Equipe 4 : « Lipides Postprandiaux et Lipoprotéines riches en Triglycérides: Régulations et Impacts Fonctionnels (LiPo) »

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Le but de l’équipe 4 est de comprendre les mécanismes et conséquences des hypertriglycéridémies (HTG) en considérant les formes primitives ou secondaires et en étudiant les altérations de l’HTG postprandiale, désormais reconnue comme facteur de risque cardiovasculaire

Thématique générale de l’équipe 4

L’équipe élucidera ces aspects du métabolisme des TG en étudiant :

  1. Comment les lipides alimentaires différemment structurés ou oxydés peuvent affecter la cinétique d’absorption intestinale, la composition et la lipolyse des lipoprotéines riches en TG (TGRL) et le devenir métabolique des lipides lors de la phase postprandiale. L’impact des lipides présents dans le tractus digestif sera considéré en termes de co-absorption de LPS du microbiote et de modifications des lignées cellulaires et de la barrière intestinale.
  2. Comment des TGRL modifiées par la nutrition et/ou altérées par les états d’obésité/diabète et de malabsorption contribuent aux processus athéro-thrombotiques et inflammatoires à jeun et en phase postprandiale. Leur impact sur l’endothélium et le transport du cholestérol dans les macrophages sera abordé en s’attachant à montrer le rôle des phospholipides oxydés et des oxystérols. Le rôle critique de dérivés oxygénés du DHA et de sa vectorisation sur les complications cardiovasculaires et ischémiques sera exploré.
  3. Comment de nouvelles régulations génétiques et épigénétiques interviennent dans la régulation de la lipolyse des TGRL. Les interactions LPL/AV/GPIHBP1 dans la plateforme lipolytique endothéliale seront explorées. Les études (i) d’associations considérant les phénotypes extrêmes et (ii) de ségrégation lors d’HTG majeures inexpliquées, seront développées pour identifier de nouveaux gènes impliqués. Les travaux sur l’impact des miRNA sur la régulation de l’expression des gènes impliqués seront approfondis.

Nous pourrons ainsi envisager des stratégies alimentaires préventives de la dérégulation de la lipémie postprandiale et de nouvelles cibles thérapeutiques pour le traitement des HTG primitives ou secondaires (e.g. obésité/diabète).

 

fig equipe 4 fs

2017

  1. Beigneux, A. P., Miyashita, K., Ploug, M., Blom, D. J., Ai, M., Linton, M. R. F., Khovidhunkit, W., Dufour, R., Garg, A., McMahon, M. A., Pullinger, C. R., Sandoval, N. P., Hu, X., Allan, C. M., Larsson, M., Machida, T., Murakami, M., Reue, K., Tontonoz, P., Goldberg, I. J., Moulin, P., Charriere, S., Fong, L. G., Nakajima, K. and Young, S. G. (2017) Autoantibodies against GPIHBP1 as a Cause of Hypertriglyceridemia. New England Journal of Medicine. 376; 1647-1658.

2. Beliard, S., Bonnet, F., Bouhanick, B., Bruckert, E., Cariou, B., Charriere, S., Durlach, V., Moulin, P., Valero, R., Verges, B., Sfe, S. F. D. and Nsfa. (2017) Consensus statement on the management of dyslipidaemias in adults. Annales D Endocrinologie. 78; 43-53.

3. Bernoud-Hubac, N., Hachem, M., Lo Van, A., Picq, M. and Lagarde, M. (2017) Specific uptake of DHA by the brain from a structured phospholipid, AceDoPC((R)). Ocl-Oilseeds and Fats Crops and Lipids. 24; 4.

4. Boschetti G, Kanjarawi R, Bardel E, Collardeau-Frachon S, Duclaux-Loras R, Moro-Sibilot L, Almeras T, Flourié B, Nancey S, Kaiserlian D.(2017) Gut Inflammation in Mice Triggers Proliferation and Function of Mucosal Foxp3+ Regulatory T Cells but Impairs Their Conversion from CD4+ T Cells. J Crohns Colitis 11; 105-117

 5. Bouazizi-Ben Messaoud H, Guichard M, Lawton P, Delton I, Azzouz-Maache S. Changes in Lipid and Fatty Acid Composition During Intramacrophagic Transformation of Leishmania donovani Complex Promastigotes into Amastigotes.(2017)Lipids. 52 433-441

6. Bruno, J., Nicolas, A., Pesenti, S., Schwarz, J., Simon, J. L., Leonil, J. and Plaisancie, P. (2017) Variants of beta-casofensin, a bioactive milk peptide, differently modulate the intestinal barrier: In vivo and ex vivo studies in rats. Journal of Dairy Science. 100; 3360-3372.

 7. Coughlin, C. R., 2nd, Swanson, M. A., Kronquist, K., Acquaviva, C., Hutchin, T., Rodriguez-Pombo, P., Vaisanen, M. L., Spector, E., Creadon-Swindell, G., Bras-Goldberg, A. M., Rahikkala, E., Moilanen, J. S., Mahieu, V., Matthijs, G., Bravo-Alonso, I., Perez-Cerda, C., Ugarte, M., Vianey-Saban, C., Scharer, G. H. and Van Hove, J. L. (2017) The genetic basis of classic nonketotic hyperglycinemia due to mutations in GLDC and AMT. Genet Med. 19; 104-111.

 8. Genere, L., Pecciarini, N., Peretti, N., Villard, F. and Lachaux, A. (2017) [Food protein-induced enterocolitis syndrome: A case report of diarrhea with hypovolemic shock and methemoglobinemia]. Arch Pediatr. 24; 28-32.

  1. Grenet, G., Lajoinie, A., Ribault, S., Nguyen, G. B., Linet, T., Metge, A., Cornu, C., Cucherat, M., Moulin, P. and Gueyffier, F. (2017) Protocol of GLUcose COntrol Safety and Efficacy in type 2 DIabetes, a NETwork meta-analysis: GLUCOSE DINET protocol Rational and design. Fundamental & Clinical Pharmacology. 31; 258-264.

10. Guerville M, Leroy A, Sinquin A, Laugerette F, Michalski MC, Boudry G. Western-diet consumption induces alteration of barrier function mechanisms in the ileum that correlates with metabolic endotoxemia in rats. (2017) Am J Physiol Endocrinol Metab

 11. Guibaud, L., Collardeau-Frachon, S., Lacalm, A., Massoud, M., Rossi, M., Cordier, M. P. and Vianey-Saban, C. (2017) Antenatal manifestations of inborn errors of metabolism: prenatal imaging findings. J Inherit Metab Dis. 40; 103-112.

12. Hacini-Rachinel F, Gomez de Agüero M, Kanjarawi R, Moro-Sibilot L, Le Luduec JB, Macari C, Boschetti G, Bardel E, Langella P, Dubois B, Kaiserlian D. Intestinal dendritic cell licensing through Toll-like receptor 4 is required for oral tolerance in allergic contact dermatitis. (2017) J Allergy Clin Immunol

 13. Lecomte, M., Couedelo, L., Meugnier, E., Loizon, E., Plaisancie, P., Durand, A., Geloen, A., Joffre, F., Vaysse, C., Michalski, M. C. and Laugerette, F. (2017) Soybean polar lipids differently impact adipose tissue inflammation and the endotoxin transporters LBP and sCD14 in flaxseed vs. palm oil-rich diets. Journal of Nutritional Biochemistry. 43; 116-124.

14. Lo Van A, Fourmaux B, Picq M, Guichardant M, Lagarde M, Bernoud-Hubac N. Synthesis and Identification of AceDoxyPC, a Protectin-Containing Structured Phospholipid, Using Liquid Chromatography/Mass Spectrometry. (2017) Lipids.

15. Makino, A., Abe, M., Ishitsuka, R., Murate, M., Kishimoto, T., Sakai, S., Hullin-Matsuda, F., Shimada, Y., Inaba, T., Miyatake, H., Tanaka, H., Kurahashi, A., Pack, C. G., Kasai, R. S., Kubo, S., Schieber, N. L., Dohmae, N., Tochio, N., Hagiwara, K., Sasaki, Y., Aida, Y., Fujimori, F., Kigawa, T., Nishibori, K., Parton, R. G., Kusumi, A., Sako, Y., Anderluh, G., Yamashita, M., Kobayashi, T., Greimel, P. and Kobayashi, T. (2017) A novel sphingomyelin/cholesterol domain-specific probe reveals the dynamics of the membrane domains during virus release and in Niemann-Pick type C. FASEB J. 31; 1301-1322.

16. Marçais C, Maucort-Boulch D, Drai J, Dantony E, Carlier MC, Blond E, Genet L, Kuentz F, Lataillade D, Legrand E, Moreau-Gaudry X, Jean G, Fouque D; ARNOGENE project. (2017) Circulating Klotho associates with cardiovascular morbidity and mortality during hemodialysis. J Clin Endocrinol Metab

 17. Michalski, M. C., Vors, C., Lecomte, M. and Laugerette, F. (2017) Metabolic and inflammatory impacts of emulsified fat. Ocl-Oilseeds and Fats Crops and Lipids. 24; 12.

 18. Poinsot, P., Frachon, S. C., Restier, L., Serusclat, A., Di Filippo, M., Charriere, S., Moulin, P., Lachaux, A. and Peretti, N. (2017) Childhood/adult-onset lysosomal acid lipase deficiency: A serious metabolic and vascular phenotype beyond liver disease-four new pediatric cases. Journal of Clinical Lipidology. 11; 167-177.

19. Spitz, M. A., Nguyen, M. A., Roche, S., Heron, B., Milh, M., de Lonlay, P., Lion-Francois, L., Testard, H., Napuri, S., Barth, M., Fournier-Favre, S., Christa, L., Vianey-Saban, C., Corne, C. and Roubertie, A. (2017) Chronic Diarrhea in L-Amino Acid Decarboxylase (AADC) Deficiency: A Prominent Clinical Finding Among a Series of Ten French Patients. JIMD Rep. 31; 85-93.

20. Thorning, T. K., Bertram, H. C., Bonjour, J. P., de Groot, L., Dupont, D., Feeney, E., Ipsen, R., Lecerf, J. M., Mackie, A., McKinley, M. C., Michalski, M. C., Remond, D., Riserus, U., Soedamah-Muthu, S. S., Tholstrup, T., Weaver, C., Astrup, A. and Givens, I. (2017) Whole dairy matrix or single nutrients in assessment of health effects: current evidence and knowledge gaps. American Journal of Clinical Nutrition. 105; 1033-1045.

21. Vors, C., Drai, J., Pineau, G., Laville, M., Vidal, H., Laugerette, F. and Michalski, M. C. (2017) Emulsifying dietary fat modulates postprandial endotoxemia associated with chylomicronemia in obese men: a pilot randomized crossover study. Lipids in Health and Disease. 16; 6.

22. Zahnd, G., Kapellas, K., van Hattem, M., van Dijk, A., Serusclat, A., Moulin, P., van der Lugt, A., Skilton, M. and Orkisz, M. (2017) A Fully-Automatic Method to Segment the Carotid Artery Layers in Ultrasound Imaging: Application to Quantify the Compression-Decompression Pattern of the Intima-Media Complex During the Cardiac Cycle. Ultrasound Med Biol. 43; 239-257.

 

2016

  1. Véricel, E., Mazur, S., Colas, R., Delaup, V., Calzada, C., Reix, P., Durieu, I., Lagarde, M., Bellon, G. (2016). Moderate intake of docosahexaenoic acid raises plasma and platelet vitamin E levels in cystic fibrosis patients. Prostaglandins, Leukotrienes and Essent Fatty Acids 115 41-47
  1. Barry, Y., Bonaldi, C., Goulet, V., Coutant, R., Leger, J., Paty, A. C., Delmas, D., Cheillan, D. and Roussey, M. (2016) Increased incidence of congenital hypothyroidism in France from 1982 to 2012: a nationwide multicenter analysis Annals of Epidemiology 26 100-105 e4
  1. Behin, A., Acquaviva-Bourdain, C., Souvannanorath, S., Streichenberger, N., Attarian, S., Bassez, G., Brivet, M., Fouilhoux, A., Labarre-Villa, A., Laquerriere, A., Perard, L., Kaminsky, P., Pouget, J., Rigal, O., Vanhulle, C., Eymard, B., Vianey-Saban, C. and Laforet, P. (2016) Multiple acyl-CoA dehydrogenase deficiency (MADD) as a cause of late-onset treatable metabolic disease Revue Neurologique (Paris) 172 231-41
  1. Beliard, S., Bonnet, F., Bouhanick, B., Bruckert, E., Cariou, B., Charriere, S., Durlach, V., Moulin, P., Valero, R. and Verges, B. (2016) Consensus statement on the management of dyslipidaemias in adults Diabetes & Metabolism 42 398-408
  1. Belkouch, M., Hachem, M., Elgot, A., Van, A. L., Picq, M., Guichardant, M., Lagarde, M. and Bernoud-Hubac, N. (2016) The pleiotropic effects of omega-3 docosahexaenoic acid on the hallmarks of Alzheimer’s disease The Journal of Nutrional Biochemistry 38 1-11
  1. Bessette, C., Benoit, B., Sekkal, S., Bruno, J., Estienne, M., Leonil, J., Ferrier, L., Theodorou, V. and Plaisancie, P. (2016) Protective effects of beta-casofensin, a bioactive peptide from bovine beta-casein, against indomethacin-induced intestinal lesions in rats Molecular Nutrition & Food Research 60 823-33
  1. Boschetti G, Nancey S, Moussata D, Cotte E, Francois Y, Flourié B, Kaiserlian D. Enrichment of Circulating and Mucosal Cytotoxic CD8+ T Cells Is Associated with Postoperative Endoscopic Recurrence in Patients with Crohn’s Disease. J Crohns Colitis. 2016 Mar;10(3):338-45.
  1. Boschetti G, Kanjarawi R, Bardel E, Collardeau-Frachon S, Duclaux-Loras R, Moro-Sibilot L, Almeras T, Flourié B, Nancey S, Kaiserlian D. Gut Inflammation in Mice Triggers Proliferation and Function of Mucosal Foxp3+ Regulatory T Cells but Impairs Their Conversion from CD4+ T Cells. J Crohns Colitis. 2016 Jun 30. pii: jjw125.
  2.  Bouvier, D., Vianey-Saban, C., Ruet, S. and Acquaviva, C. (2016) Development of a Tandem Mass Spectrometry Method for Rapid Measurement of Medium- and Very-Long-Chain Acyl-CoA Dehydrogenase Activity in Fibroblasts JIMD Reports doi: 10.1007/8904_2016_22
  1. Brault, C., Levy, P., Duponchel, S., Michelet, M., Salle, A., Pecheur, E. I., Plissonnier, M. L., Parent, R., Vericel, E., Ivanov, A. V., Demir, M., Steffen, H. M., Odenthal, M., Zoulim, F. and Bartosch, B. (2016) Glutathione peroxidase 4 is reversibly induced by HCV to control lipid peroxidation and to increase virion infectivity Gut 65 144-54
  1. Capel, F., Cheraiti, N., Acquaviva, C., Henique, C., Bertrand-Michel, J., Vianey-Saban, C., Prip-Buus, C. and Morio, B. (2016) Oleate dose-dependently regulates palmitate metabolism and insulin signaling in C2C12 myotubes Biochimica et Biophysica Acta 1861 2000-2010
  1. Caussy, C., Charriere, S., Meirhaeghe, A., Dallongeville, J., Lefai, E., Rome, S., Cuerq, C., Euthine, V., Delay, M., Marmontel, O., Di Filippo, M., Lagarde, M., Moulin, P. and Marcais, C. (2016) Multiple microRNA regulation of lipoprotein lipase gene abolished by 3’UTR polymorphisms in a triglyceride-lowering haplotype harboring p.Ser474Ter Atherosclerosis 246 280-6
  2. Collardeau-Frachon, S., Cordier, M. P., Rossi, M., Guibaud, L. and Vianey-Saban, C. (2016) Antenatal manifestations of inborn errors of metabolism: autopsy findings suggestive of a metabolic disorder Journal of Inherited Metabolic Disease 39 597-610
  1. Cuerq, C., Restier, L., Drai, J., Blond, E., Roux, A., Charriere, S., Michalski, M. C., Di Filippo, M., Levy, E., Lachaux, A. and Peretti, N. (2016) Establishment of reference values of alpha-tocopherol in plasma, red blood cells and adipose tissue in healthy children to improve the management of chylomicron retention disease, a rare genetic hypocholesterolemia Orphanet Journal of Rare Diseases 11 114
  1. Dancer, M., Caussy, C., Di Filippo, M., Moulin, P., Marcais, C. and Charriere, S. (2016) Lack of evidence for a liver or intestinal miRNA regulation involved in the hypertriglyceridemic effect of APOC3 3’UTR variant SstI Atherosclerosis 255 6-10
  1. Dimassi, S., Labalme, A., Ville, D., Calender, A., Mignot, C., Boutry-Kryza, N., de Bellescize, J., Rivier-Ringenbach, C., Bourel-Ponchel, E., Cheillan, D., Simonet, T., Maincent, K., Rossi, M., Till, M., Mougou-Zerelli, S., Edery, P., Saad, A., Heron, D., des Portes, V., Sanlaville, D. and Lesca, G. (2016) Whole-exome sequencing improves the diagnosis yield in sporadic infantile spasm syndrome Clinical Genetics 89 198-204
  1. Es Sadki, T., Badiou, S., Boubal, M., Baleine, J., Sieso, V., Vallat, C., Cristol, J. P., Vianey-Saban, C. and Cambonie, G. (2016) Isolated methylmalonic acidemia: a case report Annales de Biologie Clinique (Paris) 74 472-6
  1. Genere, L., Pecciarini, N., Peretti, N., Villard, F. and Lachaux, A. (2016) [Food protein-induced enterocolitis syndrome: A case report of diarrhea with hypovolemic shock and methemoglobinemia] Archives de Pédiatrie doi:10.1016/j.arcped.2016.10.013
  1. Guibaud, L., Collardeau-Frachon, S., Lacalm, A., Massoud, M., Rossi, M., Cordier, M. P. and Vianey-Saban, C. (2016) Antenatal manifestations of inborn errors of metabolism: prenatal imaging findings Journal of Inherited Metabolic Disease doi:10.1007/s10545-016-9992-3
  1. Hachem, M., Geloen, A., Van, A. L., Foumaux, B., Fenart, L., Gosselet, F., Da Silva, P., Breton, G., Lagarde, M., Picq, M. and Bernoud-Hubac, N. (2016) Efficient Docosahexaenoic Acid Uptake by the Brain from a Structured Phospholipid Molecular Neurobiology 53 3205-15
  1. Hubert, A., Ford-Chessel, C., Berthiller, J., Peretti, N., Javouhey, E. and Valla, F. V. (2016) Nutritional status in pediatric intermediate care: Assessment at admission, progression during the stay and after discharge Archives de Pédiatrie 23 333-9
  1. Hullin-Matsuda, F., Makino, A., Murate, M. and Kobayashi, T. (2016) Probing phosphoethanolamine-containing lipids in membranes with duramycin/cinnamycin and aegerolysin proteins Biochimie 130 81-90
  1. Jansen, J. C., Cirak, S., van Scherpenzeel, M., Timal, S., Reunert, J., Rust, S., Perez, B., Vicogne, D., Krawitz, P., Wada, Y., Ashikov, A., Perez-Cerda, C., Medrano, C., Arnoldy, A., Hoischen, A., Huijben, K., Steenbergen, G., Quelhas, D., Diogo, L., Rymen, D., Jaeken, J., Guffon, N., Cheillan, D., van den Heuvel, L. P., Maeda, Y., Kaiser, O., Schara, U., Gerner, P., van den Boogert, M. A., Holleboom, A. G., Nassogne, M. C., Sokal, E., Salomon, J., van den Bogaart, G., Drenth, J. P., Huynen, M. A., Veltman, J. A., Wevers, R. A., Morava, E., Matthijs, G., Foulquier, F., Marquardt, T. and Lefeber, D. J. (2016) CCDC115 Deficiency Causes a Disorder of Golgi Homeostasis with Abnormal Protein Glycosylation American Journal of Human Genetics 98 310-21
  1. Jones, S., Boisvert, A., Naghi, A., Hullin-Matsuda, F., Greimel, P., Kobayashi, T., Papadopoulos, V. and Culty, M. (2016) Stimulatory effects of combined endocrine disruptors on MA-10 Leydig cell steroid production and lipid homeostasis Toxicology 355-356 21-30
  1. Lagarde, M., Calzada, C., Guichardant, M. and Véricel, E. (2016) In vitro and in vivo bimodal effects of docosahexaenoic acid supplements on redox status and platelet function Prostaglandins, Leukotrienes and Essential Fatty Acids 108 1-4
  1. Lecomte, M., Couedelo, L., Meugnier, E., Plaisancie, P., Letisse, M., Benoit, B., Gabert, L., Penhoat, A., Durand, A., Pineau, G., Joffre, F., Geloen, A., Vaysse, C., Laugerette, F. and Michalski, M. C. (2016) Dietary emulsifiers from milk and soybean differently impact adiposity and inflammation in association with modulation of colonic goblet cells in high-fat fed mice Molecular Nutrition & Food Research 60 609-20
  1. Le Luduec JB, Debeer S, Piras F, Andréoni C, Boudet F, Laurent P, Kaiserlian D, Dubois B. Intradermal vaccination with un-adjuvanted sub-unit vaccines triggers skin innate immunity and confers protective respiratory immunity in domestic swine. Vaccine. 2016 Feb 10;34(7):914-22.
  1. Lo Van, A., Sakayori, N., Hachem, M., Belkouch, M., Picq, M., Lagarde, M., Osumi, N. and Bernoud-Hubac, N. (2016) Mechanisms of DHA transport to the brain and potential therapy to neurodegenerative diseases Biochimie 130 163-167
  1. Makino, A., Abe, M., Ishitsuka, R., Murate, M., Kishimoto, T., Sakai, S., Hullin-Matsuda, F., Shimada, Y., Inaba, T., Miyatake, H., Tanaka, H., Kurahashi, A., Pack, C. G., Kasai, R. S., Kubo, S., Schieber, N. L., Dohmae, N., Tochio, N., Hagiwara, K., Sasaki, Y., Aida, Y., Fujimori, F., Kigawa, T., Nishibori, K., Parton, R. G., Kusumi, A., Sako, Y., Anderluh, G., Yamashita, M., Kobayashi, T., Greimel, P. and Kobayashi, T. (2016) A novel sphingomyelin/cholesterol domain-specific probe reveals the dynamics of the membrane domains during virus release and in Niemann-Pick type C Faseb Journal doi:10.1096/fj.201500075R
  1. Makino, A., Hullin-Matsuda, F., Murate, M., Abe, M., Tomishige, N., Fukuda, M., Yamashita, S., Fujimoto, T., Vidal, H., Lagarde, M., Delton, I. and Kobayashi, T. (2016) Acute accumulation of free cholesterol induces the degradation of perilipin 2 and Rab18-dependent fusion of ER and lipid droplets in cultured human hepatocytes Molecular Biology of the Cell 27 3293-3304
  1. Mirabel-Chambaud, E., N’Guyen, M., Valdeyron, M. L., Quessada, T., Goudable, J., Loras-Duclaux, I., Marotte, S., Heissat, S., Restier, L., Lachaux, A. and Peretti, N. (2016) Dramatic increase of central venous catheter-related infections associated with a high turnover of the nursing team Clinical Nutrition 35 446-52
  1. Moro-Sibilot L, Blanc P, Taillardet M, Bardel E, Couillault C, Boschetti G, Traverse-Glehen A, Defrance T, Kaiserlian D, Dubois B. Mouse and Human Liver Contain Immunoglobulin A-Secreting Cells Originating From Peyer’s Patches and Directed Against Intestinal Antigens. Gastroenterology. 2016 Aug;151(2):311-23.
  1. Moro-Sibilot L, This S, Blanc P, Sanlaville A, Sisirak V, Bardel E, Boschetti G, Bendriss-Vermare N, Defrance T, Dubois B, Kaiserlian D. Plasmacytoid dendritic cells are dispensable for noninfectious intestinal IgA responses in vivo. Eur J Immunol. 2016 Feb;46(2):354-9.
  1. Perez-Cerda, C., Ugarte, M., Vianey-Saban, C., Scharer, G. H., Van Hove, J. L., Olsen, R. K., Konarikova, E., Giancaspero, T. A., Mosegaard, S., Boczonadi, V., Matakovic, L., Veauville-Merllie, A., Terrile, C., Schwarzmayr, T., Haack, T. B., Auranen, M., Leone, P., Galluccio, M., Imbard, A., Gutierrez-Rios, P., Palmfeldt, J., Graf, E., Vianey-Saban, C., Oppenheim, M., Schiff, M., Pichard, S., Rigal, O., Pyle, A., Chinnery, P. F., Konstantopoulou, V., Moslinger, D., Feichtinger, R. G., Talim, B., Topaloglu, H., Coskun, T., Gucer, S., Botta, A., Pegoraro, E., Malena, A., Vergani, L., Mazza, D., Zollino, M., Ghezzi, D., Acquaviva, C., Tyni, T., Boneh, A., Meitinger, T., Strom, T. M., Gregersen, N., Mayr, J. A., Horvath, R., Barile, M. and Prokisch, H. (2016) Riboflavin-Responsive and -Non-responsive Mutations in FAD Synthase Cause Multiple Acyl-CoA Dehydrogenase and Combined Respiratory-Chain Deficiency Genetics in Medicine 98 1130-45
  1. Pontoizeau, C., Habarou, F., Brassier, A., Veauville-Merllie, A., Grisel, C., Arnoux, J. B., Vianey-Saban, C., Barouki, R., Chadefaux-Vekemans, B., Acquaviva, C., de Lonlay, P. and Ottolenghi, C. (2016) Hyperprolinemia in Type 2 Glutaric Aciduria and MADD-Like Profiles JIMD Reports 27 39-45
  1. Renaud, M., Guissart, C., Mallaret, M., Ferdinandusse, S., Cheillan, D., Drouot, N., Muller, J., Claustres, M., Tranchant, C., Anheim, M. and Koenig, M. (2016) Expanding the spectrum of PEX10-related peroxisomal biogenesis disorders: slowly progressive recessive ataxia Journal of Neurology 263 1552-8
  1. Roblin, E., Dumortier, J., Di Filippo, M., Collardeau-Frachon, S., Sassolas, A., Peretti, N., Serusclat, A., Rivet, C., Boillot, O. and Lachaux, A. (2016) Lipid profile and cardiovascular risk factors in pediatric liver transplant recipients Pediatric Transplantation 20 241-8
  1. Sala, P. R., Ruijter, G., Acquaviva, C., Chabli, A., de Sain-van der Velden, M. G., Garcia-Villoria, J., Heiner-Fokkema, M. R., Jeannesson-Thivisol, E., Leckstrom, K., Franzson, L., Lynes, G., Olesen, J., Onkenhout, W., Petrou, P., Drousiotou, A., Ribes, A., Vianey-Saban, C. and Merinero, B. (2016) Pilot Experience with an External Quality Assurance Scheme for Acylcarnitines in Plasma/Serum JIMD Reports 30 23-31
  1. Sanna, C., Stephenne, X., Revencu, N., Smets, F., Sassolas, A., Di Filippo, M., Descamps, O. S. and Sokal, E. M. (2016) Homozygous familial hypercholesterolemia in childhood: Genotype-phenotype description, established therapies and perspectives Atherosclerosis 247 97-104
  1. Schiff, M., Veauville-Merllie, A., Su, C. H., Tzagoloff, A., Rak, M., Ogier de Baulny, H., Boutron, A., Smedts-Walters, H., Romero, N. B., Rigal, O., Rustin, P., Vianey-Saban, C. and Acquaviva-Bourdain, C. (2016) SLC25A32 Mutations and Riboflavin-Responsive Exercise Intolerance The New England Journal of Medicine 374 795-7
  1. Sorlin, A., Briand, G., Cheillan, D., Wiedemann, A., Montaut-Verient, B., Schmitt, E. and Feillet, F. (2016) Effect of l-Arginine in One Patient with Peroxisome Biogenesis Disorder due to PEX12 Deficiency Neuropediatrics 47 179-81
  1. Spitz, M. A., Nguyen, M. A., Roche, S., Heron, B., Milh, M., de Lonlay, P., Lion-Francois, L., Testard, H., Napuri, S., Barth, M., Fournier-Favre, S., Christa, L., Vianey-Saban, C., Corne, C. and Roubertie, A. (2016) Chronic Diarrhea in L-Amino Acid Decarboxylase (AADC) Deficiency: A Prominent Clinical Finding Among a Series of Ten French Patients JIMD Reports doi:10.1007/8904_2016_550
  1. Venugopal, S., Martinez-Arguelles, D. B., Chebbi, S., Hullin-Matsuda, F., Kobayashi, T. and Papadopoulos, V. (2016) Plasma membrane origin of the steroidogenic pool of cholesterol used in hormone-induced acute steroid formation in Leydig cells The Journal of Biological Chemistry 291 26109-26125
  1. Véricel, E., Mazur, S., Colas, R., Delaup, V., Calzada, C., Reix, P., Durieu, I., Lagarde, M. and Bellon, G. (2016) Moderate intake of docosahexaenoic acid raises plasma and platelet vitamin E levels in cystic fibrosis patients Prostaglandins, Leukotrienes and Essential Fatty Acids 115 41-47
  1. Vianey-Saban, C., Acquaviva, C., Cheillan, D., Collardeau-Frachon, S., Guibaud, L., Pagan, C., Pettazzoni, M., Piraud, M., Lamaziere, A. and Froissart, R. (2016) Antenatal manifestations of inborn errors of metabolism: biological diagnosis Journal of Inherited Metabolic Disease 39 611-24
  1. Yamaji-Hasegawa, A., Hullin-Matsuda, F., Greimel, P. and Kobayashi, T. (2016) Pore-forming toxins: Properties, diversity, and uses as tools to image sphingomyelin and ceramide phosphoethanolamine Biochimica et Biophysica Acta 1858 576-92

2015

1. Benoit, B., Bruno, J., Kayal, F., Estienne, M., Debard, C., Ducroc, R., and Plaisancie, P. (2015) Saturated and Unsaturated Fatty Acids Differently Modulate Colonic Goblet Cells In Vitro and in Rat Pups. The Journal of nutrition. 145, 1754-1762

2. Benoit, B., Laugerette, F., Plaisancie, P., Geloen, A., Bodennec, J., Estienne, M., Pineau, G., Bernalier-Donadille, A., Vidal, H., and Michalski, M. C. (2015) Increasing fat content from 20 to 45 wt% in a complex diet induces lower endotoxemia in parallel with an increased number of intestinal goblet cells in mice. Nutrition Research. 35, 346-356

3. Bessette, C., Benoit, B., Sekkal, S., Bruno, J., Estienne, M., Leonil, J., Ferrier, L., Theodorou, V., and Plaisancie, P. (2015) Protective effects of beta-casofensin, a bioactive peptide from bovine beta-casein, against indomethacin-induced intestinal lesions in rats. Molecular nutrition & food research. 60, 823-833

4. Bourlieu, C., and Michalski, M. C. (2015) Structure-function relationship of the milk fat globule. Current opinion in clinical nutrition and metabolic care. 18, 118-127

5. Capel, F., Acquaviva, C., Pitois, E., Laillet, B., Rigaudiere, J. P., Jouve, C., Pouyet, C., Gladine, C., Comte, B., Vianey Saban, C., and Morio, B. (2015) DHA at nutritional doses restores insulin sensitivity in skeletal muscle by preventing lipotoxicity and inflammation. The Journal of Nutritional Biochemistry. 26, 949-959

6. Chen, Y., Arnal-Levron, M., Lagarde, M., Moulin, P., Luquain-Costaz, C., and Delton, I. (2015) THP1 macrophages oxidized cholesterol, generating 7-derivative oxysterols specifically released by HDL. Steroids. 99, 212-218

7. Couedelo, L., Amara, S., Lecomte, M., Meugnier, E., Monteil, J., Fonseca, L., Pineau, G., Cansell, M., Carriere, F., Michalski, M. C., and Vaysse, C. (2015) Impact of various emulsifiers on ALA bioavailability and chylomicron synthesis through changes in gastrointestinal lipolysis. Food & function. 6, 1726-1735

8. Cuerq, C., Peretti, N., Chikh, K., Mialon, A., Guillaumont, M., Drai, J., and Blond, E. (2015) Overview of the in vitro stability of commonly measured vitamins and carotenoids in whole blood. Annals of Clinical Biochemistry. 52, 259-269

9. Fan, Y., Li, X., Xiao, W., Fu, J., Harris, R. C., Lindenmeyer, M., Cohen, C. D., Guillot, N., Baron, M. H., Wang, N., Lee, K., He, J. C., Schlondorff, D., and Chuang, P. Y. (2015) BAMBI elimination enhances alternative TGF-beta signaling and glomerular dysfunction in diabetic mice. Diabetes. 64, 2220-2233

10. Grange, S., Bekri, S., Artaud-Macari, E., Francois, A., Girault, C., Poitou, A. L., Benhamou, Y., Vianey-Saban, C., Benoist, J. F., Chatelet, V., Tamion, F., and Guerrot, D. (2015) Adult-onset renal thrombotic microangiopathy and pulmonary arterial hypertension in cobalamin C deficiency. Lancet. 386, 1011-1012

11. Guichardant, M., Calzada, C., Bernoud-Hubac, N., Lagarde, M., and Véricel, E. (2015) Omega-3 polyunsaturated fatty acids and oxygenated metabolism in atherothrombosis. Biochimica et biophysica acta. 1851, 485-495

12. Hachem, M., Geloen, A., Van, A. L., Foumaux, B., Fenart, L., Gosselet, F., Da Silva, P., Breton, G., Lagarde, M., Picq, M., and Bernoud-Hubac, N. (2015) Efficient Docosahexaenoic Acid Uptake by the Brain from a Structured Phospholipid. Molecular neurobiology.

13. Lagarde, M., Hachem, M., Bernoud-Hubac, N., Picq, M., Véricel, E., and Guichardant, M. (2015) Biological properties of a DHA-containing structured phospholipid (AceDoPC) to target the brain. Prostaglandins, leukotrienes, and essential fatty acids. 92, 63-65

14. Lagarde, M., and Nicolaou, A. (2015) Oxygenated metabolism of PUFA: Analysis and biological relevance. Biochimica et biophysica acta. 1851, 307

15. Lagarde M, Calzada C, Jouvène C, Bernoud-Hubac N, Létisse M, Guichardant M, Véricel E. Functional fluxolipidomics of polyunsaturated fatty acids and oxygenated metabolites in the blood vessel compartment. Prog Lipid Res. 2015 Oct;60:41-9. Review.

16. Le, Q. H., El Alaoui, M., Véricel, E., Segrestin, B., Soulere, L., Guichardant, M., Lagarde, M., Moulin, P., and Calzada, C. (2015) Glycoxidized HDL, HDL enriched with oxidized phospholipids and HDL from diabetic patients inhibit platelet function. The Journal of clinical endocrinology and metabolism. 100, 2006-2014

17. Lecomte, M., Bourlieu, C., Meugnier, E., Penhoat, A., Cheillan, D., Pineau, G., Loizon, E., Trauchessec, M., Claude, M., Menard, O., Geloen, A., Laugerette, F., and Michalski, M. C. (2015) Milk Polar Lipids Affect In Vitro Digestive Lipolysis and Postprandial Lipid Metabolism in Mice. The Journal of nutrition. 145, 1770-1777

18. Lecomte, M., Couedelo, L., Meugnier, E., Plaisancie, P., Letisse, M., Benoit, B., Gabert, L., Penhoat, A., Durand, A., Pineau, G., Joffre, F., Geloen, A., Vaysse, C., Laugerette, F., and Michalski, M. C. (2016) Dietary emulsifiers from milk and soybean differently impact adiposity and inflammation in association with modulation of colonic goblet cells in high-fat fed mice. Molecular nutrition & food research. 60, 609-620

19. Lepais, L., Cheillan, D., Frachon, S. C., Hays, S., Matthijs, G., Panagiotakaki, E., Abel, C., Edery, P., and Rossi, M. (2015) ALG3-CDG: Report of two siblings with antenatal features carrying homozygous p.Gly96Arg mutation. American journal of medical genetics. 167A, 2748-2754

20. Maniti, O., Francois-Moutal, L., Lecompte, M. F., Vial, C., Lagarde, M., Guichardant, M., Marcillat, O., and Granjon, T. (2015) Protein « amyloid-like » networks at the phospholipid membrane formed by 4-hydroxy-2-nonenal-modified mitochondrial creatine kinase. Molecular membrane biology. 32, 1-10

21. Martins, C., Hulkova, H., Dridi, L., Dormoy-Raclet, V., Grigoryeva, L., Choi, Y., Langford-Smith, A., Wilkinson, F. L., Ohmi, K., DiCristo, G., Hamel, E., Ausseil, J., Cheillan, D., Moreau, A., Svobodova, E., Hajkova, Z., Tesarova, M., Hansikova, H., Bigger, B. W., Hrebicek, M., and Pshezhetsky, A. V. (2015) Neuroinflammation, mitochondrial defects and neurodegeneration in mucopolysaccharidosis III type C mouse model. Brain. 138, 336-355

22. Mirabel-Chambaud, E., N’Guyen, M., Valdeyron, M. L., Quessada, T., Goudable, J., Loras-Duclaux, I., Marotte, S., Heissat, S., Restier, L., Lachaux, A., and Peretti, N. (2015) Dramatic increase of central venous catheter-related infections associated with a high turnover of the nursing team. Clinical nutrition. 35, 446-452

23. Plaisancie, P., Boutrou, R., Estienne, M., Henry, G., Jardin, J., Paquet, A., and Leonil, J. (2015) beta-Casein(94-123)-derived peptides differently modulate production of mucins in intestinal goblet cells. The Journal of dairy research. 82, 36-46

24. Rossi, M., Hall, C. M., Bouvier, R., Collardeau-Frachon, S., Le Breton, F., Bucourt, M., Cordier, M. P., Vianey-Saban, C., Parenti, G., Andria, G., Le Merrer, M., Edery, P., and Offiah, A. C. (2015) Radiographic features of the skeleton in disorders of post-squalene cholesterol biosynthesis. Pediatric radiology. 45, 965-976

25. Salvatore, G., Bernoud-Hubac, N., Bissay, N., Debard, C., Daira, P., Meugnier, E., Proamer, F., Hanau, D., Vidal, H., Arico, M., Delprat, C., and Mahtouk, K. (2015) Human monocyte-derived dendritic cells turn into foamy dendritic cells with IL-17A. Journal of lipid research. 56, 1110-1122

26. Soty, M., Penhoat, A., Amigo-Correig, M., Vinera, J., Sardella, A., Vullin-Bouilloux, F., Zitoun, C., Houberdon, I., and Mithieux, G. (2015) A gut-brain neural circuit controlled by intestinal gluconeogenesis is crucial in metabolic health. Molecular metabolism. 4, 106-117

27. Spahis, S., Alvarez, F., Dubois, J., Ahmed, N., Peretti, N., and Levy, E. (2015) Plasma fatty acid composition in French-Canadian children with non-alcoholic fatty liver disease: Effect of n-3 PUFA supplementation. Prostaglandins, leukotrienes, and essential fatty acids. 99, 25-34

28. Vella, R. E., Pillon, N. J., Zarrouki, B., Croze, M. L., Koppe, L., Guichardant, M., Pesenti, S., Chauvin, M. A., Rieusset, J., Geloen, A., and Soulage, C. O. (2015) Ozone exposure triggers insulin resistance through muscle c-Jun N-terminal kinase activation. Diabetes. 64, 1011-1024

29. Véricel, E., Colas, R., Calzada, C., Le, Q. H., Feugier, N., Cugnet, C., Vidal, H., Laville, M., Moulin, P., and Lagarde, M. (2015) Moderate oral supplementation with docosahexaenoic acid improves platelet function and oxidative stress in type 2 diabetic patients. Thrombosis and haemostasis. 114, 289-296

30. Vial, G., Chauvin, M. A., Bendridi, N., Durand, A., Meugnier, E., Madec, A. M., Bernoud-Hubac, N., Pais de Barros, J. P., Fontaine, E., Acquaviva, C., Hallakou-Bozec, S., Bolze, S., Vidal, H., and Rieusset, J. (2015) Imeglimin normalizes glucose tolerance and insulin sensitivity and improves mitochondrial function in liver of a high-fat, high-sucrose diet mice model. Diabetes. 64, 2254-2264

31. Vors, C., Drai, J., Gabert, L., Pineau, G., Laville, M., Vidal, H., Guichard, E., Michalski, M. C., and Feron, G. (2015) Salivary composition in obese vs normal-weight subjects: towards a role in postprandial lipid metabolism? International Journal of Obesity. 39, 1425-1428

32. Vors, C., Pineau, G., Drai, J., Meugnier, E., Pesenti, S., Laville, M., Laugerette, F., Malpuech-Brugere, C., Vidal, H., and Michalski, M. C. (2015) Postprandial Endotoxemia Linked With Chylomicrons and Lipopolysaccharides Handling in Obese Versus Lean Men: A Lipid Dose-Effect Trial. The Journal of Clinical Endocrinology and Metabolism. 100, 3427-3435

33. Zahnd, G., Salles, S., Liebgott, H., Vray, D., Serusclat, A., and Moulin, P. (2015) Real-time ultrasound-tagging to track the 2D motion of the common carotid artery wall in vivo. Medical physics. 42, 820-830

2014

1. Balas, L., Guichardant, M., Durand, T., and Lagarde, M. (2014) Confusion between protectin D1 (PD1) and its isomer protectin DX (PDX). An overview on the dihydroxy-docosatrienes described to date. Biochimie. 99, 1-7

2. Baruteau, J., Sachs, P., Broue, P., Brivet, M., Abdoul, H., Vianey-Saban, C., and Ogier de Baulny, H. (2014) Clinical and biological features at diagnosis in mitochondrial fatty acid beta-oxidation defects: a French pediatric study from 187 patients. Complementary data. Journal of inherited metabolic disease. 37, 137-139

3. Beliard, S., Carreau, V., Carrie, A., Giral, P., Duchene, E., Farnier, M., Ferrieres, J., Fredenrich, A., Krempf, M., Luc, G., Moulin, P., and Bruckert, E. (2014) Improvement in LDL-cholesterol levels of patients with familial hypercholesterolemia: can we do better? Analysis of results obtained during the past two decades in 1669 French subjects. Atherosclerosis. 234, 136-141

4. Benoit, B., Plaisancie, P., Geloen, A., Estienne, M., Debard, C., Meugnier, E., Loizon, E., Daira, P., Bodennec, J., Cousin, O., Vidal, H., Laugerette, F., and Michalski, M. C. (2014) Pasture v. standard dairy cream in high-fat diet-fed mice: improved metabolic outcomes and stronger intestinal barrier. The British journal of nutrition. 1-16

5. Caussy, C., Charriere, S., Marcais, C., Di Filippo, M., Sassolas, A., Delay, M., Euthine, V., Jalabert, A., Lefai, E., Rome, S., and Moulin, P. (2014) An APOA5 3′ UTR variant associated with plasma triglycerides triggers APOA5 downregulation by creating a functional miR-485-5p binding site. American journal of human genetics. 94, 129-134

6. Di Filippo, M., Marcais, C., Charriere, S., Marmontel, O., Broyer, M., Delay, M., Merlin, M., Nollace, A., Valero, R., Lagarde, M., Pruneta-Deloche, V., Moulin, P., and Sassolas, A. (2014) Post-heparin LPL activity measurement using VLDL as a substrate: a new robust method for routine assessment of plasma triglyceride lipolysis defects. PloS one. 9, e96482

7. Di Filippo, M., Moulin, P., Roy, P., Elisabeth Samson-Bouma, M., Collardeau-Frachon, S., Chebel-Dumont, S., Peretti, N., Dumortier, J., Zoulim, F., Fontanges, T., Parini, R., Rigoldi, M., Furlan, F., Mancini, G., Bonnefont-Rousselot, D., Bruckert, E., Schmitz, J., Yves Scoazec, J., Charriere, S., Villar-Fimbel, S., Gottrand, F., Dubern, B., Doummar, D., Joly, F., Elisabeth Liard-Meillon, M., Lachaux, A., and Sassolas, A. (2014) Hepatic steatosis and fibrosis despite metabolic differences in congenital hypocholesterolemia due to homozygous MTTP and APOB mutations. Journal of hepatology.

8. Ernande, L., Bergerot, C., Girerd, N., Thibault, H., Davidsen, E. S., Gautier Pignon-Blanc, P., Amaz, C., Croisille, P., De Buyzere, M. L., Rietzschel, E. R., Gillebert, T. C., Moulin, P., Altman, M., and Derumeaux, G. (2014) Longitudinal myocardial strain alteration is associated with left ventricular remodeling in asymptomatic patients with type 2 diabetes mellitus. Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography. 27, 479-488

9. Fabre, A., Breton, A., Coste, M. E., Colomb, V., Dubern, B., Lachaux, A., Lemale, J., Mancini, J., Marinier, E., Martinez-Vinson, C., Peretti, N., Perry, A., Roquelaure, B., Venaille, A., Sarles, J., Goulet, O., and Badens, C. (2014) Syndromic (phenotypic) diarrhoea of infancy/tricho-hepato-enteric syndrome. Archives of disease in childhood. 99, 35-38

10. Huet, F., Godefroy, A., Cheillan, D., Somma, C., and Roussey, M. (2014) [Do we need congenital adrenal hyperplasia screening for premature infants?]. Archives de pediatrie : organe officiel de la Societe francaise de pediatrie. 21, 233-236

11. Lagarde, M., Hachem, M., Bernoud-Hubac, N., Picq, M., Vericel, E., and Guichardant, M. (2014) Biological properties of a DHA-containing structured phospholipid (AceDoPC) to target the brain. Prostaglandins, leukotrienes, and essential fatty acids.

12. Lagarde, M., Liu, M., Vericel, E., Calzada, C., Chen, P., Driss, F., and Guichardant, M. (2014) Docosahexaenoic acid, protectin synthesis: relevance against atherothrombogenesis. The Proceedings of the Nutrition Society. 73, 186-189

13. Lagarde M, Véricel E, Liu M, Chen P, Guichardant M. Structure-function relationships of non-cyclic dioxygenase products from polyunsaturated fatty acids: poxytrins as a class of bioactive derivatives. Biochimie. 2014 Dec;107 Pt A:91-4. Review.

14. Laugerette, F., Alligier, M., Bastard, J. P., Drai, J., Chanseaume, E., Lambert-Porcheron, S., Laville, M., Morio, B., Vidal, H., and Michalski, M. C. (2014) Overfeeding increases postprandial endotoxemia in men: Inflammatory outcome may depend on LPS transporters LBP and sCD14. Molecular nutrition & food research.

15. Levy, E., Spahis, S., Garofalo, C., Marcil, V., Montoudis, A., Sinnet, D., Sanchez, R., Peretti, N., Beaulieu, J. F., and Sane, A. (2014) Sar1b transgenic male mice are more susceptible to high-fat diet-induced obesity, insulin insensitivity and intestinal chylomicron overproduction. The Journal of nutritional biochemistry. 25, 540-548

16. Liu, M., Boussetta, T., Makni-Maalej, K., Fay, M., Driss, F., El-Benna, J., Lagarde, M., and Guichardant, M. (2014) Protectin DX, a double lipoxygenase product of DHA, inhibits both ROS production in human neutrophils and cyclooxygenase activities. Lipids. 49, 49-57

17. Mercimek-Mahmutoglu, S., Ndika, J., Kanhai, W., de Villemeur, T. B., Cheillan, D., Christensen, E., Dorison, N., Hannig, V., Hendriks, Y., Hofstede, F. C., Lion-Francois, L., Lund, A. M., Mundy, H., Pitelet, G., Raspall-Chaure, M., Scott-Schwoerer, J. A., Szakszon, K., Valayannopoulos, V., Williams, M., and Salomons, G. S. (2014) Thirteen New Patients with Guanidinoacetate Methyltransferase Deficiency and Functional Characterization of Nineteen Novel Missense Variants in the GAMT Gene. Human mutation. 35, 462-469

18. Meynier, A., Leborgne, C., Viau, M., Schuck, P., Guichardant, M., Rannou, C., and Anton, M. (2014) N-3 fatty acid enriched eggs and production of egg yolk powders: an increased risk of lipid oxidation? Food chemistry. 153, 94-100

19. Moulin, P., Cinq-Frais, C., Gangloff, C., Peyre, M., Seguela, P. E., Charpentier, S., Cascarigny, F., Alcouffe, F., Periquet, B., Dulac, Y., and Acar, P. (2014) [Thiamine deficiency in infants: a case report]. Archives de pediatrie : organe officiel de la Societe francaise de pediatrie. 21, 392-395

20. Penhoat, A., Fayard, L., Stefanutti, A., Mithieux, G., and Rajas, F. (2014) Intestinal gluconeogenesis is crucial to maintain a physiological fasting glycemia in the absence of hepatic glucose production in mice. Metabolism: clinical and experimental. 63, 104-111

21. Sarles, J., Giorgi, R., Berthezene, P., Munck, A., Cheillan, D., Dagorn, J. C., and Roussey, M. (2014) Neonatal screening for cystic fibrosis: Comparing the performances of IRT/DNA and IRT/PAP. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society.

22. Tort, F., Ferrer-Cortes, X., Thio, M., Navarro-Sastre, A., Matalonga, L., Quintana, E., Bujan, N., Arias, A., Garcia-Villoria, J., Acquaviva, C., Vianey-Saban, C., Artuch, R., Garcia-Cazorla, A., Briones, P., and Ribes, A. (2014) Mutations in the lipoyltransferase LIPT1 gene cause a fatal disease associated with a specific lipoylation defect of the 2-ketoacid dehydrogenase complexes. Human molecular genetics. 23, 1907-1915

23. Vliegenthart, A. D., Starkey Lewis, P., Tucker, C. S., Del Pozo, J., Rider, S., Antoine, D. J., Dubost, V., Westphal, M., Moulin, P., Bailey, M. A., Moggs, J. G., Goldring, C. E., Park, B. K., and Dear, J. W. (2014) Retro-orbital Blood Acquisition Facilitates Circulating microRNA Measurement in Zebrafish with Paracetamol Hepatotoxicity. Zebrafish.

24. Wagner, S., Vianey-Saban, C., Salomons, G. S., Schmitt, E., and Feillet, F. (2014) [L-2-hydroxyglutaric aciduria: report on two cases]. Archives de pediatrie : organe officiel de la Societe francaise de pediatrie. 21, 78-85

2013

1. Arnal-Levron, M., Chen, Y., Delton-Vandenbroucke, I., and Luquain-Costaz, C. (2013) Bis(monoacylglycero)phosphate reduces oxysterol formation and apoptosis in macrophages exposed to oxidized LDL. Biochemical pharmacology. 86, 115-121

2. Awada, M., Meynier, A., Soulage, C. O., Hadji, L., Geloen, A., Viau, M., Ribourg, L., Benoit, B., Debard, C., Guichardant, M., Lagarde, M., Genot, C., and Michalski, M. C. (2013) n-3 PUFA added to high-fat diets affect differently adiposity and inflammation when carried by phospholipids or triacylglycerols in mice. Nutrition & metabolism. 10, 23

3. Baruteau, J., Sachs, P., Broue, P., Brivet, M., Abdoul, H., Vianey-Saban, C., and Ogier de Baulny, H. (2013) Clinical and biological features at diagnosis in mitochondrial fatty acid beta-oxidation defects: a French pediatric study of 187 patients. Journal of inherited metabolic disease. 36, 795-803

4. Benoit, B., Plaisancie, P., Awada, M., Geloen, A., Estienne, M., Capel, F., Malpuech-Brugere, C., Debard, C., Pesenti, S., Morio, B., Vidal, H., Rieusset, J., and Michalski, M. C. (2013) High-fat diet action on adiposity, inflammation, and insulin sensitivity depends on the control low-fat diet. Nutr Res. 33, 952-960

5. Calzada, C., Véricel, E., Colas, R., Guillot, N., El Khoury, G., Drai, J., Sassolas, A., Peretti, N., Ponsin, G., Lagarde, M., and Moulin, P. (2013) Inhibitory effects of in vivo oxidized high-density lipoproteins on platelet aggregation: evidence from patients with abetalipoproteinemia. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 27, 2855-2861

6. Camont, L., Lhomme, M., Rached, F., Le Goff, W., Negre-Salvayre, A., Salvayre, R., Calzada, C., Lagarde, M., Chapman, M. J., and Kontush, A. (2013) Small, dense high-density lipoprotein-3 particles are enriched in negatively charged phospholipids: relevance to cellular cholesterol efflux, antioxidative, antithrombotic, anti-inflammatory, and antiapoptotic functionalities. Arteriosclerosis, thrombosis, and vascular biology. 33, 2715-2723

7. Chapuy-Regaud, S., Subra, C., Requena, M., de Medina, P., Amara, S., Delton-Vandenbroucke, I., Payre, B., Cazabat, M., Carriere, F., Izopet, J., Poirot, M., and Record, M. (2013) Progesterone and a phospholipase inhibitor increase the endosomal bis(monoacylglycero)phosphate content and block HIV viral particle intercellular transmission. Biochimie. 95, 1677-1688

8. Croze, M. L., Vella, R. E., Pillon, N. J., Soula, H. A., Hadji, L., Guichardant, M., and Soulage, C. O. (2013) Chronic treatment with myo-inositol reduces white adipose tissue accretion and improves insulin sensitivity in female mice. The Journal of nutritional biochemistry. 24, 457-466

9. Flanagan, S. E., Xie, W., Caswell, R., Damhuis, A., Vianey-Saban, C., Akcay, T., Darendeliler, F., Bas, F., Guven, A., Siklar, Z., Ocal, G., Berberoglu, M., Murphy, N., O’Sullivan, M., Green, A., Clayton, P. E., Banerjee, I., Clayton, P. T., Hussain, K., Weedon, M. N., and Ellard, S. (2013) Next-generation sequencing reveals deep intronic cryptic ABCC8 and HADH splicing founder mutations causing hyperinsulinism by pseudoexon activation. American journal of human genetics. 92, 131-136

10. Fourreau, D., Peretti, N., Hengy, B., Gillet, Y., Courtil-Teyssedre, S., Hess, L., Loras-Duclaux, I., Caron, N., Didier, C., Cour-Andlauer, F., Heissat, S., Lachaux, A., and Javouhey, E. (2013) [Pediatric nutrition: Severe deficiency complications by using vegetable beverages, four cases report]. Presse Med. 42, e37-43

11. Gabriel, B. M., Pugh, J., Pruneta-Deloche, V., Moulin, P., Ratkevicius, A., and Gray, S. R. (2013) The effect of high intensity interval exercise on postprandial triacylglycerol and leukocyte activation–monitored for 48 h post exercise. PloS one. 8, e82669

12. Girard-Egrot, A., and Lagarde, M. (2013) Membranes and bioactive lipids. Biochimie. 95, 1-2

13. Joncquel-Chevalier Curt, M., Cheillan, D., …. Vianey-Saban, C., and Vamecq, J. (2013) Creatine and guanidinoacetate reference values in a French population. Molecular genetics and metabolism. 110, 263-267

14. Lagarde, M., Bernoud-Hubac, N., Calzada, C., Véricel, E., and Guichardant, M. (2013) Lipidomics of essential fatty acids and oxygenated metabolites. Molecular nutrition & food research. 57, 1347-1358

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