Retrouver ce membre sur les réseaux :

Liste complète des productions scientifiques sur la période 2015-2023

Le bilan de mes productions scientifiques depuis ma promotion DR en octobre 2015 est téléchargeable ici au format pdf : Liste des publis 2015-2023

Liste complète des publications sur PubMed

Bilan synthétique

• 28 publications (moyenne de 3,5 / an) : 2 pre-prints, 19 articles originaux et 6 publications de synthèse
• 6 productions de science ouverte : 1 pipeline, 2 data sets, 3 tableurs de données pour l’analyse statistique
• 6,5 articles / doctorant dont 1 à 3 en premier auteur pour chaque soutenance
• La Taxinomie CRediT précise nos contributions spécifiques pour chaque article (se référer aux manuscrits)

Thèses dirigées

Les doctorants et post-doc que j’ai encadrés sont indiqués en caractère gras souligné dans la liste de productions scientifiques.

Nom	Formation initiale	Soutenance	Sujet
Paul Clottes	Neurologie neurovasculaire	Début 10/2022	A new target in IscheMic stroke: EPAC1-based Therapy (IMPACT)
Elodie Ong	Neurologie neurovasculaire	21/12/2023	Evaluation de l’effet neuroprotecteur de la cyclosporine A dans un modèle murin d’ischémie cérébrale
Clément Tavakoli	Ingénieur CPE Lyon	19/06/2023	Suivi de thérapie cellulaire de l’AVC ischémique à l’aide de techniques innovantes d’imagerie basées sur les rayons X
Chloé Dumot	Neurochirurgie	14/12/2021	Apport de l’IRM multiparamétrique pour l’évaluation pré-clinique de thérapies aux stades aigü et chronique de l’AVC
Violaine Hubert	Neurosciences, Imagerie	15/11/2019	Imagerie par Résonance Magnétique des cellules phagocytaires cérébrales dans des modèles murins de neuroinflammation

Axe 1 : Imager la neuroinflammation à l’aide de nanoparticules

Publications originales

Becker G, Debatisse J, Rivière M, Crola Da Silva C, Beaudoin-Gobert M, Eker O, Wateau O, Cho  TH, Wiart M, Tremblay L, Costes N, Mérida I, Redouté  J, Léon C, Langlois JB, Le Bars D, Lancelot S, Nighoghossian  N, Mechtouff  L, Canet-Soulas E. Spatio-Temporal Characterization of Brain Inflammation in a Non-human Primate Stroke Model Mimicking Endovascular Thrombectomy. Neurotherapeutics 2023;20(3):789-802 (open access, ID HAL en cours)

Lerouge F*, Ong E*, Rositi H, Mpambani F, Berner LP, Bolbos R, Olivier C, Peyrin F, Apputukan VK, Monnereau C, Andraud C, Chaput F, Berthezène Y, Braun B, Jucker M, Åslund AK, Nyström S, Hammarström P, R Nilsson KP, Lindgren M, Wiart M, Chauveau F, Parola S. In vivo targeting and multimodal imaging of cerebral Aβ-amyloid aggregates using hybrid GdF3 nanoparticles. Nanomedicine 2023;17(29):2173-2187 *Equal contribution ⟨hal-04038718⟩

Hubert V, Hristovska I, Karpati S, Benkeder S, Dey A, Dumot C, Amaz C, Chounlamountri N, Watrin C, Comte JC, Chauveau F, Brun E, Marche P, Lerouge F, Parola S, Berthezène Y, Vorup-Jensen T, Pascual O, and Wiart M. Multimodal imaging with NanoGd reveals spatiotemporal features of neuroinflammation after experimental stroke. Adv Science 2021, e2101433 ⟨hal-03428486⟩

Karpati S, Hubert V, Hristovska I, Lerouge F, Chaput F, Bretonnière Y, Andraud C,  Banyasz A,   Micouin G,   Monteil M,   Lecouvey M,  Mercey M,   Dey A, Marche, Lindgren M, Pascual O, Wiart M, Parola S. Hybrid Multimodal Contrast Agent for Multiscale In Vivo Investigation of Neuroinflammation. Nanoscale, 2021,13, 3767-3781 ⟨hal-03134034⟩

Debatisse J, Eker O, Wateau O, Cho TH, Wiart M, Ramonet D, Costes N, Mérida I, Léon C, Dia M, Paillard M, Confais J, Rossetti F, Langlois JB, Troalen T, Iecker T, Le Bars D, Lancelot S, Bouchier B, Lukasziewic AC, Oudotte A, Nighoghossian N, Ovize M, Contamin H, Lux F, Tillement O, Canet-Soulas E. PET-MRI nanoparticles imaging of blood-brain barrier damage and modulation after stroke reperfusion. Brain Communications 2020, fcaa193 ⟨hal-03060618⟩

Hubert V, Dumot C, Ong E, Amaz C, Canet-Soulas E, Chauveau F, Wiart M. MRI coupled with clinically-applicable iron oxide nanoparticles reveals choroid plexus involvement in a murine model of neuroinflammation. Sci Rep. 2019 Jul 11;9(1):10046 ⟨hal-02397061⟩

Di Cataldo V, Geloen A, Langlois JB, Chauveau F, Theze B, Hubert V, Wiart M, Chirico EN, Rieusset J, Vidal H, Pialoux V, Canet-Soulas E: Exercise Does Not Protect against Peripheral and Central Effects of a High Cholesterol Diet Given Ad libitum in Old ApoE-/- Mice. Front Physiol 2016, 7:453. ⟨hal-01883954⟩

Tamion A, Hillenkamp M, Hillion A, Maraloiu VA, Vlaicu ID, Stefan M, Ghica D, Rositi H, Chauveau F, Blanchin MG, Wiart M, Dupuis V: Ferritin surplus in mouse spleen 14 months after intravenous injection of iron oxide nanoparticles at clinical dose, Nano Research 2016, 9:2398-2410 ⟨hal-02289463⟩

Publications de synthèse 

Wiart M, Tavakoli C, Hubert V, Hristovska I, Dumot C, Parola S, Lerouge F, Chauveau F, Canet-Soulas E, Pascual O, Cormode D, Brun E, Elleaume H. Use of metal-based contrast agents for in vivo MR and CT imaging of phagocytic cells in neurological pathologies. J of Neurosci Methods 2023; 383: 109729. ⟨hal-03865234⟩

Hubert V, Chauveau F, Dumot C, Ong E, Berner LP, Canet-Soulas E, Ghersi-Egea JF, Wiart M. Clinical Imaging of Choroid Plexus in Health and in Brain Disorders: A Mini-Review. Front Mol Neurosci. 2019; 12:34. ⟨hal-02195240⟩

Brisset JC, Gazeau F, Corot C, Nighoghossian N, Berthezène Y, Canet-Soulas E, Wiart M. INFLAM – INFLAMmation in Brain and Vessels with Iron Nanoparticles and Cell Trafficking. Innovation and Research in BioMedical engineering (IRBM), TecSan review, Elsevier Masson, 2018, 39 (2), pp.93−102 ⟨hal-02626355⟩

Productions de science ouverte

Hubert V et al 2021 : Données utilisées pour l’analyse statistique (FigShare) DOI 10.6084/m9.figshare.13046291

Axe 2 : Améliorer la méthodologie des études de neuroprotection à l’aide de l’imagerie 

Pre-publications, en cours d’évaluation

Chalet L , Debatisse J, Wateau O, Boutelier T, Wiart M, Costes N , Merida I, Redouté J, Langlois J.B., Lancelot S, Léon C, Cho T.H., Mechtouff L, Eker OF , Nighoghossian N, Canet-Soulas E, Becker G. PREMISE: A database of 20 Macaca Fascicularis PET/MRI brain imaging available for research BioRxiv 2023 ⟨hal-04126335⟩

Publications originales

Dumot C, Po C, Capin L, Hubert V, Ong E, Chourrout M, Bolbos R, Amaz C, Auxenfans C, Canet-Soulas E, Rome C, Chauveau F, Wiart M. Neurofunctional and neuroimaging readouts for designing a preclinical stem-cell therapy trial in experimental stroke. Sci Rep, 2022, 12(1): 4700 ⟨hal-03451443v2⟩

Jahandiez V, Pillot B, Bidaux G, Bolbos R, Stevic N, Wiart M, Ovize M, Argaud L, Cour M. Reassessment of mitochondrial cyclophilin D as a target for improving cardiac arrest outcomes in the era of therapeutic hypothermia. Translational Research 2022 Jun 9:S1931-5244(22)00137-2. ⟨hal-03704281⟩

Basalay MV*, Wiart M*, Chauveau F, Dumot C, Leon C, Amaz C, Bolbos R, Cash D, Kim E, Mechtouff L, Cho TH, Nighoghossian N, Davidson SM, Ovize M, Yellon DM. Neuroprotection by remote ischemic conditioning in the setting of acute ischemic stroke: a preclinical two-centre study. Sci Rep 2020 Oct 9;10(1):16874. *co-first authors ⟨hal-02964076⟩

Cuccione E, Versace A, Cho TH, Carone D, Berner LP, Ong E, Rousseau D, Cai R, Monza L, Ferrarese C, Sganzerla EP, Berthezene Y, Nighoghossian N, Wiart M, Beretta S, Chauveau F. Multi-site laser Doppler flowmetry for assessing collateral flow in experimental ischemic stroke: Validation of outcome prediction with acute MRI. J Cereb Blood Flow Metab 2017;37(6):2159-2170 ⟨hal-02308993⟩

Berner LP, Cho TH, Haesebaert J, Bouvier J, Wiart M, Hjort N, Klaerke Mikkelsen I, Derex L, Thomalla G, Pedraza S, Ostergaard L, Baron JC, Nighoghossian N, Berthezene Y: MRI Assessment of Ischemic Lesion Evolution within White and Gray Matter. Cerebrovasc Dis 2016, 41:291-297 ⟨hal-03996512⟩

Frindel C, Rouanet A, Giacalone M, Cho TH, Ostergaard L, Fiehler J, Pedraza S, Baron JC, Wiart M, Berthezene Y, Nighoghossian N, Rousseau D: Validity of shape as a predictive biomarker of final infarct volume in acute ischemic stroke. Stroke 2015, 46:976-981 ⟨hal-01131822⟩

Publications de synthèse 

Wachsmuth L, Mensen A, Barca C, Wiart M, Tristão-Pereira C, Busato A, Waiczies S, Himmelreich U, Millward JM, Reimann HM, Jelescu I, Marzola P, Pradier B, Viola A, Faber C. Contribution of preclinical MRI to responsible animal research: living up to the 3R principle. MAGMA, 2021;34(4):469-474. ⟨hal-03264434⟩

Davidson SM, Arjun S, Basalay MV, Bell RM, Bromage DI, Botker HE, Carr RD, Cunningham J, Ghosh AK, Heusch G, Ibanez B, Kleinbongard P, Lecour S, Maddock H, Ovize M, Walker M, Wiart M, Yellon DM. The 10th Biennial Hatter Cardiovascular Institute workshop: cellular protection−evaluating new directions in the setting of myocardial infarction, ischaemic stroke, and cardio−oncology. Basic Res Cardiol 2018, 113:43 ⟨hal-02397066⟩

Productions de science ouverte

Chalet et al 2023 : Data set sur PRIMatE Data Exchange (PRIME-RE) (accessible sur demande)

Dumot et al 2022 :

• Données utilisées pour l’analyse statistique (FigShare) : https://figshare.com/s/15af2a099076389d2a5e
• Data set : DOI 18112/openneuro.ds004632.v1.0.1 (OpenNeuro, Accession Number ds004632)

Basalay et al 2020 : Données utilisées pour l’analyse statistique (FigShare) DOI 10.5522/04/10529867.v1

Axe 3 : Développer les approches théranostiques basées sur les rayons X 

Pre-publications, en cours d’évaluation

Said M*, Tavakoli C*, Dumot C, Toupet K, Dong YC, Collomb N, Auxenfans C, Moisan A, Favier B, Chovelon B, Barbier EL, Jorgensen C, Cormode DP, Noël D, Brun E, Elleaume H, Wiart M, Detante O*, Rome C*, Auzély-Velty R*. A novel injectable radiopaque hydrogel with potent properties for multicolor CT imaging in the context of brain and cartilage regenerative therapy. BioRxiv 2023 *Equal contribution ⟨hal-04126192⟩

Publications originales

Chourrout M, Sandt C, Weitkamp T, Dučić T, Meyronet D, Baron T, Klohs J, Rama N, Boutin H, Singh S, Olivier C, Wiart M, Brun E, Bohic S, Chauveau F.  Virtual histology of Alzheimer’s Disease: why are amyloid-β plaques visible with X-ray phase-contrast imaging? Acta Biomaterialia 2023 (sous presse) ⟨hal-04046962⟩

Tavakoli C, Cuccione E, Dumot C, Balegamire J, Si-Mohamed S, Kim J, Crola-da-Silva- C, Chevalier Y, Berthezene Y, Boussel L, Douek P, Cormode D, Elleaume H, Brun E, Wiart M. High-resolution synchrotron K-edge subtraction CT allows tracking and quantifying therapeutic cells and their scaffold in a rat model of focal cerebral injury and can serve as a reference for spectral photon counting CT. NanoTheranostics. 2023 :16;7(2):176-186. ⟨hal-03996505⟩

Chourrout M, Rositi H, Ong E, Hubert V, Paccalet A, Foucault L, Autret A, Fayard B, Olivier C, Bolbos R, Peyrin F, Crola-da-Silva C, Meyronet D, Raineteau O, Elleaume H, Brun E, Chauveau F*, Wiart M*. Brain virtual histology with X-ray phase-contrast tomography Part I: whole-brain myelin mapping in white-matter injury models. Biomedical Optics Express 2022;13(3): pp: 1620-1639 *Equal contribution ⟨hal-03428448v2⟩

Chourrout M, Roux M, Boisvert C, Gislard C, Legland D, Arganda-Carreras I, Olivier C, Peyrin F, Boutin H, Rama N, Baron T, Meyronet D, Brun E, Rositi H, Wiart M*, Chauveau F*. Brain virtual histology with X-ray phase-contrast tomography. Part II: 3D morphologies of amyloid-β plaques in Alzheimer’s disease models. Biomedical Optics Express 2022;13(3): pp: 1640-1653 *Equal contribution ⟨hal-03451419v2⟩

Tavakoli C, Cuccione E, Dumot C, Cormode D, Wiart M, Elleaume H, Brun E. Tracking cells in the brain of small animals using synchrotron multi-spectral phase contrast imaging, Proc. SPIE 11595, Medical Imaging 2021: Physics of Medical Imaging, 115954N (2021) ⟨hal-03428586⟩

Cuccione E, Chhour P, Si-Mohamed S, Dumot C, Kim J, Hubert V, Da Silva C, Vandamme M, Chereul E, Balegamire J, Chevalier Y, Berthezene Y, Boussel L, Douek P, Cormode D, Wiart M. Multicolor spectral photon counting CT monitors and quantifies therapeutic cells and their encapsulating scaffold in a model of brain damage. NanoTheranostics 2020;4(3):129-141. ⟨hal-02841219⟩

Publications de synthèse

Albers J, Pacile S, Markus MA, Wiart M, Vande Velde G, Tromba G, Dullin C.  X-ray-Based 3D Virtual Histology—Adding the Next Dimension to Histological Analysis. Mol Imaging Biol 2018, 20:732−741 ⟨hal-02397068⟩

Productions de science ouverte

Chourrout M et al. 2021 : Pipeline de traitement d’image (Zenodo) A Fiji pipeline to segment 3D objects and retrieve shape parameters in biomedical images. DOI: 10.5281/zenodo.458475