Team 3 : “Organelle Communication and Diabetes”

Diapositive1Our team was initially created in 2011 (team 3 of CarMeN: gluco-lipotoxicity, metabolic stress and diabetes). It involved basic researchers and clinicians with complementary skills in the field of insulin action and secretion. Our aim was to identify common molecular mechanisms by which glucolipotoxicity-associated metabolic stress affects hepatic/muscle insulin action and pancreatic insulin secretion, thus contributing to the two components of type 2 diabetes (T2DM). In recent years, we focused on the involvement of mitochondria and ER in the functional alterations of these tissues, highlighting for the first time a key role of structural and functional interactions between the two organelles in the alterations of insulin action and secretion in T2DM. Therefore, our team has evolved and is now called “organelle communication and diabetes” (OrCaDia, 2016-2020). Our goal is to clarify the mechanisms by which ER-mitochondria interactions are involved in the pathogenesis of T2DM and whether the control of these interactions could be a new target to improve both insulin action and secretion in T2DM (Figure 1).


Scientific research

The communication between intracellular organelles allows the cell to adapt its metabolism according to its environment in order to maintain cellular homeostasis. More specifically, endoplasmic reticulum (ER) and mitochondria interact at contact points, called MAMs (mitochondria-associated endoplasmic reticulum membranes), in order to exchange lipids and calcium, 2 signalling molecules that play a key role in metabolic homeostasis. Indeed, lipids and calcium homeostasis control both insulin action and secretion, explaining why these two organelles play an important role in the pathogenesis of type 2 diabetes (T2DM).

We recently demonstrated a new role of ER-mitochondria cross-talk in the control of insulin action both in the liver and skeletal muscle, as well as a role of disrupted ER-mitochondria interactions in the development of hepatic and muscular insulin resistance (Tubbs E et al. Diabetes 2014, Rieusset J et al. Diabetologia 2016, Tubbs E et al. Diabetes 2018) (Figure 2). Altered structural communications between ER and mitochondria are also associated with altered insulin secretion in beta cells of pancreas of type 2 diabetic patients (Thivolet C et al. PLoS One 2017). Altogether, these data reveal a new mechanism common to both peripheral insulin resistance and beta cell dysfunction, highlighting new preventive and/or therapeutic strategies for the two features of T2DM.

In parallel, we analysed the dynamic regulations of MAM in health and diseases, in order to identify new intracellular targets to modulate ER-mitochondria interactions, and subsequently to regulate glucose homeostasis. We recently demonstrated that ER-mitochondria interactions are regulated by nutritional transitions, and more particularly are reduced at postprandial state, in the presence of high concentrations of glucose, in order to adapt mitochondria dynamics and metabolism and orientate glucose flux towards stockage (Theurey P et al. J Mol Cell Biol 2016) (Figure 3). Interestingly, this regulation is lost in liver of obese and diabetic mice. Therefore, MAMs are a new glucose sensing platform which allow hepatocytes to adapt its metabolism to nutritional transition, and disruption of this regulation could participate to metabolic inflexibility in obesity and T2DM.

The general goal of our research is to better characterize the nature and the physiological significance of MAMs in glucose homeostasis and their roles in the pathogenesis of T2DM. For that, we combine investigations in cellular models, in mouse models of T2DM and in humans. More specifically, our specific aims are:

  • To identify the molecular nature of MAM actors and their functional roles,
  • To characterize the physiological significance of MAMs in the control of insulin action and secretion,
  • To identify the regulators of MAMs and their functional impacts,
  • To validate if the MAMs could be a new target for the treatment of T2DM.

Ultimately, the combination of cellular and integrated approaches, both in animals and humans, coupled with innovative imaging tools, should allow us to clarify the role of communication between the ER and mitochondria in the T2DM physiopathology and to open new avenues for the treatment of this pathology.


  • Preclinical mouse models of T2DM
  • Human and mouse primary cells in culture (hepatocytes, myotubes and islets)
  • Structural and functional analysis of ER-mitochondria communication. Particularly, we developed and validated a new method to detect and quantify ER-mitochondria interactions by in situ proximity ligation assay (PLA), via the visualization of the VDAC1/IP3R1, Grp75/IP3R1 or CypD/IP3R1 interactions in both fixed cells and paraffin-embedded tissues (Figure 4).


  • We also performed subcellular fractionation, electronic microscopy analysis and co-immunoprecipitation analysis to access ER-mitochondria interactions, and analyse calcium transfer from ER to mitochondria by confocal microscopy using Cameleon probes.
  • Analysis of insulin action and secretion
  • Proteomic analysis
  • Lipidomic analysis
  • Strong complementarity between basic research and clinical investigations favouring translational research

Biological resources:

  • Tissues from obese and diabetic mice
  • Human and mouse primary cells in culture (hepatocytes, myotubes and islets)
  • Mitochondria, ER and MAM fractions from liver and skeletal muscle of obese and diabetic mice
  • nPOD human pancreas sections

Key words:

  • Diabetes
  • Insulin resistance
  • Insulin secretion
  • Mitochondria
  • Endoplasmic reticulum
  • MAM
  • Calcium


National and international collaborations / Poxel / Fondation de France / Activ’inside

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Team 3 leaders


BERGER Marie-Agnès AI
JI Jingwei IR
MADEC Anne-Marie MCU
MORIO Béatrice DR2
PANTHU  Baptiste  MCU


2019 (January-june)

  1. Dingreville, F., B. Panthu, C. Thivolet, S. Ducreux, Y. Gouriou, S. Pesenti, M. A. Chauvin, K. Chick, E. Errazuriz-Cerda, F. Van Coppenolle, J. Rieusset and A. M. Madec (2019) Differential effect of glucose on ER-mitochondria Ca(2+) exchange participates to insulin secretion and to glucotoxicity-mediated dysfunction of beta cells. Diabetes.              
  2. Feillet-Coudray, C., G. Fouret, C. Vigor, B. Bonafos, B. Jover, A. Blachnio-Zabielska, J. Rieusset, F. Casas, S. Gaillet, J. F. Landrier, T. Durand and C. Coudray (2019) Long-Term Measures of Dyslipidemia, Inflammation, and Oxidative Stress in Rats Fed a High-Fat/High-Fructose Diet.        Lipids. 54,   81-97
  3. Gourmelon, R., S. Donadio-Andrei, K. Chikh, M. Rabilloud, E. Kuczewski, A. S. Gauchez, A. Charrie, P. Y. Brard, R. Andreani, J. C. Bourre, C. Waterlot, D. Guedel, A. Mayer, E. Disse, C. Thivolet, H. D. Boullay, C. Falandry, T. Gilbert, A. Francois-Joubert, A. Vignoles, C. Ronin and M. Bonnefoy (2019) Subclinical Hypothyroidism: is it Really Subclinical with Aging?  Aging Dis.10, 520-529
  4. Haddouche, A., C. Bellanne-Chantelot, A. Rod, L. Fournier, L. Chiche, J. F. Gautier, J. Timsit, S. Laboureau, L. Chaillous, R. Valero, E. Larger, N. Jeandidier, J. M. Wilhelm, M. Popelier, P. J. Guillausseau, C. Thivolet, P. Lecomte, P. Y. Benhamou and Y. Reznik (2019) Liver adenomatosis in patients with hepatocyte nuclear factor-1 alpha maturity onset diabetes of the young (HNF1A-MODY): Clinical, radiological and pathological characteristics in a French series. J Diabetes.           
  5. Ilie, I., J. Vouillarmet, M. Decaussin-Petrucci, S. Jeannin-Mayer, J. C. Lifante, C. Thivolet and L. Marchand (2019) Bilateral vertebral artery dissection revealing Cushing’s syndrome. Ann Endocrinol (Paris).80,  67-69
  6. Marchand, L., S. Reffet, S. Dalle, E. Disse, J. Vouillarmet, C. Cugnet-Anceau and C. Thivolet (2019) Fulminant diabetes induced by PD-1 and PD-L1 inhibitors: what about glucose variability? Acta Diabetol.  56,  377-378
  7. Marchand, L., A. Thivolet, S. Dalle, K. Chikh, S. Reffet, J. Vouillarmet, N. Fabien, C. Cugnet-Anceau and C. Thivolet (2019) Diabetes mellitus induced by PD-1 and PD-L1 inhibitors: description of pancreatic endocrine and exocrine phenotype.  Acta Diabetol.  56,   441-448
  8. Reynaud, Q., V. Boudreau, S. Touzet, K. Desjardins, S. P. Bourdy, E. Blond, Y. Berthiaume, R. Rabasa-Lhoret and I. Durieu (2019) Glucose tolerance in Canadian and French cystic fibrosis adult patients.  Sci Rep. 9,  4763
  9. Thivolet, C., L. Marchand and K. Chikh (2019) Inappropriate glucagon and GLP-1 secretion in individuals with long-standing type 1 diabetes: effects of residual C-peptide.  Diabetologia. 62,  593-597


  1. Angebault, C., J. Fauconnier, S. Patergnani, J. Rieusset, A. Danese, C. A. Affortit, J. Jagodzinska, C. Megy, M. Quiles, C. Cazevieille, J. Korchagina, D. Bonnet-Wersinger, D. Milea, C. Hamel, P. Pinton, M. Thiry, A. Lacampagne, B. Delprat and C. Delettre (2018) ER-mitochondria cross-talk is regulated by the Ca2+ sensor NCS1 and is impaired in Wolfram syndrome. Science Signaling. 11, 10.1126/scisignal.aaq1380
  2. Britto, F. A., F. Cortade, Y. Belloum, M. Blaquiere, Y. S. Gallot, A. Docquier, A. F. Pagano, E. Jublanc, N. Bendridi, C. Koechlin-Ramonatxo, B. Chabi, M. Francaux, F. Casas, D. Freyssenet, J. Rieusset, S. Giorgetti-Peraldi, G. Carnac, V. Ollendorff and F. B. Favier (2018) Glucocorticoid-dependent REDD1 expression reduces muscle metabolism to enable adaptation under energetic stress. Bmc Biology. 16, 10.1186/s12915-018-0525-4
  3. Cuerq, C., E. Henin, L. Restier, E. Blond, J. Drai, C. Marcais, M. Di Filippo, C. Laveille, M. C. Michalski, P. Poinsot, C. Caussy, A. Sassolas, P. Moulin, E. Reboul, S. Charriere, E. Levy, A. Lachaux and N. Peretti (2018) Efficacy of two vitamin E formulations in patients with abetalipoproteinemia and chylomicron retention disease. Journal of Lipid Research. 59, 10.1194/jlr.M085043
  4. Garnier, L., L. Marchand, M. Benoit, M. Nicolino, N. Bendelac, C. Wright, P. Moulin, C. Lombard, C. Thivolet and N. Fabien (2018) Screening of ZnT8 autoantibodies in the diagnosis of autoimmune diabetes in a large French cohort. Clinica Chimica Acta. 478, 10.1016/j.cca.2017.12.043
  5. Gilbert, T., S. Roche, E. Blond, J. Y. Bar, J. Drai, C. Cuerq, M. Haution-Bitker, R. Ecochard and M. Bonnefoy (2018) Association between Peripheral Leptin and Adiponectin Levels and Cognitive Decline in Patients with Neurocognitive Disorders >= 65 Years. Journal of Alzheimers Disease. 66, 10.3233/jad-180533
  6. Ginzac, A., E. Thivat, M. A. Mouret-Reynier, P. Dubray-Longeras, I. Van Praagh, J. Passildas, C. Abrial, F. Kwiatkowski, Y. Boirie, M. Duclos, B. Morio, E. Gadea and X. Durando (2018) Weight Evolution During Endocrine Therapy for Breast Cancer in Postmenopausal Patients: Effect of Initial Fat Mass Percentage and Previous Adjuvant Treatments. Clinical Breast Cancer. 18, 10.1016/j.clbc.2018.06.010
  7. Haution-Bitker, M., T. Gilbert, A. Vignoles, C. Lecardonnel, S. Watelet, E. Blond, J. Drai and M. Bonnefoy (2018) Associations between Plasmatic Polyunsaturated Fatty Acids Concentrations and Cognitive Status and Decline in Neurocognitive Disorders. Journal of Nutrition Health & Aging. 22, 10.1007/s12603-018-1010-z
  8. Honrath, B., I. E. Krabbendam, C. Ijsebaart, V. Pegoretti, N. Bendridi, J. Rieusset, M. Schmidt, C. Culmsee and A. M. Dolga (2018) SK channel activation is neuroprotective in conditions of enhanced ER-mitochondrial coupling. Cell Death & Disease. 9, 10.1038/s41419-018-0590-1
  9. Lablanche, S., M. C. Vantyghem, L. Kessler, A. Wojtusciszyn, S. Borot, C. Thivolet, S. Girerd, D. Bosco, J. L. Bosson, C. Colin, R. Tetaz, S. Logerot, J. Kerr-Conte, E. Renard, A. Penfornis, E. Morelon, F. Buron, K. Skaare, G. Grguric, C. Camillo-Brault, H. Egelhofer, K. Benomar, L. Badet, T. Berney, F. Pattou, P. Y. Benhamou and T. T. Investigators (2018) Islet transplantation versus insulin therapy in patients with type 1 diabetes with severe hypoglycaemia or poorly controlled glycaemia after kidney transplantation (TRIMECO): a multicentre, randomised controlled trial. Lancet Diabetes & Endocrinology. 6, 10.1016/s2213-8587(18)30078-0
  10. Marchand, L., A. Thivolet, P. Saintigny, N. Fabien, J. Vouillarmet and C. Thivolet (2018) Anti-Programmed Death 1 (PD-1) Antibodies and the Pancreas: A Diabetic Storm Ahead? Diabetes Care. 41, 10.2337/dc17-2243
  11. Mure, F., B. Panthu, I. Zanella-Cleon, F. Delolme, E. Manet, T. Ohlmann and H. Gruffat (2018) Epstein-Barr Virus Protein EB2 Stimulates Translation Initiation of mRNAs through Direct Interactions with both Poly(A)-Binding Protein and Eukaryotic Initiation Factor 4G. Journal of Virology. 92, 10.1128/jvi.01917-17
  12. Panthu, B., T. Ohlmann, J. Perrier, U. Schlattner, P. Jalinot, B. Elena-Herrmann and G. J. P. Rautureau (2018) Cell-Free Protein Synthesis Enhancement from Real-Time NMR Metabolite Kinetics: Redirecting Energy Fluxes in Hybrid RRL Systems. Acs Synthetic Biology. 7, 10.1021/acssynbio.7b00280
  13. Reynaud, Q., M. Rabilloud, S. Roche, S. Poupon-Bourdy, J. Iwaz, R. Nove-Josserand, E. Blond, M. Laville, C. Llerena, S. Quetant, P. Reix, S. Touzet and I. Durieu (2018) Glucose trajectories in cystic fibrosis and their association with pulmonary function. Journal of Cystic Fibrosis. 17, 10.1016/j.jcf.2017.09.010
  14. Rieusset, J. (2018) Mitochondria-associated membranes (MAMs): An emerging platform connecting energy and immune sensing to metabolic flexibility. Biochemical and Biophysical Research Communications. 500, 10.1016/j.bbrc.2017.06.097
  15. Rieusset, J. (2018) The role of endoplasmic reticulum-mitochondria contact sites in the control of glucose homeostasis: an update. Cell Death & Disease. 9, 10.1038/s41419-018-0416-1
  16. Roucher-Boulez, F., A. B. de la Perriere, A. Jacquez, D. Chau, L. Guignat, C. Vial, Y. Morel, M. Nicolino, G. Raverot and M. Pugeat (2018) Triple-A syndrome: a wide spectrum of adrenal dysfunction. European Journal of Endocrinology. 178, 10.1530/eje-17-0642
  17. Sowers, C. R., R. Wang, R. A. Bourne, B. C. McGrath, J. J. Hu, S. C. Bevilacqua, J. C. Paton, A. W. Paton, S. Collardeau-Frachon, M. Nicolino and D. R. Cavener (2018) The protein kinase PERK/EIF2AK3 regulates proinsulin processing not via protein synthesis but by controlling endoplasmic reticulum chaperones. Journal of Biological Chemistry. 293, 10.1074/jbc.M117.813790
  18. Tappy, L., B. Morio, D. Azzout-Marniche, M. Champ, M. Gerber, S. Houdart, E. Mas, S. Rizkalla, G. Slama, F. Mariotti and I. Margaritis (2018) French Recommendations for Sugar Intake in Adults: A Novel Approach Chosen by ANSES. 10, 10.3390/nu10080989
  19. Tubbs, E., A. S. Axelsson, G. Vial, C. B. Wollheim, J. Rieusset and A. H. Rosengren (2018) Sulforaphane improves disrupted ER-mitochondria interactions and suppresses exaggerated hepatic glucose production. Molecular and Cellular Endocrinology. 461, 10.1016/j.mce.2017.09.016
  20. Tubbs, E., S. Chanon, M. Robert, N. Bendridi, G. Bidaux, M. A. Chauvin, J. C. Jingwei, C. Durand, D. Gauvrit-Ramette, H. Vidal, E. Lefai and J. Rieusset (2018) Disruption of Mitochondria-Associated Endoplasmic Reticulum Membrane (MAM) Integrity Contributes to Muscle Insulin Resistance in Mice and Humans. 67, 10.2337/db17-0316
  21. Valla, F. V., M. Bost, S. Roche, M. Pitance, C. Cuerq, J. Ridout, R. Ecochard, T. Ginhoux, A. Bellon, C. Ford-Chessel, A. Portefaix, E. Javouhey and E. Blond (2018) Multiple Micronutrient Plasma Level Changes Are Related to Oxidative Stress Intensity in Critically Ill Children*. Pediatric Critical Care Medicine. 19, 10.1097/pcc.0000000000001626


  1. Barquissau, V., Capel, F., Dardevet, D., Feillet-Coudray, C., Gallinier, A., Chauvin, M. A., Rieusset, J. and Morio, B. (2017) Reactive oxygen species enhance mitochondrial function, insulin sensitivity and glucose uptake in skeletal muscle of senescence accelerated prone mice SAMP8 Free Radical Biology and Medicine 113 267-279
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  4. Delile, E., Neviere, R., Thiebaut, P. A., Maupoint, J., Mulder, P., Coquerel, D., Renet, S., Rieusset, J., Richard, V. and Tamion, F. (2017) Reduced insulin resistance contributes to the beneficial effect of protein tyrosine phosphatase-1b deletion in a mouse model of sepsis Shock 48 355-363
  5. Dos Santos, R. S., Daures, M., Philippi, A., Romero, S., Marselli, L., Marchetti, P., Senee, V., Bacq, D., Besse, C., Baz, B., Marroqui, L., Ivanoff, S., Masliah-Planchon, J., Nicolino, M., Soulier, J., Socie, G., Eizirik, D. L., Gautier, J. F. and Julier, C. (2017) dUTPase (DUT) Is Mutated in a Novel Monogenic Syndrome With Diabetes and Bone Marrow Failure Diabetes 66 1086-1096
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  7. Helfre, M., Grange, C., Riche, B., Maucort-Boulch, D., Thivolet, C. and Vouillarmet, J. (2017) Usefulness of a systematic screening of carotid atherosclerosis in asymptomatic people with type 2 diabetes for cardiovascular risk reclassification. Annales D Endocrinologie. 78; 14-19.
  8. Lablanche, S., David-Tchouda, S., Margier, J., Schir, E., Wojtusciszyn, A., Borot, S., Kessler, L., Morelon, E., Thivolet, C., Pattou, F., Vantyghem, M. C., Berney, T. and Benhamou, P. Y. (2017) Randomised, prospective, medicoeconomic nationwide French study of islet transplantation in patients with severely unstable type 1 diabetes: the STABILOT study protocol Bmj Open 7 7
  9. Lenfant, C., Baz, P., Degavre, A., Philippi, A., Senee, V., Vandiedonck, C., Derbois, C., Nicolino, M., Zalloua, P. and Julier, C. (2017) Juvenile-Onset Diabetes and Congenital Cataract: “Double-Gene” Mutations Mimicking a Syndromic Diabetes Presentation Genes 8 11
  10. Marchand, L., Decaussin-Petrucci, M., Giraud, S., Cotton, F., Thivolet, C. and Simon, C. (2017) Hibernoma and multiple endocrine neoplasia type 1 syndrome: A non-fortuitous association? A case report and literature review Annales D Endocrinologie 78 194-197
  11. Marchand, L., Garnier, L., Fabien, N. and Thivolet, C. (2017) Comment on Jackson et al. Insulitis in Autoantibody-Positive Pancreatic Donor With History of Gestational Diabetes Mellitus. Diabetes Care 40 E155-E155
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  1. Buron, F., Vouillarmet, J., Thaunat, O., Thivolet, C., Badet, L. and Morelon, E. (2016) Autoimmune recurrence as a cause of adrenal gland graft loss? American Journal of Transplantation doi: 10.1111/ajt.13737
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  1. Chehimi, M., Robert, M., Bechwaty, M. E., Vial, G., Rieusset, J., Vidal, H., Pirola, L. and Eljaafari, A. (2016) Adipocytes, like their progenitors, contribute to inflammation of adipose tissues through promotion of Th-17 cells and activation of monocytes, in obese subjects Adipocyte 5 275-82
  1. Coudray, C., Fouret, G., Lambert, K., Ferreri, C., Rieusset, J., Blachnio-Zabielska, A., Lecomte, J., Ebabe Elle, R., Badia, E., Murphy, M. P. and Feillet-Coudray, C. (2016) A mitochondrial-targeted ubiquinone modulates muscle lipid profile and improves mitochondrial respiration in obesogenic diet-fed rats The British Journal of Nutrition 115 1155-66
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  1. Jalabert, A., Vial, G., Guay, C., Wiklander, O. P., Nordin, J. Z., Aswad, H., Forterre, A., Meugnier, E., Pesenti, S., Regazzi, R., Danty-Berger, E., Ducreux, S., Vidal, H., El-Andaloussi, S., Rieusset, J. and Rome, S. (2016) Exosome-like vesicles released from lipid-induced insulin-resistant muscles modulate gene expression and proliferation of beta recipient cells in mice Diabetologia 59 1049-58
  1. Le Guen, M., Chate, V., Hininger-Favier, I., Laillet, B., Morio, B., Pieroni, G., Schlattner, U., Pison, C. and Dubouchaud, H. (2016) A 9-wk docosahexaenoic acid-enriched supplementation improves endurance exercise capacity and skeletal muscle mitochondrial function in adult rats American Journal of Physiology. Endocrinology and Metabolism 310 E213-24
  1. Marchand, L., Jalabert, A., Meugnier, E., Van den Hende, K., Fabien, N., Nicolino, M., Madec, A. M., Thivolet, C. and Rome, S. (2016) miRNA-375 a Sensor of Glucotoxicity Is Altered in the Serum of Children with Newly Diagnosed Type 1 Diabetes Journal of Diabetes Research
  1. Marchand, L., Nicolino, M., Fabien, N., Roep, B. O. and Thivolet, C. (2016) Multiple autoantibodies at onset do not accurately predict long-term pancreatic beta-cell fate in a 13-year-old obese child with immediate insulin-requiring diabetes Diabetes & Metabolism 42 69-70
  1. Morio, B., Fardet, A., Legrand, P. and Lecerf, J. M. (2016) Involvement of dietary saturated fats, from all sources or of dairy origin only, in insulin resistance and type 2 diabetes Nutrition Reviews 74 33-47
  1. Nouvel, M., Rabilloud, M., Raverot, V., Subtil, F., Vouillarmet, J., Thivolet, C., Jouanneau, E., Borson-Chazot, F., Pugeat, M. and Raverot, G. (2016) Performance of the 4-mg intravenous dexamethasone suppression test in differentiating Cushing disease from pseudo-Cushing syndrome Annales d’ Endocrinologie (Paris) 77 30-6
  1. Pinel, A., Pitois, E., Rigaudiere, J. P., Jouve, C., De Saint-Vincent, S., Laillet, B., Montaurier, C., Huertas, A., Morio, B. and Capel, F. (2016) EPA prevents fat mass expansion and metabolic disturbances in mice fed with a Western diet Journal of Lipid Research 57 1382-97
  1. Rieusset, J., Fauconnier, J., Paillard, M., Belaidi, E., Tubbs, E., Chauvin, M. A., Durand, A., Bravard, A., Teixeira, G., Bartosch, B., Michelet, M., Theurey, P., Vial, G., Demion, M., Blond, E., Zoulim, F., Gomez, L., Vidal, H., Lacampagne, A. and Ovize, M. (2016) Disruption of calcium transfer from ER to mitochondria links alterations of mitochondria-associated ER membrane integrity to hepatic insulin resistance Diabetologia 59 614-23
  1. Schloot, N. C., Pham, M. N., Hawa, M. I., Pozzilli, P., Scherbaum, W. A., Schott, M., Kolb, H., Hunter, S., Schernthaner, G., Thivolet, C., Seissler, J. and Leslie, R. D. (2016) Inverse Relationship Between Organ-Specific Autoantibodies and Systemic Immune Mediators in Type 1 Diabetes and Type 2 Diabetes: Action LADA 11 Diabetes Care 39 1932-1939
  1. Schwarzer, M., Makki, K., Storelli, G., Machuca-Gayet, I., Srutkova, D., Hermanova, P., Martino, M. E., Balmand, S., Hudcovic, T., Heddi, A., Rieusset, J., Kozakova, H., Vidal, H. and Leulier, F. (2016) Lactobacillus plantarum strain maintains growth of infant mice during chronic undernutrition Science 351 854-7
  1. Theurey, P. and Rieusset, J. (2016) Mitochondria-Associated Membranes Response to Nutrient Availability and Role in Metabolic Diseases Trends in Endocrinology & Metabolism
  1. Theurey, P., Tubbs, E., Vial, G., Jacquemetton, J., Bendridi, N., Chauvin, M. A., Alam, M. R., Le Romancer, M., Vidal, H. and Rieusset, J. (2016) Mitochondria-associated endoplasmic reticulum membranes allow adaptation of mitochondrial metabolism to glucose availability in the liver Journal of Molecular Cell Biology 8 129-43
  1. Tian, S., Morio, B., Denis, J. B. and Mioche, L. (2016) Age-Related Changes in Segmental Body Composition by Ethnicity and History of Weight Change across the Adult Lifespan International Journal of Environmental Research and Public Health 13
  1. Vouillarmet, J., Fernandes-Rosa, F., Graeppi-Dulac, J., Lantelme, P., Decaussin-Petrucci, M., Thivolet, C., Peix, J. L., Boulkroun, S., Clauser, E. and Zennaro, M. C. (2016) Aldosterone-Producing Adenoma With a Somatic KCNJ5 Mutation Revealing APC-Dependent Familial Adenomatous Polyposis Journal of clinical Endocrinology and Metabolism 101 3874-3878
  2. Vouillarmet, J., Helfre, M., Maucort-Boulch, D., Riche, B., Thivolet, C. and Grange, C. (2016) Carotid atherosclerosis progression and cerebrovascular events in patients with diabetes Journal of Diabetes and its Complications 30 638-43


1. Abdulkarim, B., Nicolino, M., Igoillo-Esteve, M., Daures, M., Romero, S., Philippi, A., Senee, V., Lopes, M., Cunha, D. A., Harding, H. P., Derbois, C., Bendelac, N., Hattersley, A. T., Eizirik, D. L., Ron, D., Cnop, M., and Julier, C. (2015) A Missense Mutation in PPP1R15B Causes a Syndrome Including Diabetes, Short Stature, and Microcephaly. Diabetes. 64, 3951-39622. Betry, C., Challan-Belval, M. A., Bernard, A., Charrie, A., Drai, J., Laville, M., Thivolet, C., and Disse, E. (2015) Increased TSH in obesity: Evidence for a BMI-independent association with leptin. Diabetes & Metabolism. 41, 248-251

3. Chirico, E. N., Faes, C., Connes, P., Canet-Soulas, E., Martin, C., and Pialoux, V. (2015) Role of Exercise-Induced Oxidative Stress in Sickle Cell Trait and Disease. Sports medicine. 46, 629-639

4. Collardeau-Frachon, S., Vasiljevic, A., Jouvet, A., Bouvier, R., Senee, V., and Nicolino, M. (2015) Microscopic and ultrastructural features in Wolcott-Rallison syndrome, a permanent neonatal diabetes mellitus: about two autopsy cases. Pediatric diabetes. 16, 510-520

5. Eljaafari, A., Robert, M., Chehimi, M., Chanon, S., Durand, C., Vial, G., Bendridi, N., Madec, A. M., Disse, E., Laville, M., Rieusset, J., Lefai, E., Vidal, H., and Pirola, L. (2015) Adipose Tissue-Derived Stem Cells From Obese Subjects Contribute to Inflammation and Reduced Insulin Response in Adipocytes Through Differential Regulation of the Th1/Th17 Balance and Monocyte Activation. Diabetes. 64, 2477-2488

6. Gueraud, F., Tache, S., Steghens, J. P., Milkovic, L., Borovic-Sunjic, S., Zarkovic, N., Gaultier, E., Naud, N., Helies-Toussaint, C., Pierre, F., and Priymenko, N. (2015) Dietary polyunsaturated fatty acids and heme iron induce oxidative stress biomarkers and a cancer promoting environment in the colon of rats. Free radical biology & medicine. 83, 192-200

7. Huvenne, H., Le Beyec, J., Pepin, D., Alili, R., Kherchiche, P. P., Jeannic, E., Frelut, M. L., Lacorte, J. M., Nicolino, M., Viard, A., Laville, M., Ledoux, S., Tounian, P., Poitou, C., Dubern, B., and Clement, K. (2015) Seven novel deleterious LEPR mutations found in early-onset obesity: a DeltaExon6-8 shared by subjects from Reunion Island, France, suggests a founder effect. The Journal of Clinical Endocrinology and Metabolism. 100, E757-766

8. Lablanche, S., Borot, S., Wojtusciszyn, A., Bayle, F., Tetaz, R., Badet, L., Thivolet, C., Morelon, E., Frimat, L., Penfornis, A., Kessler, L., Brault, C., Colin, C., Tauveron, I., Bosco, D., Berney, T., Benhamou, P. Y., and Network, Gragil (2015) Five-Year Metabolic, Functional, and Safety Results of Patients With Type 1 Diabetes Transplanted With Allogenic Islets Within the Swiss-French GRAGIL Network. Diabetes Care. 38, 1714-1722

9. Millon, A., Sigovan, M., Boussel, L., Mathevet, J. L., Louzier, V., Paquet, C., Geloen, A., Provost, N., Majd, Z., Patsouris, D., Serusclat, A., and Canet-Soulas, E. (2015) Low WSS Induces Intimal Thickening, while Large WSS Variation and Inflammation Induce Medial Thinning, in an Animal Model of Atherosclerosis. PLoS One. 10, e0141880

10. Mlih, M., Host, L., Martin, S., Niederhoffer, N., Monassier, L., Terrand, J., Messaddeq, N., Radke, M., Gotthardt, M., Bruban, V., Kober, F., Bernard, M., Canet-Soulas, E., Abt-Jijon, F., Boucher, P., and Matz, R. L. (2015) The Src homology and collagen A (ShcA) adaptor protein is required for the spatial organization of the costamere/Z-disk network during heart development. The Journal of biological chemistry. 290, 2419-2430

11. Naville, D., Labaronne, E., Vega, N., Pinteur, C., Canet-Soulas, E., Vidal, H., and Le Magueresse-Battistoni, B. (2015) Metabolic outcome of female mice exposed to a mixture of low-dose pollutants in a diet-induced obesity model. PLoS One. 10, e0124015

12. Rieusset, J. (2015) Contribution of mitochondria and endoplasmic reticulum dysfunction in insulin resistance: Distinct or interrelated roles? Diabetes & metabolism. 41, 358-368

13. Rieusset, J., Fauconnier, J., Paillard, M., Belaidi, E., Tubbs, E., Chauvin, M. A., Durand, A., Bravard, A., Teixeira, G., Bartosch, B., Michelet, M., Theurey, P., Vial, G., Demion, M., Blond, E., Zoulim, F., Gomez, L., Vidal, H., Lacampagne, A., and Ovize, M. (2016) Disruption of calcium transfer from ER to mitochondria links alterations of mitochondria-associated ER membrane integrity to hepatic insulin resistance. Diabetologia. 59, 614-623

14. Roche, C., Besnier, M., Cassel, R., Harouki, N., Coquerel, D., Guerrot, D., Nicol, L., Loizon, E., Remy-Jouet, I., Morisseau, C., Mulder, P., Ouvrard-Pascaud, A., Madec, A. M., Richard, V., and Bellien, J. (2015) Soluble epoxide hydrolase inhibition improves coronary endothelial function and prevents the development of cardiac alterations in obese insulin-resistant mice. American journal of physiology. Heart and circulatory physiology. 308, H1020-1029

15. Vella, R. E., Pillon, N. J., Zarrouki, B., Croze, M. L., Koppe, L., Guichardant, M., Pesenti, S., Chauvin, M. A., Rieusset, J., Geloen, A., and Soulage, C. O. (2015) Ozone exposure triggers insulin resistance through muscle c-Jun N-terminal kinase activation. Diabetes. 64, 1011-1024

16. Vial, G., Chauvin, M. A., Bendridi, N., Durand, A., Meugnier, E., Madec, A. M., Bernoud-Hubac, N., Pais de Barros, J. P., Fontaine, E., Acquaviva, C., Hallakou-Bozec, S., Bolze, S., Vidal, H., and Rieusset, J. (2015) Imeglimin normalizes glucose tolerance and insulin sensitivity and improves mitochondrial function in liver of a high-fat, high-sucrose diet mice model. Diabetes. 64, 2254-2264


1. Blond, E., Rieusset, J., Alligier, M., Lambert-Porcheron, S., Bendridi, N., Gabert, L., Chetiveaux, M., Debard, C., Chauvin, M. A., Normand, S., Roth, H., de Gouville, A. C., Krempf, M., Vidal, H., Goudable, J., and Laville, M. (2014) Nicotinic Acid effects on insulin sensitivity and hepatic lipid metabolism: an in vivo to in vitro study. Hormone and metabolic research. 46, 390-396

2. Bravard, A., Vial, G., Chauvin, M. A., Rouille, Y., Bailleul, B., Vidal, H., and Rieusset, J. (2014) FTO contributes to hepatic metabolism regulation through regulation of leptin action and STAT3 signalling in liver. Cell communication and signaling : CCS. 12, 4

3. Chaussenot, A., Rouzier, C., Quere, M., Plutino, M., Ait-El-Mkadem, S., Bannwarth, S., Barth, M., Dollfus, H., Charles, P., Nicolino, M., Chabrol, B., Vialettes, B., and Paquis-Flucklinger, V. (2014) Mutation update and uncommon phenotypes in a French cohort of 96 patients with WFS1-related disorders. Clinical genetics.

4. Choleau, C., Maitre, J., Filipovic Pierucci, A., Elie, C., Barat, P., Bertrand, A. M., de Kerdanet, M., Letallec, C., Levy-Marchal, C., Nicolino, M., Tubiana-Rufi, N., Cahane, M., and Robert, J. J. (2014) Ketoacidosis at diagnosis of type 1 diabetes in French children and adolescents. Diabetes & metabolism. 40, 137-142

5. Ciumas, C., Schaefers, G., Bouvard, S., Tailhades, E., Perrin, E., Comte, J. C., Canet-Soulas, E., Bonnet, C., Ibarrola, D., Polo, G., Moya, J., Beuf, O., and Ryvlin, P. (2014) A phantom and animal study of temperature changes during fMRI with intracerebral depth electrodes. Epilepsy research. 108, 57-65

6. Franc, S., Borot, S., Ronsin, O., Quesada, J. L., Dardari, D., Fagour, C., Renard, E., Leguerrier, A. M., Vigeral, C., Moreau, F., Winiszewski, P., Vambergue, A., Mosnier-Pudar, H., Kessler, L., Reffet, S., Guerci, B., Millot, L., Halimi, S., Thivolet, C., Benhamou, P. Y., Penfornis, A., Charpentier, G., and Hanaire, H. (2014) Telemedicine and type 1 diabetes: is technology per se sufficient to improve glycaemic control? Diabetes & metabolism. 40, 61-66

7. Grimaldi-Bensouda, L., Guillemot, D., Godeau, B., Benichou, J., Lebrun-Frenay, C., Papeix, C., Labauge, P., Berquin, P., Penfornis, A., Benhamou, P. Y., Nicolino, M., Simon, A., Viallard, J. F., Costedoat-Chalumeau, N., Courcoux, M. F., Pondarre, C., Hilliquin, P., Chatelus, E., Foltz, V., Guillaume, S., Rossignol, M., and Abenhaim, L. (2014) Autoimmune disorders and quadrivalent human papillomavirus vaccination of young female subjects. Journal of internal medicine. 275, 398-408

8. Lablanche, S., Borot, S., Thaunat, O., Bayle, F., Badet, L., Morelon, E., Thivolet, C., Wojtusciszyn, A., Frimat, L., Kessler, L., Penfornis, A., Brault, C., Colin, C., Bosco, D., Berney, T., and Benhamou, P. Y. (2014) Impact of Anti-Insulin Antibodies on Islet Transplantation Outcome: Data From the GRAGIL Network. Transplantation.

9. Li, S., Yao, Y., Xu, R., Pesenti, S., Cottet-Rousselle, C., Rieusset, J., Tokarska-Schlattner, M., Liao, K., Schlattner, U., and Rousseau, D. (2014) ATAD3 is a limiting factor in mitochondrial biogenesis and adipogenesis of white adipocyte-like 3T3-L1 cells. Molecular and cellular biology.

10. Ortega, F. J., Mercader, J. M., Moreno-Navarrete, J. M., Rovira, O., Guerra, E., Esteve, E., Xifra, G., Martinez, C., Ricart, W., Rieusset, J., Rome, S., Karczewska-Kupczewska, M., Straczkowski, M., and Fernandez-Real, J. M. (2014) Profiling of circulating microRNAs reveals common microRNAs linked to type 2 diabetes that change with insulin sensitization. Diabetes care. 37, 1375-1383

11. Poulain, L., Thomas, A., Rieusset, J., Casteilla, L., Levy, P., Arnaud, C., and Dematteis, M. (2014) Visceral white fat remodelling contributes to intermittent hypoxia-induced atherogenesis. The European respiratory journal. 43, 513-522

12. Roman, S., Marjoux, S., Thivolet, C., and Mion, F. (2014) Oesophageal function assessed by high-resolution manometry in patients with diabetes and inadequate glycaemic control. Diabetic medicine : a journal of the British Diabetic Association.

13. Seyssel, K., Alligier, M., Meugnier, E., Chanseaume, E., Loizon, E., Canto, C., Disse, E., Lambert-Porcheron, S., Brozek, J., Blond, E., Rieusset, J., Morio, B., Laville, M., and Vidal, H. (2014) Regulation of Energy Metabolism and Mitochondrial Function in Skeletal Muscle during Lipid Overfeeding in Healthy Men. The Journal of clinical endocrinology and metabolism. jc20134379

14. Tubbs, E., Theurey, P., Vial, G., Bendridi, N., Bravard, A., Chauvin, M. A., Ji-Cao, J., Zoulim, F., Bartosch, B., Ovize, M., Vidal, H., and Rieusset, J. (2014) Mitochondria-Associated Endoplasmic Reticulum Membrane (MAM) Integrity Is Required for Insulin Signaling and Is Implicated in Hepatic Insulin Resistance. Diabetes.

15. Vouillarmet, J., Morelec, I., and Thivolet, C. (2014) Assessing diabetic foot osteomyelitis remission with white blood cell SPECT/CT imaging. Diabetic medicine : a journal of the British Diabetic Association.