. Jaeschke, M. Kanning, F. Ling, A. Luzak, G. Napolitano, J. A. Nazare, C. Perchoux, C. Pesce, T. Pischon, A. Polito, A. Sannella, H. Schulz, C. Simon, R. Sohun, A. Steinbrecher, W. Schlicht, C. MacDonncha, L. Capranica and S. Boccia (2018) Socio-economic determinants of physical activity across the life course: A “DEterminants of DIet and Physical ACtivity” (DEDIPAC) umbrella literature review. Plos One. 13, 10.1371/journal.pone.0190737
- Ohannessian, R., M. P. Gustin, T. Benet, S. Gerbier-Colomban, R. Girard, L. Argaud, T. Rimmele, C. Guerin, J. Bohe, V. Piriou and P. Vanhems (2018) Estimation of Extra Length of Stay Attributable to Hospital-Acquired Infections in Adult ICUs Using a Time-Dependent Multistate Model. Critical Care Medicine. 46, 10.1097/ccm.0000000000003131
- Pasquer, A., E. Pelascini, G. Poncet and M. Robert (2018) Laparoscopic Treatment of Gastro-Gastric Fistula After RYGB: Technical Points. Obesity Surgery. 28, 10.1007/s11695-018-3164-5
- Perrin, L., U. Loizides-Mangold, S. Chanon, C. Gobet, N. Hulo, L. Isenegger, B. D. Weger, E. Migliavacca, A. Charpagne, J. A. Betts, J. P. Walhin, L. Templeman, K. Stokes, D. Thompson, K. Tsintzas, M. Robert, C. Howald, H. Riezman, J. N. Feige, L. G. Karagounis, J. D. Johnston, E. T. Dermitzakis, F. Gachon, E. Lefai and C. Dibner (2018) Transcriptomic analyses reveal rhythmic and CLOCK-driven pathways in human skeletal muscle. 7, 10.7554/eLife.34114
- Puertas, R. D., A. Jalabert, E. Meugnier, V. Euthine, P. Chevalier and S. Rome (2018) Analysis of the microRNA signature in left atrium from patients with valvular heart disease reveals their implications in atrial fibrillation. Plos One. 13, 10.1371/journal.pone.0196666
- Robert, M., E. Pelascini, G. Poncet and A. Pasquer (2018) Blind biliary limb dilatation (Candy cane syndrome) of jejuno-jejunal anastomosis after Roux en Y Gastric Bypass (with video). Journal of Visceral Surgery. 155, 10.1016/j.jviscsurg.2017.12.013
- Rudwill, F., D. O’Gorman, E. Lefai, I. Chery, A. Zahariev, S. Normand, A. F. Pagano, A. Chopard, A. Damiot, C. Laurens, L. Hodson, E. Canet-Soulas, M. Heer, P. F. Meuthen, J. Buehlmeier, N. Baecker, L. Meiller, G. Gauquelin-Koch, S. Blanc, C. Simon and A. Bergouignan (2018) Metabolic Inflexibility Is an Early Marker of Bed-Rest-Induced Glucose Intolerance Even When Fat Mass Is Stable. Journal of Clinical Endocrinology & Metabolism. 103, 10.1210/jc.2017-02267
- Seyssel, K., M. Suter, F. Pattou, R. Caiazzo, H. Verkindt, V. Raverdy, M. Jolivet, E. Disse, M. Robert and V. Giusti (2018) A Predictive Model of Weight Loss After Roux-en-Y Gastric Bypass up to 5 Years After Surgery: a Useful Tool to Select and Manage Candidates to Bariatric Surgery. Obesity Surgery. 28, 10.1007/s11695-018-3355-0
- Tubbs, E., S. Chanon, M. Robert, N. Bendridi, G. Bidaux, M. A. Chauvin, J. C. Jingwei, C. Durand, D. Gauvrit-Ramette, H. Vidal, E. Lefai and J. Rieusset (2018) Disruption of Mitochondria-Associated Endoplasmic Reticulum Membrane (MAM) Integrity Contributes to Muscle Insulin Resistance in Mice and Humans. 67, 10.2337/db17-0316
- Adrait, A., Perrot, X., Nguyen, M. F., Gueugnon, M., Petitot, C., Collet, L., Roux, A., Bonnefoy, M. and Grp, A. S. (2017) Do Hearing Aids Influence Behavioral and Psychological Symptoms of Dementia and Quality of Life in Hearing Impaired Alzheimer’s Disease Patients and Their Caregivers? Journal of Alzheimers Disease 58 109-121
- Andrieu, S., Guyonnet, S., Coley, N., Cantet, C., Bonnefoy, M., Bordes, S., Bories, L., Cufi, M. N., Dantoine, T., Dartigues, J. F., Desclaux, F., Gabelle, A., Gasnier, Y., Pesce, A., Sudres, K., Touchon, J., Robert, P., Rouaud, O., Legrand, P., Payoux, P., Caubere, J. P., Weiner, M., Carrie, I., Ousset, P. J., Vellas, B. and Grp, M. S. (2017) Effect of long-term omega 3 polyunsaturated fatty acid supplementation with or without multidomain intervention on cognitive function in elderly adults with memory complaints (MAPT): a randomised, placebo-controlled trial Lancet Neurology 16 377-389
- Benoit B, Meugnier E, Castelli M, Chanon S, Vieille-Marchiset A, Durand C, Bendridi N, Pesenti S, Monternier PA, Durieux AC, Freyssenet D, Rieusset J, Lefai E, Vidal H, Ruzzin J. (2017) Fibroblast growth factor 19 regulates skeletal muscle mass and ameliorates muscle wasting in mice. Nat Med 23; 990-996
- Blond, E., Disse, E., Cuerq, C., Drai, J., Valette, P. J., Laville, M., Thivolet, C., Simon, C. and Caussy, C. (2017) EASL-EASD-EASO clinical practice guidelines for the management of non-alcoholic fatty liver disease in severely obese people: do they lead to over-referral? Diabetologia 60 1218-1222
- Bost, F., Chanon, S., Durand, C., Vieille-Marchiset, A., Robert, M., Dibner, C., Simon, C. and Lefai, E. (2017) Glucose Uptake Measurement and Response to Insulin Stimulation in In Vitro Cultured Human Primary Myotubes Sci Rep
- Caillet, P., Liuu, E., Simon, A. R., Bonnefoy, M., Guerin, O., Berrut, G., Lesourd, B., Jeandel, C., Ferry, M., Rolland, Y. and Paillaud, E. (2017) Association between cachexia, chemotherapy and outcomes in older cancer patients: A systematic review Clinical Nutrition 36 1473-1482
- Chanon, S., Durand, C., Vieille-Marchiset, A., Robert, M., Dibner, C., Simon, C. and Lefai, E. (2017) Glucose Uptake Measurement and Response to Insulin Stimulation in In Vitro Cultured Human Primary Myotubes Jove-Journal of Visualized Experiments
- Condello, G., Puggina, A., Aleksovska, K., Buck, C., Burns, C., Cardon, G., Carlin, A., Simon, C., Ciarapica, D., Coppinger, T., Cortis, C., D’Haese, S., De Craemer, M., Di Blasio, A., Hansen, S., Iacoviello, L., Issartel, J., Izzicupo, P., Jaeschke, L., Kanning, M., Kennedy, A., Ling, F. C. M., Luzak, A., Napolitano, G., Nazare, J. A., Perchoux, C., Pesce, C., Pischon, T., Polito, A., Sannella, A., Schulz, H., Sohun, R., Steinbrecher, A., Schlicht, W., Ricciardi, W., MacDonncha, C., Capranica, L., Boccia, S. and Consortium, D. (2017) Behavioral determinants of physical activity across the life course: a “DEterminants of DIet and Physical ACtivity” (DEDIPAC) umbrella systematic literature review International Journal of Behavioral Nutrition and Physical Activity 14 23
- Cortis, C., Puggina, A., Pesce, C., Aleksovska, K., Buck, C., Burns, C., Cardon, G., Carlin, A., Simon, C., Ciarapica, D., Condello, G., Coppinger, T., D’Haese, S., De Craemer, M., Di Blasio, A., Hansen, S., Iacoviello, L., Issartel, J., Izzicupo, P., Jaeschke, L., Kanning, M., Kennedy, A., Ling, F. C. M., Luzak, A., Napolitano, G., Nazare, J. A., O’Donoghue, G., Perchoux, C., Pischon, T., Polito, A., Sannella, A., Schulz, H., Sohun, R., Steinbrecher, A., Schlicht, W., Ricciardi, W., Castellani, L., MacDonncha, C., Capranica, L. and Boccia, S. (2017) Psychological determinants of physical activity across the life course: A “DEterminants of DIet and Physical ACtivity” (DEDIPAC) umbrella systematic literature review Plos One 12 25
- Disse, E., Ledoux, S., Betry, C., Caussy, C., Maitrepierre, C., Coupaye, M., Laville, M. and Simon, C. (2017) An artificial neural network to predict resting energy expenditure in obesity Clin Nutr
- Dupuis, M., Kuczewski, E., Villeneuve, L., Bin-Dorel, S., Haine, M., Falandry, C., Gilbert, T., Passot, G., Glehen, O. and Bonnefoy, M. (2017) Age Nutrition Chirurgie (ANC) study: impact of a geriatric intervention on the screening and management of undernutrition in elderly patients operated on for colon cancer, a stepped wedge controlled trial Bmc Geriatrics 17 9
- Garnotel, M., Bastian, T., Romero-Ugalde, H. M., Maire, A., Dugas, J., Zahariev, A., Doron, M., Jallon, P., Charpentier, G., Franc, S., Blanc, S., Bonnet, S. and Simon, C. (2017) Prior automatic posture and activity identification improves physical activity energy expenditure prediction from hip-worn triaxial accelerometry J Appl Physiol (1985) jap.00556.2017
- Gilbert, T., Bosquet, A., Thomas-Anterion, C., Bonnefoy, M. and Le Saux, O. (2017) Assessing capacity to consent for research in cognitively impaired older patients Clinical Interventions in Aging 12 1553-1563
- Hess, F., Salze, P., Weber, C., Feuillet, T., Charreire, H., Menai, M., Perchoux, C., Nazare, J. A., Simon, C., Oppert, J. M. and Enaux, C. (2017) Active Mobility and Environment: A Pilot Qualitative Study for the Design of a New Questionnaire Plos One 12 15
- Lefai, E., Blanc, S., Momken, I., Antoun, E., Chery, I., Zahariev, A., Gabert, L., Bergouignan, A. and Simon, C. (2017) Exercise training improves fat metabolism independent of total energy expenditure in sedentary overweight men, but does not restore lean metabolic phenotype Int J Obes (Lond) 41 1728-1736
- Loizides-Mangold, U., Perrin, L., Vandereycken, B., Betts, J. A., Walhin, J. P., Templeman, I., Chanon, S., Weger, B. D., Durand, C., Robert, M., Montoya, J. P., Moniatte, M., Karagounis, L. G., Johnston, J. D., Gachon, F., Lefai, E., Riezman, H. and Dibner, C. (2017) Lipidomics reveals diurnal lipid oscillations in human skeletal muscle persisting in cellular myotubes cultured in vitro Proceedings of the National Academy of Sciences of the United States of America 114 E8565-E8574
- Marchand, L., Decaussin-Petrucci, M., Giraud, S., Cotton, F., Thivolet, C. and Simon, C. (2017) Hibernoma and multiple endocrine neoplasia type 1 syndrome: A non-fortuitous association? A case report and literature review Annales D Endocrinologie 78 194-197
- Nguyen, M. F., Bonnefoy, M., Adrait, A., Gueugnon, M., Petitot, C., Collet, L., Roux, A., Perrot, X. and Grp, A. S. (2017) Efficacy of Hearing Aids on the Cognitive Status of Patients with Alzheimer’s Disease and Hearing Loss: A Multicenter Controlled Randomized Trial Journal of Alzheimers Disease 58 123-137
- Perchoux, C., Enaux, C., Oppert, J. M., Menai, M., Charreire, H., Salze, P., Weber, C., Hercberg, S., Feuillet, T., Hess, F., Roda, C., Simon, C. and Nazare, J. A. (2017) Individual, Social, and Environmental Correlates of Active Transportation Patterns in French Women Biomed Research International 11
- Perchoux, C., Nazare, J. A., Benmarhnia, T., Salze, P., Feuillet, T., Hercberg, S., Hess, F., Menai, M., Weber, C., Charreire, H., Enaux, C., Oppert, J. M. and Simon, C. (2017) Neighborhood educational disparities in active commuting among women: the effect of distance between the place of residence and the place of work/study (an ACTI-Cites study) Bmc Public Health 17 12
- Pickering, M. E., Simon, M., Sornay-Rendu, E., Chikh, K., Carlier, M. C., Raby, A. L., Szulc, P. and Confavreux, C. B. (2017) Serum Sclerostin Increases After Acute Physical Activity Calcified Tissue International 101 170-173
- Puertas, R. D., Meugnier, E., Romestaing, C., Rey, C., Morel, E., Lachuer, J., Gadot, N., Scridon, A., Julien, C., Tronc, F., Chapuis, B., Valla, C., Janin, A., Pirola, L., Mejat, A., Rome, S. and Chevalier, P. (2017) Atrial fibrillation is associated with hypermethylation in human left atrium, and treatment with decitabine reduces atrial tachyarrhythmias in spontaneously hypertensive rats Translational Research 184 57-67
- Romero-Ugalde, H. M., Garnotel, M., Doron, M., Jallon, P., Charpentier, G., Franc, S., Huneker, E., Simon, C. and Bonnet, S. (2017) An original piecewise model for computing energy expenditure from accelerometer and heart rate signals Physiological Measurement 38 1599-161
- Ru P, Hu P, Geng F, Mo X, Cheng C, Yoo JY, Cheng X, Wu X, Guo JY, Nakano I, Lefai E, Kaur B, Chakravarti A, Guo D.(2017) Feedback Loop Regulation of SCAP/SREBP-1 by miR-29 Modulates EGFR Signaling-Driven Glioblastoma Growth. Cell Rep 18; 1076
- Thomas, F., Rome, S., Mery, F., Dawson, E., Montagne, J., Biro, P. A., Beckmann, C., Renaud, F., Poulin, R., Raymond, M. and Ujvari, B. (2017) Changes in diet associated with cancer: An evolutionary perspective Evolutionary Applications 10 651-65
- Aswad, H., Jalabert, A. and Rome, S. (2016) Depleting extracellular vesicles from fetal bovine serum alters proliferation and differentiation of skeletal muscle cells in vitro BMC Biotechnology 16 32
- Bongard, V., Arveiler, D., Dallongeville, J., Ruidavets, J. B., Wagner, A., Simon, C., Marecaux, N. and Ferrieres, J. (2016) Food groups associated with a reduced risk of 15-year all-cause death European Journal of Clinical Nutrition 70 715-22
- Bonnefoy, M., Berrut, G. and Gilbert, T. (2016) Prevention of impaired mobility in the elderly in primary care: a brief report Gériatrie et Psychologie Neuropsychiatrie du Vieillissement 14 16-22
- Cassel, R., Ducreux, S., Alam, M. R., Dingreville, F., Berle, C., Burda-Jacob, K., Chauvin, M. A., Chikh, K., Paita, L., Al-Mawla, R., Crola Da Silva, C., Rieusset, J., Thivolet, C., Van Coppenolle, F. and Madec, A. M. (2016) Protection of Human Pancreatic Islets from Lipotoxicity by Modulation of the Translocon PLoS One 11 e0148686
- Caussy, C., Charriere, S., Meirhaeghe, A., Dallongeville, J., Lefai, E., Rome, S., Cuerq, C., Euthine, V., Delay, M., Marmontel, O., Di Filippo, M., Lagarde, M., Moulin, P. and Marcais, C. (2016) Multiple microRNA regulation of lipoprotein lipase gene abolished by 3’UTR polymorphisms in a triglyceride-lowering haplotype harboring p.Ser474Ter Atherosclerosis 246 280-6
- Condello G, Ling FC, Bianco A, Chastin S, Cardon G, Ciarapica D, Conte D, Cortis C, De Craemer M, Di Blasio A, Gjaka M, Hansen S, Holdsworth M, Iacoviello L, Izzicupo P, Jaeschke L, Leone L, Manoni L, Menescardi C, Migliaccio S, Nazare JA, Perchoux C, Pesce C, Pierik F, Pischon T, Polito A, Puggina A, Sannella A, Schlicht W, Schulz H, Simon C, Steinbrecher A, MacDonncha C, Capranica L; DEDIPAC consortium.. Using concept mapping in the development of the EU-PAD framework (EUropean-Physical Activity Determinants across the life course): a DEDIPAC-study. BMC Public Health. 2016 Nov 9;16(1):1145.
- De Arcangelis, V., Strimpakos, G., Gabanella, F., Corbi, N., Luvisetto, S., Magrelli, A., Onori, A., Passananti, C., Pisani, C., Rome, S., Severini, C., Naro, F., Mattei, E., Di Certo, M. G. and Monaco, L. (2016) Pathways Implicated in Tadalafil Amelioration of Duchenne Muscular Dystrophy Journal of Cellular Physiology 231 224-32
- Gastebois, C., Chanon, S., Rome, S., Durand, C., Pelascini, E., Jalabert, A., Euthine, V., Pialoux, V., Blanc, S., Simon, C. and Lefai, E. (2016) Transition from physical activity to inactivity increases skeletal muscle miR-148b content and triggers insulin resistance Physiological Reports 4 17 e12902
- Gastebois, C., Villars, C., Drai, J., Canet-Soulas, E., Blanc, S., Bergouignan, A., Lefai, E. and Simon, C. (2016) Effects of training and detraining on adiponectin plasma concentration and muscle sensitivity in lean and overweight men European Journal of Applied Physiology 116 2135-2144
- Geng, F., Cheng, X., Wu, X., Yoo, J. Y., Cheng, C., Guo, J. Y., Mo, X., Ru, P., Hurwitz, B., Kim, S. H., Otero, J., Puduvalli, V., Lefai, E., Ma, J., Nakano, I., Horbinski, C., Kaur, B., Chakravarti, A. and Guo, D. (2016) Inhibition of SOAT1 Suppresses Glioblastoma Growth via Blocking SREBP-1-Mediated Lipogenesis Clinical Cancer Research 22 5337-5348
- Jalabert, A., Vial, G., Guay, C., Wiklander, O. P., Nordin, J. Z., Aswad, H., Forterre, A., Meugnier, E., Pesenti, S., Regazzi, R., Danty-Berger, E., Ducreux, S., Vidal, H., El-Andaloussi, S., Rieusset, J. and Rome, S. (2016) Exosome-like vesicles released from lipid-induced insulin-resistant muscles modulate gene expression and proliferation of beta recipient cells in mice Diabetologia 59 1049-58
- Liminet, C., Vouillarmet, J., Chikh, K. and Disse, E. (2016) Antibody-Mediated Insulin Resistance: When Insulin and Insulin Receptor Act as Autoantigens in Humans Canadian Journal of Diabetes 40 462-465
- Marchand, L., Jalabert, A., Meugnier, E., Van den Hende, K., Fabien, N., Nicolino, M., Madec, A. M., Thivolet, C. and Rome, S. (2016) miRNA-375 a Sensor of Glucotoxicity Is Altered in the Serum of Children with Newly Diagnosed Type 1 Diabetes Journal of Diabetes Research doi.org/10.1155/2016/1869082
- Mensah, K., Maire, A., Oppert, J. M., Dugas, J., Charreire, H., Weber, C., Simon, C. and Nazare, J. A. (2016) Assessment of sedentary behaviors and transport-related activities by questionnaire: a validation study BMC Public Health 16 753
- Nozieres, C., Chardon, L., Goichot, B., Borson-Chazot, F., Hervieu, V., Chikh, K., Lombard-Bohas, C. and Walter, T. (2016) Neuroendocrine tumors producing calcitonin: characteristics, prognosis and potential interest of calcitonin monitoring during follow-up European Journal of Endocrinology 174 335-41
- Occelli, P., Touzet, S., Rabilloud, M., Ganne, C., Poupon Bourdy, S., Galamand, B., Debray, M., Dartiguepeyrou, A., Chuzeville, M., Comte, B., Turkie, B., Tardy, M., Luiggi, J. S., Jacquet-Francillon, T., Gilbert, T. and Bonnefoy, M. (2016) Impact of a transition nurse program on the prevention of thirty-day hospital readmissions of elderly patients discharged from short-stay units: study protocol of the PROUST stepped-wedge cluster randomised trial BMC Geriatrics 16 57
- O’Donoghue, G., Perchoux, C., Mensah, K., Lakerveld, J., van der Ploeg, H., Bernaards, C., Chastin, S. F., Simon, C., O’Gorman, D., Nazare, J. A. and consortium, D. (2016) A systematic review of correlates of sedentary behaviour in adults aged 18-65 years: a socio-ecological approach BMC Public Health 16 163
- Rouveure, A. C., Bonnefoy, M. and Laville, M. (2016) Conservative treatment, hemodialysis or peritoneal dialysis for elderly patients: The choice of treatment does not influence the survival Néphrologie & Thérapeutique 12 32-7
- Ru, P., Hu, P., Geng, F., Mo, X., Cheng, C., Yoo, J. Y., Cheng, X., Wu, X., Guo, J. Y., Nakano, I., Lefai, E., Kaur, B., Chakravarti, A. and Guo, D. (2016) Feedback Loop Regulation of SCAP/SREBP-1 by miR-29 Modulates EGFR Signaling-Driven Glioblastoma Growth Physiological Reports 16 1527-35
1. Bastian, T., Maire, A., Dugas, J., Ataya, A., Villars, C., Gris, F., Perrin, E., Caritu, Y., Doron, M., Blanc, S., Jallon, P., and Simon, C. (2015) Automatic identification of physical activity types and sedentary behaviors from triaxial accelerometer: laboratory-based calibrations are not enough. Journal of applied physiology. 118, 716-722
2. Bonnefoy, M., Berrut, G., Lesourd, B., Ferry, M., Gilbert, T., Guerin, O., Hanon, O., Jeandel, C., Paillaud, E., Raynaud-Simon, A., Ruault, G., and Rolland, Y. (2015) Frailty and nutrition: searching for evidence. The journal of nutrition, health & aging. 19, 250-257
3. Cheng, C., Ru, P., Geng, F., Liu, J., Yoo, J. Y., Wu, X., Cheng, X., Euthine, V., Hu, P., Guo, J. Y., Lefai, E., Kaur, B., Nohturfft, A., Ma, J., Chakravarti, A., and Guo, D. (2015) Glucose-Mediated N-glycosylation of SCAP Is Essential for SREBP-1 Activation and Tumor Growth. Cancer Cell. 28, 569-581
4. Cuerq, C., Peretti, N., Chikh, K., Mialon, A., Guillaumont, M., Drai, J., and Blond, E. (2015) Overview of the in vitro stability of commonly measured vitamins and carotenoids in whole blood. Annals of Clinical Biochemistry. 52, 259-269
5. Eljaafari, A., Robert, M., Chehimi, M., Chanon, S., Durand, C., Vial, G., Bendridi, N., Madec, A. M., Disse, E., Laville, M., Rieusset, J., Lefai, E., Vidal, H., and Pirola, L. (2015) Adipose Tissue-Derived Stem Cells From Obese Subjects Contribute to Inflammation and Reduced Insulin Response in Adipocytes Through Differential Regulation of the Th1/Th17 Balance and Monocyte Activation. Diabetes. 64, 2477-2488
6. Feuillet, T., Charreire, H., Menai, M., Salze, P., Simon, C., Dugas, J., Hercberg, S., Andreeva, V. A., Enaux, C., Weber, C., and Oppert, J. M. (2015) Spatial heterogeneity of the relationships between environmental characteristics and active commuting: towards a locally varying social ecological model. International journal of health geographics. 14, 12
7. Gilbert, T., Chidiac, C., Bonnefoy, M., and Ferry, T. (2015) Tuberculosis of the cavum revealed by acute facial pain. BMJ case reports. 2015,
8. Guay, C., Menoud, V., Rome, S., and Regazzi, R. (2015) Horizontal transfer of exosomal microRNAs transduce apoptotic signals between pancreatic beta-cells. Cell communication and signaling. 13, 17
9. Honnorat, D., Disse, E., Millot, L., Mathiotte, E., Claret, M., Charrie, A., Drai, J., Garnier, L., Maurice, C., Durand, E., Simon, C., Dupuis, O., and Thivolet, C. (2015) Are third-trimester adipokines associated with higher metabolic risk among women with gestational diabetes? Diabetes & Metabolism. 41, 393-400
10. Menai, M., Charreire, H., Feuillet, T., Salze, P., Weber, C., Enaux, C., Andreeva, V. A., Hercberg, S., Nazare, J. A., Perchoux, C., Simon, C., and Oppert, J. M. (2015) Walking and cycling for commuting, leisure and errands: relations with individual characteristics and leisure-time physical activity in a cross-sectional survey (the ACTI-Cites project). The international journal of behavioral nutrition and physical activity. 12, 150
11. Perrin, L., Loizides-Mangold, U., Skarupelova, S., Pulimeno, P., Chanon, S., Robert, M., Bouzakri, K., Modoux, C., Roux-Lombard, P., Vidal, H., Lefai, E., and Dibner, C. (2015) Human skeletal myotubes display a cell-autonomous circadian clock implicated in basal myokine secretion. Molecular metabolism. 4, 834-845
12. Prabu, P., Rome, S., Sathishkumar, C., Aravind, S., Mahalingam, B., Shanthirani, C. S., Gastebois, C., Villard, A., Mohan, V., and Balasubramanyam, M. (2015) Circulating MiRNAs of ‘Asian Indian Phenotype’ Identified in Subjects with Impaired Glucose Tolerance and Patients with Type 2 Diabetes. PLoS One. 10, e0128372
13. Revel, F., Gilbert, T., Roche, S., Drai, J., Blond, E., Ecochard, R., and Bonnefoy, M. (2015) Influence of oxidative stress biomarkers on cognitive decline. Journal of Alzheimer’s disease. 45, 553-560
14. Rome, S. (2015) Use of miRNAs in biofluids as biomarkers in dietary and lifestyle intervention studies. Genes & nutrition. 10, 483
15. Rouveure, A. C., Bonnefoy, M., and Laville, M. (2016) [Conservative treatment, hemodialysis or peritoneal dialysis for elderly patients: The choice of treatment does not influence the survival]. Nephrologie & therapeutique. 12, 32-37
16. Rudwill, F., Bergouignan, A., Gastebois, C., Gauquelin-Koch, G., Lefai, E., Blanc, S., and Simon, C. (2015) Effect of enforced physical inactivity induced by 60-day of bed rest on hepatic markers of NAFLD in healthy normal-weight women. Liver international. 35, 1700-1706
17. Saidj, M., Menai, M., Charreire, H., Weber, C., Enaux, C., Aadahl, M., Kesse-Guyot, E., Hercberg, S., Simon, C., and Oppert, J. M. (2015) Descriptive study of sedentary behaviours in 35,444 French working adults: cross-sectional findings from the ACTI-Cites study. BMC public health. 15, 379
18. Scherdel, P., Botton, J., Rolland-Cachera, M. F., Leger, J., Pele, F., Ancel, P. Y., Simon, C., Castetbon, K., Salanave, B., Thibault, H., Lioret, S., Peneau, S., Gusto, G., Charles, M. A., and Heude, B. (2015) Should the WHO growth charts be used in France? PLoS One. 10, e0120806
19. Scridon, A., Fouilloux-Meugnier, E., Loizon, E., Rome, S., Julien, C., Barres, C., and Chevalier, P. (2015) Long-standing arterial hypertension is associated with Pitx2 down-regulation in a rat model of spontaneous atrial tachyarrhythmias. European pacing, arrhythmias, and cardiac electrophysiology. 17, 160-165