1) How dietary lipids, through their different structures and oxidation, can metabolically impact on intestinal absorption, triglyceride-rich lipoproteins (TGRL) composition and lipolysis, and the metabolic fate of lipids in the postprandial phase. The role of specific lipids present in the gut on LPS coabsorption and biology of the gut cell lienage will be considered.

2) How TGRL modified by nutrition and/or altered by abdominal obesity/diabetes or malabsorption play a role in atherothrombotic and inflammatory processes both in the fasting and postprandial phase. The role of oxidized phospholipids and oxysterols in endothelial cells and cholesterol transport alterations in macrophage will be considered. The role of oxygenated species derived from DHA on ischemic cardiovascular disease will be studied.

3) How new genetic and epigenetic regulations interfere with TGRL lipolysis. Interactions between LPL/AV/GPIHBP1 on endothelial cells will be studied. Association studies in extreme phenotypes and segregation studies in families with unexplained familial chylomicronemia syndrome will be conducted to identify new genes involved in TG metabolism. Studies considering the role of miRNA in the regulation of lipolysis gene expression will be expended.

This research project should therefore provide new dietary strategies to prevent the alterations of postprandial lipemia and identify new therapeutic targets for improving treatment of hypertriglyceridemia, primary or secondary (e.g. obesity, diabetes).

Click on the name in order to view the full profile

2018 (january-june)

1. Yilmaz, N., Yamaji-Hasegawa, A., Hullin-Matsuda, F. and Kobayashi, T. (2018) Molecular mechanisms of action of sphingomyelin-specific pore-forming toxin, lysenin Semin Cell Dev Biol 73 188-198 10.1016/j.semcdb.2017.07.036
2. Yi, D., Monteiro, E. B., Chambert, S., Soula, H. A., Daleprane, J. B. and Soulage, C. O. (2018) Determination of the binding properties of p-cresyl glucuronide to human serum albumin Biochimie 150 1-7 10.1016/j.biochi.2018.04.019
3. Sowers, C. R., Wang, R., Bourne, R. A., McGrath, B. C., Hu, J. J., Bevilacqua, S. C., Paton, J. C., Paton, A. W., Collardeau-Frachon, S., Nicolino, M. and Cavener, D. R. (2018) The protein kinase PERK/EIF2AK3 regulates proinsulin processing not via protein synthesis but by controlling endoplasmic reticulum chaperones Journal of Biological Chemistry 293 5134-5149 10.1074/jbc.M117.813790
4. Soulage, C. O., Puig, L. S., Soulere, L., Zarrouki, B., Guichardant, M., Lagarde, M. and Pillon, N. J. (2018) Skeletal muscle insulin resistance is induced by 4-hydroxy-2-hexenal, a by-product of n-3 fatty acid peroxidation Diabetologia 61 688-699 10.1007/s00125-017-4528-4
5. Poinsot, P., Geoffroy, P., Braillon, P., Denis, A., Loras-Duclaux, I., Marotte, S., Boutroy, S., Bacchetta, J., Touzet, S., Lachaux, A. and Peretti, N. (2018) Longitudinal Bone Mineralization Assessment in Children Treated With Long-Term Parenteral Nutrition for Severe Intestinal Failure Journal of Parenteral and Enteral Nutrition 42 613-622 10.1177/0148607117701399
6. Piraud, M., Pettazzoni, M., Lavoie, P., Ruet, S., Pagan, C., Cheillan, D., Latour, P., Vianey-Saban, C., Auray-Blais, C. and Froissart, R. (2018) Contribution of tandem mass spectrometry to the diagnosis of lysosomal storage disorders Journal of Inherited Metabolic Disease 41 457-477 10.1007/s10545-017-0126-3
7. Peretti, N. (2018) Lessons from chylomicron retention disease: a potential new approach for the treatment of hypercholesterolemia? Expert Opinion on Orphan Drugs 6 163-165 10.1080/21678707.2018.1438259
8. Paillassa, J., Leguay, T., Thomas, X., Huguet, F., Audrain, M., Lheritier, V., Vianey-Saban, C., Acquaviva-Bourdain, C., Pagan, C., Dombret, H., Ifrah, N., Boissel, N. and Hunault-Berger, M. (2018) Monitoring of asparagine depletion and anti-L-asparaginase antibodies in adult acute lymphoblastic leukemia treated in the pediatric-inspired GRAALL-2005 trial Blood Cancer Journal 8 4 10.1038/s41408-018-0084-5
9. Nader, E., Guillot, N., Lavorel, L., Hancco, I., Fort, R., Stauffer, E., Renoux, C., Joly, P., Germain, M. and Connes, P. (2018) Eryptosis and hemorheological responses to maximal exercise in athletes: Comparison between running and cycling Scandinavian Journal of Medicine & Science in Sports 28 1532-1540 10.1111/sms.13059
10. Marmontel, O., Charriere, S., Simonet, T., Bonnet, V., Dumont, S., Mahl, M., Jacobs, C., Nony, S., Chabane, K., Bozon, D., Janin, A., Peretti, N., Lachaux, A., Bardel, C., Millat, G., Moulin, P., Marcais, C. and Di Filippo, M. (2018) Single, short in-del, and copy number variations detection in monogenic dyslipidemia using a next-generation sequencing strategy Clinical Genetics 94 132-140 10.1111/cge.13250
11. Leger, T., Hininger-Favier, I., Capel, F., Geloen, A., Rigaudiere, J. P., Jouve, C., Pitois, E., Pineau, G., Vaysse, C., Chardigny, J. M., Michalski, M. C., Malpuech-Brugere, C. and Demaison, L. (2018) Dietary canolol protects the heart against the deleterious effects induced by the association of rapeseed oil, vitamin E and coenzyme Q10 in the context of a high-fat diet Nutrition & Metabolism 15 14 10.1186/s12986-018-0252-4
12. Lagarde, M., Guichardant, M., Bemoud-Hubac, N., Calzada, C. and Vericel, E. (2018) Oxygenation of polyunsaturated fatty acids and oxidative stress within blood platelets Biochimica Et Biophysica Acta-Molecular and Cell Biology of Lipids 1863 651-656 10.1016/j.bbalip.2018.03.005
13. Jouvene, C., Fourmaux, B., Geloen, A., Balas, L., Durand, T., Lagarde, M., Letisse, M. and Guichardant, M. (2018) Ultra-Performance Liquid Chromatography-Mass Spectrometry Analysis of Free and Esterified Oxygenated Derivatives from Docosahexaenoic Acid in Rat Brain Lipids 53 103-116 10.1002/lipd.12006
14. Hacini-Rachinel, F., de Aguero, M. G., Kanjarawi, R., Moro-Sibilot, L., Le Luduec, J. B., Macari, C., Boschetti, G., Bardel, E., Langella, P., Dubois, B. and Kaiserlian, D. (2018) Intestinal dendritic cell licensing through Toll-like receptor 4 is required for oral tolerance in allergic contact dermatitis Journal of Allergy and Clinical Immunology 141 163-170 10.1016/j.jaci.2017.02.022
15. Guillaud, O., Brunet, A. S., Mallet, I., Dumortier, J., Pelosse, M., Heissat, S., Rivet, C., Lachaux, A. and Bost, M. (2018) Relative exchangeable copper: A valuable tool for the diagnosis of Wilson disease Liver International 38 350-357 10.1111/liv.13520
16. Ghaleb, Y., Elbitar, S., El Khoury, P., Bruckert, E., Carreau, V., Carrie, A., Moulin, P., Di-Filippo, M., Charriere, S., Iliozer, H., Farnier, M., Luc, G., Rabes, J. P., Boileau, C., Abifadel, M. and Varret, M. (2018) Usefulness of the genetic risk score to identify phenocopies in families with familial hypercholesterolemia? European Journal of Human Genetics 26 570-578 10.1038/s41431-017-0078-y
17. Garnier, L., Marchand, L., Benoit, M., Nicolino, M., Bendelac, N., Wright, C., Moulin, P., Lombard, C., Thivolet, C. and Fabien, N. (2018) Screening of ZnT8 autoantibodies in the diagnosis of autoimmune diabetes in a large French cohort Clinica Chimica Acta 478 162-165 10.1016/j.cca.2017.12.043
18. Fontaine, M., Kim, I., Dessein, A. F., Mention-Mulliez, K., Dobbelaere, D., Douillard, C., Sole, G., Schiff, M., Jaussaud, R., Espil-Taris, C., Boutron, A., Wuyts, W., Acquaviva, C., Vianey-Saban, C., Roland, D., Curt, M. J. C. and Vamecq, J. (2018) Fluxomic assay-assisted diagnosis orientation in a cohort of 11 patients with myopathic form of CPT2 deficiency Molecular Genetics and Metabolism 123 441-448 10.1016/j.ymgme.2018.02.005
19. Curt, M. J. C., Bout, M. A., Fontaine, M., Kim, I., Huet, G., Bekri, S., Morin, G., Moortgat, S., Moerman, A., Cuisset, J. M., Cheillan, D. and Vamecq, J. (2018) Functional assessment of creatine transporter in control and X-linked SLC6A8-deficient fibroblasts Molecular Genetics and Metabolism 123 463-471 10.1016/j.ymgme.2018.02.01
20. Citterio-Quentin, A., Moulsma, M., Gustin, M. P., Lachaux, A. and Boulieu, R. (2018) ITPA Activity in Children Treated by Azathioprine: Relationship to the Occurrence of Adverse Drug Reactions and Inflammatory Response Basic & Clinical Pharmacology & Toxicology 122 588-595 10.1111/bcpt.12958
21. Caussy, C., Alquiraish, M. H., Nguyen, P., Hernandez, C., Cepin, S., Fortney, L. E., Ajmera, V., Bettencourt, R., Collier, S., Hooker, J., Sy, E., Rizo, E., Richards, L., Sirlin, C. B. and Loomba, R. (2018) Optimal threshold of controlled attenuation parameter with MRI-PDFF as the gold standard for the detection of hepatic steatosis Hepatology 67 1348-1359 10.1002/hep.29639
22. Capel, F., Geloen, A., Vaysse, C., Pineau, G., Demaison, L., Chardigny, J. M., Michalski, M. C. and Malpuech-Brugere, C. (2018) Rapeseed oil fortified with micronutrients can reduce glucose intolerance during a high fat challenge in rats Nutrition & Metabolism 15 12 10.1186/s12986-018-0259-x
23. Bourlieu, C., Cheillan, D., Blot, M., Daira, P., Trauchessec, M., Ruet, S., Gassi, J. Y., Beaucher, E., Robert, B., Leconte, N., Bouhallab, S., Gaucheron, F., Gesan-Guiziou, G. and Michalski, M. C. (2018) Polar lipid composition of bioactive dairy co-products buttermilk and butterserum: Emphasis on sphingolipid and ceramide isoforms Food Chemistry 240 67-74 10.1016/j.foodchem.2017.07.091
24. Bergerot, C., Davidsen, E. S., Amaz, C., Thibault, H., Altman, M., Bellaton, A., Moulin, P., Derumeaux, G. and Ernande, L. (2018) Diastolic function deterioration in type 2 diabetes mellitus: predictive factors over a 3-year follow-up European Heart Journal-Cardiovascular Imaging 19 67-73 10.1093/ehjci/jew331

2017

1. Beigneux, A. P., Miyashita, K., Ploug, M., Blom, D. J., Ai, M., Linton, M. R. F., Khovidhunkit, W., Dufour, R., Garg, A., McMahon, M. A., Pullinger, C. R., Sandoval, N. P., Hu, X., Allan, C. M., Larsson, M., Machida, T., Murakami, M., Reue, K., Tontonoz, P., Goldberg, I. J., Moulin, P., Charriere, S., Fong, L. G., Nakajima, K. and Young, S. G. (2017) Autoantibodies against GPIHBP1 as a Cause of Hypertriglyceridemia New England Journal of Medicine 376 1647-1658
2. Berger, E., Nassra, M., Atgie, C., Plaisancié, P. and Geloen, A. (2017) Oleic Acid Uptake Reveals the Rescued Enterocyte Phenotype of Colon Cancer Caco-2 by HT29-MTX Cells in Co-Culture Mode International Journal of Molecular Sciences 18 21
3. Bernoud-Hubac, N., Hachem, M., Lo Van, A., Picq, M. and Lagarde, M. (2017) Specific uptake of DHA by the brain from a structured phospholipid, AceDoPC((R)) Ocl-Oilseeds and Fats Crops and Lipids 24 4
4. Boschetti, G., Kanjarawi, R., Bardel, E., Collardeau-Frachon, S., Duclaux-Loras, R., Moro-Sibilot, L., Almeras, T., Flourie, B., Nancey, S. and Kaiserlian, D. (2017) Gut Inflammation in Mice Triggers Proliferation and Function of Mucosal Foxp3+ Regulatory T Cells but Impairs Their Conversion from CD4+ T Cells J Crohns Colitis 11 105-117
5. Bruno, J., Nicolas, A., Pesenti, S., Schwarz, J., Simon, J. L., Leonil, J. and Plaisancié, P. (2017) Variants of beta-casofensin, a bioactive milk peptide, differently modulate the intestinal barrier: In vivo and ex vivo studies in rats Journal of Dairy Science 100 3360-3372
6. Coughlin, C. R., Swanson, M. A., Kronquist, K., Acquaviva, C., Hutchin, T., Rodriguez-Pomba, P., Vaisanen, M. L., Spector, E., Creadon-Swindell, G., Bras-Goldberg, A. M., Rahikkala, E., Moilanen, J. S., Mahieu, V., Matthijs, G., Bravo-Alonso, I., Perez-Cerda, C., Ugarte, M., Vianey-Saban, C., Scharer, G. H. and Van Hove, J. L. K. (2017) The genetic basis of classic nonketotic hyperglycinemia due to mutations in GLDC and AMT Genetics in Medicine 19 104-111
7. Dessein, A. F., Fontaine, M., Curt, M. J. C., Briand, G., Sechter, C., Mention-Mulliez, K., Dobbelaere, D., Douillard, C., Lacour, A., Redonnet-Vernhet, I., Lamireau, D., Barth, M., Minot-Myhie, M. C., Kuster, A., de Lonlay, P., Gregersen, N., Acquaviva, C., Vianey-Saban, C. and Vamecq, J. (2017) Fluxomic evidence for impaired contribution of short-chain acyl-CoA dehydrogenase to mitochondrial palmitate beta-oxidation in symptomatic patients with ACADS gene susceptibility variants Clinica Chimica Acta 471 101-106
8. Dubois-Laforgue, D., Bellanne-Chantelot, C., Charles, P., Jacquette, A., Larger, E., Ciangura, C., Saint-Martin, C., Rastel, C., Keren, B., Timsit, J., Ajzenberg, C., Azar, R., Badet, E., Baechler-Sadoul, E., Barrande, G., Bertin, E., Bony, H., Gross, M. S., Bouche, C., Gautier, J. F., Guillausseau, P. J., Bourcigaux, N., Jacquesson, L., Bruzeau, J., Lefort, G., Colmar-Montiel, C., Cordonnier, M., Couzi, L., Delgrange, E., Pasquier, L. D., Ronco, P., Dupont, J., Dusselier, L., El Etr, M., Franchini, A., Godart, C., Vincent-Dejean, C., Guemazi, F., Jeanjean, M. E., Jeannea, S., Loric, S., Joubert, M., Reznik, Y., Kaloustian, E., Kessler, L., Paris-Bockel, D., Perrin, P., Kitzis, A., Lemoine, A., Le Penher, D., Perlemoine, C., Lesire, V., Smati, D., Le Thai, F., Levy, D., Maury, E., Moulin, P., Pierre, P., Plat, F., Poynard, J. P., Raffin-Sanson, M. L., Coz, S., Requeda, E., Roussey-Kesler, G., Schillo, F., Subra, J. F., Sonnet, E., Valero, R., Vantyghem, M. C., Wautelet, R., Wojtusciszyn, A. and Sfd (2017) Intellectual disability in patients with MODY due to hepatocyte nuclear factor 1B (HNF1B) molecular defects Diabetes & Metabolism 43 89-92
9. Ernande, L., Audureau, E., Jellis, C. L., Bergerot, C., Henegar, C., Sawaki, D., Czibik, G., Volpi, C., Canoui-Poitrine, F., Thibault, H., Ternacle, J., Moulin, P., Marwick, T. H. and Derumeaux, G. (2017) Clinical Implications of Echocardiographic Phenotypes of Patients With Diabetes Mellitus Journal of the American College of Cardiology 70 1704-1716
10. Fourrier, C., Remus-Borel, J., Greenhalgh, A. D., Guichardant, M., Bernoud-Hubac, N., Lagarde, M., Joffre, C. and Laye, S. (2017) Docosahexaenoic acid-containing choline phospholipid modulates LPS-induced neuroinflammation in vivo and in microglia in vitro Journal of Neuroinflammation 14 13
11. Grenet, G., Lajoinie, A., Ribault, S., Ngueyn, G. B., Linet, T., Metge, A., Cornu, C., Cucherat, M., Moulin, P. and Gueyffier, F. (2017) Protocol of GLUcose COntrol Safety & Efficacy in type 2 DIabetes, a NETwork meta-analysis (GLUCOSE DINET protocol) Fundamental & Clinical Pharmacology 31 23-23
12. Guerville, M., Leroy, A., Sinquin, A., Laugerette, F., Michalski, M. C. and Boudry, G. (2017) Western-diet consumption induces alteration of barrier function mechanisms in the ileum that correlates with metabolic endotoxemia in rats American Journal of Physiology-Endocrinology and Metabolism 313 E107-E120
13. Guibaud, L., Collardeau-Frachon, S., Lacalm, A., Massoud, M., Rossi, M., Cordier, M. P. and Vianey-Saban, C. (2017) Antenatal manifestations of inborn errors of metabolism: prenatal imaging findings J Inherit Metab Dis 40 103-112
14. Lecomte, M., Couedelo, L., Meugnier, E., Loizon, E., Plaisancié, P., Durand, A., Geloen, A., Joffre, F., Vaysse, C., Michalski, M. C. and Laugerette, F. (2017) Soybean polar lipids differently impact adipose tissue inflammation and the endotoxin transporters LBP and sCD14 in flaxseed vs. palm oil-rich diets Journal of Nutritional Biochemistry 43 116-124
15. Lefort, B., Gouache, E., Acquaviva, C., Tardieu, M., Benoist, J. F., Dumas, J. F., Servais, S., Chevalier, S., Vianey-Saban, C. and Labarthe, F. (2017) Pharmacological inhibition of carnitine palmitoyltransferase 1 restores mitochondrial oxidative phosphorylation in human trifunctional protein deficient fibroblasts Biochimica Et Biophysica Acta-Molecular Basis of Disease 1863 1292-1299
16. Lo Van, A., Fourmaux, B., Picq, M., Guichardant, M., Lagarde, M. and Bernoud-Hubac, N. (2017) Synthesis and Identification of AceDoxyPC, a Protectin-Containing Structured Phospholipid, Using Liquid Chromatography/Mass Spectrometry Lipids 52 751-76
17. Makino, A., Abe, M., Ishitsuka, R., Murate, M., Kishimoto, T., Sakai, S., Hullin-Matsuda, F., Shimada, Y., Inaba, T., Miyatake, H., Tanaka, H., Kurahashi, A., Pack, C. G., Kasai, R. S., Kubo, S., Schieber, N. L., Dohmae, N., Tochio, N., Hagiwara, K., Sasaki, Y., Aida, Y., Fujimori, F., Kigawa, T., Nishibori, K., Parton, R. G., Kusumi, A., Sako, Y., Anderluh, G., Yamashita, M., Kobayashi, T., Greimel, P. and Kobayashi, T. (2017) A novel sphingomyelin/cholesterol domain-specific probe reveals the dynamics of the membrane domains during virus release and in Niemann-Pick type C. FASEB J. 31; 1301-1322.
18. Marcais, C., Maucort-Boulch, D., Drai, J., Dantony, E., Carlier, M. C., Blond, E., Genet, L., Kuentz, F., Lataillade, D., Legrand, E., Moreau-Gaudry, X., Jean, G., Fouque, D. and Project, A. (2017) Circulating Klotho Associates cith Cardiovascular Morbidity and Mortality During Hemodialysis Journal of Clinical Endocrinology & Metabolism 102 3154-3161
19. Marmontel, O., Di Filippo, M., Marcais, C., Nony, S., Dumoux, M., Dancer, M., Caussy, C., Charriere, S. and Moulin, P. (2017) STRONG HETEROGENEITY IN PLASMA TRIGLYCERIDE LIPOLYSIS IN MULTIFACTORIAL CHYLOMICRONEMIA Atherosclerosis 263 E67-E67
20. Marmontel, O., Di Filippo, M., Marcais, C., Nony, S., Dumoux, M., Serveaux-Dancer, M., Caussy, C., Charriere, S. and Moulin, P. (2017) Alterations in plasma triglycerides lipolysis in patients with history of multifactorial chylomicronemia Atherosclerosis 265 22-28
21. Mendes, M. I., Smith, D. E. C., Pop, A., Lennertz, P., Ojeda, M. R. F., Kanhai, W. A., van Dooren, S. J. M., Anikster, Y., Baric, I., Boelen, C., Campistol, J., de Boer, L., Kariminejad, A., Kayserili, H., Roubertie, A., Verbruggen, K. T., Vianey-Saban, C., Williams, M. and Salomons, G. S. (2017) Clinically Distinct Phenotypes of Canavan Disease Correlate with Residual Aspartoacylase Enzyme Activity Human Mutation 38 524-531
22. Michalski, M. C., Vors, C., Lecomte, M. and Laugerette, F. (2017) Metabolic and inflammatory impacts of emulsified fat Ocl-Oilseeds and Fats Crops and Lipids 24 12
23. Michalski, M. C., Vors, C., Lecomte, M. and Laugerette, F. (2017) Metabolic and inflammatory impacts of emulsified fats and oils Cahiers De Nutrition Et De Dietetique 52 244-256
24. Morzel, M., Truntzer, C., Neyraud, E., Brignot, H., Ducoroy, P., Lucchi, G., Canlet, C., Gaillard, S., Nicod, F., Nicklaus, S., Peretti, N. and Feron, G. (2017) Associations between food consumption patterns and saliva composition: Specificities of eating difficulties children Physiology & Behavior 173 116-123
25. Paquay, S., Bourillon, A., Pichard, S., Benoist, J. F., de Lonlay, P., Dobbelaere, D., Fouilhoux, A., Guffon, N., Rouvet, I., Labarthe, F., Mention, K., Touati, G., Valayannopoulos, V., de Baulny, H. O., Elmaleh-Berges, M., Acquaviva-Bourdain, C., Vianey-Saban, C. and Schiff, M. (2017) Mitochondrial acetoacetyl-CoA thiolase deficiency: basal ganglia impairment may occur independently of ketoacidosis Journal of Inherited Metabolic Disease 40 415-422
26. Pena-Quintana, L., Scherer, G., Curbelo-Estevez, M. L., Jimenez-Acosta, F., Hartmann, B., La Roche, F., Meavilla-Olivas, S., Perez-Cerda, C., Garcia-Segarra, N., Giguere, Y., Huppke, P., Mitchell, G. A., Monch, E., Trump, D., Vianey-Saban, C., Trimble, E. R., Vitoria-Minana, I., Reyes-Suarez, D., Ramirez-Lorenzo, T. and Tugores, A. (2017) Tyrosinemia type II: Mutation update, 11 novel mutations and description of 5 independent subjects with a novel founder mutation Clinical Genetics 92 306-317
27. Pettazzoni, M., Froissart, R., Pagan, C., Vanier, M. T., Ruet, S., Latour, P., Guffon, N., Fouilhoux, A., Germain, D. P., Levade, T., Vianey-Saban, C., Piraud, M. and Cheillan, D. (2017) LC-MS/MS multiplex analysis of lysosphingolipids in plasma and amniotic fluid: A novel tool for the screening of sphingolipidoses and Niemann-Pick type C disease Plos One 12 19
28. Piraud, M., Pettazzoni, M., Menegaut, L., Caillaud, C., Nadjar, Y., Vianey-Saban, C. and Froissart, R. (2017) Development of a new tandem mass spectrometry method for urine and amniotic fluid screening of oligosaccharidoses Rapid Communications in Mass Spectrometry 31 951-963
29. Poinsot, P., Frachon, S. C., Restier, L., Serusclat, A., Di Filippo, M., Charriere, S., Moulin, P., Lachaux, A. and Peretti, N. (2017) Childhood/adult-onset lysosomal acid lipase deficiency: A serious metabolic and vascular phenotype beyond liver disease-four new pediatric cases Journal of Clinical Lipidology 11 167-177
30. Poinsot, P., Geoffroy, P., Braillon, P., Denis, A., Loras-Duclaux, I., Marotte, S., Boutroy, S., Bacchetta, J., Touzet, S., Lachaux, A. and Peretti, N. (2017) Longitudinal Bone Mineralization Assessment in Children Treated With Long-Term Parenteral Nutrition for Severe Intestinal Failure JPEN J Parenter Enteral Nutr 148607117701399
31. Rossi, M., Vasiljevic, A., Labalme, A., Dijoud, F., Mallet-Motak, D., Petcu, C. A., Touraine, R., Vianey-Saban, C., Guibaud, L., Edery, P., Sanlaville, D. and Morel, Y. (2017) A Novel Disorder of Sex Development, Characterized by Progressive Regression of Testicular Function and Cystic Leukoencephalopathy American Journal of Medical Genetics Part A 173 654-660
32. Sane, A. T., Seidman, E., Peretti, N., Kleme, M. L., Delvin, E., Deslandres, C., Garofalo, C., Spahis, S. and Levy, E. (2017) Understanding Chylomicron Retention Disease Through Sar1b Gtpase Gene Disruption Insight From Cell Culture Arteriosclerosis Thrombosis and Vascular Biology 37 2243-+
33. Santangelo, B., Robin, A., Simpson, K., Potier, J., Guichardant, M. and Portier, K. (2017) The Modification and Performance of a Large Animal Anesthesia Machine (Tafonius((R))) in Order to Deliver Xenon to a Horse Front Vet Sci 4 162
34. Serveaux-Dancer, M., Marcais, C., Di Filippo, M., Marmontel, O., Moulin, P. and Charriere, S. (2017) coding variants identified in lmf1 gene in a cohort of hyperchylomicronemic patients Atherosclerosis 263 E211-E211
35. Spitz, M. A., Nguyen, M. A., Roche, S., Heron, B., Milh, M., de Lonlay, P., Lion-Francois, L., Testard, H., Napuri, S., Barth, M., Fournier-Favre, S., Christa, L., Vianey-Saban, C., Corne, C. and Roubertie, A. (2017) Chronic Diarrhea in L-Amino Acid Decarboxylase (AADC) Deficiency: A Prominent Clinical Finding Among a Series of Ten French Patients JIMD Rep 31 85-93
36. Steinhagen-Thiessen, E., Stroes, E., Soran, H., Johnson, C., Moulin, P., Iotti, G., Zibellini, M., Ossenkoppele, B., Dippel, M., Averna, M. R. and Investigators, G. (2017) The role of registries in rare genetic lipid disorders: Review and introduction of the first global registry in lipoprotein lipase deficiency Atherosclerosis 262 146-153
37. Stroes, E., Moulin, P., Parhofer, K. G., Rebours, V., Lohr, J. M. and Averna, M. (2017) Diagnostic algorithm for familial chylomicronemia syndrome Atherosclerosis Supplements 23 1-7
38. Thorning, T. K., Bertram, H. C., Bonjour, J. P., de Groot, L., Dupont, D., Feeney, E., Ipsen, R., Lecerf, J. M., Mackie, A., McKinley, M. C., Michalski, M. C., Remond, D., Riserus, U., Soedamah-Muthu, S. S., Tholstrup, T., Weaver, C., Astrup, A. and Givens, I. (2017) Whole dairy matrix or single nutrients in assessment of health effects: current evidence and knowledge gaps American Journal of Clinical Nutrition 105 1033-1045
39. Vors, C., Drai, J., Pineau, G., Laville, M., Vidal, H., Laugerette, F. and Michalski, M. C. (2017) Emulsifying dietary fat modulates postprandial endotoxemia associated with chylomicronemia in obese men: a pilot randomized crossover study Lipids in Health and Disease 16 6
40. Vors, C., Gabert, L., Drai, J., Louche-Pelissier, C., Laville, M., Vidal, H. and Michalski, M. C. (2017) Altered Postprandial Lipemia and Fatty Acid Handling in Obese vs. Normal-Weight Men Is Rectified by Reducing Dietary Fat Load: A Dose-Response Trial Faseb Journal 31 1
41. Yilmaz, N., Yamaji-Hasegawa, A., Hullin-Matsuda, F. and Kobayashi, T. (2017) Molecular mechanisms of action of sphingomyelin-specific pore-forming toxin, lysenin Semin Cell Dev Biol
42. Zahnd, G., Kapellas, K., van Hattem, M., van Dijk, A., Serusclat, A., Moulin, P., van der Lugt, A., Skilton, M. and Orkisz, M. (2017) A Fully-Automatic Method to Segment the Carotid Artery Layers in Ultrasound Imaging: Application to Quantify the Compression-Decompression Pattern of the Intima-Media Complex During the Cardiac Cycle Ultrasound Med Biol 43 239-257

2016

1. Véricel, E., Mazur, S., Colas, R., Delaup, V., Calzada, C., Reix, P., Durieu, I., Lagarde, M., Bellon, G. (2016). Moderate intake of docosahexaenoic acid raises plasma and platelet vitamin E levels in cystic fibrosis patients. Prostaglandins, Leukotrienes and Essent Fatty Acids 115 41-47

2. Barry, Y., Bonaldi, C., Goulet, V., Coutant, R., Leger, J., Paty, A. C., Delmas, D., Cheillan, D. and Roussey, M. (2016) Increased incidence of congenital hypothyroidism in France from 1982 to 2012: a nationwide multicenter analysis Annals of Epidemiology 26 100-105 e4

3. Behin, A., Acquaviva-Bourdain, C., Souvannanorath, S., Streichenberger, N., Attarian, S., Bassez, G., Brivet, M., Fouilhoux, A., Labarre-Villa, A., Laquerriere, A., Perard, L., Kaminsky, P., Pouget, J., Rigal, O., Vanhulle, C., Eymard, B., Vianey-Saban, C. and Laforet, P. (2016) Multiple acyl-CoA dehydrogenase deficiency (MADD) as a cause of late-onset treatable metabolic disease Revue Neurologique (Paris) 172 231-41

4. Beliard, S., Bonnet, F., Bouhanick, B., Bruckert, E., Cariou, B., Charriere, S., Durlach, V., Moulin, P., Valero, R. and Verges, B. (2016) Consensus statement on the management of dyslipidaemias in adults Diabetes & Metabolism 42 398-408

5. Belkouch, M., Hachem, M., Elgot, A., Van, A. L., Picq, M., Guichardant, M., Lagarde, M. and Bernoud-Hubac, N. (2016) The pleiotropic effects of omega-3 docosahexaenoic acid on the hallmarks of Alzheimer’s disease The Journal of Nutrional Biochemistry 38 1-11

6. Bessette, C., Benoit, B., Sekkal, S., Bruno, J., Estienne, M., Leonil, J., Ferrier, L., Theodorou, V. and Plaisancie, P. (2016) Protective effects of beta-casofensin, a bioactive peptide from bovine beta-casein, against indomethacin-induced intestinal lesions in rats Molecular Nutrition & Food Research 60 823-33

7. Boschetti G, Nancey S, Moussata D, Cotte E, Francois Y, Flourié B, Kaiserlian D. Enrichment of Circulating and Mucosal Cytotoxic CD8+ T Cells Is Associated with Postoperative Endoscopic Recurrence in Patients with Crohn’s Disease. J Crohns Colitis. 2016 Mar;10(3):338-45.

8. Boschetti G, Kanjarawi R, Bardel E, Collardeau-Frachon S, Duclaux-Loras R, Moro-Sibilot L, Almeras T, Flourié B, Nancey S, Kaiserlian D. Gut Inflammation in Mice Triggers Proliferation and Function of Mucosal Foxp3+ Regulatory T Cells but Impairs Their Conversion from CD4+ T Cells. J Crohns Colitis. 2016 Jun 30. pii: jjw125.
9.  Bouvier, D., Vianey-Saban, C., Ruet, S. and Acquaviva, C. (2016) Development of a Tandem Mass Spectrometry Method for Rapid Measurement of Medium- and Very-Long-Chain Acyl-CoA Dehydrogenase Activity in Fibroblasts JIMD Reports doi: 10.1007/8904_2016_22

10. Brault, C., Levy, P., Duponchel, S., Michelet, M., Salle, A., Pecheur, E. I., Plissonnier, M. L., Parent, R., Vericel, E., Ivanov, A. V., Demir, M., Steffen, H. M., Odenthal, M., Zoulim, F. and Bartosch, B. (2016) Glutathione peroxidase 4 is reversibly induced by HCV to control lipid peroxidation and to increase virion infectivity Gut 65 144-54

11. Capel, F., Cheraiti, N., Acquaviva, C., Henique, C., Bertrand-Michel, J., Vianey-Saban, C., Prip-Buus, C. and Morio, B. (2016) Oleate dose-dependently regulates palmitate metabolism and insulin signaling in C2C12 myotubes Biochimica et Biophysica Acta 1861 2000-2010

12. Caussy, C., Charriere, S., Meirhaeghe, A., Dallongeville, J., Lefai, E., Rome, S., Cuerq, C., Euthine, V., Delay, M., Marmontel, O., Di Filippo, M., Lagarde, M., Moulin, P. and Marcais, C. (2016) Multiple microRNA regulation of lipoprotein lipase gene abolished by 3’UTR polymorphisms in a triglyceride-lowering haplotype harboring p.Ser474Ter Atherosclerosis 246 280-6
13. Collardeau-Frachon, S., Cordier, M. P., Rossi, M., Guibaud, L. and Vianey-Saban, C. (2016) Antenatal manifestations of inborn errors of metabolism: autopsy findings suggestive of a metabolic disorder Journal of Inherited Metabolic Disease 39 597-610

14. Cuerq, C., Restier, L., Drai, J., Blond, E., Roux, A., Charriere, S., Michalski, M. C., Di Filippo, M., Levy, E., Lachaux, A. and Peretti, N. (2016) Establishment of reference values of alpha-tocopherol in plasma, red blood cells and adipose tissue in healthy children to improve the management of chylomicron retention disease, a rare genetic hypocholesterolemia Orphanet Journal of Rare Diseases 11 114

15. Dancer, M., Caussy, C., Di Filippo, M., Moulin, P., Marcais, C. and Charriere, S. (2016) Lack of evidence for a liver or intestinal miRNA regulation involved in the hypertriglyceridemic effect of APOC3 3’UTR variant SstI Atherosclerosis 255 6-10

16. Dimassi, S., Labalme, A., Ville, D., Calender, A., Mignot, C., Boutry-Kryza, N., de Bellescize, J., Rivier-Ringenbach, C., Bourel-Ponchel, E., Cheillan, D., Simonet, T., Maincent, K., Rossi, M., Till, M., Mougou-Zerelli, S., Edery, P., Saad, A., Heron, D., des Portes, V., Sanlaville, D. and Lesca, G. (2016) Whole-exome sequencing improves the diagnosis yield in sporadic infantile spasm syndrome Clinical Genetics 89 198-204

17. Es Sadki, T., Badiou, S., Boubal, M., Baleine, J., Sieso, V., Vallat, C., Cristol, J. P., Vianey-Saban, C. and Cambonie, G. (2016) Isolated methylmalonic acidemia: a case report Annales de Biologie Clinique (Paris) 74 472-6

18. Genere, L., Pecciarini, N., Peretti, N., Villard, F. and Lachaux, A. (2016) [Food protein-induced enterocolitis syndrome: A case report of diarrhea with hypovolemic shock and methemoglobinemia] Archives de Pédiatrie doi:10.1016/j.arcped.2016.10.013

19. Guibaud, L., Collardeau-Frachon, S., Lacalm, A., Massoud, M., Rossi, M., Cordier, M. P. and Vianey-Saban, C. (2016) Antenatal manifestations of inborn errors of metabolism: prenatal imaging findings Journal of Inherited Metabolic Disease doi:10.1007/s10545-016-9992-3

20. Hachem, M., Geloen, A., Van, A. L., Foumaux, B., Fenart, L., Gosselet, F., Da Silva, P., Breton, G., Lagarde, M., Picq, M. and Bernoud-Hubac, N. (2016) Efficient Docosahexaenoic Acid Uptake by the Brain from a Structured Phospholipid Molecular Neurobiology 53 3205-15

21. Hubert, A., Ford-Chessel, C., Berthiller, J., Peretti, N., Javouhey, E. and Valla, F. V. (2016) Nutritional status in pediatric intermediate care: Assessment at admission, progression during the stay and after discharge Archives de Pédiatrie 23 333-9

22. Hullin-Matsuda, F., Makino, A., Murate, M. and Kobayashi, T. (2016) Probing phosphoethanolamine-containing lipids in membranes with duramycin/cinnamycin and aegerolysin proteins Biochimie 130 81-90

23. Jansen, J. C., Cirak, S., van Scherpenzeel, M., Timal, S., Reunert, J., Rust, S., Perez, B., Vicogne, D., Krawitz, P., Wada, Y., Ashikov, A., Perez-Cerda, C., Medrano, C., Arnoldy, A., Hoischen, A., Huijben, K., Steenbergen, G., Quelhas, D., Diogo, L., Rymen, D., Jaeken, J., Guffon, N., Cheillan, D., van den Heuvel, L. P., Maeda, Y., Kaiser, O., Schara, U., Gerner, P., van den Boogert, M. A., Holleboom, A. G., Nassogne, M. C., Sokal, E., Salomon, J., van den Bogaart, G., Drenth, J. P., Huynen, M. A., Veltman, J. A., Wevers, R. A., Morava, E., Matthijs, G., Foulquier, F., Marquardt, T. and Lefeber, D. J. (2016) CCDC115 Deficiency Causes a Disorder of Golgi Homeostasis with Abnormal Protein Glycosylation American Journal of Human Genetics 98 310-21

24. Jones, S., Boisvert, A., Naghi, A., Hullin-Matsuda, F., Greimel, P., Kobayashi, T., Papadopoulos, V. and Culty, M. (2016) Stimulatory effects of combined endocrine disruptors on MA-10 Leydig cell steroid production and lipid homeostasis Toxicology 355-356 21-30

25. Lagarde, M., Calzada, C., Guichardant, M. and Véricel, E. (2016) In vitro and in vivo bimodal effects of docosahexaenoic acid supplements on redox status and platelet function Prostaglandins, Leukotrienes and Essential Fatty Acids 108 1-4

26. Lecomte, M., Couedelo, L., Meugnier, E., Plaisancie, P., Letisse, M., Benoit, B., Gabert, L., Penhoat, A., Durand, A., Pineau, G., Joffre, F., Geloen, A., Vaysse, C., Laugerette, F. and Michalski, M. C. (2016) Dietary emulsifiers from milk and soybean differently impact adiposity and inflammation in association with modulation of colonic goblet cells in high-fat fed mice Molecular Nutrition & Food Research 60 609-20

27. Le Luduec JB, Debeer S, Piras F, Andréoni C, Boudet F, Laurent P, Kaiserlian D, Dubois B. Intradermal vaccination with un-adjuvanted sub-unit vaccines triggers skin innate immunity and confers protective respiratory immunity in domestic swine. Vaccine. 2016 Feb 10;34(7):914-22.

28. Lo Van, A., Sakayori, N., Hachem, M., Belkouch, M., Picq, M., Lagarde, M., Osumi, N. and Bernoud-Hubac, N. (2016) Mechanisms of DHA transport to the brain and potential therapy to neurodegenerative diseases Biochimie 130 163-167

29. Makino, A., Abe, M., Ishitsuka, R., Murate, M., Kishimoto, T., Sakai, S., Hullin-Matsuda, F., Shimada, Y., Inaba, T., Miyatake, H., Tanaka, H., Kurahashi, A., Pack, C. G., Kasai, R. S., Kubo, S., Schieber, N. L., Dohmae, N., Tochio, N., Hagiwara, K., Sasaki, Y., Aida, Y., Fujimori, F., Kigawa, T., Nishibori, K., Parton, R. G., Kusumi, A., Sako, Y., Anderluh, G., Yamashita, M., Kobayashi, T., Greimel, P. and Kobayashi, T. (2016) A novel sphingomyelin/cholesterol domain-specific probe reveals the dynamics of the membrane domains during virus release and in Niemann-Pick type C Faseb Journal doi:10.1096/fj.201500075R

30. Makino, A., Hullin-Matsuda, F., Murate, M., Abe, M., Tomishige, N., Fukuda, M., Yamashita, S., Fujimoto, T., Vidal, H., Lagarde, M., Delton, I. and Kobayashi, T. (2016) Acute accumulation of free cholesterol induces the degradation of perilipin 2 and Rab18-dependent fusion of ER and lipid droplets in cultured human hepatocytes Molecular Biology of the Cell 27 3293-3304

31. Mirabel-Chambaud, E., N’Guyen, M., Valdeyron, M. L., Quessada, T., Goudable, J., Loras-Duclaux, I., Marotte, S., Heissat, S., Restier, L., Lachaux, A. and Peretti, N. (2016) Dramatic increase of central venous catheter-related infections associated with a high turnover of the nursing team Clinical Nutrition 35 446-52

32. Moro-Sibilot L, Blanc P, Taillardet M, Bardel E, Couillault C, Boschetti G, Traverse-Glehen A, Defrance T, Kaiserlian D, Dubois B. Mouse and Human Liver Contain Immunoglobulin A-Secreting Cells Originating From Peyer’s Patches and Directed Against Intestinal Antigens. Gastroenterology. 2016 Aug;151(2):311-23.

33. Moro-Sibilot L, This S, Blanc P, Sanlaville A, Sisirak V, Bardel E, Boschetti G, Bendriss-Vermare N, Defrance T, Dubois B, Kaiserlian D. Plasmacytoid dendritic cells are dispensable for noninfectious intestinal IgA responses in vivo. Eur J Immunol. 2016 Feb;46(2):354-9.

34. Perez-Cerda, C., Ugarte, M., Vianey-Saban, C., Scharer, G. H., Van Hove, J. L., Olsen, R. K., Konarikova, E., Giancaspero, T. A., Mosegaard, S., Boczonadi, V., Matakovic, L., Veauville-Merllie, A., Terrile, C., Schwarzmayr, T., Haack, T. B., Auranen, M., Leone, P., Galluccio, M., Imbard, A., Gutierrez-Rios, P., Palmfeldt, J., Graf, E., Vianey-Saban, C., Oppenheim, M., Schiff, M., Pichard, S., Rigal, O., Pyle, A., Chinnery, P. F., Konstantopoulou, V., Moslinger, D., Feichtinger, R. G., Talim, B., Topaloglu, H., Coskun, T., Gucer, S., Botta, A., Pegoraro, E., Malena, A., Vergani, L., Mazza, D., Zollino, M., Ghezzi, D., Acquaviva, C., Tyni, T., Boneh, A., Meitinger, T., Strom, T. M., Gregersen, N., Mayr, J. A., Horvath, R., Barile, M. and Prokisch, H. (2016) Riboflavin-Responsive and -Non-responsive Mutations in FAD Synthase Cause Multiple Acyl-CoA Dehydrogenase and Combined Respiratory-Chain Deficiency Genetics in Medicine 98 1130-45

35. Pontoizeau, C., Habarou, F., Brassier, A., Veauville-Merllie, A., Grisel, C., Arnoux, J. B., Vianey-Saban, C., Barouki, R., Chadefaux-Vekemans, B., Acquaviva, C., de Lonlay, P. and Ottolenghi, C. (2016) Hyperprolinemia in Type 2 Glutaric Aciduria and MADD-Like Profiles JIMD Reports 27 39-45

36. Renaud, M., Guissart, C., Mallaret, M., Ferdinandusse, S., Cheillan, D., Drouot, N., Muller, J., Claustres, M., Tranchant, C., Anheim, M. and Koenig, M. (2016) Expanding the spectrum of PEX10-related peroxisomal biogenesis disorders: slowly progressive recessive ataxia Journal of Neurology 263 1552-8

37. Roblin, E., Dumortier, J., Di Filippo, M., Collardeau-Frachon, S., Sassolas, A., Peretti, N., Serusclat, A., Rivet, C., Boillot, O. and Lachaux, A. (2016) Lipid profile and cardiovascular risk factors in pediatric liver transplant recipients Pediatric Transplantation 20 241-8

38. Sala, P. R., Ruijter, G., Acquaviva, C., Chabli, A., de Sain-van der Velden, M. G., Garcia-Villoria, J., Heiner-Fokkema, M. R., Jeannesson-Thivisol, E., Leckstrom, K., Franzson, L., Lynes, G., Olesen, J., Onkenhout, W., Petrou, P., Drousiotou, A., Ribes, A., Vianey-Saban, C. and Merinero, B. (2016) Pilot Experience with an External Quality Assurance Scheme for Acylcarnitines in Plasma/Serum JIMD Reports 30 23-31

39. Sanna, C., Stephenne, X., Revencu, N., Smets, F., Sassolas, A., Di Filippo, M., Descamps, O. S. and Sokal, E. M. (2016) Homozygous familial hypercholesterolemia in childhood: Genotype-phenotype description, established therapies and perspectives Atherosclerosis 247 97-104

40. Schiff, M., Veauville-Merllie, A., Su, C. H., Tzagoloff, A., Rak, M., Ogier de Baulny, H., Boutron, A., Smedts-Walters, H., Romero, N. B., Rigal, O., Rustin, P., Vianey-Saban, C. and Acquaviva-Bourdain, C. (2016) SLC25A32 Mutations and Riboflavin-Responsive Exercise Intolerance The New England Journal of Medicine 374 795-7

41. Sorlin, A., Briand, G., Cheillan, D., Wiedemann, A., Montaut-Verient, B., Schmitt, E. and Feillet, F. (2016) Effect of l-Arginine in One Patient with Peroxisome Biogenesis Disorder due to PEX12 Deficiency Neuropediatrics 47 179-81

42. Spitz, M. A., Nguyen, M. A., Roche, S., Heron, B., Milh, M., de Lonlay, P., Lion-Francois, L., Testard, H., Napuri, S., Barth, M., Fournier-Favre, S., Christa, L., Vianey-Saban, C., Corne, C. and Roubertie, A. (2016) Chronic Diarrhea in L-Amino Acid Decarboxylase (AADC) Deficiency: A Prominent Clinical Finding Among a Series of Ten French Patients JIMD Reports doi:10.1007/8904_2016_550

43. Venugopal, S., Martinez-Arguelles, D. B., Chebbi, S., Hullin-Matsuda, F., Kobayashi, T. and Papadopoulos, V. (2016) Plasma membrane origin of the steroidogenic pool of cholesterol used in hormone-induced acute steroid formation in Leydig cells The Journal of Biological Chemistry 291 26109-26125

44. Véricel, E., Mazur, S., Colas, R., Delaup, V., Calzada, C., Reix, P., Durieu, I., Lagarde, M. and Bellon, G. (2016) Moderate intake of docosahexaenoic acid raises plasma and platelet vitamin E levels in cystic fibrosis patients Prostaglandins, Leukotrienes and Essential Fatty Acids 115 41-47

45. Vianey-Saban, C., Acquaviva, C., Cheillan, D., Collardeau-Frachon, S., Guibaud, L., Pagan, C., Pettazzoni, M., Piraud, M., Lamaziere, A. and Froissart, R. (2016) Antenatal manifestations of inborn errors of metabolism: biological diagnosis Journal of Inherited Metabolic Disease 39 611-24

46. Yamaji-Hasegawa, A., Hullin-Matsuda, F., Greimel, P. and Kobayashi, T. (2016) Pore-forming toxins: Properties, diversity, and uses as tools to image sphingomyelin and ceramide phosphoethanolamine Biochimica et Biophysica Acta 1858 576-92

2015

2014