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The functional lipidomics
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Team 1 : “Nutritional adaptations, Environment and Diabetes”
Team 2 : “Regulation of Muscle Mass and Metabolic disorders”
Team 3 : “Organelle Communication and Diabetes”
Team 4 : “Postprandial Lipids and Triglycerides-rich Lipoproteins”
Team 5 : “Cardioprotection”
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Our discoveries
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2018-02-23T13:11:29+00:00
RECENT DISCOVERIES
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RECENT DISCOVERIES
June 2018 – Teams 5 and 2: Two TRPV1 (Transient receptor potential vanilloid 1) variants impair intracellular Ca2+ signaling and may confer susceptibility to malignant hyperthermia (Genetics in Medicine)
March 2018 – Teams 1 and 4 : Skeletal muscle insulin resistance induced by the by-product of omega-3 fatty acid peroxidation 4-hydroxy-2-hexenal (4-HHE) (Diabetologia)
January 2018 – Teams 3, 2 and 5: ER-mitochondria miscommunication involved in muscle insulin resistance (Diabetes)
Oct 2017 – Team 2 :Lipidomics reveals diurnal lipid oscillations in human skeletal muscle persisting in cellular myotubes cultured in vitro. (PNAS)
July 2017 – Team 5 :Mesenchymal stem cells sense mitochondria released from damaged cells as danger signals to activate their rescue properties. (Cell Death and Differentiation)
July 2017 – Team 1, 2, 3, 4 and 5 :EASL-EASD-EASO clinical practice guidelines for the management of non-alcoholic fatty liver disease in severely obese people: do they lead to over-referral? (Diabetologia)
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December 2016- Team 5 : Unacylated ghrelin analog prevents myocardial reperfusion injury independently of permeability transition pore
April 2016- Team 3 : Mitochondria-associated endoplasmic reticulum membranes allow adaptation of mitochondrial metabolism to glucose availability in the liver (J Mol Cell Biol)
March 2016 – Teams 3 and 5 : Disruption of calcium transfer from ER to mitochondria links alterations of mitochondria-associated ER membrane integrity to hepatic insulin resistance.( Diabetologia)
February 2016 – Teams 1 and 3: The intestinal microbiota: a new ally for optimum growth (Science)
Sept 2015 – Team 4: Postprandial Endotoxemia Linked With Chylomicrons and Lipopolysaccharides Handling in Obese Versus Lean Men: A Lipid Dose-Effect Trial (J Clin Endocrinol Metab)
July 2015- Teams 1,2,3 and 4 : Adipose Tissue-Derived Stem Cells From Obese Subjects Contribute to Inflammation and Reduced Insulin Response in Adipocytes Through Differential Regulation of the Th1/Th17 Balance and Monocyte Activation (Diabetes)
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