Team 3 : “Organelle Communication and Diabetes”

Diapositive1Our team was initially created in 2011 (team 3 of CarMeN: gluco-lipotoxicity, metabolic stress and diabetes). It involved basic researchers and clinicians with complementary skills in the field of insulin action and secretion. Our aim was to identify common molecular mechanisms by which glucolipotoxicity-associated metabolic stress affects hepatic/muscle insulin action and pancreatic insulin secretion, thus contributing to the two components of type 2 diabetes (T2DM). In recent years, we focused on the involvement of mitochondria and ER in the functional alterations of these tissues, highlighting for the first time a key role of structural and functional interactions between the two organelles in the alterations of insulin action and secretion in T2DM. Therefore, our team has evolved and is now called “organelle communication and diabetes” (OrCaDia, 2016-2020). Our goal is to clarify the mechanisms by which ER-mitochondria interactions are involved in the pathogenesis of T2DM and whether the control of these interactions could be a new target to improve both insulin action and secretion in T2DM (Figure 1).


Scientific research

The communication between intracellular organelles allows the cell to adapt its metabolism according to its environment in order to maintain cellular homeostasis. More specifically, endoplasmic reticulum (ER) and mitochondria interact at contact points, called MAMs (mitochondria-associated endoplasmic reticulum membranes), in order to exchange lipids and calcium, 2 signalling molecules that play a key role in metabolic homeostasis. Indeed, lipids and calcium homeostasis control both insulin action and secretion, explaining why these two organelles play an important role in the pathogenesis of type 2 diabetes (T2DM).

We recently demonstrated a new role of ER-mitochondria cross-talk in the control of insulin action both in the liver and skeletal muscle, as well as a role of disrupted ER-mitochondria interactions in the development of hepatic and muscular insulin resistance (Tubbs E et al. Diabetes 2014, Rieusset J et al. Diabetologia 2016, Tubbs E et al. Diabetes 2018) (Figure 2). Altered structural communications between ER and mitochondria are also associated with altered insulin secretion in beta cells of pancreas of type 2 diabetic patients (Thivolet C et al. PLoS One 2017). Altogether, these data reveal a new mechanism common to both peripheral insulin resistance and beta cell dysfunction, highlighting new preventive and/or therapeutic strategies for the two features of T2DM.

In parallel, we analysed the dynamic regulations of MAM in health and diseases, in order to identify new intracellular targets to modulate ER-mitochondria interactions, and subsequently to regulate glucose homeostasis. We recently demonstrated that ER-mitochondria interactions are regulated by nutritional transitions, and more particularly are reduced at postprandial state, in the presence of high concentrations of glucose, in order to adapt mitochondria dynamics and metabolism and orientate glucose flux towards stockage (Theurey P et al. J Mol Cell Biol 2016) (Figure 3). Interestingly, this regulation is lost in liver of obese and diabetic mice. Therefore, MAMs are a new glucose sensing platform which allow hepatocytes to adapt its metabolism to nutritional transition, and disruption of this regulation could participate to metabolic inflexibility in obesity and T2DM.

The general goal of our research is to better characterize the nature and the physiological significance of MAMs in glucose homeostasis and their roles in the pathogenesis of T2DM. For that, we combine investigations in cellular models, in mouse models of T2DM and in humans. More specifically, our specific aims are:

  • To identify the molecular nature of MAM actors and their functional roles,
  • To characterize the physiological significance of MAMs in the control of insulin action and secretion,
  • To identify the regulators of MAMs and their functional impacts,
  • To validate if the MAMs could be a new target for the treatment of T2DM.

Ultimately, the combination of cellular and integrated approaches, both in animals and humans, coupled with innovative imaging tools, should allow us to clarify the role of communication between the ER and mitochondria in the T2DM physiopathology and to open new avenues for the treatment of this pathology.


  • Preclinical mouse models of T2DM
  • Human and mouse primary cells in culture (hepatocytes, myotubes and islets)
  • Structural and functional analysis of ER-mitochondria communication. Particularly, we developed and validated a new method to detect and quantify ER-mitochondria interactions by in situ proximity ligation assay (PLA), via the visualization of the VDAC1/IP3R1, Grp75/IP3R1 or CypD/IP3R1 interactions in both fixed cells and paraffin-embedded tissues (Figure 4).


  • We also performed subcellular fractionation, electronic microscopy analysis and co-immunoprecipitation analysis to access ER-mitochondria interactions, and analyse calcium transfer from ER to mitochondria by confocal microscopy using Cameleon probes.
  • Analysis of insulin action and secretion
  • Proteomic analysis
  • Lipidomic analysis
  • Strong complementarity between basic research and clinical investigations favouring translational research

Biological resources:

  • Tissues from obese and diabetic mice
  • Human and mouse primary cells in culture (hepatocytes, myotubes and islets)
  • Mitochondria, ER and MAM fractions from liver and skeletal muscle of obese and diabetic mice
  • nPOD human pancreas sections

Key words:

  • Diabetes
  • Insulin resistance
  • Insulin secretion
  • Mitochondria
  • Endoplasmic reticulum
  • MAM
  • Calcium


National and international collaborations / Poxel / Fondation de France / Activ’inside

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Team 3 leaders


BERGER Marie-Agnès AI
JI Jingwei IR
MADEC Anne-Marie MCU
MORIO Béatrice DR2
PANTHU  Baptiste  MCU


2018 (January-june)

  1. Tubbs, E., Chanon, S., Robert, M., Bendridi, N., Bidaux, G., Chauvin, M. A., Jingwei, J. C., Durand, C., Gauvrit-Ramette, D., Vidal, H., Lefai, E. and Rieusset, J. (2018) Disruption of Mitochondria-Associated Endoplasmic Reticulum Membrane (MAM) Integrity Contributes to Muscle Insulin Resistance in Mice and Humans Diabetes 67 636-650 10.2337/db17-0316
  2. Tubbs, E., Axelsson, A. S., Vial, G., Wollheim, C. B., Rieusset, J. and Rosengren, A. H. (2018) Sulforaphane improves disrupted ER-mitochondria interactions and suppresses exaggerated hepatic glucose production Mol Cell Endocrinol 461 205-214 10.1016/j.mce.2017.09.016
  3. Sowers, C. R., Wang, R., Bourne, R. A., McGrath, B. C., Hu, J. J., Bevilacqua, S. C., Paton, J. C., Paton, A. W., Collardeau-Frachon, S., Nicolino, M. and Cavener, D. R. (2018) The protein kinase PERK/EIF2AK3 regulates proinsulin processing not via protein synthesis but by controlling endoplasmic reticulum chaperones Journal of Biological Chemistry 293 5134-5149 10.1074/jbc.M117.813790
  4. Roucher-Boulez, F., de la Perriere, A. B., Jacquez, A., Chau, D., Guignat, L., Vial, C., Morel, Y., Nicolino, M., Raverot, G. and Pugeat, M. (2018) Triple-A syndrome: a wide spectrum of adrenal dysfunction European Journal of Endocrinology 178 199-207 10.1530/eje-17-0642
  5. Rieusset, J. (2018) The role of endoplasmic reticulum-mitochondria contact sites in the control of glucose homeostasis: an update Cell Death & Disease 9 12 10.1038/s41419-018-0416-1
  6. Rieusset, J. (2018) Mitochondria-associated membranes (MAMs): An emerging platform connecting energy and immune sensing to metabolic flexibility Biochemical and Biophysical Research Communications 500 35-44 10.1016/j.bbrc.2017.06.097
  7. Reynaud, Q., Rabilloud, M., Roche, S., Poupon-Bourdy, S., Iwaz, J., Nove-Josserand, R., Blond, E., Laville, M., Llerena, C., Quetant, S., Reix, P., Touzet, S. and Durieu, I. (2018) Glucose trajectories in cystic fibrosis and their association with pulmonary function Journal of Cystic Fibrosis 17 400-406 10.1016/j.jcf.2017.09.01
  8. Marchand, L., Thivolet, A., Saintigny, P., Fabien, N., Vouillarmet, J. and Thivolet, C. (2018) Anti-Programmed Death 1 (PD-1) Antibodies and the Pancreas: A Diabetic Storm Ahead? Diabetes Care 41 638-639 10.2337/dc17-2243
  9. Honrath, B., Krabbendam, I. E., Ijsebaart, C., Pegoretti, V., Bendridi, N., Rieusset, J., Schmidt, M., Culmsee, C. and Dolga, A. M. (2018) SK channel activation is neuroprotective in conditions of enhanced ER-mitochondrial coupling Cell Death & Disease 9 11 10.1038/s41419-018-0590-1
  10. Haution-Bitker, M., Gilbert, T., Vignoles, A., Lecardonnel, C., Watelet, S., Blond, E., Drai, J. and Bonnefoy, M. (2018) Associations between Plasmatic Polyunsaturated Fatty Acids Concentrations and Cognitive Status and Decline in Neurocognitive Disorders Journal of Nutrition Health & Aging 22 718-725 10.1007/s12603-018-1010-z
  11. Garnier, L., Marchand, L., Benoit, M., Nicolino, M., Bendelac, N., Wright, C., Moulin, P., Lombard, C., Thivolet, C. and Fabien, N. (2018) Screening of ZnT8 autoantibodies in the diagnosis of autoimmune diabetes in a large French cohort Clinica Chimica Acta 478 162-165 10.1016/j.cca.2017.12.043
  12. Britto, F. A., Cortade, F., Belloum, Y., Blaquiere, M., Gallot, Y. S., Docquier, A., Pagano, A. F., Jublanc, E., Bendridi, N., Koechlin-Ramonatxo, C., Chabi, B., Francaux, M., Casas, F., Freyssenet, D., Rieusset, J., Giorgetti-Peraldi, S., Carnac, G., Ollendorff, V. and Favier, F. B. (2018) Glucocorticoid-dependent REDD1 expression reduces muscle metabolism to enable adaptation under energetic stress Bmc Biology 16 17 10.1186/s12915-018-0525-4


  1. Barquissau, V., Capel, F., Dardevet, D., Feillet-Coudray, C., Gallinier, A., Chauvin, M. A., Rieusset, J. and Morio, B. (2017) Reactive oxygen species enhance mitochondrial function, insulin sensitivity and glucose uptake in skeletal muscle of senescence accelerated prone mice SAMP8 Free Radical Biology and Medicine 113 267-279
  2. Benoit, B., Meugnier, E., Castelli, M., Chanon, S., Vieille-Marchiset, A., Durand, C., Bendridi, N., Pesenti, S., Monternier, P. A., Durieux, A. C., Freyssenet, D., Rieusset, J., Lefai, E., Vidal, H. and Ruzzin, J. (2017) Fibroblast growth factor 19 regulates skeletal muscle mass and ameliorates muscle wasting in mice Nature Medicine 23 990
  3. Blond, E., Disse, E., Cuerq, C., Drai, J., Valette, P. J., Laville, M., Thivolet, C., Simon, C. and Caussy, C. (2017) EASL-EASD-EASO clinical practice guidelines for the management of non-alcoholic fatty liver disease in severely obese people: do they lead to over-referral? Diabetologia 60 1218-1222
  4. Delile, E., Neviere, R., Thiebaut, P. A., Maupoint, J., Mulder, P., Coquerel, D., Renet, S., Rieusset, J., Richard, V. and Tamion, F. (2017) Reduced insulin resistance contributes to the beneficial effect of protein tyrosine phosphatase-1b deletion in a mouse model of sepsis Shock 48 355-363
  5. Dos Santos, R. S., Daures, M., Philippi, A., Romero, S., Marselli, L., Marchetti, P., Senee, V., Bacq, D., Besse, C., Baz, B., Marroqui, L., Ivanoff, S., Masliah-Planchon, J., Nicolino, M., Soulier, J., Socie, G., Eizirik, D. L., Gautier, J. F. and Julier, C. (2017) dUTPase (DUT) Is Mutated in a Novel Monogenic Syndrome With Diabetes and Bone Marrow Failure Diabetes 66 1086-1096
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  7. Helfre, M., Grange, C., Riche, B., Maucort-Boulch, D., Thivolet, C. and Vouillarmet, J. (2017) Usefulness of a systematic screening of carotid atherosclerosis in asymptomatic people with type 2 diabetes for cardiovascular risk reclassification. Annales D Endocrinologie. 78; 14-19.
  8. Lablanche, S., David-Tchouda, S., Margier, J., Schir, E., Wojtusciszyn, A., Borot, S., Kessler, L., Morelon, E., Thivolet, C., Pattou, F., Vantyghem, M. C., Berney, T. and Benhamou, P. Y. (2017) Randomised, prospective, medicoeconomic nationwide French study of islet transplantation in patients with severely unstable type 1 diabetes: the STABILOT study protocol Bmj Open 7 7
  9. Lenfant, C., Baz, P., Degavre, A., Philippi, A., Senee, V., Vandiedonck, C., Derbois, C., Nicolino, M., Zalloua, P. and Julier, C. (2017) Juvenile-Onset Diabetes and Congenital Cataract: “Double-Gene” Mutations Mimicking a Syndromic Diabetes Presentation Genes 8 11
  10. Marchand, L., Decaussin-Petrucci, M., Giraud, S., Cotton, F., Thivolet, C. and Simon, C. (2017) Hibernoma and multiple endocrine neoplasia type 1 syndrome: A non-fortuitous association? A case report and literature review Annales D Endocrinologie 78 194-197
  11. Marchand, L., Garnier, L., Fabien, N. and Thivolet, C. (2017) Comment on Jackson et al. Insulitis in Autoantibody-Positive Pancreatic Donor With History of Gestational Diabetes Mellitus. Diabetes Care 40 E155-E155
  12. Rieusset, J. (2017) Endoplasmic reticulum-mitochondria calcium signaling in hepatic metabolic diseases Biochimica Et Biophysica Acta-Molecular Cell Research 1864 865-876
  13. Rieusset, J. (2017) Role of Endoplasmic Reticulum-Mitochondria Communication in Type 2 Diabetes Adv Exp Med Biol 997 171-186
  14. Rieusset, J. (2017) Mitochondria-associated membranes (MAMs): An emerging platform connecting energy and immune sensing to metabolic flexibility Mol Cell Proteomics
  15. Theurey, P. and Rieusset, J. (2017) Mitochondria-Associated Membranes Response to Nutrient Availability and Role in Metabolic Diseases Trends Endocrinol Metab 28 32-45
  16. Thivolet, C., Vial, G., Cassel, R., Rieusset, J. and Madec, A. M. (2017) Reduction of endoplasmic reticulummitochondria interactions in beta cells from patients with type 2 diabetes Plos One 12 17
  17. Tubbs, E. and Rieusset, J. (2017) Metabolic signaling functions of ER-mitochondria contact sites: role in metabolic diseases Journal of Molecular Endocrinology 58 R87-R106


  1. Buron, F., Vouillarmet, J., Thaunat, O., Thivolet, C., Badet, L. and Morelon, E. (2016) Autoimmune recurrence as a cause of adrenal gland graft loss? American Journal of Transplantation doi: 10.1111/ajt.13737
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1. Abdulkarim, B., Nicolino, M., Igoillo-Esteve, M., Daures, M., Romero, S., Philippi, A., Senee, V., Lopes, M., Cunha, D. A., Harding, H. P., Derbois, C., Bendelac, N., Hattersley, A. T., Eizirik, D. L., Ron, D., Cnop, M., and Julier, C. (2015) A Missense Mutation in PPP1R15B Causes a Syndrome Including Diabetes, Short Stature, and Microcephaly. Diabetes. 64, 3951-39622. Betry, C., Challan-Belval, M. A., Bernard, A., Charrie, A., Drai, J., Laville, M., Thivolet, C., and Disse, E. (2015) Increased TSH in obesity: Evidence for a BMI-independent association with leptin. Diabetes & Metabolism. 41, 248-251

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4. Collardeau-Frachon, S., Vasiljevic, A., Jouvet, A., Bouvier, R., Senee, V., and Nicolino, M. (2015) Microscopic and ultrastructural features in Wolcott-Rallison syndrome, a permanent neonatal diabetes mellitus: about two autopsy cases. Pediatric diabetes. 16, 510-520

5. Eljaafari, A., Robert, M., Chehimi, M., Chanon, S., Durand, C., Vial, G., Bendridi, N., Madec, A. M., Disse, E., Laville, M., Rieusset, J., Lefai, E., Vidal, H., and Pirola, L. (2015) Adipose Tissue-Derived Stem Cells From Obese Subjects Contribute to Inflammation and Reduced Insulin Response in Adipocytes Through Differential Regulation of the Th1/Th17 Balance and Monocyte Activation. Diabetes. 64, 2477-2488

6. Gueraud, F., Tache, S., Steghens, J. P., Milkovic, L., Borovic-Sunjic, S., Zarkovic, N., Gaultier, E., Naud, N., Helies-Toussaint, C., Pierre, F., and Priymenko, N. (2015) Dietary polyunsaturated fatty acids and heme iron induce oxidative stress biomarkers and a cancer promoting environment in the colon of rats. Free radical biology & medicine. 83, 192-200

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8. Lablanche, S., Borot, S., Wojtusciszyn, A., Bayle, F., Tetaz, R., Badet, L., Thivolet, C., Morelon, E., Frimat, L., Penfornis, A., Kessler, L., Brault, C., Colin, C., Tauveron, I., Bosco, D., Berney, T., Benhamou, P. Y., and Network, Gragil (2015) Five-Year Metabolic, Functional, and Safety Results of Patients With Type 1 Diabetes Transplanted With Allogenic Islets Within the Swiss-French GRAGIL Network. Diabetes Care. 38, 1714-1722

9. Millon, A., Sigovan, M., Boussel, L., Mathevet, J. L., Louzier, V., Paquet, C., Geloen, A., Provost, N., Majd, Z., Patsouris, D., Serusclat, A., and Canet-Soulas, E. (2015) Low WSS Induces Intimal Thickening, while Large WSS Variation and Inflammation Induce Medial Thinning, in an Animal Model of Atherosclerosis. PLoS One. 10, e0141880

10. Mlih, M., Host, L., Martin, S., Niederhoffer, N., Monassier, L., Terrand, J., Messaddeq, N., Radke, M., Gotthardt, M., Bruban, V., Kober, F., Bernard, M., Canet-Soulas, E., Abt-Jijon, F., Boucher, P., and Matz, R. L. (2015) The Src homology and collagen A (ShcA) adaptor protein is required for the spatial organization of the costamere/Z-disk network during heart development. The Journal of biological chemistry. 290, 2419-2430

11. Naville, D., Labaronne, E., Vega, N., Pinteur, C., Canet-Soulas, E., Vidal, H., and Le Magueresse-Battistoni, B. (2015) Metabolic outcome of female mice exposed to a mixture of low-dose pollutants in a diet-induced obesity model. PLoS One. 10, e0124015

12. Rieusset, J. (2015) Contribution of mitochondria and endoplasmic reticulum dysfunction in insulin resistance: Distinct or interrelated roles? Diabetes & metabolism. 41, 358-368

13. Rieusset, J., Fauconnier, J., Paillard, M., Belaidi, E., Tubbs, E., Chauvin, M. A., Durand, A., Bravard, A., Teixeira, G., Bartosch, B., Michelet, M., Theurey, P., Vial, G., Demion, M., Blond, E., Zoulim, F., Gomez, L., Vidal, H., Lacampagne, A., and Ovize, M. (2016) Disruption of calcium transfer from ER to mitochondria links alterations of mitochondria-associated ER membrane integrity to hepatic insulin resistance. Diabetologia. 59, 614-623

14. Roche, C., Besnier, M., Cassel, R., Harouki, N., Coquerel, D., Guerrot, D., Nicol, L., Loizon, E., Remy-Jouet, I., Morisseau, C., Mulder, P., Ouvrard-Pascaud, A., Madec, A. M., Richard, V., and Bellien, J. (2015) Soluble epoxide hydrolase inhibition improves coronary endothelial function and prevents the development of cardiac alterations in obese insulin-resistant mice. American journal of physiology. Heart and circulatory physiology. 308, H1020-1029

15. Vella, R. E., Pillon, N. J., Zarrouki, B., Croze, M. L., Koppe, L., Guichardant, M., Pesenti, S., Chauvin, M. A., Rieusset, J., Geloen, A., and Soulage, C. O. (2015) Ozone exposure triggers insulin resistance through muscle c-Jun N-terminal kinase activation. Diabetes. 64, 1011-1024

16. Vial, G., Chauvin, M. A., Bendridi, N., Durand, A., Meugnier, E., Madec, A. M., Bernoud-Hubac, N., Pais de Barros, J. P., Fontaine, E., Acquaviva, C., Hallakou-Bozec, S., Bolze, S., Vidal, H., and Rieusset, J. (2015) Imeglimin normalizes glucose tolerance and insulin sensitivity and improves mitochondrial function in liver of a high-fat, high-sucrose diet mice model. Diabetes. 64, 2254-2264


1. Blond, E., Rieusset, J., Alligier, M., Lambert-Porcheron, S., Bendridi, N., Gabert, L., Chetiveaux, M., Debard, C., Chauvin, M. A., Normand, S., Roth, H., de Gouville, A. C., Krempf, M., Vidal, H., Goudable, J., and Laville, M. (2014) Nicotinic Acid effects on insulin sensitivity and hepatic lipid metabolism: an in vivo to in vitro study. Hormone and metabolic research. 46, 390-396

2. Bravard, A., Vial, G., Chauvin, M. A., Rouille, Y., Bailleul, B., Vidal, H., and Rieusset, J. (2014) FTO contributes to hepatic metabolism regulation through regulation of leptin action and STAT3 signalling in liver. Cell communication and signaling : CCS. 12, 4

3. Chaussenot, A., Rouzier, C., Quere, M., Plutino, M., Ait-El-Mkadem, S., Bannwarth, S., Barth, M., Dollfus, H., Charles, P., Nicolino, M., Chabrol, B., Vialettes, B., and Paquis-Flucklinger, V. (2014) Mutation update and uncommon phenotypes in a French cohort of 96 patients with WFS1-related disorders. Clinical genetics.

4. Choleau, C., Maitre, J., Filipovic Pierucci, A., Elie, C., Barat, P., Bertrand, A. M., de Kerdanet, M., Letallec, C., Levy-Marchal, C., Nicolino, M., Tubiana-Rufi, N., Cahane, M., and Robert, J. J. (2014) Ketoacidosis at diagnosis of type 1 diabetes in French children and adolescents. Diabetes & metabolism. 40, 137-142

5. Ciumas, C., Schaefers, G., Bouvard, S., Tailhades, E., Perrin, E., Comte, J. C., Canet-Soulas, E., Bonnet, C., Ibarrola, D., Polo, G., Moya, J., Beuf, O., and Ryvlin, P. (2014) A phantom and animal study of temperature changes during fMRI with intracerebral depth electrodes. Epilepsy research. 108, 57-65

6. Franc, S., Borot, S., Ronsin, O., Quesada, J. L., Dardari, D., Fagour, C., Renard, E., Leguerrier, A. M., Vigeral, C., Moreau, F., Winiszewski, P., Vambergue, A., Mosnier-Pudar, H., Kessler, L., Reffet, S., Guerci, B., Millot, L., Halimi, S., Thivolet, C., Benhamou, P. Y., Penfornis, A., Charpentier, G., and Hanaire, H. (2014) Telemedicine and type 1 diabetes: is technology per se sufficient to improve glycaemic control? Diabetes & metabolism. 40, 61-66

7. Grimaldi-Bensouda, L., Guillemot, D., Godeau, B., Benichou, J., Lebrun-Frenay, C., Papeix, C., Labauge, P., Berquin, P., Penfornis, A., Benhamou, P. Y., Nicolino, M., Simon, A., Viallard, J. F., Costedoat-Chalumeau, N., Courcoux, M. F., Pondarre, C., Hilliquin, P., Chatelus, E., Foltz, V., Guillaume, S., Rossignol, M., and Abenhaim, L. (2014) Autoimmune disorders and quadrivalent human papillomavirus vaccination of young female subjects. Journal of internal medicine. 275, 398-408

8. Lablanche, S., Borot, S., Thaunat, O., Bayle, F., Badet, L., Morelon, E., Thivolet, C., Wojtusciszyn, A., Frimat, L., Kessler, L., Penfornis, A., Brault, C., Colin, C., Bosco, D., Berney, T., and Benhamou, P. Y. (2014) Impact of Anti-Insulin Antibodies on Islet Transplantation Outcome: Data From the GRAGIL Network. Transplantation.

9. Li, S., Yao, Y., Xu, R., Pesenti, S., Cottet-Rousselle, C., Rieusset, J., Tokarska-Schlattner, M., Liao, K., Schlattner, U., and Rousseau, D. (2014) ATAD3 is a limiting factor in mitochondrial biogenesis and adipogenesis of white adipocyte-like 3T3-L1 cells. Molecular and cellular biology.

10. Ortega, F. J., Mercader, J. M., Moreno-Navarrete, J. M., Rovira, O., Guerra, E., Esteve, E., Xifra, G., Martinez, C., Ricart, W., Rieusset, J., Rome, S., Karczewska-Kupczewska, M., Straczkowski, M., and Fernandez-Real, J. M. (2014) Profiling of circulating microRNAs reveals common microRNAs linked to type 2 diabetes that change with insulin sensitization. Diabetes care. 37, 1375-1383

11. Poulain, L., Thomas, A., Rieusset, J., Casteilla, L., Levy, P., Arnaud, C., and Dematteis, M. (2014) Visceral white fat remodelling contributes to intermittent hypoxia-induced atherogenesis. The European respiratory journal. 43, 513-522

12. Roman, S., Marjoux, S., Thivolet, C., and Mion, F. (2014) Oesophageal function assessed by high-resolution manometry in patients with diabetes and inadequate glycaemic control. Diabetic medicine : a journal of the British Diabetic Association.

13. Seyssel, K., Alligier, M., Meugnier, E., Chanseaume, E., Loizon, E., Canto, C., Disse, E., Lambert-Porcheron, S., Brozek, J., Blond, E., Rieusset, J., Morio, B., Laville, M., and Vidal, H. (2014) Regulation of Energy Metabolism and Mitochondrial Function in Skeletal Muscle during Lipid Overfeeding in Healthy Men. The Journal of clinical endocrinology and metabolism. jc20134379

14. Tubbs, E., Theurey, P., Vial, G., Bendridi, N., Bravard, A., Chauvin, M. A., Ji-Cao, J., Zoulim, F., Bartosch, B., Ovize, M., Vidal, H., and Rieusset, J. (2014) Mitochondria-Associated Endoplasmic Reticulum Membrane (MAM) Integrity Is Required for Insulin Signaling and Is Implicated in Hepatic Insulin Resistance. Diabetes.

15. Vouillarmet, J., Morelec, I., and Thivolet, C. (2014) Assessing diabetic foot osteomyelitis remission with white blood cell SPECT/CT imaging. Diabetic medicine : a journal of the British Diabetic Association.


1. Aspord, C., Laurin, D., Janier, M. F., Mandon, C. A., Thivolet, C., Villiers, C., Mowat, P., Madec, A. M., Tillement, O., Perriat, P., Louis, C., Berard, F., Marche, P. N., Plumas, J., and Billotey, C. (2013) Paramagnetic nanoparticles to track and quantify in vivo immune human therapeutic cells. Nanoscale. 5, 11409-114152. Aufradet, E., DeSouza, G., Bourgeaux, V., Bessaad, A., Campion, Y., Canet-Soulas, E., Pialoux, V., Chirico, E. N., Chevrier, A. M., Godfrin, Y., and Martin, C. (2013) Hypoxia/reoxygenation stress increases markers of vaso-occlusive crisis in sickle SAD mice. Clinical hemorheology and microcirculation. 54, 297-312

3. Benoit, B., Plaisancie, P., Awada, M., Geloen, A., Estienne, M., Capel, F., Malpuech-Brugere, C., Debard, C., Pesenti, S., Morio, B., Vidal, H., Rieusset, J., and Michalski, M. C. (2013) High-fat diet action on adiposity, inflammation, and insulin sensitivity depends on the control low-fat diet. Nutr Res. 33, 952-960

4. Bravard, A., Veilleux, A., Disse, E., Laville, M., Vidal, H., Tchernof, A., and Rieusset, J. (2013) The expression of FTO in human adipose tissue is influenced by fat depot, adiposity, and insulin sensitivity. Obesity (Silver Spring). 21, 1165-1173

5. Buron, F., Thaunat, O., Demuylder-Mischler, S., Badet, L., Brunet, M., Ber, C. E., Thivolet, C., Martin, X., Berney, T., and Morelon, E. (2013) Pancreas retransplantation: a second chance for diabetic patients? Transplantation. 95, 347-352

6. Cipierre, C., Hays, S., Maucort-Boulch, D., Steghens, J. P., and Picaud, J. C. (2013) Malondialdehyde adduct to hemoglobin: a new marker of oxidative stress suitable for full-term and preterm neonates. Oxidative medicine and cellular longevity. 2013, 694014

7. Cipierre, C., Hays, S., Maucort-Boulch, D., Steghens, J. P., and Picaud, J. C. (2013) Adduct of malondialdehyde to hemoglobin: a new marker of oxidative stress that is associated with significant morbidity in preterm infants. Oxidative medicine and cellular longevity. 2013, 901253

8. Disse, E., Graeppi-Dulac, J., Joncour-Mills, G., Dupuis, O., and Thivolet, C. (2013) Heterogeneity of pregnancy outcomes and risk of LGA neonates in Caucasian females according to IADPSG criteria for gestational diabetes mellitus. Diabetes & metabolism. 39, 132-138

9. Fowler, R. A., Fossheim, S. L., Mestas, J. L., Ngo, J., Canet-Soulas, E., and Lafon, C. (2013) Non-invasive magnetic resonance imaging follow-up of sono-sensitive liposome tumor delivery and controlled release after high-intensity focused ultrasound. Ultrasound in medicine & biology. 39, 2342-2350

10. Hawa, M. I., Kolb, H., Schloot, N., Beyan, H., Paschou, S. A., Buzzetti, R., Mauricio, D., De Leiva, A., Yderstraede, K., Beck-Neilsen, H., Tuomilehto, J., Sarti, C., Thivolet, C., Hadden, D., Hunter, S., Schernthaner, G., Scherbaum, W. A., Williams, R., Brophy, S., Pozzilli, P., and Leslie, R. D. (2013) Adult-onset autoimmune diabetes in Europe is prevalent with a broad clinical phenotype: Action LADA 7. Diabetes care. 36, 908-913

11. Hokayem, M., Blond, E., Vidal, H., Lambert, K., Meugnier, E., Feillet-Coudray, C., Coudray, C., Pesenti, S., Luyton, C., Lambert-Porcheron, S., Sauvinet, V., Fedou, C., Brun, J. F., Rieusset, J., Bisbal, C., Sultan, A., Mercier, J., Goudable, J., Dupuy, A. M., Cristol, J. P., Laville, M., and Avignon, A. (2013) Grape polyphenols prevent fructose-induced oxidative stress and insulin resistance in first-degree relatives of type 2 diabetic patients. Diabetes care. 36, 1454-1461

12. Llano, J. P., Beaufils, E., and Nicolino, M. (2013) Uncommon cause of large paravertebral calcification in a child. The Journal of pediatrics. 162, 881

13. Madec, A. M., Cassel, R., Dubois, S., Ducreux, S., Vial, G., Chauvin, M. A., Mesnier, A., Chikh, K., Bosco, D., Rieusset, J., Van Coppenolle, F., and Thivolet, C. (2013) Losartan, an angiotensin II type 1 receptor blocker, protects human islets from glucotoxicity through the phospholipase C pathway. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 27, 5122-5130

14. Millon, A., Canet-Soulas, E., Boussel, L., Fayad, Z., and Douek, P. (2013) Animal models of atherosclerosis and magnetic resonance imaging for monitoring plaque progression. Vascular.

15. Paillard, M., Tubbs, E., Thiebaut, P. A., Gomez, L., Fauconnier, J., Da Silva, C. C., Teixeira, G., Mewton, N., Belaidi, E., Durand, A., Abrial, M., Lacampagne, A., Rieusset, J., and Ovize, M. (2013) Depressing mitochondria-reticulum interactions protects cardiomyocytes from lethal hypoxia-reoxygenation injury. Circulation. 128, 1555-1565

16. Robert, M., Ferrand-Gaillard, C., Disse, E., Espalieu, P., Simon, C., Laville, M., Gouillat, C., and Thivolet, C. (2013) Predictive factors of type 2 diabetes remission 1 year after bariatric surgery: impact of surgical techniques. Obesity surgery. 23, 770-775

17. Rouffet, D., Villars, C., Fissoune, R., Sappey-Marinier, D., Laville, M., Ibarrola, D., Sothier, M., Monnet, M. F., Ovize, M., Bonnefoy, M., Boesch, C., and Canet-Soulas, E. (2013) Intramyocellular lipid variations in active older men: relationship with aerobic fitness. Acta Physiol (Oxf). 207, 516-523

18. Vouillarmet, J., Buron, F., Houzard, C., Carlier, M. C., Chauvet, C., Brunet, M., Thivolet, C., Morelon, E., and Badet, L. (2013) The first simultaneous kidney-adrenal gland-pancreas transplantation: outcome at 1 year. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 13, 1905-1909

19. Vouillarmet, J., Maucort-Boulch, D., Michon, P., and Thivolet, C. (2013) Advanced glycation end products assessed by skin autofluorescence: a new marker of diabetic foot ulceration. Diabetes technology & therapeutics. 15, 601-605


1. Aufradet, E., Bessaad, A., Alsaid, H., Schafer, F., Sigovan, M., De Souza, G., Chirico, E., Martin, C., and Canet-Soulas, E. (2012) In vivo cardiac anatomical and functional effects of wheel running in mice by magnetic resonance imaging. Exp Biol Med (Maywood) 237, 263-2702. Barriere, D. A., Rieusset, J., Chanteranne, D., Busserolles, J., Chauvin, M. A., Chapuis, L., Salles, J., Dubray, C., and Morio, B. (2012) Paclitaxel therapy potentiates cold hyperalgesia in streptozotocin-induced diabetic rats through enhanced mitochondrial reactive oxygen species production and TRPA1 sensitization. Pain 153, 553-561

3. Bourgeaux, V., Aufradet, E., Campion, Y., De Souza, G., Horand, F., Bessaad, A., Chevrier, A. M., Canet-Soulas, E., Godfrin, Y., and Martin, C. (2012) Efficacy of homologous inositol hexaphosphate-loaded red blood cells in sickle transgenic mice. Br J Haematol 157, 357-369

4. Chirico, E. N., Martin, C., Faes, C., Feasson, L., Oyono-Enguelle, S., Aufradet, E., Dubouchaud, H., Francina, A., Canet-Soulas, E., Thiriet, P., Messonnier, L., and Pialoux, V. (2012) Exercise training blunts oxidative stress in sickle cell trait carriers. J Appl Physiol 112, 1445-1453

5. Disse, E., Graeppi-Dulac, J., Joncour-Mills, G., Dupuis, O., and Thivolet, C. (2012) Heterogeneity of pregnancy outcomes and risk of LGA neonates in Caucasian females according to IADPSG criteria for gestational diabetes mellitus. Diabetes Metab

6. Flamment, M., Rieusset, J., Vidal, H., Simard, G., Malthiery, Y., Fromenty, B., and Ducluzeau, P. H. (2012) Regulation of hepatic mitochondrial metabolism in response to a high fat diet: a longitudinal study in rats. J Physiol Biochem 68, 335-344

7. Fouillet, A., Levet, C., Virgone, A., Robin, M., Dourlen, P., Rieusset, J., Belaidi, E., Ovize, M., Touret, M., Nataf, S., and Mollereau, B. (2012) ER stress inhibits neuronal death by promoting autophagy. Autophagy 8, 915-926

8. Gaspari, L., Paris, F., Nicolino, M., Hameury, F., Bonnaure, H., Pienkowski, C., Servant, N., Kalfa, N., and Sultan, C. (2012) Fetal ovarian cysts: an early manifestation of McCune-Albright syndrome? Prenat Diagn 32, 859-863

9. Klee, P., Bellanne-Chantelot, C., Depret, G., Llano, J. P., Paget, C., and Nicolino, M. (2012) A novel ABCC8 mutation illustrates the variability of the diabetes phenotypes associated with a single mutation. Diabetes Metab 38, 179-182

10. Rieusset, J., Chauvin, M. A., Durand, A., Bravard, A., Laugerette, F., Michalski, M. C., and Vidal, H. (2012) Reduction of endoplasmic reticulum stress using chemical chaperones or Grp78 overexpression does not protect muscle cells from palmitate-induced insulin resistance. Biochem Biophys Res Commun 417, 439-445

11. Riveline, J. P., Schaepelynck, P., Chaillous, L., Renard, E., Sola-Gazagnes, A., Penfornis, A., Tubiana-Rufi, N., Sulmont, V., Catargi, B., Lukas, C., Radermecker, R. P., Thivolet, C., Moreau, F., Benhamou, P. Y., Guerci, B., Leguerrier, A. M., Millot, L., Sachon, C., Charpentier, G., and Hanaire, H. (2012) Assessment of patient-led or physician-driven continuous glucose monitoring in patients with poorly controlled type 1 diabetes using basal-bolus insulin regimens: a 1-year multicenter study. Diabetes Care 35, 965-971

12. Sigovan, M., Kaye, E., Lancelot, E., Corot, C., Provost, N., Majd, Z., Breisse, M., and Canet-Soulas, E. (2012) Anti-inflammatory drug evaluation in ApoE-/- mice by ultrasmall superparamagnetic iron oxide-enhanced magnetic resonance imaging. Invest Radiol 47, 546-552

13. Vallet, A. E., Verschueren, A., Petiot, P., Vandenberghe, N., Nicolino, M., Roman, S., Pouget, J., and Vial, C. (2012) Neurological features in adult Triple-A (Allgrove) syndrome. J Neurol 259, 39-46


1. Al Faraj, A., Fauvelle, F., Luciani, N., Lacroix, G., Levy, M., Cremillieux, Y., and Canet-Soulas, E. (2011) In vivo biodistribution and biological impact of injected carbon nanotubes using magnetic resonance techniques. Int J Nanomedicine 6, 351-3612. Beilvert, A., Vassy, R., Canet-Soulas, E., Rousseaux, O., Picton, L., Letourneur, D., and Chaubet, F. (2011) Synthesis and evaluation of a tri-tyrosine decorated dextran MR contrast agent for vulnerable plaque detection. Chem Commun (Camb) 47, 5506-5508

3. Benko, S., Gordon, C. T., Mallet, D., Sreenivasan, R., Thauvin-Robinet, C., Brendehaug, A., Thomas, S., Bruland, O., David, M., Nicolino, M., Labalme, A., Sanlaville, D., Callier, P., Malan, V., Huet, F., Molven, A., Dijoud, F., Munnich, A., Faivre, L., Amiel, J., Harley, V., Houge, G., Morel, Y., and Lyonnet, S. (2011) Disruption of a long distance regulatory region upstream of SOX9 in isolated disorders of sex development. J Med Genet 48, 825-830

4. Borot, S., Niclauss, N., Wojtusciszyn, A., Brault, C., Demuylder-Mischler, S., Muller, Y., Giovannoni, L., Parnaud, G., Meier, R., Badet, L., Bayle, F., Frimat, L., Kessler, L., Morelon, E., Penfornis, A., Thivolet, C., Toso, C., Morel, P., Bosco, D., Colin, C., Benhamou, P. Y., and Berney, T. (2011) Impact of the number of infusions on 2-year results of islet-after-kidney transplantation in the GRAGIL network. Transplantation 92, 1031-1038

5. Bravard, A., Bonnard, C., Durand, A., Chauvin, M. A., Favier, R., Vidal, H., and Rieusset, J. (2011) Inhibition of xanthine oxidase reduces hyperglycemia-induced oxidative stress and improves mitochondrial alterations in skeletal muscle of diabetic mice. Am J Physiol Endocrinol Metab 300, E581-591

6. Bravard, A., Lefai, E., Meugnier, E., Pesenti, S., Disse, E., Vouillarmet, J., Peretti, N., Rabasa-Lhoret, R., Laville, M., Vidal, H., and Rieusset, J. (2011) FTO is increased in muscle during type 2 diabetes, and its overexpression in myotubes alters insulin signaling, enhances lipogenesis and ROS production, and induces mitochondrial dysfunction. Diabetes 60, 258-268

7. Brisset, J. C., Sigovan, M., Chauveau, F., Riou, A., Devillard, E., Desestret, V., Touret, M., Nataf, S., Honnorat, J., Canet-Soulas, E., Nighoghossian, N., Berthezene, Y., and Wiart, M. (2011) Quantification of iron-labeled cells with positive contrast in mouse brains. Mol Imaging Biol 13, 672-678

8. Buron, F., Hadj-Aissa, A., Dubourg, L., Morelon, E., Steghens, J. P., Ducher, M., and Fauvel, J. P. (2011) Estimating glomerular filtration rate in kidney transplant recipients: performance over time of four creatinine-based formulas. Transplantation 92, 1005-1011

9. Ducluzeau, P. H., Priou, M., Weitheimer, M., Flamment, M., Duluc, L., Iacobazi, F., Soleti, R., Simard, G., Durand, A., Rieusset, J., Andriantsitohaina, R., and Malthiery, Y. (2011) Dynamic regulation of mitochondrial network and oxidative functions during 3T3-L1 fat cell differentiation. J Physiol Biochem 67, 285-296

10. Grand, A., Jalabert, A., Mercier, G., Florent, M., Hansel-Esteller, S., Cambonie, G., Steghens, J. P., and Picaud, J. C. (2011) Influence of vitamins, trace elements, and iron on lipid peroxidation reactions in all-in-one admixtures for neonatal parenteral nutrition. JPEN J Parenter Enteral Nutr 35, 505-510

11. Jalabert, A., Grand, A., Steghens, J. P., Barbotte, E., Pigue, C., and Picaud, J. C. (2011) Lipid peroxidation in all-in-one admixtures for preterm neonates: impact of amount of lipid, type of lipid emulsion and delivery condition. Acta Paediatr 100, 1200-1205

12. Lievre, M. M., Moulin, P., Thivolet, C., Rodier, M., Rigalleau, V., Penfornis, A., Pradignac, A., and Ovize, M. (2011) Detection of silent myocardial ischemia in asymptomatic patients with diabetes: results of a randomized trial and meta-analysis assessing the effectiveness of systematic screening. Trials 12, 23

13. Miskinyte, S., Butler, M. G., Herve, D., Sarret, C., Nicolino, M., Petralia, J. D., Bergametti, F., Arnould, M., Pham, V. N., Gore, A. V., Spengos, K., Gazal, S., Woimant, F., Steinberg, G. K., Weinstein, B. M., and Tournier-Lasserve, E. (2011) Loss of BRCC3 deubiquitinating enzyme leads to abnormal angiogenesis and is associated with syndromic moyamoya. Am J Hum Genet 88, 718-728

14. Rieusset, J. (2011) Mitochondria and endoplasmic reticulum: mitochondria-endoplasmic reticulum interplay in type 2 diabetes pathophysiology. Int J Biochem Cell Biol 43, 1257-1262

15. Salmon-Musial, A. S., Rosilio, M., David, M., Huber, C., Pichot, E., Cormier-Daire, V., and Nicolino, M. (2011) Clinical and radiological characteristics of 22 children with SHOX anomalies and familial short stature suggestive of Leri-Weill Dyschondrosteosis. Horm Res Paediatr 76, 178-185

16. Sigovan, M., Hamoudeh, M., Al Faraj, A., Charpigny, D., Fessi, H., and Canet-Soulas, E. (2011) Positive contrast with therapeutic iron nanoparticles at 4.7 T. MAGMA 24, 259-265


1. Al Faraj, A., Bessaad, A., Cieslar, K., Lacroix, G., Canet-Soulas, E., and Cremillieux, Y. (2010) Long-term follow-up of lung biodistribution and effect of instilled SWCNTs using multiscale imaging techniques. Nanotechnology 21, 1751032. Bessaad, A., Sigovan, M., Alsaid, H., De Souza, G., Provost, N., Majd, Z., Menager, C., Honnorat, J., Lagarde, F., Nighoghossian, N., Nataf, S., and Canet-Soulas, E. (2010) M1-activated macrophages migration, a marker of aortic atheroma progression: a preclinical MRI study in mice. Invest Radiol 45, 262-269

3. Bunescu, A., Garric, J., Vollat, B., Canet-Soulas, E., Graveron-Demilly, D., and Fauvelle, F. (2010) In vivo proton HR-MAS NMR metabolic profile of the freshwater cladoceran Daphnia magna. Mol Biosyst 6, 121-125

4. Chabroux, S., Canoui-Poitrine, F., Reffet, S., Mills-Joncour, G., Morelon, E., Colin, C., and Thivolet, C. (2010) Advanced glycation end products assessed by skin autofluorescence in type 1 diabetics are associated with nephropathy, but not retinopathy. Diabetes Metab 36, 152-157

5. Dubois, S., Madec, A. M., Mesnier, A., Armanet, M., Chikh, K., Berney, T., and Thivolet, C. (2010) Glucose inhibits angiogenesis of isolated human pancreatic islets. J Mol Endocrinol 45, 99-105

6. Nicolino, M., Claiborn, K. C., Senee, V., Boland, A., Stoffers, D. A., and Julier, C. (2010) A novel hypomorphic PDX1 mutation responsible for permanent neonatal diabetes with subclinical exocrine deficiency. Diabetes 59, 733-740

7. Reynier, F., Pachot, A., Paye, M., Xu, Q., Turrel-Davin, F., Petit, F., Hot, A., Auffray, C., Bendelac, N., Nicolino, M., Mougin, B., and Thivolet, C. (2010) Specific gene expression signature associated with development of autoimmune type-I diabetes using whole-blood microarray analysis. Genes Immun 11, 269-278

8. Sigovan, M., Bessaad, A., Alsaid, H., Lancelot, E., Corot, C., Neyran, B., Provost, N., Majd, Z., Breisse, M., and Canet-Soulas, E. (2010) Assessment of age modulated vascular inflammation in ApoE-/- mice by USPIO-enhanced magnetic resonance imaging. Invest Radiol 45, 702-707


1. Al Faraj, A., Cieslar, K., Lacroix, G., Gaillard, S., Canet-Soulas, E., and Cremillieux, Y. (2009) In vivo imaging of carbon nanotube biodistribution using magnetic resonance imaging. Nano Lett 9, 1023-10272. Alsaid, H., De Souza, G., Bourdillon, M. C., Chaubet, F., Sulaiman, A., Desbleds-Mansard, C., Chaabane, L., Zahir, C., Lancelot, E., Rousseaux, O., Corot, C., Douek, P., Briguet, A., Letourneur, D., and Canet-Soulas, E. (2009) Biomimetic MRI contrast agent for imaging of inflammation in atherosclerotic plaque of ApoE-/- mice: a pilot study. Invest Radiol 44, 151-158

3. Bacchetta, J., Plotton, I., Ranchin, B., Vial, T., Nicolino, M., Morel, Y., and Cochat, P. (2009) Precocious puberty and unlicensed paediatric drugs for severe hyperparathyroidism. Nephrol Dial Transplant 24, 2595-2598

4. Bannier, E., Neyran, B., Cieslar, K., Rivoire, J., Heidemann, R. M., Gaillard, S., Sulaiman, A. R., Canet-Soulas, E., and Cremillieux, Y. (2009) Free breathing hyperpolarized 3He lung ventilation spiral MR imaging. Invest Radiol 44, 185-191

5. Benhamou, P. Y., Milliat-Guittard, L., Wojtusciszyn, A., Kessler, L., Toso, C., Baertschiger, R., Debaty, I., Badet, L., Penfornis, A., Thivolet, C., Renard, E., Bayle, F., Morel, P., Morelon, E., Colin, C., and Berney, T. (2009) Quality of life after islet transplantation: data from the GRAGIL 1 and 2 trials. Diabet Med 26, 617-621

6. Fontaine, P., Gin, H., Pinget, M., Thivolet, C., Hanaire, H., Robert, J. J., Marre, M., and Venkatanarasimhachar, S. (2009) Effect of insulin detemir dose frequency on clinical outcomes in patients with diabetes in PREDICTIVE. Adv Ther 26, 535-551

7. Granjon, A., Gustin, M. P., Rieusset, J., Lefai, E., Meugnier, E., Guller, I., Cerutti, C., Paultre, C., Disse, E., Rabasa-Lhoret, R., Laville, M., Vidal, H., and Rome, S. (2009) The microRNA signature in response to insulin reveals its implication in the transcriptional action of insulin in human skeletal muscle and the role of a sterol regulatory element-binding protein-1c/myocyte enhancer factor 2C pathway. Diabetes 58, 2555-2564

8. Hawa, M. I., Thivolet, C., Mauricio, D., Alemanno, I., Cipponeri, E., Collier, D., Hunter, S., Buzzetti, R., de Leiva, A., Pozzilli, P., and Leslie, R. D. (2009) Metabolic syndrome and autoimmune diabetes: action LADA 3. Diabetes Care 32, 160-164

9. Ignace, S., Fouque, D., Arkouche, W., Steghens, J. P., and Guebre-Egziabher, F. (2009) Preserved residual renal function is associated with lower oxidative stress in peritoneal dialysis patients. Nephrol Dial Transplant 24, 1685-1689

10. Madec, A. M., Mallone, R., Afonso, G., Abou Mrad, E., Mesnier, A., Eljaafari, A., and Thivolet, C. (2009) Mesenchymal stem cells protect NOD mice from diabetes by inducing regulatory T cells. Diabetologia 52, 1391-1399

11. Marre, M., Pinget, M., Gin, H., Thivolet, C., Hanaire, H., Robert, J. J., and Fontaine, P. (2009) Insulin detemir improves glycaemic control with less hypoglycaemia and no weight gain: 52-week data from the PREDICTIVE study in a cohort of French patients with type 1 or type 2 diabetes. Diabetes Metab 35, 469-475

12. Nicolino, M., Byrne, B., Wraith, J. E., Leslie, N., Mandel, H., Freyer, D. R., Arnold, G. L., Pivnick, E. K., Ottinger, C. J., Robinson, P. H., Loo, J. C., Smitka, M., Jardine, P., Tato, L., Chabrol, B., McCandless, S., Kimura, S., Mehta, L., Bali, D., Skrinar, A., Morgan, C., Rangachari, L., Corzo, D., and Kishnani, P. S. (2009) Clinical outcomes after long-term treatment with alglucosidase alfa in infants and children with advanced Pompe disease. Genet Med 11, 210-219

13. Pugeat, M., and Nicolino, M. (2009) From paediatric to adult endocrinology care: the challenge of the transition period. Pediatr Endocrinol Rev 6 Suppl 4, 519-522

14. Raccah, D., Sulmont, V., Reznik, Y., Guerci, B., Renard, E., Hanaire, H., Jeandidier, N., and Nicolino, M. (2009) Incremental value of continuous glucose monitoring when starting pump therapy in patients with poorly controlled type 1 diabetes: the RealTrend study. Diabetes Care 32, 2245-2250

15. Schluth-Bolard, C., Sanlaville, D., Labalme, A., Till, M., Michel-Calemard, L., Rafat, A., Zabot, M. T., Nicolino, M., Guibaud, L., and Edery, P. (2009) Unexpected diagnosis of 45,X/47,XX,+18 mosaicism in a girl with mild phenotype. Am J Med Genet A 149A, 2584-2587

16. Sigovan, M., Boussel, L., Sulaiman, A., Sappey-Marinier, D., Alsaid, H., Desbleds-Mansard, C., Ibarrola, D., Gamondes, D., Corot, C., Lancelot, E., Raynaud, J. S., Vives, V., Lacledere, C., Violas, X., Douek, P. C., and Canet-Soulas, E. (2009) Rapid-clearance iron nanoparticles for inflammation imaging of atherosclerotic plaque: initial experience in animal model. Radiology 252, 401-409

17. Tournoud, M., Ecochard, R., Iwaz, J., Steghens, J. P., Bellon, G., and Durieu, I. (2009) Structural equations to model relationships between pulmonary function, fatty acids and oxidation in cystic fibrosis. Scand J Clin Lab Invest 69, 36-44

18. Villeneuve, L., Alberti, L., Steghens, J. P., Lancelin, J. M., and Mestas, J. L. (2009) Assay of hydroxyl radicals generated by focused ultrasound. Ultrason Sonochem 16, 339-344

19. Vong, C. H., Forest, M., and Nicolino, M. (2009) Ketoconazole treatment for Cushing syndrome in McCune-Albright syndrome. J Pediatr 154, 467-468; author reply 468-469


1. Raher MJ, Thibault HB, Buys ES, Kuruppu D, Shimizu N, Brownell AL, Blake SL, Rieusset J, Kaneki M, Derumeaux G, Picard MH, Bloch KD, Scherrer-Crosbie M. A short duration of high-fat diet induces insulin resistance and predisposes to adverse left ventricular remodeling after pressure overload. Am J Physiol Heart Circ Physiol. 2008 295(6):H2495-502.2. Rome S, Lecomte V, Meugnier E, Rieusset J, Debard C, Euthine V, Vidal H, Lefai E. Microarray analyses of SREBP-1a and SREBP-1c target genes identify new regulatory pathways in muscle. Physiol Genomics. 2008 34(3):327-37.

3. Bonnard C, Durand A, Peyrol S, Chanseaume E, Chauvin MA, Morio B,Vidal H, Rieusset J (2008). Mitochondrial dysfunction results from oxidative stress in skeletal muscle of diet-induced insulin resistant mice. J Clin Invest: 118: 789-800.

4. Padmos RC, Schloot NC, Beyan H, Ruwhof C, Staal FJ, de Ridder D, Aanstoot HJ, Lam-Tse WK, de Wit H, de Herder C, Drexhage RC, Menart B, Leslie RD, Drexhage HA; LADA Consortium. Distinct monocyte gene-expression profiles in autoimmune diabetes. Diabetes. 2008 Oct;57(10):2768-73. 5. Aptel F, Denis P, Rouberol F, Thivolet C. Screening of diabetic retinopathy: effect of field number and mydriasis on sensitivity and specificity of digital fundus photography. Diabetes Metab. 2008 Jun;34(3):290-3.

6. Laforêt P, Petiot P, M. Nicolino M, Orlikowski D, Caillaud C, Pellegrini N, Froissart R, Petitjean T, Maire I, Chabriat H, Hadrane L, Eymard B. Dilatative arteriopathy and basilar artery dolichoectasia complicating late-onset Pompe disease. Neurology 2008 ; 70: 2063-2066.

7. Belot A, B Ranchin, C Fichtner, L Pujo, BC Rossier, A Liutkus, C Morlat, M Nicolino, MC Zennaro, P Cochat. Pseudohypoaldosteronisms: report on a 10-patients series. Nephrology Dialysis Transplantation 2008 ; 23: 1636-41.

8. Danne T, Battelino T, Jarosz-Chobot P, Kordonouri O, Pánkowska E, Ludvigsson J, Schober E, Kaprio E, Saukkonen T, Nicolino M, Tubiana-Rufi N, Klinkert C, Haberland H, Vazeou A, Madacsy L, Zangen D, Cherubini V, Rabbone I, Toni S, de Beaufort C, Bakkar-van Waarde W, van den Berg N, Volkov I, Barrio R, Hanas R, Zumsteg U, Girard J, Aebi C, Schumacher U, Gschwend S, Hindmarsh P, Phillip M and the PedPump Study Group. Establishing glycaemic control with continuous subcutaneous insulin infusion in children and adolescents with type 1 diabetes: experience from the PedPump Study in 17 countries. Diabetologia 2008 ; 51: 1594-601

9. Boussel L, Herigault G, Sigovan M, Loffroy R, Canet-Soulas E, Douek PC. Modified electrocardiograph-triggered black-blood turbo spin-echo technique to improve T1-weighting in contrast-enhanced MRI of atherosclerotic carotid arteries. J Magn Reson Imaging. 2008 Aug;28(2):533-7.

10. Al Faraj A, Lacroix G, Alsaid H, Elgrabi D, Stupar V, Robidel F, Gaillard S, Canet-Soulas E, Crémillieux Y. Longitudinal 3He and proton imaging of magnetite biodistribution in a rat model of instilled nanoparticles. Magn Reson Med. 2008 Jun;59(6):1298-303.