Team 1 : “Nutritional Adaptations, Environment and Diabetes”

Nutritional Adaptations, Environment and Diabetes

To maintain homeostasis in normal range, all living species are able to develop appropriate responses to transient or sustained changes occuring in their direct environment. Humans, all life-long from embryo to elderly, are exposed to environmental modifications including lifestyle changes, nutritional habits or pollutant contaminations. Good health and long-life expectancy are thus strongly dependent on the ability to correctly adapt and respond to these modifications. It is now suspected that metabolic diseases, such as obesity, type 2 diabetes and their related complications, are linked to defects in these adaptive mechanisms.

The main objectives of Team 1 of CarMeN laboratory are to define the mechanisms involved in the physiological response to metabolic stress in humans, to identify potential defects in these processes and to develop new strategies to  fight metabolic and nutritional diseases. 

Our different research projects combine clinical investigations, studies with animal model and experimental research, based on nutrigenomics and epigenetics. They benefit from the close collaboration of scientists specialized in biochemistry, physiology, immunology, cellular and molecular biology and of clinicians from diabetology, metabolism, nutrition and nephrology.

Our Team is mainly located at the Faculty of Medicine Lyon-Sud and the Biochemistry department of Hospital Lyon-Sud in the vicinity of the Rhone-Alpes Research Center in Human Nutrition (CRNH-RA). Part of the team is located in IMBL at INSA Lyon.

Main research topics of Team 1

During the last decades, major modifications in our nutritional environment and eating behavior, have largely contributed to the observed overweight, obesity and diabetes epidemics. The main objectives of our research program are 1) to understand at the molecular level the adaptive responses to changes in our nutritional environment and 2) to identify the potential defects in these processes that could contribute to the metabolic pathologies. To this aim, we investigate the adaptive mechanisms to metabolic stress and pollutant exposure under different experimental conditions reflecting as much as possible normal life. Based on the significant advances made over the last years, our strategy rely on 5 complementary and connected research programs:

– “Metabolic adaptation and inflammation of fat tissues during overfeeding” to understand adipose tissue depots remodeling and to propose strategies to fight obesity and prevent its complications;

«Adipose stem cells in healthy or pathological adipose tissues» to understand the  mechanisms initiating adipose tissue alterations and inflammation which lead to the complications of obesity;

Metabolic disrupters: impact of environmental pollutants in metabolic diseases to unravel the contribution and the mechanisms of action of pollutants in triggering or amplifying metabolic diseases;

Metabolic adaptations in chronic kidney disease to define the determinants of metabolic complications, especially insulin resistance, in chronic kidney disease and provide new treatments;

– “Probiotics as a new strategy to fight metabolic diseases to demonstrate that selected bacterial strains can be powerful agents to treat obese and diabetic patients

Main technical  approaches and tools

Nutritional studies in humans in the Research Center for Human Nutrition CRNH-RA. Measurement of insulin sensitivity (hyperinsulinemic euglycemic clamp) / Human tissue resources (muscle and adipose tissue) / Animal models (mice) / Cell culture (stem cells, adipocytes, muscle cells) / Genomics and epigenetics (DNA arrays, RT-qPCR) / Intracellular signaling studies (insulin) / Adipocyte size measurement / Immunocytology / In vitro utilization of adenovirus or shRNA



Topic 1 : Metabolic adaptation and inflammation of fat tissues during oveequipe1_fig3rfeeding

Excess calorie intake, exceeding energy expenditure, is one of the characteristics of the modern life and largely contributes to the development of obesity. The mechanisms responsible for the metabolic orientation of energy between storage and catabolism in vivo during overfeeding are not known. In collaboration with the CRNH-RA, we are developing an ambitious research program to characterize these mechanisms usinga overfeeding protocols in humans and in animal models.

In the clinical studies, volunteers (lean and overweight subjects) are submitted to an overfeeding protocol during which they receive about 30% calorie excess each day for several weeks. A detailed analysis of biological, metabolic and anthropometric modifications is performed during the protocol. Several protocols are conducted with different types of supplementation (lipids, fructose or junk food). We are also testing new strategies to prevent the deleterious effects of overfeeding (polyphenols, probiotics). Important results have been already obtained to allow understanding the mechanisms of fuel partitioning in skeletal muscle and the first steps of adipose tissue development when people are gaining weight (Seyssel et al, JCEM, 20145; Alligier et al JCEM, 2012).

Interestingly, some subjects show a preferred orientation of lipid storage in visceral adipose tissue and other ectopic depots such as liver and muscle. This suggests that these subjects probably display a higher risk for the development of metabolic syndrome. We are currently investigating in more details these subjects with the objective of identifying novel risk biomarkers using transcriptomic approach in adipose tissue and skeletal muscle and a metabolomics approach in blood and urine. Parallel to the clinical studies, fat accumulation mechanisms and functions of adipocytes are studied in vitro using human adipocytes in primary culture.



Topic 2 : Adipose stem cells in healthy or pathological adipose tissues

Adipose tissue-derived mesenchymal stem cells (Adipose Stem Cells, ASC), present in large numbers in adipose tissue, not only have the ability to differentiate into adipocytes, but also have many regulatory functions in particular with respect to immune cells. We explore the contribution of these cells to adipose tissue functions and its pathological changes across different lines of research.

One research axis, developed by A. El Jaafari and L. Pirola, is devoted to the understanding of inflammation in adipose tissue. While the well documented presence of macrophages in adipose tissue have been shown to contribute to the low grade inflammation associated with obesity, we have recently involved 2 new players in this process:  the adipose-derived mesenchymal stem cells (ASC) and the Th17-lymphocytes (El Jaafari et al, Diabetes, 2015). We have demonstrated that ASC harvested from the adipose tissue of obese individuals (but not from lean donors) can increase IL-17A and IL-1beta secretion by blood mononuclear cells. In turn these cytokines inhibit adipogenesis and reduce insulin action in mature adipocytes. This opens new fields of research to understand the mechanisms of adipose tissue inflammation during weight gain. Because interactions of ASC with Th17 lymphocytes appear to mainly involve cell-cell contact, our goal now is to identify the molecules implicated in these interactions, including the antigens, which might be presented by ASC to Th17 lymphocytes.

Another research project, developed by A. Mey, seeks to understand the origin of the functional differences between the fat depots and their contributions to obesity. She investigates the molecular and biological characteristics of the adipose mesenchymal stem cells (ASC) which contribute to the developmental origin of these depots and remain present in the tissues in adulthood. To understand how the nutritional environment impacts the properties of the ASC at different periodes of life, we have developed the isolation and culture of these cells from different adipose tissue depots in mice and humans.

An interesting property of the ASC is the possibility, as stem cells, to be differentiated in different cell types. We have developed a protocol to generate beta-pancreatic-like cells from human-derived ASC. We will now use these cells to study the impact of ASC-mediated inflammation on beta-cell generation and function in order to better understand the mechanisms leading to beta-cell dysfunction in type-2 diabetes. We also hope to optimize the production of beta-like cells from ASC to propose in the future these cells as therapeutic tools. This will be performed by A. El Jaafari in collaboration with members of team 3 (A-M Madec and C. thivolet) and of the Cell Therapy Unit of Lyon Hospital who recently joined team 1.



Topic 3 : Metabolic disrupters

Apart from genetics, excess calories and lack of physical activity, it is known that environmental pollutants, specifically those endowed with hormonal disrupting activities and acting at low dosage (i.e., the endocrine disruptors), contribute to the epidemic of metabolic disorders. Several epidemiological studies have shown a significant correlation between criteria of the metabolic syndrome and the presence in the blood or urine of pollutants or their metabolites. In addition, experimental studies in rodents, including works from our team (Naville et al, FASEB J, 2013; PLOSOne, 2015; Ruzzin et al, EHP, 2011) established a causal relationship between exposure to chemicals and obesity-related metabolic dysfunctions, such as insulin resistance. Because of the high vulnerability of embryos and newborns, D. Naville and B. Le Magueresse in the team, have developped a model of exposure to very low doses of a cocktail of pollutants (dioxins, PCB153, DEHP and BPA) added to a high-fat high sucrose diet and provide to mice dams and then to their progeny. Changes in biological parameters, fat mass measurement, glucose tolerance and insulin sensitivity tests in the progeny (F1 and after) are studied. Molecular mechanisms are as well investigated both using a candidate-gene approach and a transcriptomic large approach to identify specific genes and pathways leading to the observed metabolic disturbances.

We are also exploring the phenotype of PXR KO mice in collaboration with the group of J. Ruzzin, Bergen University, Norway. Besides, taking into account the crutial role of gut in metabolic health, we make the hypothesis that variations in microbiota may alter the way individuals metabolize and respond to pollutants and we will also test whether interventions on microbiota hold the potential to offer protection from the adverse effects of pollutants.



Topic  4 : Metabolic adptations in chronique kidney disease

Chronic kidney disease (CKD) is frequently associated with peripheral insulin resistance, which is a major cardiovascular risk factor. However, the reasons why CKD patients so often develop insulin resistance, even in absence of overweight or obesity, are largely unknown.

D. Fouque and Ch. Soulage in the team recently demonstrated that the accumulation of uremic toxins, such as p-cresol, in end-stage renal disease could be a key factor for the development of insulin resistance (Koppe et al. Amer Soc Nephrol, 2013). Using mouse model of CKD, we are currently extend this concept to other uremic toxins, like endoxyl sulfate, and try to define their mechanisms of action, focusing on the activation of nuclear receptors, such as arylhydrocarbon receptor (AhR, i.e. the nuclear receptor of dioxins). The mechanisms underlying the development of insulin resistance will be investigated in vitro using adipocytes and muscle cells in culture incubated with uremic toxins. Identifications of the pathways mediating the deleterious effects of these compounds and the potential role of AhR will be explored in details in these in vitro systems. We will then further explore the relevance of the findings in our cohort of patients with CKD. The role of the intestinal flora will also be investigated with the aim of elaborating pro/pre-biotics strategies to modulate the production of uremic toxins.

Other research projects include the study of the impact of peritoneal dialysis on intra-abdominal white adipose tissue functions using an original mouse model of peritoneal dialysis under development in the laboratory. The relevance of this pre-clinical model will be assessed in subcutaneous and omental adipose tissue biopsies from patients treated by peritoneal dialysis in which we will analyse fat cell size, histology (immune cell infiltration, fibrosis), adipocyte functions and adipokine secretion in relation to glucose exposure, peritoneal transport type and metabolic risk factors.


Topic  5 : Probiotics as a new stategy to fight metabolic diseases

The use of probiotics with the aim of modulating blood glucose and hence improving diabetes has been envisaged for a long time, particularly as nutritional supplements, but the discovery of the critical role of gut microbiota in metabolic diseases has logically boosted research efforts in this field. Obesity and type 2 diabetes are indeed associated with perturbation of the composition and function of the gut microbiota (called dysbiosis), globally characterized by change in the ratio between Firmicutes (Gram-positive) and Bacteroidetes (Gram-negative), the two major phyla in the gut. Furthermore, it has been recently demonstrated that the gut microbiota certainly plays a critical role in the pathogenesis of these diseases. Several bacterial strains, used as probiotics, have recently shown clear beneficial actions on glucose tolerance and insulin sensitivity in mouse models. However, the effects are less important in humans and their mechanisms of action only partly defined. Our goal is therefore to identify potent bacterial strains with strong beneficial effects for human health and to propose them as new  probiotics for metabolic diseases prevention and/or treatment.

To identify these new strains, we are working in close collaboration with the IGFL team of F. Leulier (a leader in the field of host-bacteria interactions in drosophila) (mettre le lien: who has developed an innovative screening system to qualify Lactobacillus strains with anti-diabetic properties (under patenting).


We recently used together a variant of this powerful screening system for functional strain qualification to demonstrate for the first time the critical role of microbiota and of a selected L.plantarum strain in the juvenile growth (Schwarzer et al. Science 2016). We are currently qualifying relevant strains for their anti-diabetic properties in diabetic mice, as a pre-clinical test before their evaluation in patients. In parallel, as indicated in the Topics 2 and 3 before, bacterial strains with probiotic properties are also evaluated for their potential to buffer the toxic effects of a cocktail of pollutants in exposed mice and to control the production of uremic toxins in a model of mouse with chronic kidney disease.

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Team 1 Leaders
VIDAL Hubert DR1
 LAVILLE Martine DR1


DA SILVA Joao Henriq Postdoctorant
DRAI Jocelyne PH
DURAND Christine TR
GERARD Céline Postdoctorante
MEUGNIER Emmanuelle IR
MEY Anne CR1
NAVILLE Danielle CR1
PAYS Laurent MCU
PIROLA Luciano CR1
PUGEAT Michel PUPH émérite
SOULAGE Christophe MCU
VEGA Nathalie TR

2018 (january-june)

  1. Yi, D., Monteiro, E. B., Chambert, S., Soula, H. A., Daleprane, J. B. and Soulage, C. O. (2018). Determination of the binding properties of p-cresyl glucuronide to human serum albumin Biochimie 150 1-7 10.1016/j.biochi.2018.04.019
  2. Wojtala, M., Macierzynska-Piotrowska, E., Rybaczek, D., Pirola, L. and Balcerczyk, A. (2018).  Pharmacological and transcriptional inhibition of the G9a histone methyltransferase suppresses proliferation and modulates redox homeostasis in human microvascular endothelial cells Pharmacological Research 128 252-263 10.1016/j.phrs.2017.10.014
  3. Tubbs, E., Chanon, S., Robert, M., Bendridi, N., Bidaux, G., Chauvin, M. A., Jingwei, J. C., Durand, C., Gauvrit-Ramette, D., Vidal, H., Lefai, E. and Rieusset, J. (2018) Disruption of Mitochondria-Associated Endoplasmic Reticulum Membrane (MAM) Integrity Contributes to Muscle Insulin Resistance in Mice and Humans Diabetes 67 636-650 10.2337/db17-0316
  4. Stockler-Pinto, M. B., Soulage, C. O., Borges, N. A., Cardozo, L., Dolenga, C. J., Nakao, L. S., Pecoits-Filho, R., Fouque, D. and Mafra, D. (2018) From bench to the hemodialysis clinic: protein-bound uremic toxins modulate NF-kappaB/Nrf2 expression Int Urol Nephrol 50 347-354 10.1007/s11255-017-1748-y
  5. Soulere, L., Alix, P. M., Croze, M. L. and Soulage, C. O. (2018) Identification of novel antilipogenic agents targeting fatty acid biosynthesis through structure-based virtual screening Chemical Biology & Drug Design 92 1366-1372 10.1111/cbdd.13202
  6. Soulage, C. O., Puig, L. S., Soulere, L., Zarrouki, B., Guichardant, M., Lagarde, M. and Pillon, N. J. (2018) Skeletal muscle insulin resistance is induced by 4-hydroxy-2-hexenal, a by-product of n-3 fatty acid peroxidation Diabetologia 61 688-699 10.1007/s00125-017-4528-4
  7. Snoek, H. M., Eijssen, L. M. T., Geurts, M., Vors, C., Brown, K. A., Bogaardt, M. J., Dhonukshe-Rutten, R. A. M., Evelo, C. T., Fezeu, L. K., Finglas, P. M., Laville, M., Ocke, M., Perozzi, G., Poppe, K., Slimani, N., Tetens, I., Timotijevic, L., Zimmermann, K. and van’t Veer, P. (2018) Advancing food, nutrition, and health research in Europe by connecting and building research infrastructures in a DISH-RI: Results of the EuroDISH project Trends in Food Science & Technology 73 58-66 10.1016/j.tifs.2017.12.015
  8. Sigaux, N., Ganry, L., Mojallal, A., Breton, P. and Bouletreau, P. (2018) Stereophotogrammetry and facial surgery: Principles, applications and prospects Annales De Chirurgie Plastique Esthetique 63 62-68 10.1016/j.anplas.2017.07.006
  9. Rovere, M. R., Rousselle, P., Haftek, M., Charleux, B., Kocaba, V., Auxenfans, C., Nataf, S. and Damour, O. (2018) Preserving Basement Membranes during Detachment of Cultivated Oral Mucosal Epithelial Cell Sheets for the Treatment of Total Bilateral Limbal Stem Cell Deficiency Cell Transplantation 27 264-274 10.1177/0963689717741140
  10. Roucher-Boulez, F., de la Perriere, A. B., Jacquez, A., Chau, D., Guignat, L., Vial, C., Morel, Y., Nicolino, M., Raverot, G. and Pugeat, M. (2018) Triple-A syndrome: a wide spectrum of adrenal dysfunction European Journal of Endocrinology 178 199-207 10.1530/eje-17-0642
  11. Reynaud, Q., Rabilloud, M., Roche, S., Poupon-Bourdy, S., Iwaz, J., Nove-Josserand, R., Blond, E., Laville, M., Llerena, C., Quetant, S., Reix, P., Touzet, S. and Durieu, I. (2018) Glucose trajectories in cystic fibrosis and their association with pulmonary function Journal of Cystic Fibrosis 17 400-406 10.1016/j.jcf.2017.09.010
  12. Pugeat, M., Plotton, I., de la Perriere, A. B., Raverot, G., Dechaud, H. and Raverot, V. (2018) Hyperandrogenic states in women: pitfalls in laboratory diagnosis European Journal of Endocrinology 178 R141-R154 10.1530/eje-17-0776
  13. Puertas, R. D., Jalabert, A., Meugnier, E., Euthine, V., Chevalier, P. and Rome, S. (2018) Analysis of the microRNA signature in left atrium from patients with valvular heart disease reveals their implications in atrial fibrillation Plos One 13 20 10.1371/journal.pone.0196666
  14. Perier-Muzet, M., Gatt, E., Peron, J., Falandry, C., Amini-Adle, M., Thomas, L., Dalle, S. and Boespflug, A. (2018) Association of Immunotherapy With Overall Survival in Elderly Patients With Melanoma Jama Dermatology 154 82-87 10.1001/jamadermatol.2017.4584
  15. Neto, M. P. C., Aquino, J. D., da Silva, L. D. R., Silva, R. D., Guimaraes, K. S. D., de Oliveira, Y., de Souza, E. L., Magnani, M., Vidal, H. and Alves, J. L. D. (2018) Gut microbiota and probiotics intervention: A potential therapeutic target for management of cardiometabolic disorders and chronic kidney disease? Pharmacological Research 130 152-163 10.1016/j.phrs.2018.01.020
  16. Metzger, M., Yuan, W. L., Haymann, J. P., Flamant, M., Houillier, P., Thervet, E., Boffa, J. J., Vrtovsnik, F., Froissart, M., Bankir, L., Fouque, D., Stengel, B. and NephroTest Study, G. (2018) Association of a Low-Protein Diet With Slower Progression of CKD Kidney International Reports 3 105-114 10.1016/j.ekir.2017.08.010
  17. Martin, K. A., Anderson, R. R., Chang, R. J., Ehrmann, D. A., Lobo, R. A., Murad, M. H., Pugeat, M. M. and Rosenfield, R. L. (2018) Evaluation and Treatment of Hirsutism in Premenopausal Women: An Endocrine Society* Clinical Practice Guideline Journal of Clinical Endocrinology & Metabolism 103 1233-1257 10.1210/jc.2018-00241
  18. Luce, M., Bouchara, A., Pastural, M., Granjon, S., Szelag, J. C., Laville, M., Arkouche, W., Fouque, D., Soulage, C. O. and Koppe, L. (2018) Is 3-Carboxy-4-methyl-5-propyl-2-furanpropionate (CMPF) a Clinically Relevant Uremic Toxin in Haemodialysis Patients? Toxins 10 16 10.3390/toxins10050205
  19. Leger, T., Hininger-Favier, I., Capel, F., Geloen, A., Rigaudiere, J. P., Jouve, C., Pitois, E., Pineau, G., Vaysse, C., Chardigny, J. M., Michalski, M. C., Malpuech-Brugere, C. and Demaison, L. (2018) Dietary canolol protects the heart against the deleterious effects induced by the association of rapeseed oil, vitamin E and coenzyme Q10 in the context of a high-fat diet Nutrition & Metabolism 15 14 10.1186/s12986-018-0252-4
  20. Le Saux, O. and Falandry, C. (2018) Is There an Age Threshold for Holding Off on Testing Novel Therapies? Current Oncology Reports 20 7 10.1007/s11912-018-0663-4
  21. Le Saux, O. and Falandry, C. (2018) Toxicity of Cancer Therapies in Older Patients Current Oncology Reports 20 11 10.1007/s11912-018-0705-y
  22. Kopple, J. D. and Fouque, D. (2018) Con: The role of diet for people with advanced Stage 5 CKD Opponent’s comments Nephrology Dialysis Transplantation 33 384-387 10.1093/ndt/gfx294a
  23. Kopple, J. D. and Fouque, D. (2018) Pro: The rationale for dietary therapy for patients with advanced chronic kidney disease Nephrology Dialysis Transplantation 33 373-378 10.1093/ndt/gfx333
  24. Koppe, L., Fouque, D. and Soulage, C. O. (2018) The Role of Gut Microbiota and Diet on Uremic Retention Solutes Production in the Context of Chronic Kidney Disease Toxins 10 12 10.3390/ toxins10040155
  25. Kalantar-Zadeh, K. and Fouque, D. (2018) Nutritional Management of Chronic Kidney Disease REPLY New England Journal of Medicine 378 584-585 10.1056/NEJMc1715765
  26. Julien, B., Pinteur, C., Vega, N., Labaronne, E., Vidal, H., Naville, D. and Le Magueresse-Battistoni, B. (2018) Evidence for estrogeno-mimetic effects of a mixture of low-dose pollutants in a model of ovariectomized mice Environmental Toxicology and Pharmacology 57 34-40 10.1016/ j.etap.2017.11.008
  27. Jouvene, C., Fourmaux, B., Geloen, A., Balas, L., Durand, T., Lagarde, M., Letisse, M. and Guichardant, M. (2018) Ultra-Performance Liquid Chromatography-Mass Spectrometry Analysis of Free and Esterified Oxygenated Derivatives from Docosahexaenoic Acid in Rat Brain Lipids 53 103-116 10.1002/lipd.12006
  28. Iceta, S., Disse, E. and Robert, M. (2018) Are we really assessing safety and efficacy of bariatric surgery in patients suffering from bipolar disorder? Surgery for Obesity and Related Diseases 14 723-724 10.1016/j.soard.2018.01.037
  29. Hoibian, E., Florens, N., Koppe, L., Vidal, H. and Soulage, C. O. (2018) Distal Colon Motor Dysfunction in Mice with Chronic Kidney Disease: Putative Role of Uremic Toxins Toxins 10 15 10.3390/toxins10050204
  30. Haution-Bitker, M., Gilbert, T., Vignoles, A., Lecardonnel, C., Watelet, S., Blond, E., Drai, J. and Bonnefoy, M. (2018) Associations between Plasmatic Polyunsaturated Fatty Acids Concentrations and Cognitive Status and Decline in Neurocognitive Disorders Journal of Nutrition Health & Aging 22 718-725 10.1007/s12603-018-1010-z
  31. Florens, N., Yi, D., Juillard, L. and Soulage, C. O. (2018) Using binding competitors of albumin to promote the removal of protein-bound uremic toxins in hemodialysis: Hope or pipe dream? Biochimie 144 1-8 10.1016/j.biochi.2017.09.018
  32. Falandry, C., Krakowski, I., Cure, H., Carola, E., Soubeyran, P., Guerin, O., Gaudin, H. and Freyer, G. (2018) Impact of geriatric assessment for the therapeutic decision-making of breast cancer: results of a French survey. AFSOS and SOFOG collaborative work Breast Cancer Research and Treatment 168 433-441 10.1007/s10549-017-4607-8
  33. Duhamel, M., Rose, M., Rodet, F., Murgoci, A. N., Zografidou, L., Regnier-Vigouroux, A., Vanden Abeele, F., Kobeissy, F., Nataf, S., Pays, L., Wisztorski, M., Cizkova, D., Fournier, I. and Salzet, M. (2018) Paclitaxel Treatment and Proprotein Convertase 1/3 (PC1/3) Knockdown in Macrophages is a Promising Antiglioma Strategy as Revealed by Proteomics and Cytotoxicity Studies Molecular & Cellular Proteomics 17 1126-1143 10.1074/mcp.RA117.000443
  34. Chauveau, P., Aparicio, M., Bellizzi, V., Campbell, K., Hong, X., Johansson, L., Kolko, A., Molina, P., Sezer, S., Wanner, C., ter Wee, P. M., Teta, D., Fouque, D., Carrero, J. J. and European Renal Nutr, E. R. N. W. (2018) Mediterranean diet as the diet of choice for patients with chronic kidney disease Nephrology Dialysis Transplantation 33 725-735 10.1093/ndt/gfx085
  35. Capel, F., Geloen, A., Vaysse, C., Pineau, G., Demaison, L., Chardigny, J. M., Michalski, M. C. and Malpuech-Brugere, C. (2018) Rapeseed oil fortified with micronutrients can reduce glucose intolerance during a high fat challenge in rats Nutrition & Metabolism 15 12 10.1186/s12986-018-0259-x
  36. Burton, K. J., Pimentel, G., Zangger, N., Vionnet, N., Drai, J., McTernan, P. G., Pralong, F. P., Delorenzi, M. and Vergeres, G. (2018) Modulation of the peripheral blood transcriptome by the ingestion of probiotic yoghurt and acidified milk in healthy, young men Plos One 13 24 10.1371/journal.pone.0192947
  37. Bougaret, L., Delort, L., Billard, H., Le Huede, C., Boby, C., De la Foye, A., Rossary, A., Mojallal, A., Damour, O., Auxenfans, C., Vasson, M. P. and Caldefie-Chezet, F. (2018) Adipocyte/breast cancer cell crosstalk in obesity interferes with the anti-proliferative efficacy of tamoxifen Plos One 13 14 10.1371/journal.pone.0191571
  38. Borges, N. A., Carmo, F. L., Stockler-Pinto, M. B., de Brito, J. S., Dolenga, C. J., Ferreira, D. C., Nakao, L. S., Rosado, A., Fouque, D. and Mafra, D. (2018) Probiotic Supplementation in Chronic Kidney Disease: A Double-blind, Randomized, Placebo-controlled Trial Journal of Renal Nutrition 28 28-36 10.1053/j.jrn.2017.06.01
  39. Bonnefond-Ortega, M., Goudable, J., Chambrier, C. and Betry, C. (2018) Intestinal absorption of water-soluble and fat-soluble vitamins in clinical practice Nutrition Clinique Et Metabolisme 32 57-66 10.1016/j.nupar.2017.09.00
  40. Anjos, J. S., Cardozo, L., Esgalhado, M., Lindholm, B., Stenvinkel, P., Fouque, D. and Mafra, D. (2018) Could Low-Protein Diet Modulate Nrf2 Pathway in Chronic Kidney Disease? Journal of Renal Nutrition 28 229-234 10.1053/j.jrn.2017.11.005


  1. Adrait, A., Perrot, X., Nguyen, M. F., Gueugnon, M., Petitot, C., Collet, L., Roux, A., Bonnefoy, M. and Grp, A. S. (2017) Do Hearing Aids Influence Behavioral and Psychological Symptoms of Dementia and Quality of Life in Hearing Impaired Alzheimer’s Disease Patients and Their Caregivers? Journal of Alzheimers Disease 58 109-121
  2. Andrieu, S., Guyonnet, S., Coley, N., Cantet, C., Bonnefoy, M., Bordes, S., Bories, L., Cufi, M. N., Dantoine, T., Dartigues, J. F., Desclaux, F., Gabelle, A., Gasnier, Y., Pesce, A., Sudres, K., Touchon, J., Robert, P., Rouaud, O., Legrand, P., Payoux, P., Caubere, J. P., Weiner, M., Carrie, I., Ousset, P. J., Vellas, B. and Grp, M. S. (2017) Effect of long-term omega 3 polyunsaturated fatty acid supplementation with or without multidomain intervention on cognitive function in elderly adults with memory complaints (MAPT): a randomised, placebo-controlled trial Lancet Neurology 16 377-389
  3. Benoit B, Meugnier E, Castelli M, Chanon S, Vieille-Marchiset A, Durand C, Bendridi N, Pesenti S, Monternier PA, Durieux AC, Freyssenet D, Rieusset J, Lefai E, Vidal H, Ruzzin J. (2017) Fibroblast growth factor 19 regulates skeletal muscle mass and ameliorates muscle wasting in mice. Nat Med 23; 990-996
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  1. Pelascini, E., Disse, E., Pasquer, A., Poncet, G., Gouillat, C. and Robert, M. (2016) Should we wait for metabolic complications before operating on obese patients? Gastric bypass outcomes in metabolically healthy obese individuals Surgery for Obesity and Related Diseases 12 49-56
  1. Pelletier, S., Roth, H., Bouchet, J. L., Drueke, T. B., Hannedouche, T., Jean, G., London, G. and Fouque, D. (2016) Changes in mineral and bone disorder management in a French cohort of hemodialysis patients between 2008 and 2012: The National Bone and Mineral Metabolism observatory (Photo-Graphe 2 and 3) Néphrologie & Thérapeutique 12 171-7
  1. Pippias, M., Jager, K. J., Kramer, A., Leivestad, T., Sanchez, M. B., Caskey, F. J., Collart, F., Couchoud, C., Dekker, F. W., Finne, P., Fouque, D., Heaf, J. G., Hemmelder, M. H., Kramar, R., De Meester, J., Noordzij, M., Palsson, R., Pascual, J., Zurriaga, O., Wanner, C. and Stel, V. S. (2016) The changing trends and outcomes in renal replacement therapy: data from the ERA-EDTA Registry Nephrology Dialysis Transplantation 31 831-41
  1. Rieusset, J., Fauconnier, J., Paillard, M., Belaidi, E., Tubbs, E., Chauvin, M. A., Durand, A., Bravard, A., Teixeira, G., Bartosch, B., Michelet, M., Theurey, P., Vial, G., Demion, M., Blond, E., Zoulim, F., Gomez, L., Vidal, H., Lacampagne, A. and Ovize, M. (2016) Disruption of calcium transfer from ER to mitochondria links alterations of mitochondria-associated ER membrane integrity to hepatic insulin resistance Diabetologia 59 614-23
  1. Robert, M., Pasquer, A., Pelascini, E., Valette, P. J., Gouillat, C. and Disse, E. (2016) Impact of sleeve gastrectomy volumes on weight loss results: a prospective study Surgery for Obesity Related Diseases 12 1286-1291
  1. Rodrigues MJ, Zapardiel I, Frélaut M, Brain E, Falandry C. A call for specific geriatric data on cervical cancers. Future Oncol. 2016 May;12(9):1101-4.
  1. Saldanha, J. F., Yi, D., Stockler-Pinto, M. B., Soula, H. A., Chambert, S., Fouque, D., Mafra, D. and Soulage, C. O. (2016) Determination of the binding properties of the uremic toxin phenylacetic acid to human serum albumin Biochimie 125 53-8
  1. Schwarzer, M., Makki, K., Storelli, G., Machuca-Gayet, I., Srutkova, D., Hermanova, P., Martino, M. E., Balmand, S., Hudcovic, T., Heddi, A., Rieusset, J., Kozakova, H., Vidal, H. and Leulier, F. (2016) Lactobacillus plantarum strain maintains growth of infant mice during chronic undernutrition Science 351 854-7
  1. Seyssel, K., Allirot, X., Nazare, J. A., Roth, H., Blond, E., Charrie, A., Mialon, A., Drai, J., Laville, M. and Disse, E. (2016) Plasma acyl-ghrelin increases after meal initiation: a new insight European Journal of Clinical Nutrition 70 790-4
  1. Seyssel, K., Meugnier, E., Le, K. A., Durand, C., Disse, E., Blond, E., Pays, L., Nataf, S., Brozek, J., Vidal, H., Tappy, L. and Laville, M. (2016) Fructose overfeeding in first-degree relatives of type 2 diabetic patients impacts energy metabolism and mitochondrial functions in skeletal muscle Molecular Nutrition & Food Research 60 2691-2699
  1. Souberbielle, J. C., Deschenes, G., Fouque, D., Groussin, L., Guggenbuhl, P., Jean, G., Linglart, A. and Thomas, T. (2016) Recommendations for the measurement of blood 25-OH vitamin D Annales de Biologie Cliniques (Paris) 74 7-19
  1. Stengel, B., Combe, C., Jacquelinet, C., Briancon, S., Fouque, D., Laville, M., Frimat, L., Pascal, C., Herpe, Y. E., Morel, P., Deleuze, J. F., Schanstra, J. P., Pisoni, R. L., Robinson, B. M. and Massy, Z. A. (2016) [The French Chronic Kidney Disease-Renal Epidemiology and Information Network (CKD-REIN) cohort study: To better understand chronic kidney disease] Néphrologie & Thérapeutique 12 Suppl 1 S49-56
  1. Stockler-Pinto, M. B., Saldanha, J. F., Yi, D., Mafra, D., Fouque, D. and Soulage, C. O. (2016) The uremic toxin indoxyl sulfate exacerbates reactive oxygen species production and inflammation in 3T3-L1 adipose cells Free Radical Research 50 337-44
  1. Surowska, A., De Giorgi, S., Theytaz, F., Campos, V., Hodson, L., Stefanoni, N., Rey, V., Schneiter, P., Laville, M., Giusti, V., Gabert, L. and Tappy, L. (2016) Effects of roux-en-Y gastric bypass surgery on postprandial fructose metabolism Obesity (Silver Spring) 24 589-96
  1. Szulc, P., Amri, E. Z., Varennes, A., Panaia-Ferrari, P., Fontas, E., Goudable, J., Chapurlat, R. and Breuil, V. (2016) High serum oxytocin is associated with metabolic syndrome in older men – The MINOS study Diabetes Research and Clinical Practice 122 17-27
  1. Teuma, C., Perier-Muzet, M., Pelletier, S., Nouvier, M., Amini-Adl, M., Dijoud, F., Duru, G., Thomas, L., Fouque, D., Laville, M. and Dalle, S. (2016) New insights into renal toxicity of the B-RAF inhibitor, vemurafenib, in patients with metastatic melanoma Cancer Chemotherapy and Pharmacology 78 419-26
  1. Theurey, P., Tubbs, E., Vial, G., Jacquemetton, J., Bendridi, N., Chauvin, M. A., Alam, M. R., Le Romancer, M., Vidal, H. and Rieusset, J. (2016) Mitochondria-associated endoplasmic reticulum membranes allow adaptation of mitochondrial metabolism to glucose availability in the liver Journal of Molecular Cell Biology 8 129-43
  1. Tinquaut F, Freyer G, Chauvin F, Gane N, Pujade-Lauraine E, Falandry C. Prognostic factors for overall survival in elderly patients with advanced ovarian cancer treated with chemotherapy: Results of a pooled analysis of three GINECO phase II trials. Gynecol Oncol. 2016 Oct;143(1):22-6
  1. Vanholder, R., Fouque, D., Glorieux, G., Heine, G. H., Kanbay, M., Mallamaci, F., Massy, Z. A., Ortiz, A., Rossignol, P., Wiecek, A., Zoccali, C., London, G. M., European Renal Association European, D., Transplant Association European, R. and Cardiovascular Medicine working, g. (2016) Clinical management of the uraemic syndrome in chronic kidney disease Lancet Diabetes Endocrinology 4 360-73
  1. Vervloet, M. G., Sezer, S., Massy, Z. A., Johansson, L., Cozzolino, M. and Fouque, D. (2016) The role of phosphate in kidney disease Nature Reviews Nephrology 2017 13:27-38
  1. Viel, S., Besson, L., Charrier, E., Marcais, A., Disse, E., Bienvenu, J., Walzer, T. and Dumontet, C. (2016) Alteration of Natural Killer cell phenotype and function in obese individuals Clinical Immunology doi:10.1016/j.clim.2016.01.007
  1. Villain, C., Fouque, D., Genet, L., Jean, G., Kuentz, F., Lataillade, D., Legrand, E., Moreau-Gaudry, X. and Ecochard, R. (2016) Prognostic Value of Serum Albumin Changes Over Time in Elderly Adults Undergoing Hemodialysis Journal of the American Geriatrics Society 64 1353-4
  1. Vinoy, S., Laville, M. and Feskens, E. J. (2016) Slow-release carbohydrates: growing evidence on metabolic responses and public health interest. Summary of the symposium held at the 12th European Nutrition Conference (FENS 2015) Food Nutrition Research 60 31662
  1. Vouillarmet, J. and Laville, M. (2016) A Case of Familial Partial Lipodystrophy: From Clinical Phenotype to Genetics Canadian Journal of Diabetes 40 376-37
  1. Wojtala, M., Pirola, L. and Balcerczyk, A. (2016) Modulation of the vascular endothelium functioning by dietary components, the role of epigenetics Biofactors doi: 10.1002/biof.1306


1. Bastard, J. P., Rabasa-Lhoret, R., Laville, M., and Disse, E. (2015) Surrogate measures of insulin sensitivity vs the hyperinsulinaemic-euglycaemic clamp: a meta-analysis. Are there not some surrogate indexes lost in this story? Diabetologia. 58, 414-415

2. Benoit, B., Laugerette, F., Plaisancie, P., Geloen, A., Bodennec, J., Estienne, M., Pineau, G., Bernalier-Donadille, A., Vidal, H., and Michalski, M. C. (2015) Increasing fat content from 20 to 45 wt% in a complex diet induces lower endotoxemia in parallel with an increased number of intestinal goblet cells in mice. Nutrition Research. 35, 346-356

3. Berger, E., Heraud, S., Mojallal, A., Lequeux, C., Weiss-Gayet, M., Damour, O., and Geloen, A. (2015) Pathways commonly dysregulated in mouse and human obese adipose tissue: FAT/CD36 modulates differentiation and lipogenesis. Adipocyte. 4, 161-180

4. Berger, E., Vega, N., Weiss-Gayet, M., and Geloen, A. (2015) Gene Network Analysis of Glucose Linked Signaling Pathways and Their Role in Human Hepatocellular Carcinoma Cell Growth and Survival in HuH7 and HepG2 Cell Lines. BioMed Research International. 2015, 821761

5. Betry, C., Challan-Belval, M. A., Bernard, A., Charrie, A., Drai, J., Laville, M., Thivolet, C., and Disse, E. (2015) Increased TSH in obesity: Evidence for a BMI-independent association with leptin. Diabetes & Metabolism. 41, 248-251

6. Blond, E., Goudable, J., and Laville, M. (2015) Nonalcoholic Fatty liver disease and hyperuricemia: a close relation with hepatic insulin resistance after nicotinic Acid treatment? Hormone and Metabolic Research. 47, 546-547

7. Boschetti, G., Garnero, P., Moussata, D., Cuerq, C., Preaudat, C., Duclaux-Loras, R., Mialon, A., Drai, J., Flourie, B., and Nancey, S. (2015) Accuracies of serum and fecal S100 proteins (calprotectin and calgranulin C) to predict the response to TNF antagonists in patients with Crohn’s disease. Inflammatory Bowel Diseases. 21, 331-336

8. Boschetti, G., Laidet, M., Moussata, D., Stefanescu, C., Roblin, X., Phelip, G., Cotte, E., Passot, G., Francois, Y., Drai, J., Del Tedesco, E., Bouhnik, Y., Flourie, B., and Nancey, S. (2015) Levels of Fecal Calprotectin Are Associated With the Severity of Postoperative Endoscopic Recurrence in Asymptomatic Patients With Crohn’s Disease. The American Journal of Gastroenterology. 110, 865-872

9. Capel, F., Acquaviva, C., Pitois, E., Laillet, B., Rigaudiere, J. P., Jouve, C., Pouyet, C., Gladine, C., Comte, B., Vianey Saban, C., and Morio, B. (2015) DHA at nutritional doses restores insulin sensitivity in skeletal muscle by preventing lipotoxicity and inflammation. The Journal of Nutritional Biochemistry. 26, 949-959

10. Chevalier, N., Brucker-Davis, F., Lahlou, N., Coquillard, P., Pugeat, M., Pacini, P., Panaia-Ferrari, P., Wagner-Mahler, K., and Fenichel, P. (2015) A negative correlation between insulin-like peptide 3 and bisphenol A in human cord blood suggests an effect of endocrine disruptors on testicular descent during fetal development. Human Reproduction. 30, 447-453

11. Chriett, S., and Pirola, L. (2015) Essential roles of four-carbon backbone chemicals in the control of metabolism. World Journal of Biological Chemistry. 6, 223-230

12. Croze, M. L., Geloen, A., and Soulage, C. O. (2015) Abnormalities in myo-inositol metabolism associated with type 2 diabetes in mice fed a high-fat diet: benefits of a dietary myo-inositol supplementation. The British Journal of Nutrition. 113, 1862-1875

13. Cuerq, C., Peretti, N., Chikh, K., Mialon, A., Guillaumont, M., Drai, J., and Blond, E. (2015) Overview of the in vitro stability of commonly measured vitamins and carotenoids in whole blood. Annals of Clinical Biochemistry. 52, 259-269

14. Eljaafari, A., Robert, M., Chehimi, M., Chanon, S., Durand, C., Vial, G., Bendridi, N., Madec, A. M., Disse, E., Laville, M., Rieusset, J., Lefai, E., Vidal, H., and Pirola, L. (2015) Adipose Tissue-Derived Stem Cells From Obese Subjects Contribute to Inflammation and Reduced Insulin Response in Adipocytes Through Differential Regulation of the Th1/Th17 Balance and Monocyte Activation. Diabetes. 64, 2477-2488

15. Hachem, M., Geloen, A., Van, A. L., Foumaux, B., Fenart, L., Gosselet, F., Da Silva, P., Breton, G., Lagarde, M., Picq, M., and Bernoud-Hubac, N. (2015) Efficient Docosahexaenoic Acid Uptake by the Brain from a Structured Phospholipid. Molecular neurobiology.
16. Heinrich-Balard, L., Zeinyeh, W., Dechaud, H., Rivory, P., Roux, A., Pugeat, M., and Cohen, R. (2015) Inverse relationship between hSHBG affinity for testosterone and hSHBG concentration revealed by surface plasmon resonance. Molecular and cellular endocrinology. 399, 201-207

17. Honnorat, D., Disse, E., Millot, L., Mathiotte, E., Claret, M., Charrie, A., Drai, J., Garnier, L., Maurice, C., Durand, E., Simon, C., Dupuis, O., and Thivolet, C. (2015) Are third-trimester adipokines associated with higher metabolic risk among women with gestational diabetes? Diabetes & Metabolism. 41, 393-400

18. Huvenne, H., Le Beyec, J., Pepin, D., Alili, R., Kherchiche, P. P., Jeannic, E., Frelut, M. L., Lacorte, J. M., Nicolino, M., Viard, A., Laville, M., Ledoux, S., Tounian, P., Poitou, C., Dubern, B., and Clement, K. (2015) Seven novel deleterious LEPR mutations found in early-onset obesity: a DeltaExon6-8 shared by subjects from Reunion Island, France, suggests a founder effect. The Journal of Clinical Endocrinology and Metabolism. 100, E757-766

19. Koppe, L., Mafra, D., and Fouque, D. (2015) Probiotics and chronic kidney disease. Kidney international. 88, 958-966

20. Le Guen, M., Chate, V., Hininger-Favier, I., Laillet, B., Morio, B., Pieroni, G., Schlattner, U., Pison, C., and Dubouchaud, H. (2016) A 9-wk docosahexaenoic acid-enriched supplementation improves endurance exercise capacity and skeletal muscle mitochondrial function in adult rats. Am J Physiol Endocrinol Metab. 310, E213-224

21. Lecomte, M., Couedelo, L., Meugnier, E., Plaisancie, P., Letisse, M., Benoit, B., Gabert, L., Penhoat, A., Durand, A., Pineau, G., Joffre, F., Geloen, A., Vaysse, C., Laugerette, F., and Michalski, M. C. (2016) Dietary emulsifiers from milk and soybean differently impact adiposity and inflammation in association with modulation of colonic goblet cells in high-fat fed mice. Molecular nutrition & food research. 60, 609-620

22. Mafra, D., and Fouque, D. (2015) Gut microbiota and inflammation in chronic kidney disease patients. Clin Kidney J. 8, 332-334

23. Millon, A., Sigovan, M., Boussel, L., Mathevet, J. L., Louzier, V., Paquet, C., Geloen, A., Provost, N., Majd, Z., Patsouris, D., Serusclat, A., and Canet-Soulas, E. (2015) Low WSS Induces Intimal Thickening, while Large WSS Variation and Inflammation Induce Medial Thinning, in an Animal Model of Atherosclerosis. PLoS One. 10, e0141880

24. Naville, D., Labaronne, E., Vega, N., Pinteur, C., Canet-Soulas, E., Vidal, H., and Le Magueresse-Battistoni, B. (2015) Metabolic outcome of female mice exposed to a mixture of low-dose pollutants in a diet-induced obesity model. PLoS One. 10, e0124015

25. Papastathi, C., Disse, E., Berthiller, J., Laville, M., Gouillat, C., and Robert, M. (2015) Impact of Pregnancy on Weight Loss and Quality of Life Following Gastric Banding. Obesity surgery.
26. Perez, E. C., Elie, J. E., Boucaud, I. C., Crouchet, T., Soulage, C. O., Soula, H. A., Theunissen, F. E., and Vignal, C. (2015) Physiological resonance between mates through calls as possible evidence of empathic processes in songbirds. Hormones and Behavior. 75, 130-141

27. Perrin, L., Loizides-Mangold, U., Skarupelova, S., Pulimeno, P., Chanon, S., Robert, M., Bouzakri, K., Modoux, C., Roux-Lombard, P., Vidal, H., Lefai, E., and Dibner, C. (2015) Human skeletal myotubes display a cell-autonomous circadian clock implicated in basal myokine secretion. Molecular metabolism. 4, 834-845

28. Revel, F., Gilbert, T., Roche, S., Drai, J., Blond, E., Ecochard, R., and Bonnefoy, M. (2015) Influence of oxidative stress biomarkers on cognitive decline. Journal of Alzheimer’s disease. 45, 553-560

29. Rieusset, J., Fauconnier, J., Paillard, M., Belaidi, E., Tubbs, E., Chauvin, M. A., Durand, A., Bravard, A., Teixeira, G., Bartosch, B., Michelet, M., Theurey, P., Vial, G., Demion, M., Blond, E., Zoulim, F., Gomez, L., Vidal, H., Lacampagne, A., and Ovize, M. (2016) Disruption of calcium transfer from ER to mitochondria links alterations of mitochondria-associated ER membrane integrity to hepatic insulin resistance. Diabetologia. 59, 614-623

30. Robert, M., Pechoux, A., Marion, D., Laville, M., Gouillat, C., and Disse, E. (2015) Relevance of Roux-en-Y gastric bypass volumetry using 3-dimensional gastric computed tomography with gas to predict weight loss at 1 year. Surgery for obesity and related diseases. 11, 26-31

31. Rossignol, P., Massy, Z. A., Azizi, M., Bakris, G., Ritz, E., Covic, A., Goldsmith, D., Heine, G. H., Jager, K. J., Kanbay, M., Mallamaci, F., Ortiz, A., Vanholder, R., Wiecek, A., Zoccali, C., London, G. M., Stengel, B., Fouque, D., group, Era-Edta Eureca- m working, Red de Investigacion Renal, network, Cardiovascular, and Renal Clinical Trialists, network (2015) The double challenge of resistant hypertension and chronic kidney disease. Lancet. 386, 1588-1598

32. Salvatore, G., Bernoud-Hubac, N., Bissay, N., Debard, C., Daira, P., Meugnier, E., Proamer, F., Hanau, D., Vidal, H., Arico, M., Delprat, C., and Mahtouk, K. (2015) Human monocyte-derived dendritic cells turn into foamy dendritic cells with IL-17A. Journal of lipid research. 56, 1110-1122

33. Soula, H. A., Geloen, A., and Soulage, C. O. (2015) Model of adipose tissue cellularity dynamics during food restriction. Journal of theoretical biology. 364, 189-196

34. Steiber, A. L., Leon, J. B., Hand, R. K., Murphy, W. J., Fouque, D., Parrott, J. S., Kalantar-Zadeh, K., and Cuppari, L. (2015) Using a web-based nutrition algorithm in hemodialysis patients. Journal of renal nutrition. 25, 6-16

35. Vella, R. E., Pillon, N. J., Zarrouki, B., Croze, M. L., Koppe, L., Guichardant, M., Pesenti, S., Chauvin, M. A., Rieusset, J., Geloen, A., and Soulage, C. O. (2015) Ozone exposure triggers insulin resistance through muscle c-Jun N-terminal kinase activation. Diabetes. 64, 1011-1024

36. Vericel, E., Colas, R., Calzada, C., Le, Q. H., Feugier, N., Cugnet, C., Vidal, H., Laville, M., Moulin, P., and Lagarde, M. (2015) Moderate oral supplementation with docosahexaenoic acid improves platelet function and oxidative stress in type 2 diabetic patients. Thrombosis and haemostasis. 114, 289-296

37. Vial, G., Chauvin, M. A., Bendridi, N., Durand, A., Meugnier, E., Madec, A. M., Bernoud-Hubac, N., Pais de Barros, J. P., Fontaine, E., Acquaviva, C., Hallakou-Bozec, S., Bolze, S., Vidal, H., and Rieusset, J. (2015) Imeglimin normalizes glucose tolerance and insulin sensitivity and improves mitochondrial function in liver of a high-fat, high-sucrose diet mice model. Diabetes. 64, 2254-2264

38. Villain, C., Ecochard, R., Genet, L., Jean, G., Kuentz, F., Lataillade, D., Legrand, E., Moreau-Gaudry, X., and Fouque, D. (2015) Impact of BMI Variations on Survival in Elderly Hemodialysis Patients. Journal of renal nutrition. 25, 488-493

39. Vogelzang, J. L., van Stralen, K. J., Noordzij, M., Diez, J. A., Carrero, J. J., Couchoud, C., Dekker, F. W., Finne, P., Fouque, D., Heaf, J. G., Hoitsma, A., Leivestad, T., de Meester, J., Metcalfe, W., Palsson, R., Postorino, M., Ravani, P., Vanholder, R., Wallner, M., Wanner, C., Groothoff, J. W., and Jager, K. J. (2015) Mortality from infections and malignancies in patients treated with renal replacement therapy: data from the ERA-EDTA registry. Nephrology, dialysis, transplantation. 30, 1028-1037

40. Vors, C., Drai, J., Gabert, L., Pineau, G., Laville, M., Vidal, H., Guichard, E., Michalski, M. C., and Feron, G. (2015) Salivary composition in obese vs normal-weight subjects: towards a role in postprandial lipid metabolism? International Journal of Obesity. 39, 1425-1428

41. Vors, C., Pineau, G., Drai, J., Meugnier, E., Pesenti, S., Laville, M., Laugerette, F., Malpuech-Brugere, C., Vidal, H., and Michalski, M. C. (2015) Postprandial Endotoxemia Linked With Chylomicrons and Lipopolysaccharides Handling in Obese Versus Lean Men: A Lipid Dose-Effect Trial. The Journal of Clinical Endocrinology and Metabolism. 100, 3427-3435


1. Allirot, X., Seyssel, K., Saulais, L., Roth, H., Charrie, A., Drai, J., Goudable, J., Blond, E., Disse, E., and Laville, M. (2014) Effects of a breakfast spread out over time on the food intake at lunch and the hormonal responses in obese men. Physiology & behavior. 127, 37-44

2. Bacchetta, J., Pelletier, S., Jean, G., and Fouque, D. (2014) Immune, metabolic and epidemiological aspects of vitamin D in chronic kidney disease and transplant patients. Clinical biochemistry.

3. Benoit, B., Plaisancie, P., Geloen, A., Estienne, M., Debard, C., Meugnier, E., Loizon, E., Daira, P., Bodennec, J., Cousin, O., Vidal, H., Laugerette, F., and Michalski, M. C. (2014) Pasture v. standard dairy cream in high-fat diet-fed mice: improved metabolic outcomes and stronger intestinal barrier. The British journal of nutrition. 1-16

4. Bessa, B., de Oliveira Leal, V., Moraes, C., Barboza, J., Fouque, D., and Mafra, D. (2014) Resistance Training in Hemodialysis Patients: A Review. Rehabilitation nursing : the official journal of the Association of Rehabilitation Nurses.

5. Blanc, S., Ruggiero, F., Birot, A. M., Acloque, H., Decimo, D., Lerat, E., Ohlmann, T., Samarut, J., and Mey, A. (2014) Subcellular localization of ENS-1/ERNI in chick embryonic stem cells. PloS one. 9, e92039

6. Blond, E., Rieusset, J., Alligier, M., Lambert-Porcheron, S., Bendridi, N., Gabert, L., Chetiveaux, M., Debard, C., Chauvin, M. A., Normand, S., Roth, H., de Gouville, A. C., Krempf, M., Vidal, H., Goudable, J., and Laville, M. (2014) Nicotinic Acid effects on insulin sensitivity and hepatic lipid metabolism: an in vivo to in vitro study. Hormone and metabolic research. 46, 390-396

7. Boirie, Y., Morio, B., Caumon, E., and Cano, N. J. (2014) Nutrition and protein energy homeostasis in elderly. Mechanisms of ageing and development. 136-137, 76-84

8. Borges, N., Moraes, C., Barros, A. F., Carraro-Eduardo, J. C., Fouque, D., and Mafra, D. (2014) Acyl-ghrelin and obestatin plasma levels in different stages of chronic kidney disease. Journal of renal nutrition. 24, 100-104

9. Bravard, A., Vial, G., Chauvin, M. A., Rouille, Y., Bailleul, B., Vidal, H., and Rieusset, J. (2014) FTO contributes to hepatic metabolism regulation through regulation of leptin action and STAT3 signalling in liver. Cell communication and signaling : CCS. 12, 4

10. Conway, G. S., Dewailly, D., Diamanti-Kandarakis, E., Escobar Morreale, H., Franks, S., Gambineri, A., Kelestimur, F., Macut, D., Micic, D., Pasquali, R., Pfeifer, M., Pignatelli, D., Pugeat, M., and Yildiz, B. (2014) The Polycystic Ovary Syndrome: an Endocrinological Perspective from the European Society of Endocrinology. European journal of endocrinology / European Federation of Endocrine Societies.

11. Disse, E., Pasquer, A., Espalieu, P., Poncet, G., Gouillat, C., and Robert, M. (2014) Greater Weight Loss with the Omega Loop Bypass Compared to the Roux-en-Y Gastric Bypass: a Comparative Study. Obesity surgery.

12. Eyenga, P., Roussel, D., Morel, J., Rey, B., Romestaing, C., Teulier, L., Sheu, S. S., Goudable, J., Negrier, C., and Viale, J. P. (2014) Early septic shock induces loss of oxidative phosphorylation yield plasticity in liver mitochondria. Journal of physiology and biochemistry. 70, 285-296

13. Fluck, R. J., Fouque, D., and Lockridge, R. S., Jr. (2014) Nephrologists’ perspectives on dialysis treatment: results of an international survey. BMC nephrology. 15, 16

14. Fontas, M., Poulain, J. P., Souquet, P. J., Laville, M., Giboreau, A., Bensafi, M., and Mazieres, J. (2014) [Socio-anthropological perspective of the under nutrition care of cancer patients]. Bulletin du cancer. 101, 258-265

15. Forterre, A., Jalabert, A., Chikh, K., Pesenti, S., Euthine, V., Granjon, A., Errazuriz, E., Lefai, E., Vidal, H., and Rome, S. (2014) Myotube-derived exosomal miRNAs downregulate Sirtuin1 in myoblasts during muscle cell differentiation. Cell Cycle. 13, 78-89

16. Fouque, D., Cruz Casal, M., Lindley, E., Rogers, S., Pancirova, J., Kernc, J., and Copley, J. B. (2014) Dietary trends and management of hyperphosphatemia among patients with chronic kidney disease: an international survey of renal care professionals. Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation. 24, 110-115

17. Gadea, E., Thivat, E., Paulon, R., Mishellany, F., Gimbergues, P., Capel, F., Mosoni, L., Merlin, C., Lombes, M., Morio, B., and Durando, X. (2014) Hibernoma: a clinical model for exploring the role of brown adipose tissue in the regulation of body weight? The Journal of clinical endocrinology and metabolism. 99, 1-6

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