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Short bio

During her PhD under the supervision of Dr. Susan Treves at the University of Basel, Switzerland (2002-2006), she studied the functional effects of mutations in the ryanodine receptor type 1 (RyR1) in association with several skeletal muscle disorders (malignant hyperthermia, central cortex disease, multi-minicore disease).

As a postdoctoral researcher at the University of Fribourg in Switzerland in the group of Prof. Beat Schwaller (2006-2010), she focused on the role of parvalbumin, a Ca²⁺ binding protein, in skeletal muscle physiology.

During her second postdoctoral fellowship at the University Claude Bernard Lyon 1 (UCBL1) in the Center of Genetics and Molecular and Cellular Physiology (2010-2012), she contributed to establish the role of the non-selective Ca²⁺ channel Transient Receptor Potential Vanilloid 1 (TRPV1 ) in skeletal muscle.

Since 2012, she is a lecturer in Physiology at UCBL1 and member of the CaRMeN laboratory.

Since 2013, she is also co-leader of the CarMeN microscopy technical platform.

Today, she focuses her research work on the role of different ion channels and reticulum-mitochondria interactions in myocardial infarction and in the development of secondary cardiac events.

Skills

• Physiology & Cell Biology
• Calcium Imaging & Confocal Microscopy
• Ion channels & Ca²⁺ homeostasis

Funding

• 2002-2006 : PhD scholarship from the Swiss National Science Foundation.
• 2008 : PENS (Programme for European Neuroscience Schools) scholarship for the summer school “Imaging Brain Function: From Synapses to Networks” (Switzerland).
• 2009 : Travel grant from the Swiss Society for Cellular, Molecular and Genetic Biology for the 16th Congress “Ca2+ Binding Proteins and Ca2+ Function in Health and Diseases” (Chile).
• 2010: Research grant from the Swiss National Science Foundation: “Knock-out mice for the calcium-binding proteins parvalbumin, calbindin D-28k and calretinin. Models for muscle and brain diseases” = associate.
• 2014-2017: Servier Laboratories research grant: “Pharmacological modulation of ER calcium leak in cardiomyocytes undergoing hypoxia-reoxygenation” = co-principal investigator.
• 2020 & 2021 : Project Pedagogical Platforms of the Auvergne Rhône Alpes Region / UCBL1, project leader = Zeiss Digital classroom
• 2022-2025: RYP (Rise Your Project) internal funding, project leader “Role of reticulum-mitochondria interactions in B lymphocytes of patients with ischemic heart disease”.

5 major publications:

1. Aude Lafoux, Sabine Lotteau, Corinne Huchet and Sylvie Ducreux. The contractile phenotype of skeletal muscle in TRPV1 knockout mice is gender-specific and exercise-dependent. Life. 2020.
2. Al-Mawla R*, Ducrozet M*, Tessier N*, Païta L, Pillot B, Gouriou Y, Villedieu C, Harhous Z, Paccalet A, Crola Da Silva C, Ovize M, Bidaux G, Ducreux S‡ and Van Coppenolle F‡. Acute induction of translocon-mediated Ca2+ leak from sarcoplasmic reticulum protects cardiomyocytes against ischemia/reperfusion injury. Cells. 2020.
3. Vanden Abeele F*, Lotteau S*, Ducreux S, Dubois C, Monnier N, Hanna A, Gkika D, Romestaing C, Noyer L, Flourakis M, Tessier N, Al-Mawla R, Chouabe C, Lefai E, Lunardi J, Hamilton S, Fauré J, Van Coppenolle F, Prevarskaya. TRPV1 variants impair intracellular Ca2+ signaling and may confer susceptibility to malignant hyperthermia. N. Genet Med. 2018.
4. Ducreux S, Zorzato F, Ferreiro A, Jungbluth H, Muntoni F, Monnier N, Muller CR, Treves S. Functional properties of ryanodine receptors carrying 3 amino acid substitutions identified in patients affected by multi-minicore disease and central core disease, expressed in immortalised lymphocytes. Biochem J. 2006.
5. Ducreux S, Zorzato F, Muller C, Sewry C, Muntoni F, Quinlivan R, Restagno G, Girard T, Treves S. Effect of ryanodine receptor mutations on interleukin-6 release and intracellular calcium homeostasis in human myotubes from malignant hyperthermia-susceptible individuals and patients affected by central core disease. J Biol Chem. 2004.

Complete list of publications on Pubmed