el jaafari 2016 fig ang


Adipose tissue (AT) inflammation due to obesity is known to contribute to insulin resistance and/or T2D. Indeed, obese AT are known to be infiltrated with variety of immune cells. In addition to macrophages, we have recently pointed out two new actors in obesity-mediated  inflammation processes, such as, adipose-derived mesenchymal stem cells (ASC) and Th17 cells. Indeed, ASC from obese, but not (or much less), lean subjects were shown to polarize interacting T cells towards the Th17 pathway, while inhibiting Th1 cell activation. Activation of monocyte/macrophages through the M1 subset was also mediated by ASC, as assessed by increased IL-1b secretion. In turn, mononuclear cell interaction with ASC resulted in increased IL-6 secretion by ASC, inhibition of adipogenesis, and decreased ASC-derived adipocyte insulin sensitivity (Eljaafari et al,  2015. Diabetes. 64:2477-88). Finally in a more recent report ( M. Chehimi et al, Adipocyte J, 2016) we have demonstrated similar pro-inflammatory properties in  adipocytes harvested from obese, but not lean  AT.

Eljaafari A, Robert M, Chehimi M, Chanon S, Durand C, Vial G, Bendridi N, Madec AM, Disse E, Laville M, Rieusset J, Lefai E, Vidal H, Pirola L.  Adipose Tissue-Derived Stem Cells From Obese Subjects Contribute to Inflammation and Reduced Insulin Response in Adipocytes Through Differential Regulation of the Th1/Th17 Balance and Monocyte Activation. Diabetes. 2015 Jul;64(7):2477-88 Pub Med








Team 1 – Laboratoire CarMeN
Mail :assia.eljaafari@univ-lyon1.fr