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Team 1 : “Nutritional adaptations, Environment and Diabetes”
Team 2 : “Regulation of Muscle Mass and Metabolic disorders”
Team 3 : “Organelle Communication and Diabetes”
Team 4 : “Postprandial Lipids and Triglycerides-rich Lipoproteins”
Team 5 : “Cardioprotection”
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Our discoveries
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2018-02-23T13:11:29+00:00
RECENT DISCOVERIES
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RECENT DISCOVERIES
sept 2019- Teams 3,5: Regulation of Mitochondria-Associated Membranes (MAMs) by NO/sGC/PKG Participates in the Control of Hepatic Insulin Response (Cells)
sept 2019- Equipes 2,3,5: Differential Effect of Glucose on ER-Mitochondria Ca2+ Exchange Participates in Insulin Secretion and Glucotoxicity-Mediated Dysfunction of β-Cells (Diabetes)
june 2019: Milk polar lipids reduce lipid cardiovascular risk factors in overweight postmenopausal women: towards a gut sphingomyelin-cholesterol interplay (Gut)
dec. 2018- Equipe 4: augmentation des complications vasculaires liées au diabète chez les personnes atteintes du trait drépanocytaire (Diabetes Care)
June 2018 – Teams 5 and 2: Two TRPV1 (Transient receptor potential vanilloid 1) variants impair intracellular Ca2+ signaling and may confer susceptibility to malignant hyperthermia (Genetics in Medicine)
March 2018 – Teams 1 and 4 : Skeletal muscle insulin resistance induced by the by-product of omega-3 fatty acid peroxidation 4-hydroxy-2-hexenal (4-HHE) (Diabetologia)
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December 2016- Team 5 : Unacylated ghrelin analog prevents myocardial reperfusion injury independently of permeability transition pore
April 2016- Team 3 : Mitochondria-associated endoplasmic reticulum membranes allow adaptation of mitochondrial metabolism to glucose availability in the liver (J Mol Cell Biol)
March 2016 – Teams 3 and 5 : Disruption of calcium transfer from ER to mitochondria links alterations of mitochondria-associated ER membrane integrity to hepatic insulin resistance.( Diabetologia)
February 2016 – Teams 1 and 3: The intestinal microbiota: a new ally for optimum growth (Science)
Sept 2015 – Team 4: Postprandial Endotoxemia Linked With Chylomicrons and Lipopolysaccharides Handling in Obese Versus Lean Men: A Lipid Dose-Effect Trial (J Clin Endocrinol Metab)
July 2015- Teams 1,2,3 and 4 : Adipose Tissue-Derived Stem Cells From Obese Subjects Contribute to Inflammation and Reduced Insulin Response in Adipocytes Through Differential Regulation of the Th1/Th17 Balance and Monocyte Activation (Diabetes)
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