Selection of major scientific publications of CarMeN laboratory

Gut. 2016, 65, 144-154 Brault, C et al. Glutathione peroxidase 4 is reversibly induced by HCV to control lipid peroxidation and to increase virion infectivity. PubMed

Am J Hum Genet. 2016, 98, 310-321. Jansen, J. C. et al. CCDC115 Deficiency Causes a Disorder of Golgi Homeostasis with Abnormal Protein Glycosylation. PubMed

N Engl J Med. 2016, 374, 795-797. Schiff, M., et al. SLC25A32 Mutations and Riboflavin-Responsive Exercise Intolerance. PubMed

Lancet Diabetes Endocrinol. 2016, 4:360-73. Vanholder R et al. Clinical management of the uraemic syndrome in chronic kidney disease. Pubmed

Am J Clin Nutr. 2016, 103:348-55. Egli L et al. Exercise performed immediately after fructose ingestion enhances fructose oxidation and suppresses fructose storage. Pubmed

Cancer Cell. 2015, 28:569-81. Cheng C et al. Glucose-Mediated N-glycosylation of SCAP Is Essential for SREBP-1 Activation and Tumor Growth. Pubmed

N Engl J Med. 2015, 373:232-42. Green JB et al. Effect of Sitagliptin on Cardiovascular Outcomes in Type 2 Diabetes. Pubmed

N Engl J Med. 2015, 373:11-22. Pi-Sunyer X et al. A Randomized, Controlled Trial of 3.0 mg of Liraglutide in Weight Management. Pubmed

Lancet. 2015, 386:1588-98. Rossignol P et al. The double challenge of resistant hypertension and chronic kidney disease. Pubmed

N Engl J Med. 2015, 372:2387-97. Cannon CP et al. Ezetimibe Added to Statin Therapy after Acute Coronary Syndromes. Pubmed

N Engl J Med. 2015, 372:1489-99. Robinson JG et al. Efficacy and safety of alirocumab in reducing lipids and cardiovascular events. Pubmed

Lancet Diabetes Endocrinol. 2015 3:948-57. Becker C et al. Myostatin antibody (LY2495655) in older weak fallers: a proof-of-concept, randomised, phase 2 trial. Pubmed

Diabetes. 2015, 64:3951-62. Abdulkarim B et al. A Missense Mutation in PPP1R15B Causes a Syndrome Including Diabetes, Short Stature, and Microcephaly. Pubmed

Circulation 2015 132:27-39. Moe SM et al. Cinacalcet, Fibroblast Growth Factor-23, and Cardiovascular Disease in Hemodialysis: The Evaluation of Cinacalcet HCl Therapy to Lower Cardiovascular Events (EVOLVE) Trial. Pubmed

Lancet. 2015, 385:331-40. Raal FJ et al. PCSK9 inhibition with evolocumab (AMG 145) in heterozygous familial hypercholesterolaemia (RUTHERFORD-2): a randomised, double-blind, placebo-controlled trial. Pubmed

Hum Mutat. 2015, 36:743-52. Mansour-Hendili L et al. Mutation Update of the CLCN5 Gene Responsible for Dent Disease 1. Pubmed

J Clin Endocrinol Metab. 2015, 100:E757-66. Huvenne H et al. Seven novel deleterious LEPR mutations found in early-onset obesity: a ΔExon6-8 shared by subjects from Reunion Island, France, suggests a founder effect. Pubmed

Lancet. 2014, 383:1831-43. Ortiz A et al. Epidemiology, contributors to, and clinical trials of mortality risk in chronic kidney failure. Pubmed

N Engl J Med. 2014, 371:1091-9. Fox K et al. Ivabradine in stable coronary artery disease without clinical heart failure. Pubmed

JAMA. 2014, 311:1515-25. Lincoff AM et al. Effect of aleglitazar on cardiovascular outcomes after acute coronary syndrome in patients with type 2 diabetes mellitus: the AleCardio randomized clinical trial. Pubmed

N Engl J Med. 2014, 370:1702-11. STABILITY Investigators, White HD et al. Darapladib for preventing ischemic events in stable coronary heart disease. Pubmed

Free Radic Res 2014, Vol. 48, No. 10 , Pages 1232-1246. Feillet-Coudray C, et al. The mitochondrial-targeted antioxidant MitoQ ameliorates metabolic syndrome features in obesogenic diet-fed rats better than Apocynin or Allopurinol.Pubmed

Clin Infect Dis 2014 Aug 11 pii: ciu640. Pérez-Valero I, et al. A prospective cohort study of neurocognitive function in aviremic HIV-infected patients treated with one or three antiretrovirals.Pubmed

Circulation 2014, 129: 173-185. Van Belle E, et al. Outcome impact of coronary revascularization strategy reclassification with fractional flow reserve at time of diagnostic angiography: insights from a large French multicenter fractional flow reserve registry.Pubmed

J Clin Invest 2014, 124: 1914-1927. Sala D, et al. Autophagy-regulating The TP53INP2 mediates muscle wasting and is repressed in diabetes.Pubmed

Diabetes Care 2014, 37: 1375-1383. Ortega FJ, et al. Profiling of circulating microRNAs reveals common microRNAs linked to type 2 diabetes that change with insulin sensitization.Pubmed

N Engl J Med 2013, 368: 2169-2181. Legendre CM, et al. Terminal complement inhibitor eculizumab in atypical hemolytic-uremic syndrome.Pubmed

Nature Medicine 2013, 19: 1331-1337. Wei KA, et al. Liver Hif-2alpha-Irs2 pathway sensitizes hepatic insulin signaling and is modulated by VEGF inhibition.Pubmed

Amer J Hum Genet 2013, 93:141-9. Thauvin-Robinet C, et al. PIK3R1 Mutations Cause Syndromic Insulin Resistance with Lipoatrophy.Pubmed

Diabetes 2013, 62: 3697-3708. Carobbio S, et al. Adaptive changes of the Insig1/SREBP1/SCD1 set point help adipose tissue to cope with increased storage demands of obesity.Pubmed

BMJ 2012, 344: d7541. Beckett N, et al. Immediate and late benefits of treating very elderly people with hypertension: results from active treatment extension to Hypertension in the Very Elderly randomised controlled trial.Pubmed

J Clin Invest 2012, 122: 3541-3551. Jacovetti C, et al. MicroRNAs contribute to compensatory beta cell expansion during pregnancy and obesity.Pubmed

N Engl J Med 2012, 367:991-1001. De Bruyne B, et al and the FAME 2 Trial Investigators. Fractional flow reserve-guided PCI versus medical therapy in stable coronary disease.Pubmed

N Engl J Med 2012, 366:1705-15. Gilard M, et al and the FRANCE 2 Investigators. Registry of transcatheter aortic-valve implantation in high-risk patients.Pubmed

PLOS Genet 2012, 8:e1002896. Hanchate NK, et al. SEMA3A, a gene involved in axonal pathfinding, is mutated in patients with Kallmann Syndrome.Pubmed

Diabetes 2012, Jul 30 [Epub ahead of print]. Volat FE, Pointud JC, Pastel E, Morio B, Sion B, Hamard G, Guichardant M, Colas R, Lefrançois-Martinez AM, Martinez A. Depressed levels of prostaglandin F2α in mice lacking Akr1b7 increase basal adiposity and predispose to diet-induced obesity.Pubmed

J Clin Endocrinol Metab 2012, 97:E575-83. Schoppet M, Hofbauer LC, Brinskelle-Schmal N, Varennes A, Goudable J, Richard M, Hawa G, Chapurlat R, Szulc P. Serum level of the phosphaturic factor FGF23 is associated with abdominal aortic calcification in men: the STRAMBO study.Pubmed

Hepatology 2012, 55:1406-15. Kozakova M, et al and the RISC Investigators. Fatty liver index, gamma-glutamyltransferase, and early carotid plaques.Pubmed

Diabetes Care 2012, 35:965-71. Riveline JP, et al and the EVADIAC Sensor Study Group. Assessment of patient-led or physician-driven continuous glucose monitoring in patients with poorly controlled type 1 diabetes using basal-bolus insulin regimens: a 1-year multicenter study.Pubmed

Diabetes Care 2011 34:533-9. Charpentier G, et al, and the TeleDiab Study Group. The Diabeo software enabling individualized insulin dose adjustments combined with telemedicine support improves HbA1c in poorly controlled type 1 diabetic patients: a 6-month, randomized, open-label, parallel-group, multicenter trial (TeleDiab 1 Study).Pubmed

Diabetes 2011 60:2830-42. Cohen G, Riahi Y, Shamni O, Guichardant M, Chatgilialoglu C, Ferreri C, Kaiser N, Sasson S. Role of lipid peroxidation and PPAR-δ in amplifying glucose-stimulated insulin secretion.Pubmed

N Engl J Med 2011, 60:1938-45. Dooley MA, et al and the ALMS Group. Mycophenolate versus azathioprine as maintenance therapy for lupus nephritis.Pubmed

Circulation 2011, 60:1938-45. Schwartz Longacre L, et al. and National Heart, Lung, and Blood Institute, National Institutes of Health. : New horizons in cardioprotection: recommendations from the 2010 National Heart, Lung, and Blood Institute Workshop.Pubmed

Am J Hum Genet 2011, 60:1938-45. Miskinyte S, Butler MG, Hervé D, Sarret C, Nicolino M, et al. Loss of BRCC3 deubiquitinating enzyme leads to abnormal angiogenesis and is associated with syndromic moyamoya.Pubmed

Diabetes 2011, 60:1938-45. Rebelos E, and RISC Study Investigators. Body weight, not insulin sensitivity or secretion, may predict spontaneous weight changes in nondiabetic and prediabetic subjects: the RISC study.Pubmed

Diabetes 2011, 60:1660-7. Bonnet F, Ducluzeau PH, Gastaldelli A, Laville M, et al and RISC Study Group. Liver enzymes are associated with hepatic insulin resistance, insulin secretion, and glucagon concentration in healthy men and women.Pubmed

J. Clin. Endocrinol. Metab. 2011, 96:E962-6. Jiao H, Arner P, Dickson SL, Vidal H, et al. Genetic association and gene expression analysis identify FGFR1 as a new susceptibility gene for human obesity.Pubmed

Cell Metab. 2011, 13:376-88. Li Y, Xu S, Mihaylova MM, Zheng B, Hou X, Jiang B, Park O, Luo Z, Lefai E, Shyy JY, Gao B, Wierzbicki M, Verbeuren TJ, Shaw RJ, Cohen RA, Zang M. AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice.Pubmed

Lancet 2011 377:715. Giral P, Moulin P, Rosenbaum D. Efficacy and safety of more intensive lowering of LDL cholesterol. Pubmed

N Engl J Med. 2010 363:905-17. James WP and SCOUT Investigators. Effect of sibutramine on cardiovascular outcomes in overweight and obese subjects. Pubmed

Lancet. 2010, 376:875-85. Swedberg et al. Ivabradine and outcomes in chronic heart failure (SHIFT): a randomised placebo-controlled study. Pubmed

Lancet. 2010 376:517-23. Topol EJ and CRESCENDO Investigators. Rimonabant for prevention of cardiovascular events (CRESCENDO): a randomised, multicentre, placebo-controlled trial. Pubmed