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MERISM TEAM : « Mitochondria-ER Interactions and Signalling in Metabolic health and diseases »

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Publications 2024

Abeysekera, K. W. M., Valenti, L., Younossi, Z., Dillon, J. F., Allen, A. M., Nourredin, M., Rinella, M. E., Tacke, F., Francque, S., Ginès, P., Thiele, M., Newsome, P. N., Guha, I. N., Eslam, M., Schattenberg, J. M., Alqahtani, S. A., Arrese, M., Berzigotti, A., Holleboom, A. G., Caussy, C., Cusi, K., Roden, M., Hagström, H., Wong, V. W., Mallet, V., Castera, L., Lazarus, J. V. and Tsochatzis, E. A. Implementation of a liver health check in people with type 2 diabetes Lancet Gastroenterol Hepatol. 2024 Jan;9(1). doi: 10.1016/s2468-1253(23)00270-4.

Aubin, A., Hornero-Ramirez, H., Ranaivo, H., Simon, C., Van Den Berghe, L., Favier, N. F., Dussous, I., Roger, L., Laville, M., Béra-Maillet, C., Doré, J., Caussy, C. and Nazare, J. A. Assessing metabolic flexibility response to a multifibre diet: a randomised-controlled trial J Hum Nutr Diet. 2024 Aug 13;doi: 10.1111/jhn.13350.

Badawi, S., Leboullenger, C., Chourrout, M., Gouriou, Y., Paccalet, A., Pillot, B., Augeul, L., Bolbos, R., Bongiovani, A., Mewton, N., Bochaton, T., Ovize, M., Tardivel, M., Kurdi, M., Canet-Soulas, E., Da Silva, C. C. and Bidaux, G. Oxidation-reduction imaging of myoglobin reveals two-phase oxidation in the reperfused myocardium Basic Res Cardiol. 2024 Jun;119(3). doi: 10.1007/s00395-024-01040-6.

Balcerczyk, A., Eljaafari, A. and Pirola, L. Adipose stem cells drive T cell infiltration in obesity Trends Endocrinol Metab. 2024 Jun 29;doi: 10.1016/j.tem.2024.06.013.

Bashir, B., Kwok, S., Wierzbicki, A. S., Jones, A., Dawson, C., Downie, P., Jenkinson, F., Delaney, H., Mansfield, M., Datta, D., Teoh, Y., Hamilton, P., Forrester, N., O’Sullivan, D., Ferdousi, M., Durrington, P. N., AbdelRazik, A., Gallo, A., Moulin, P. and Soran, H. Validation of the familial chylomicronaemia syndrome (FCS) score in an ethnically diverse cohort from UK FCS registry: Implications for diagnosis and differentiation from multifactorial chylomicronaemia syndrome (MCS) Atherosclerosis. 2024 Apr;391(doi: 10.1016/j.atherosclerosis.2024.117476.

Boccalini, S., Teulade, M., Paquet, E., Si-Mohamed, S., Rapallo, F., Moreau-Triby, C., Charrière, S., Mewton, N., Boussel, L., Bergerot, C., Douek, P. and Moulin, P. Silent myocardial infarction fatty scars detected by coronary calcium score CT scan in diabetic patients without history of coronary heart disease Eur Radiol. 2024 Jan;34(1). doi: 10.1007/s00330-023-09940-2.

Bonnot Ruget, M., Moulin, P., Pagan, C., Cheillan, D., Marmontel, O., Raverot, G., Benlian, P. and Di Filippo, M. Diagnostic challenge between a frequent polygenic hypocholesterolemia and an unusual Smith Lemli Opitz syndrome related to bi-allelic DHCR7 mutations Clin Chem Lab Med. 2024 Aug 27;62(9). doi: 10.1515/cclm-2024-0162.

Campos, J. O., Oliveira, T., Vitalis, O., Pereira, J. G., Nogueira, I., Santos, G. C. J., Chikh, K., Leandro, C. G., Costa-Silva, J. H. D. and Pirola, L. Association between Childhood Overweight and Altered Concentrations of Circulating Amino Acids Nutrients. 2024 Jun 12;16(12). doi: 10.3390/nu16121843.

Chouik, Y., Aubin, A., Maynard-Muet, M., Segrestin, B., Milot, L., Hervieu, V., Zoulim, F., Disse, E., Levrero, M. and Caussy, C. The grade of obesity affects the noninvasive diagnosis of advanced fibrosis in individuals with MASLD Obesity (Silver Spring). 2024 Jun;32(6). doi: 10.1002/oby.24033.

Chouik, Y., Di Filippo, M., Radenne, S., Dumortier, J., Moulin, P. and Levrero, M. Combination of heterozygous APOB gene mutation with PNPLA3 and TM6SF2 variants promotes steatotic liver disease, cirrhosis and HCC development Liver Int. 2024 Jun;44(6). doi: 10.1111/liv.15837.

Ciesielski, O., Pirola, L. and Balcerczyk, A. Peptidylarginine Deiminases Inhibitors Decrease Endothelial Cells Angiogenic Potential by Affecting Akt Signaling and the Expression and Secretion of Angiogenic Factors Cell Physiol Biochem. 2024 Feb 19;58(1). doi: 10.33594/000000683.

Costa, P. C. T., de Luna Freire, M. O., de Oliveira Coutinho, D., Godet, M., Magnani, M., Antunes, V. R., de Souza, E. L., Vidal, H. and de Brito Alves, J. L. Nutraceuticals in the management of autonomic function and related disorders: A comprehensive review Pharmacol Res. 2024 Aug 25;208(doi: 10.1016/j.phrs.2024.107368.

Drevet Mulard, E., Guibert, S., Mey, A., Lefevre, C., Chauvin, M. A., Pinteur, C., Monet, M. A., Godet, M., Madec, A. M., Morio, B., Rieusset, J., Rautureau, G. J. P. and Panthu, B. A Cross-Sectional Quantitative Metabolomics Study Evidencing the Metabolic Signature in Six Organs during a 14-Week High-Fat High-Sucrose and Standard Diet in Mice Nutrients. 2024 Mar 12;16(6). doi: 10.3390/nu16060803.

Erard, D., Villeret, F., Chouik, Y., Guillaud, O., Scoazec, J. Y., Caussy, C., Disse, E., Boillot, O., Hervieu, V. and Dumortier, J. Dual alcohol and metabolic-related liver disease: Results from a population of liver transplant patients Liver Int. 2024 Feb;44(2). doi: 10.1111/liv.15779.

Fiscus, J., Fraison, É., Renault, L., Salle, B., Panthu, B. and Labrune, E. Metabolic signature of follicular fluid in infertility-related diseases: a narrative review Reprod Biomed Online. 2024 Jun;48(6). doi: 10.1016/j.rbmo.2023.103762.

Grynblat, J., Khouri, C., Hlavaty, A., Jais, X., Savale, L., Chaumais, M. C., Kularatne, M., Jevnikar, M., Boucly, A., Antigny, F., Perros, F., Simonneau, G., Sitbon, O., Humbert, M. and Montani, D. Characteristics and outcomes of patients developing pulmonary hypertension associated with proteasome inhibitors Eur Respir J. 2024 May 2;doi: 10.1183/13993003.02158-2023.

Henry, Z., Villar Fimbel, S., Bendelac, N., Perge, K. and Thivolet, C. Beneficial effects of automated insulin delivery over one-year follow-up in real life for youths and adults with type 1 diabetes irrespective of patient characteristics Diabetes Obes Metab. 2024 Feb;26(2). doi: 10.1111/dom.15344.

Hong, J., Medzikovic, L., Sun, W., Wong, B., Ruffenach, G., Rhodes, C. J., Brownstein, A., Liang, L. L., Aryan, L., Li, M., Vadgama, A., Kurt, Z., Schwantes-An, T. H., Mickler, E. A., Gräf, S., Eyries, M., Lutz, K. A., Pauciulo, M. W., Trembath, R. C., Perros, F., Montani, D., Morrell, N. W., Soubrier, F., Wilkins, M. R., Nichols, W. C., Aldred, M. A., Desai, A. A., Trégouët, D. A., Umar, S., Saggar, R., Channick, R., Tuder, R. M., Geraci, M. W., Stearman, R. S., Yang, X. and Eghbali, M. Integrative Multiomics in the Lung Reveals a Protective Role of Asporin in Pulmonary Arterial Hypertension Circulation. 2024 Aug 21;doi: 10.1161/circulationaha.124.069864.

Hornero-Ramirez, H., Aubin, A., Michalski, M. C., Vinoy, S., Caussy, C. and Nazare, J. A. Multifunctional dietary interventions, low-grade inflammation and cardiometabolic profile: a scoping review Front Immunol. 2024 Mar;15(doi: 10.3389/fimmu.2024.1304686.

Khanafer, N., Oudot, S., Maligeay, M., Planckaert, C., Mena, C., Mandel, N. T., Bouhalila, R., Ader, F., Berard, F., Bouhour, F., Chapurlat, R., Charriere, S., Confavreux, C., Devouassoux, G., Disse, E., Fouque, D., Ghesquieres, H., Hyvert, S., Jolivot, A., Durand, A., Martin-Gaujard, G., Mornex, J. F., Nicolino, M., André-Obadia, N., Raverot, G., Reix, P., Ruffion, A., Seve, P., Hermann, R., Zoulim, F., Clamens, J., Ayala, M. P. and Vanhems, P. A quick access to information on influenza burden and prevention in Lyon university hospital: A prospective QR code-based information campaign in 2022-2023 Vaccine. 2024 Aug 30;42(21). doi: 10.1016/j.vaccine.2024.126160.

Lebbar, M., Henry, Z. and Thivolet, C. Comment on Beato-Víbora et al. A Multicenter Prospective Evaluation of the Benefits of Two Advanced Hybrid Closed-Loop Systems in Glucose Control and Patient-Reported Outcomes in a Real-World Setting. Diabetes Care 2024;47:216-224 Diabetes Care. 2024 May 1;47(5). doi: 10.2337/dc24-0055.

Michenaud, L., Marrié, N., Rimbert, A., Marmontel, O., Charrière, S., Gibert, C., Bouveyron, C., Mammi, J., Cariou, B., Moulin, P. and Di Filippo, M. Evaluation of biochemical algorithms to screen dysbetalipoproteinemia in ε2ε2 and rare APOE variants carriers Clin Chem Lab Med. 2024 Jul 29;doi: 10.1515/cclm-2024-0587.

Paccalet, A., Badawi, S., Pillot, B., Augeul, L., Mechtouff, L., Harhous, Z., Gouriou, Y., Paillard, M., Breuilly, M., Amaz, C., Varillon, Y., Leboube, S., Brun, C., Prieur, C., Rioufol, G., Mewton, N., Ovize, M., Bidaux, G., Bochaton, T. and Crola Da Silva, C. Deleterious Anti-Inflammatory Macrophage Recruitment in Early Post-Infarction Phase: Unraveling the IL-6/MCP-1/STAT3 Axis JACC Basic Transl Sci. 2024 May;9(5). doi: 10.1016/j.jacbts.2024.01.019.

Pacheco, A. L. G., Bocanegra, W. M., Ferreira É, K. L., Dos Santos, R. T., Simões, P. M., Malinga, E., Guiliche, E. D. C., Isaías, A. F. J., Nobre, I. G., Silva, J., Silva, W., Padrón-Hernandez, E., Pirola, L., Henrique, R. D. S. and Leandro, C. G. The Similarity Degree of the Anthropometric and Body Composition Variables of Brazilian and Mozambican Schoolchildren: A New Approach Using the Smoothed Jaccard Index Surface Children (Basel). 2024 Jun 30;11(7). doi: 10.3390/children11070804.

Péchoux, C., Antigny, F. and Perros, F. A correlated light and electron microscopy approach to study the subcellular localization of phosphorylated vimentin in human lung tissue Methods Cell Biol. 2024 May;187(doi: 10.1016/bs.mcb.2024.02.034.

Piecyk, M., Ferraro-Peyret, C., Laville, D., Perros, F. and Chaveroux, C. Novel insights into the GCN2 pathway and its targeting. Therapeutic value in cancer and lessons from lung fibrosis development Febs j. 2024 Jun 16;doi: 10.1111/febs.17203.

Qi, X., Li, J., Caussy, C., Teng, G. J. and Loomba, R. Epidemiology, screening, and Co-management of type 2 diabetes mellitus and Metabolic-dysfunction associated steatotic liver disease Hepatology. 2024 May 8;doi: 10.1097/hep.0000000000000913.

Rachedi, N. S., Tang, Y., Tai, Y. Y., Zhao, J., Chauvet, C., Grynblat, J., Akoumia, K. K. F., Estephan, L., Torrino, S., Sbai, C., Ait-Mouffok, A., Latoche, J. D., Al Aaraj, Y., Brau, F., Abélanet, S., Clavel, S., Zhang, Y., Guillermier, C., Kumar, N. V. G., Tavakoli, S., Mercier, O., Risbano, M. G., Yao, Z. K., Yang, G., Ouerfelli, O., Lewis, J. S., Montani, D., Humbert, M., Steinhauser, M. L., Anderson, C. J., Oldham, W. M., Perros, F., Bertero, T. and Chan, S. Y. Dietary intake and glutamine-serine metabolism control pathologic vascular stiffness Cell Metab. 2024 Jun 4;36(6). doi: 10.1016/j.cmet.2024.04.010.

Rome, S. and Tacconi, S. High-fat diets: You are what you eat….your extracellular vesicles too! J Extracell Vesicles. 2024 Jan;13(1). doi: 10.1002/jev2.12382.

Sango-Solanas, P., Tse Ve Koon, K., Van Reeth, E., Nicolle, S., Palierne, J. F., Caussy, C. and Beuf, O. Ultrashort echo time magnetic resonance elastography for quantification of the mechanical properties of short T2 tissues via optimal control-based radiofrequency pulses NMR Biomed. 2024 Jul 11;doi: 10.1002/nbm.5210.

Santos-Gomes, J., Mendes-Ferreira, P., Adão, R., Maia-Rocha, C., Rego, B., Poels, M., Saint-Martin Willer, A., Masson, B., Provencher, S., Bonnet, S., Montani, D., Perros, F., Antigny, F., Leite-Moreira, A. F. and Brás-Silva, C. Unraveling the Impact of miR-146a in Pulmonary Arterial Hypertension Pathophysiology and Right Ventricular Function Int J Mol Sci. 2024 Jul 24;25(15). doi: 10.3390/ijms25158054.

Smati, S., Wargny, M., Boursier, J., Moulin, P., Di Filippo, M. and Cariou, B. Prevalence of Liver Steatosis and Fibrosis in Adults With Primary Hypobetaliproteinemia: Results From the HYPOCHOL Study Clin Gastroenterol Hepatol. 2024 Jul 5;doi: 10.1016/j.cgh.2024.06.031.

Tacconi, S., Vari, F., Sbarigia, C., Vardanyan, D., Longo, S., Mura, F., Angilè, F., Jalabert, A., Blangero, F., Eljaafari, A., Canaple, L., Vergara, D., Fanizzi, F. P., Rossi, M., Da Silva, C. C., Errazuriz-Cerda, E., Cassin, C., Nieuwland, R., Giudetti, A. M., Rome, S. and Dini, L. M1-derived extracellular vesicles polarize recipient macrophages into M2-like macrophages and alter skeletal muscle homeostasis in a hyper-glucose environment Cell Commun Signal. 2024 Mar 27;22(1). doi: 10.1186/s12964-024-01560-7.

Teoli, J., Chikh, K., Jouini-Bouhamri, R., Charriere, S., Fabien, N. and Raverot, V. When discordant insulin and C-peptide levels lead to a medical diagnosis in a patient with transient hypoglycemia: Varying degrees of interference of insulin-antibody complexes on three insulin immunoassays Heliyon. 2024 Jul 15;10(13). doi: 10.1016/j.heliyon.2024.e34009.

Thivolet, C. Hope, hype and present limitations of hybrid closed loop systems for persons with type 1 diabetes Diabetes Metab. 2024 Mar;50(2). doi: 10.1016/j.diabet.2024.101510.

Thivolet, C., Lebbar, M., Perge, K., Nicolino, M. and Villar-Fimbel, S. Ascertaining the Utility of the Glycemia Risk Index for Glucose Outcomes With Hybrid Closed-Loop Therapy in Adolescents and Adults With Type 1 Diabetes J Diabetes Sci Technol. 2024 Sep;18(5). doi: 10.1177/19322968241258742.

Todesco, A., Grynblat, J., Akoumia, K. K. F., Bonnet, D., Mendes-Ferreira, P., Morisset, S., Chemla, D., Levy, M., Méot, M., Malekzadeh-Milani, S. G., Tielemans, B., Decante, B., Vastel-Amzallag, C., Habert, P., Ghigna, M. R., Humbert, M., Montani, D., Boulate, D. and Perros, F. Pulmonary Hypertension Induced by Right Pulmonary Artery Occlusion: Hemodynamic Consequences of Bmpr2 Mutation J Am Heart Assoc. 2024 Jul 16;13(14). doi: 10.1161/jaha.124.034621.

Tóth, E. N., Celant, L. R., Niglas, M., Jansen, S., Tramper, J., Baxan, N., Ashek, A., Wessels, J. N., Marcus, J. T., Meijboom, L. J., Houweling, A. C., Nossent, E. J., Aman, J., Grynblat, J., Perros, F., Montani, D., Vonk Noordegraaf, A., Zhao, L., de Man, F. S. and Bogaard, H. J. Deep phenotyping of unaffected carriers of pathogenic BMPR2 variants screened for pulmonary arterial hypertension Eur Respir J. 2024 Jul 26;doi: 10.1183/13993003.00442-2024.

Vasse, J., Lassartesse, A., Marmontel, O., Charrière, S., Bouveyron, C., Marrié, N., Moulin, P. and Di Filippo, M. Assessment of three equations to calculate plasma LDL cholesterol concentration in fasting and non-fasting hypertriglyceridemic patients Clin Chem Lab Med. 2024 Jan 26;62(2). doi: 10.1515/cclm-2023-0360.

Ziegler, D. V., Czarnecka-Herok, J., Vernier, M., Scholtes, C., Camprubi, C., Huna, A., Massemin, A., Griveau, A., Machon, C., Guitton, J., Rieusset, J., Vigneron, A. M., Giguère, V., Martin, N. and Bernard, D. Cholesterol biosynthetic pathway induces cellular senescence through ERRα NPJ Aging. 2024 Jan 12;10(1). doi: 10.1038/s41514-023-00128-y.

Publications 2023

Alves, A. and Morio, B. Alterations in glycine metabolism in obesity and chronic metabolic diseases – an update on new advances Curr Opin Clin Nutr Metab Care. 2023 Jan 1;26(1). doi: 10.1097/mco.0000000000000883.

Amadou, C., Melki, V., Allain, J., Clavel, S., Gouet, D., Chaillous, L., Catargi, B., Schaeplynck-Belicard, P., Petit, C., Thivolet, C. and Penfornis, A. Performance and patients’ satisfaction with the A7+TouchCare insulin patch pump system: A randomized controlled non-inferiority study PLoS One. 2023 18(8). doi: 10.1371/journal.pone.0289684.

Anaganti, N., Chattopadhyay, A., Di Filippo, M. and Hussain, M. M. New CRISPR Technology for Creating Cell Models of Lipoprotein Assembly and Secretion Curr Atheroscler Rep. 2023 May;25(5). doi: 10.1007/s11883-023-01095-1.

Beau, A., Benoit, B., Le Barz, M., Meugnier, E., Penhoat, A., Calzada, C., Pinteur, C., Loizon, E., Chanon, S., Vieille-Marchiset, A., Sauvinet, V., Godet, M., Laugerette, F., Holowacz, S., Jacouton, E., Michalski, M. C. and Vidal, H. Inhibition of intestinal FXR activity as a possible mechanism for the beneficial effects of a probiotic mix supplementation on lipid metabolism alterations and weight gain in mice fed a high fat diet Gut Microbes. 2023 Dec;15(2). doi: 10.1080/19490976.2023.2281015.

Bignard, J., Atassi, F., Claude, O., Ghigna, M. R., Mougenot, N., Abdoulkarim, B. S., Deknuydt, F., Gestin, A., Monceau, V., Montani, D., Nadaud, S., Soubrier, F. and Perros, F. T-cell dysregulation and inflammatory process in Gcn2 (Eif2ak4(-/-))-deficient rats in basal and stress conditions Am J Physiol Lung Cell Mol Physiol. 2023 May 1;324(5). doi: 10.1152/ajplung.00460.2021.

Bonnet, J. B., Couvert, P., Di-Filippo, M., Boissiere, F., Cristol, J. P., Sutra, T., Cheillan, D., Moulin, P. and Sultan, A. Tuberous xanthomatosis is not necessarily associated with increased plasma concentrations of cholestanol in cerebrotendinous xanthomatosis J Intern Med. 2023 Jan;293(1). doi: 10.1111/joim.13568.

Castro-Sepulveda, M., Fernández-Verdejo, R., Zbinden-Foncea, H. and Rieusset, J. Mitochondria-SR interaction and mitochondrial fusion/fission in the regulation of skeletal muscle metabolism Metabolism. 2023 Jul;144(doi: 10.1016/j.metabol.2023.155578.

Caussy, C. Editorial: improvement of cardiovascular risk factor control in patients with type 2 diabetes and nonalcoholic fatty liver disease-time for action! Aliment Pharmacol Ther. 2023 May;57(10). doi: 10.1111/apt.17467.

Caussy, C., Telliam, C., Al-Nuaimi, B., Maynard-Muet, M., Dumortier, J., Zoulim, F., Disse, E., Colin, C., Levrero, M. and Moulin, P. Comparison of Pathway Referrals for Liver Fibrosis Risk Stratification Performed in Diabetology and Nutrition Clinics Diabetes Metab Syndr Obes. 2023 16(doi: 10.2147/dmso.S407511.

Charrière, S., Maillot, F., Bouée, S., Douillard, C., Jacob, C., Schneider, K. M., Theil, J. and Arnoux, J. B. Health status and comorbidities of adult patients with phenylketonuria (PKU) in France with a focus on early-diagnosed patients – A nationwide study of health insurance claims data Mol Genet Metab. 2023 Jul;139(3). doi: 10.1016/j.ymgme.2023.107625.

Daverio, Z., Balcerczyk, A., Rautureau, G. J. P. and Panthu, B. How Warburg-Associated Lactic Acidosis Rewires Cancer Cell Energy Metabolism to Resist Glucose Deprivation Cancers (Basel). 2023 Feb 23;15(5). doi: 10.3390/cancers15051417.

Daverio, Z., Kolkman, M., Perrier, J., Brunet, L., Bendridi, N., Sanglar, C., Berger, M. A., Panthu, B. and Rautureau, G. J. P. Warburg-associated acidification represses lactic fermentation independently of lactate, contribution from real-time NMR on cell-free systems Sci Rep. 2023 Oct 18;13(1). doi: 10.1038/s41598-023-44783-3.

Douillard, C., Arnoux, J. B., Bouée, S., Jacob, C., Schneider, K. M., Theil, J., Charrière, S. and Maillot, F. Health status and comorbidities of adult patients with late-diagnosed phenylketonuria (PKU) born before the newborn screening in France – A nationwide study of health insurance claims data Mol Genet Metab. 2023 Nov;140(3). doi: 10.1016/j.ymgme.2023.107704.

Duponchel, S., Monnier, L., Molle, J., Bendridi, N., Alam, M. R., Gaballah, A., Grigorov, B., Ivanov, A., Schmiel, M., Odenthal, M., Ovize, M., Rieusset, J., Zoulim, F. and Bartosch, B. Hepatitis C virus replication requires integrity of mitochondria-associated ER membranes JHEP Rep. 2023 Mar;5(3). doi: 10.1016/j.jhepr.2022.100647.

Edd, S. N., Castañeda, J., Choudhary, P., Kolassa, R., Keuthage, W., Kroeger, J., Thivolet, C., Evans, M., Ré, R., Cellot, J., de Portu, S., Vorrink, L., Shin, J., van den Heuvel, T. and Cohen, O. Twelve-month results of the ADAPT randomized controlled trial: Reproducibility and sustainability of advanced hybrid closed-loop therapy outcomes versus conventional therapy in adults with type 1 diabetes Diabetes Obes Metab. 2023 Nov;25(11). doi: 10.1111/dom.15217.

Gonnot, F., Boulogne, L., Brun, C., Dia, M., Gouriou, Y., Bidaux, G., Chouabe, C., Crola Da Silva, C., Ducreux, S., Pillot, B., Kaczmarczyk, A., Leon, C., Chanon, S., Perret, C., Sciandra, F., Dargar, T., Gache, V., Farhat, F., Sebbag, L., Bochaton, T., Thibault, H., Ovize, M., Paillard, M. and Gomez, L. SERCA2 phosphorylation at serine 663 is a key regulator of Ca(2+) homeostasis in heart diseases Nat Commun. 2023 Jun 8;14(1). doi: 10.1038/s41467-023-39027-x.

Gouriou, Y., Gonnot, F., Wehbi, M., Brun, C., Gomez, L. and Bidaux, G. High-sensitivity calcium biosensor on the mitochondrial surface reveals that IP3R channels participate in the reticular Ca2+ leak towards mitochondria PLoS One. 2023 18(6). doi: 10.1371/journal.pone.0285670.

Grynblat, J., Malekzadeh-Milani, S. G., Meot, M., Perros, F., Szezepanski, I., Morisset, S., Ovaert, C., Bonnet, C., Maragnes, P., Ranchoup, J., Humbert, M., Montani, I. D., Levy, M. and Bonnet, D. Monitoring of Hemodynamics With Right Heart Catheterization in Children With Pulmonary Arterial Hypertension J Am Heart Assoc. 2023 Apr 4;12(7). doi: 10.1161/jaha.122.029085.

Henry, Z., Janin, A., Nony, S., Marmontel, O., Cariou, B., Marrec, M., Caussy, C., Charrière, S., Moulin, P., Rieusset, J., Perros, F. and Di Filippo, M. Interest of minigene splicing reporter assay in familial hypobetalipoproteinemia genetic diagnosis: the example of the missense mutation APOB c.1468C>T Clin Chem Lab Med. 2023 Nov 27;61(12). doi: 10.1515/cclm-2023-0330.

Humbert, A., Lefebvre, R., Nawrot, M., Caussy, C. and Rieusset, J. Calcium signalling in hepatic metabolism: Health and diseases Cell Calcium. 2023 Sep;114(doi: 10.1016/j.ceca.2023.102780.

Karolak, J. A., Welch, C. L., Mosimann, C., Bzdęga, K., West, J. D., Montani, D., Eyries, M., Mullen, M. P., Abman, S. H., Prapa, M., Gräf, S., Morrell, N. W., Hemnes, A. R., Perros, F., Hamid, R., Logan, M. P. O., Whitsett, J., Galambos, C., Stankiewicz, P., Chung, W. K. and Austin, E. D. Molecular Function and Contribution of TBX4 in Development and Disease Am J Respir Crit Care Med. 2023 Apr 1;207(7). doi: 10.1164/rccm.202206-1039TR.

Lefèvre, C. R., Gibert, C., Maucorps, L., Vasse, J., Michel, M., Chupin, M., Zhao, F., Desmurs, L., Collet, N., Di Filippo, M., Cartier, R., Monneret, D. and Marmontel, O. Pseudohyponatremia: interference of hyperglycemia on indirect potentiometry Clin Chem Lab Med. 2023 Jan 27;61(2). doi: 10.1515/cclm-2022-0766.

Leuillier, M., Duflot, T., Ménoret, S., Messaoudi, H., Djerada, Z., Groussard, D., Denis, R. G. P., Chevalier, L., Karoui, A., Panthu, B., Thiébaut, P. A., Schmitz-Afonso, I., Nobis, S., Campart, C., Henry, T., Sautreuil, C., Luquet, S. H., Beseme, O., Féliu, C., Peyret, H., Nicol, L., Henry, J. P., Renet, S., Mulder, P., Wan, D., Tesson, L., Heslan, J. M., Duché, A., Jacques, S., Ziegler, F., Brunel, V., Rautureau, G. J. P., Monteil, C., do Rego, J. L., do Rego, J. C., Afonso, C., Hammock, B., Madec, A. M., Pinet, F., Richard, V., Anegon, I., Guignabert, C., Morisseau, C. and Bellien, J. CRISPR/Cas9-mediated inactivation of the phosphatase activity of soluble epoxide hydrolase prevents obesity and cardiac ischemic injury J Adv Res. 2023 Jan;43(doi: 10.1016/j.jare.2022.03.004.

Lezoualc’h, F., Badimon, L., Baker, H., Bernard, M., Czibik, G., de Boer, R. A., D’Humières, T., Kergoat, M., Kowala, M., Rieusset, J., Vilahur, G., Détrait, M., Watson, C. and Derumeaux, G. A. Diabetic cardiomyopathy: the need for adjusting experimental models to meet clinical reality Cardiovasc Res. 2023 May 22;119(5). doi: 10.1093/cvr/cvac152.

Marmontel, O., Abou-Khalil, Y., Bluteau, O., Cariou, B., Carreau, V., Charrière, S., Divry, E., Gallo, A., Moulin, P., Paillard, F., Peretti, N., Rabès, J. P., Varret, M., Carrié, A. and Di Filippo, M. Additive Effect of APOE Rare Variants on the Phenotype of Familial Hypercholesterolemia Arterioscler Thromb Vasc Biol. 2023 Jul;43(7). doi: 10.1161/atvbaha.123.319146.

Massemin, A., Goehrig, D., Flaman, J. M., Jaber, S., Griveau, A., Djebali, S., Marcos, E., Payen, L., Marvel, J., Parent, R., Adnot, S., Bertolino, P., Rieusset, J., Tortereau, A., Vindrieux, D. and Bernard, D. Loss of Pla2r1 decreases cellular senescence and age-related alterations caused by aging and Western diets Aging Cell. 2023 Nov;22(11). doi: 10.1111/acel.13971.

Monneret, D., Moreau, A., Chirica, C., Guergour, D., Richet, C., Desmurs, L., Colognac, S., Frugier, A., Chévrier, M., Marmontel, O., Bonnefont-Rousselot, D., Gonzalo, P., Rodriguez-Lafrasse, C. and Cartier, R. Non-linearity in lipase assays: A multicentric comparison on different analysers Clin Biochem. 2023 Apr;114(doi: 10.1016/j.clinbiochem.2023.02.003.

Mourre, F., Giorgi, R., Gallo, A., Boccara, F., Bruckert, E., Carrié, A., Hankard, R., Inamo, J., Laboureau, S., Moulin, P., Valéro, R. and Béliard, S. Maternal Inheritance of Familial Hypercholesterolemia Gene Mutation Predisposes to Coronary Atherosclerosis as Assessed by Calcium Score in Adulthood Arterioscler Thromb Vasc Biol. 2023 Feb;43(2). doi: 10.1161/atvbaha.122.318119.

Mumby, S., Perros, F., Grynblat, J., Manaud, G., Papi, A., Casolari, P., Caramori, G., Humbert, M., John Wort, S. and Adcock, I. M. Differential responses of pulmonary vascular cells from PAH patients and controls to TNFα and the effect of the BET inhibitor JQ1 Respir Res. 2023 Jul 29;24(1). doi: 10.1186/s12931-023-02499-y.

Nocturne, G., Marmontel, O., di Filippo, M., Chretien, P., Krzysiek, R., Lifermann, F., Rahal, N., Belkhir, R., Moulin, P. and Mariette, X. Efficacy of daratumumab in refractory primary Sjögren disease RMD Open. 2023 Sep;9(3). doi: 10.1136/rmdopen-2023-003464.

Peretti, N., Vimont, A., Mas, E., Ferrières, J., Tounian, P., Lemale, J., Boccara, F., Di Filippo, M., Charriere, S., Moulin, P., Poinsot, P., Cottin, Y., Ducluzeau, P. H., Dourmap, C., Cariou, B., Farnier, M., Paillard, F., Pradignac, A., Yelnik, C., Gallo, A., Bruckert, E. and Beliard, S. Factors Predicting Statin Initiation During Childhood in Familial Hypercholesterolemia: Importance of Genetic Diagnosis J Pediatr. 2023 Feb;253(doi: 10.1016/j.jpeds.2022.08.041.

Perrier, J., Nawrot, M., Madec, A. M., Chikh, K., Chauvin, M. A., Damblon, C., Sabatier, J., Thivolet, C. H., Rieusset, J., Rautureau, G. J. P. and Panthu, B. Human Pancreatic Islets React to Glucolipotoxicity by Secreting Pyruvate and Citrate Nutrients. 2023 Nov 15;15(22). doi: 10.3390/nu15224791.

Perros, F., Jutant É, M., Savale, L., Dorfmüller, P., Humbert, M. and Montani, D. [Physiopathology and treatment of pulmonary arterial hypertension] Med Sci (Paris). 2023 Apr;39(4). doi: 10.1051/medsci/2023053.

Pestel, J., Blangero, F., Watson, J., Pirola, L. and Eljaafari, A. Adipokines in obesity and metabolic-related-diseases Biochimie. 2023 Sep;212(doi: 10.1016/j.biochi.2023.04.008.

Quarck, R., Willems, L., Tielemans, B., Stoian, L., Ronisz, A., Wagenaar, A., Perros, F., Claessen, G., Ciarka, A., Godinas, L., Belge, C., Jacquemin, M. and Delcroix, M. Impairment of Angiogenesis-Driven Clot Resolution Is a Key Event in the Progression to Chronic Thromboembolic Pulmonary Hypertension: Validation in a Novel Rabbit Model Arterioscler Thromb Vasc Biol. 2023 Jul;43(7). doi: 10.1161/atvbaha.122.317262.

Santos-Ribeiro, D., Lecocq, M., de Beukelaer, M., Bouzin, C., Palmai-Pallag, M., Yakoub, Y., Huaux, F., Horman, S., Perros, F., Pilette, C. and Godinas, L. Bleomycin-induced lung injury: Revisiting an old tool to model group III PH associated with pulmonary fibrosis Pulm Circ. 2023 Jan;13(1). doi: 10.1002/pul2.12177.

Santos-Ribeiro, D., Lecocq, M., de Beukelaer, M., Verleden, S., Bouzin, C., Ambroise, J., Dorfmuller, P., Yakoub, Y., Huaux, F., Quarck, R., Karmouty-Quintana, H., Ghigna, M. R., Bignard, J., Nadaud, S., Soubrier, F., Horman, S., Perros, F., Godinas, L. and Pilette, C. Disruption of GCN2 Pathway Aggravates Vascular and Parenchymal Remodeling during Pulmonary Fibrosis Am J Respir Cell Mol Biol. 2023 Mar;68(3). doi: 10.1165/rcmb.2021-0541OC.

Schattenberg, J. M., Allen, A. M., Jarvis, H., Zelber-Sagi, S., Cusi, K., Dillon, J. F., Caussy, C., Francque, S. M., Younossi, Z., Alkhouri, N. and Lazarus, J. V. A multistakeholder approach to innovations in NAFLD care Commun Med (Lond). 2023 Jan 3;3(1). doi: 10.1038/s43856-022-00228-y.

Simões-Alves, A. C., Costa-Silva, J. H., Bassot, A., Leandro, C. G., Pirola, L., Fernandes, M. P. and Morio, B. Diet enriched in saturated fatty acids induces liver oxidative stress and elicits inflammatory pathways prior to metabolic disruption in perinatal protein undernutrition Nutr Res. 2023 Oct;118(doi: 10.1016/j.nutres.2023.08.001.

Thivolet, C., Larger, E., Cariou, B., Renard, E., Hanaire, H., Benhamou, P. Y., Guerci, B., Mathiotte, É. and Chikh, K. Dulaglutide and insulin microsecretion in people with type 1 diabetes (DIAMOND-GLP-1): A randomized double-blind placebo-controlled trial Diabetes Metab. 2023 Mar;49(2). doi: 10.1016/j.diabet.2023.101433.

Vanhoye, X., Bardel, C., Rimbert, A., Moulin, P., Rollat-Farnier, P. A., Muntaner, M., Marmontel, O., Dumont, S., Charrière, S., Cornélis, F., Ducluzeau, P. H., Fonteille, A., Nobecourt, E., Peretti, N., Schillo, F., Wargny, M., Cariou, B., Meirhaeghe, A. and Di Filippo, M. A new 165-SNP low-density lipoprotein cholesterol polygenic risk score based on next generation sequencing outperforms previously published scores in routine diagnostics of familial hypercholesterolemia Transl Res. 2023 May;255(doi: 10.1016/j.trsl.2022.12.002.

Publications 2022

Abou Khalil, Y., Marmontel, O., Ferrières, J., Paillard, F., Yelnik, C., Carreau, V., Charrière, S., Bruckert, E., Gallo, A., Giral, P., Philippi, A., Bluteau, O., Boileau, C., Abifadel, M., Di-Filippo, M., Carrié, A., Rabès, J. P. and Varret, M. APOE Molecular Spectrum in a French Cohort with Primary Dyslipidemia Int J Mol Sci. 2022 May 21;23(10). doi: 10.3390/ijms23105792.

Alves, A., Lamarche, F., Lefebvre, R., Drevet Mulard, E., Bassot, A., Chanon, S., Loizon, E., Pinteur, C., Bloise, A., Godet, M., Rautureau, G. J. P., Panthu, B. and Morio, B. Glycine Supplementation in Obesity Worsens Glucose Intolerance through Enhanced Liver Gluconeogenesis Nutrients. 2022 Dec 24;15(1). doi: 10.3390/nu15010096.

Beaulant, A., Dia, M., Pillot, B., Chauvin, M. A., Ji-Cao, J., Durand, C., Bendridi, N., Chanon, S., Vieille-Marchiset, A., Da Silva, C. C., Patouraux, S., Anty, R., Iannelli, A., Tran, A., Gual, P., Vidal, H., Gomez, L., Paillard, M. and Rieusset, J. Endoplasmic reticulum-mitochondria miscommunication is an early and causal trigger of hepatic insulin resistance and steatosis J Hepatol. 2022 Sep;77(3). doi: 10.1016/j.jhep.2022.03.017.

Bellien, J., Bozec, E., Bounoure, F., Khettab, H., Malloizel-Delaunay, J., Skiba, M., Iacob, M., Donnadieu, N., Coquard, A., Morio, B., Laillet, B., Rigaudière, J. P., Chardigny, J. M., Monteil, C., Vendeville, C., Mercier, A., Cailleux, A. F., Blanchard, A., Amar, J., Fezeu, L. K., Pannier, B., Bura-Rivière, A., Boutouyrie, P. and Joannidès, R. The effect of camelina oil on vascular function in essential hypertensive patients with metabolic syndrome: a randomized, placebo-controlled, double-blind study Am J Clin Nutr. 2022 Mar 4;115(3). doi: 10.1093/ajcn/nqab374.

Bendridi, N., Selmi, A., Balcerczyk, A. and Pirola, L. Ketone Bodies as Metabolites and Signalling Molecules at the Crossroad between Inflammation and Epigenetic Control of Cardiometabolic Disorders Int J Mol Sci. 2022 Nov 23;23(23). doi: 10.3390/ijms232314564.

Blanchard, C., Perennec, T., Smati, S., Tramunt, B., Guyomarch, B., Bigot-Corbel, E., Bordier, L., Borot, S., Bourron, O., Caussy, C., Coffin-Boutreux, C., Dutour, A., Germain, N., Gonfroy-Leymarie, C., Meyer, L., Prevost, G., Roussel, R., Seret-Bégué, D., Thivolet, C., Vergès, B., Pichelin, M., Gourdy, P., Hadjadj, S., Wargny, M., Pattou, F. and Cariou, B. History of bariatric surgery and COVID-19 outcomes in patients with type 2 diabetes: Results from the CORONADO study Obesity (Silver Spring). 2022 Mar;30(3). doi: 10.1002/oby.23314.

Bloise, A., Simões-Alves, A. C., Debora Santos, A., Morio, B. and Costa-Silva, J. H. Cardiometabolic impacts of saturated fatty acids: are they all comparable? Int J Food Sci Nutr. 2022 Feb;73(1). doi: 10.1080/09637486.2021.1940885.

Boulet, M. M., Calzada, C., Pettazzoni, M., Lelekov-Boissard, T., Buisson, C., Di Filippo, M., Durand, A., Lambert-Porcheron, S., Nazare, J. A., Moulin, P., Michalski, M. C. and Cheillan, D. A meal rich in palm oil or butter modifies the sphingolipid profile of postprandial triglyceride-rich lipoproteins from type 2 diabetic women Biochimie. 2022 Dec;203(doi: 10.1016/j.biochi.2022.07.003.

Brandman, D., Boyle, M., McPherson, S., Van Natta, M. L., Sanyal, A. J., Kowdley, K., Neuschwander-Tetri, B., Chalasani, N., Abdelmalek, M. F., Terrault, N. A., McCullough, A., Bettencourt, R., Caussy, C., Kleiner, D. E., Behling, C., Tonascia, J., Anstee, Q. M. and Loomba, R. Comparison of clinical prediction rules for ruling out cirrhosis in nonalcoholic fatty liver disease (NAFLD) Aliment Pharmacol Ther. 2022 Jun;55(11). doi: 10.1111/apt.16874.

Bredefeld, C., Hussain, M. M., Averna, M., Black, D. D., Brin, M. F., Burnett, J. R., Charrière, S., Cuerq, C., Davidson, N. O., Deckelbaum, R. J., Goldberg, I. J., Granot, E., Hegele, R. A., Ishibashi, S., Karmally, W., Levy, E., Moulin, P., Okazaki, H., Poinsot, P., Rader, D. J., Takahashi, M., Tarugi, P., Traber, M. G., Di Filippo, M. and Peretti, N. Guidance for the diagnosis and treatment of hypolipidemia disorders J Clin Lipidol. 2022 Nov-Dec;16(6). doi: 10.1016/j.jacl.2022.08.009.

Cambet, T., Bochaton, T., Bel, F., Derimay, F., Varillon, Y., Amaz, C., Bonnefoy-Cudraz, E., Angoulvant, D., Charriere, S., Moulin, P., Mewton, N. and Bergerot, C. Lipid goal achievements after acute myocardial infarction: the gap between real-life and ESC 2019 guidelines Eur J Prev Cardiol. 2022 Mar 11;29(2). doi: 10.1093/eurjpc/zwaa160.

Cariou, B., Wargny, M., Boureau, A. S., Smati, S., Tramunt, B., Desailloud, R., Lebeault, M., Amadou, C., Ancelle, D., Balkau, B., Bordier, L., Borot, S., Bourgeon, M., Bourron, O., Cosson, E., Eisinger, M., Gonfroy-Leymarie, C., Julla, J. B., Marchand, L., Meyer, L., Seret-Bégué, D., Simon, D., Sultan, A., Thivolet, C., Vambergue, A., Vatier, C., Winiszewski, P., Saulnier, P. J., Bauduceau, B., Gourdy, P. and Hadjadj, S. Impact of diabetes on COVID-19 prognosis beyond comorbidity burden: the CORONADO initiative Diabetologia. 2022 Sep;65(9). doi: 10.1007/s00125-022-05734-1.

Chavanelle, V., Chanon, S., Pinteur, C., Loizon, E., Vial, G., Otero, Y. F., Le Joubioux, F., Maugard, T., Peltier, S. L., Sirvent, P. and Morio, B. Impact of TOTUM-63, a fibre and polyphenol rich plant-based composition, on gut and pancreatic hormone secretion in diet-induced obese mice Nutr Metab Cardiovasc Dis. 2022 Jul;32(7). doi: 10.1016/j.numecd.2022.04.001.

Choudhary, P., Kolassa, R., Keuthage, W., Kroeger, J., Thivolet, C., Evans, M., Ré, R., de Portu, S., Vorrink, L., Shin, J., Habteab, A., Castañeda, J., da Silva, J. and Cohen, O. Advanced hybrid closed loop therapy versus conventional treatment in adults with type 1 diabetes (ADAPT): a randomised controlled study Lancet Diabetes Endocrinol. 2022 Oct;10(10). doi: 10.1016/s2213-8587(22)00212-1.

Ciesielski, O., Biesiekierska, M., Panthu, B., Soszyński, M., Pirola, L. and Balcerczyk, A. Citrullination in the pathology of inflammatory and autoimmune disorders: recent advances and future perspectives Cell Mol Life Sci. 2022 Jan 25;79(2). doi: 10.1007/s00018-022-04126-3.

Combot, Y., Salo, V. T., Chadeuf, G., Hölttä, M., Ven, K., Pulli, I., Ducheix, S., Pecqueur, C., Renoult, O., Lak, B., Li, S., Karhinen, L., Belevich, I., Le May, C., Rieusset, J., Le Lay, S., Croyal, M., Tayeb, K. S., Vihinen, H., Jokitalo, E., Törnquist, K., Vigouroux, C., Cariou, B., Magré, J., Larhlimi, A., Ikonen, E. and Prieur, X. Seipin localizes at endoplasmic-reticulum-mitochondria contact sites to control mitochondrial calcium import and metabolism in adipocytes Cell Rep. 2022 Jan 11;38(2). doi: 10.1016/j.celrep.2021.110213.

D’Ambrogio, G., Zahhaf, O., Le, M. Q., Gouriou, Y., Josset, L., Pialoux, V., Lermusiaux, P., Capsal, J. F., Cottinet, P. J. and Schiava, N. D. Investigation of Blood Coagulation Using Impedance Spectroscopy: Toward Innovative Biomarkers to Assess Fibrinogenesis and Clot Retraction Biomedicines. 2022 Jul 29;10(8). doi: 10.3390/biomedicines10081833.

Dia, M., Leon, C., Chanon, S., Bendridi, N., Gomez, L., Rieusset, J., Thibault, H. and Paillard, M. Effect of Metformin on T2D-Induced MAM Ca(2+) Uncoupling and Contractile Dysfunction in an Early Mouse Model of Diabetic HFpEF Int J Mol Sci. 2022 Mar 25;23(7). doi: 10.3390/ijms23073569.

Dijk, W., Di Filippo, M., Kooijman, S., van Eenige, R., Rimbert, A., Caillaud, A., Thedrez, A., Arnaud, L., Pronk, A., Garçon, D., Sotin, T., Lindenbaum, P., Ozcariz Garcia, E., Pais de Barros, J. P., Duvillard, L., Si-Tayeb, K., Amigo, N., Le Questel, J. Y., Rensen, P. C. N., Le May, C., Moulin, P. and Cariou, B. Identification of a Gain-of-Function LIPC Variant as a Novel Cause of Familial Combined Hypocholesterolemia Circulation. 2022 Sep 6;146(10). doi: 10.1161/circulationaha.121.057978.

Fneich, A., Poinsot, P., Elias, C., Restier, L., Vanhems, P., Wallet, F., Caussy, C., Duclos, A. and Peretti, N. Undernourished patients do not have increased risk of severe COVID-19 outcomes Clin Nutr Open Sci. 2022 Aug;44(doi: 10.1016/j.nutos.2022.03.002.

Fourgeaud, M., Lebreton, L., Belabbas, K., Di Filippo, M., Rigalleau, V., Couffinhal, T., Pucheu, Y., Barat, P., Ged, C. and Bérard, A. M. Phenotypic and genotypic characterization of familial hypercholesterolemia in French adult and pediatric populations J Clin Lipidol. 2022 May-Jun;16(3). doi: 10.1016/j.jacl.2022.03.002.

Galgani, J. E., Bergouignan, A., Rieusset, J., Moro, C. and Nazare, J. A. Editorial: Metabolic Flexibility Front Nutr. 2022 9(doi: 10.3389/fnut.2022.946300.

Ghaleb, Y., Elbitar, S., Philippi, A., El Khoury, P., Azar, Y., Andrianirina, M., Loste, A., Abou-Khalil, Y., Nicolas, G., Le Borgne, M., Moulin, P., Di-Filippo, M., Charrière, S., Farnier, M., Yelnick, C., Carreau, V., Ferrières, J., Lecerf, J. M., Derksen, A., Bernard, G., Gauthier, M. S., Coulombe, B., Lütjohann, D., Fin, B., Boland, A., Olaso, R., Deleuze, J. F., Rabès, J. P., Boileau, C., Abifadel, M. and Varret, M. Whole Exome/Genome Sequencing Joint Analysis of a Family with Oligogenic Familial Hypercholesterolemia Metabolites. 2022 Mar 18;12(3). doi: 10.3390/metabo12030262.

Hullin-Matsuda, F., Colosetti, P., Rabia, M., Luquain-Costaz, C. and Delton, I. Exosomal lipids from membrane organization to biomarkers: Focus on an endolysosomal-specific lipid Biochimie. 2022 Dec;203(doi: 10.1016/j.biochi.2022.09.016.

Karolak, J. A., Welch, C. L., Mosimann, C., Bzdega, K., West, J. D., Montani, D., Eyries, M., Mullen, M. P., Abman, S. H., Prapa, M., Gräf, S., Morrell, N. W., Hemnes, A. R., Perros, F., Hamid, R., Logan, M. P. O., Whitsett, J., Galambos, C., Stankiewicz, P., Chung, W. K. and Austin, E. D. Molecular Function and Contribution of TBX4 in Development and Disease Am J Respir Crit Care Med. 2022 Nov 11;doi: 10.1164/rccm.202206-1039TR.

Khoury, S., Beauvais, A., Colas, J., Saint-Martin Willer, A., Perros, F., Humbert, M., Vandebrouck, C., Montani, D., Ferreira, T. and Antigny, F. Lipidomic Profile Analysis of Lung Tissues Revealed Lipointoxication in Pulmonary Veno-Occlusive Disease Biomolecules. 2022 Dec 14;12(12). doi: 10.3390/biom12121878.

Lange, N. F., Graf, V., Caussy, C. and Dufour, J. F. PPAR-Targeted Therapies in the Treatment of Non-Alcoholic Fatty Liver Disease in Diabetic Patients Int J Mol Sci. 2022 Apr 13;23(8). doi: 10.3390/ijms23084305.

Lebossé, F. and Caussy, C. Editorial: screening for hepatocellular carcinoma in NAFLD-towards abbreviated MRI alternative in patients with obesity? Aliment Pharmacol Ther. 2022 May;55(9). doi: 10.1111/apt.16887.

Lezoualc’h, F., Badimon, L., Baker, H., Bernard, M., Czibik, G., de Boer, R. A., D’Humières, T., Kergoat, M., Kowala, M., Rieusset, J., Vilahur, G., Détrait, M., Watson, C. and Derumeaux, G. A. The need for adjusting experimental models to meet clinical reality Cardiovasc Res. 2022 Sep 9;doi: 10.1093/cvr/cvac152.

Marilly, E., Cottin, J., Cabrera, N., Cornu, C., Boussageon, R., Moulin, P., Lega, J. C., Gueyffier, F., Cucherat, M. and Grenet, G. SGLT2 inhibitors in type 2 diabetes: a systematic review and meta-analysis of cardiovascular outcome trials balancing their risks and benefits Diabetologia. 2022 Dec;65(12). doi: 10.1007/s00125-022-05773-8.

Mounié, M., Costa, N., Gourdy, P., Latorre, C., Schirr-Bonnans, S., Lagarrigue, J. M., Roussel, H., Martini, J., Buisson, J. C., Chauchard, M. C., Delaunay, J., Taoui, S., Poncet, M. F., Cosma, V., Lablanche, S., Coustols-Valat, M., Chaillous, L., Thivolet, C., Sanz, C., Penfornis, A., Lepage, B., Colineaux, H., Hanaire, H., Molinier, L. and Turnin, M. C. Cost-Effectiveness Evaluation of a Remote Monitoring Programme Including Lifestyle Education Software in Type 2 Diabetes: Results of the Educ@dom Study Diabetes Ther. 2022 Apr;13(4). doi: 10.1007/s13300-022-01207-1.

Mulvaney, E. P., Renzo, F., Adão, R., Dupre, E., Bialesova, L., Salvatore, V., Reid, H. M., Conceição, G., Grynblat, J., Llucià-Valldeperas, A., Michel, J. B., Brás-Silva, C., Laurent, C. E., Howard, L. S., Montani, D., Humbert, M., Vonk Noordegraaf, A., Perros, F., Mendes-Ferreira, P. and Kinsella, B. T. The thromboxane receptor antagonist NTP42 promotes beneficial adaptation and preserves cardiac function in experimental models of right heart overload Front Cardiovasc Med. 2022 9(doi: 10.3389/fcvm.2022.1063967.

Nasser, S., Solé, T., Vega, N., Thomas, T., Balcerczyk, A., Strigini, M. and Pirola, L. Ketogenic diet administration to mice after a high-fat-diet regimen promotes weight loss, glycemic normalization and induces adaptations of ketogenic pathways in liver and kidney Mol Metab. 2022 Nov;65(doi: 10.1016/j.molmet.2022.101578.

Navarese, E. P., Grzelakowska, K., Mangini, F., Kubica, J., Banach, M., Benn, M., Binder, C. J., Borén, J., Catapano, A., Kronenberg, F., Mallat, Z., Moulin, P., Öörni, K., Ray, K. K., Roeters van Lennep, J. E., Romeo, S., Tokgozoglu, L., von Eckardstein, A., Zambon, A. and Raggi, P. The spoils of war and the long-term spoiling of health conditions of entire nations Atherosclerosis. 2022 Jul;352(doi: 10.1016/j.atherosclerosis.2022.05.012.

Nobre, I. G., Jurema Santos, G. C., Santos de Almeida Oliveira, T. L. P., Ribeiro, I. D. C., Dos Santos, R. M., Rodrigues, C. P. S., Moura-Dos-Santos, M. A., Nazare, J. A., Pirola, L. and Leandro, C. G. Food consumption habits, gestational age and birth weight are predictive for children with excess weight: An analysis based on artificial neural network Nutr Health. 2022 Sep 16;doi: 10.1177/02601060221124040.

Orliaguet, L., Ejlalmanesh, T., Humbert, A., Ballaire, R., Diedisheim, M., Julla, J. B., Chokr, D., Cuenco, J., Michieletto, J., Charbit, J., Lindén, D., Boucher, J., Potier, C., Hamimi, A., Lemoine, S., Blugeon, C., Legoix, P., Lameiras, S., Baudrin, L. G., Baulande, S., Soprani, A., Castelli, F. A., Fenaille, F., Riveline, J. P., Dalmas, E., Rieusset, J., Gautier, J. F., Venteclef, N. and Alzaid, F. Early macrophage response to obesity encompasses Interferon Regulatory Factor 5 regulated mitochondrial architecture remodelling Nat Commun. 2022 Aug 30;13(1). doi: 10.1038/s41467-022-32813-z.

Panzarini, E., Leporatti, S., Tenuzzo, B. A., Quarta, A., Hanafy, N. A. N., Giannelli, G., Moliterni, C., Vardanyan, D., Sbarigia, C., Fidaleo, M., Tacconi, S. and Dini, L. Therapeutic Effect of Polymeric Nanomicelles Formulation of LY2157299-Galunisertib on CCl(4)-Induced Liver Fibrosis in Rats J Pers Med. 2022 Nov 1;12(11). doi: 10.3390/jpm12111812.

Paramasivam, P., Meugnier, E., Gokulakrishnan, K., Ranjini, H., Staimez, L. R., Weber, M. B., Narayan, K. M. V., Vidal, H., Tandon, N., Prabhakaran, D., Mohan, A. R., Mohan, V., Rome, S. and Balasubramanyam, M. Blood-derived miRNA levels are not correlated with metabolic or anthropometric parameters in obese pre-diabetic subjects but with systemic inflammation PLoS One. 2022 17(2). doi: 10.1371/journal.pone.0263479.

Pirola, L., Ciesielski, O. and Balcerczyk, A. Fat not so bad? The role of ketone bodies and ketogenic diet in the treatment of endothelial dysfunction and hypertension Biochem Pharmacol. 2022 Dec;206(doi: 10.1016/j.bcp.2022.115346.

Rimbert, A., Yeung, M. W., Dalila, N., Thio, C. H. L., Yu, H., Loaiza, N., Oldoni, F., van der Graaf, A., Wang, S., Said, M. A., Blauw, L. L., Girardeau, A., Bray, L., Caillaud, A., Bloks, V. W., Marrec, M., Moulin, P., Rensen, P. C. N., van de Sluis, B., Snieder, H., Di Filippo, M., van der Harst, P., Tybjaerg-Hansen, A., Zimmerman, P., Cariou, B. and Kuivenhoven, J. A. Variants in the GPR146 Gene Are Associated With a Favorable Cardiometabolic Risk Profile Arterioscler Thromb Vasc Biol. 2022 Oct;42(10). doi: 10.1161/atvbaha.122.317514.

Rome, S. Muscle and Adipose Tissue Communicate with Extracellular Vesicles Int J Mol Sci. 2022 Jun 24;23(13). doi: 10.3390/ijms23137052.

Sango-Solanas, P., Tse Ve Koon, K., Van Reeth, E., Ratiney, H., Millioz, F., Caussy, C. and Beuf, O. Short echo time dual-frequency MR Elastography with Optimal Control RF pulses Sci Rep. 2022 Jan 26;12(1). doi: 10.1038/s41598-022-05262-3.

Santos-Ribeiro, D., Lecocq, M., De Beukelaer, M., Verleden, S., Bouzin, C., Ambroise, J., Dorfmuller, P., Yakoub, Y., Huaux, F., Quarck, R., Karmouty-Quintana, H., Ghigna, M. R., Bignard, J., Nadaud, S., Soubrier, F., Horman, S., Perros, F., Godinas, L. and Pilette, C. Disruption of GCN2 Pathway Aggravates Vascular and Parenchymal Remodeling During Pulmonary Fibrosis Am J Respir Cell Mol Biol. 2022 Dec 7;doi: 10.1165/rcmb.2021-0541OC.

Stevic, N., Maalouf, J., Argaud, L., Gallo-Bona, N., Lo Grasso, M., Gouriou, Y., Gomez, L., Crola Da Silva, C., Ferrera, R., Ovize, M., Cour, M. and Bidaux, G. Cooling Uncouples Differentially ROS Production from Respiration and Ca(2+) Homeostasis Dynamic in Brain and Heart Mitochondria Cells. 2022 Mar 14;11(6). doi: 10.3390/cells11060989.

Therizols, G., Bash-Imam, Z., Panthu, B., Machon, C., Vincent, A., Ripoll, J., Nait-Slimane, S., Chalabi-Dchar, M., Gaucherot, A., Garcia, M., Laforêts, F., Marcel, V., Boubaker-Vitre, J., Monet, M. A., Bouclier, C., Vanbelle, C., Souahlia, G., Berthel, E., Albaret, M. A., Mertani, H. C., Prudhomme, M., Bertrand, M., David, A., Saurin, J. C., Bouvet, P., Rivals, E., Ohlmann, T., Guitton, J., Dalla Venezia, N., Pannequin, J., Catez, F. and Diaz, J. J. Alteration of ribosome function upon 5-fluorouracil treatment favors cancer cell drug-tolerance Nat Commun. 2022 Jan 10;13(1). doi: 10.1038/s41467-021-27847-8.

Vanhoye, X., Janin, A., Caillaud, A., Rimbert, A., Venet, F., Gossez, M., Dijk, W., Marmontel, O., Nony, S., Chatelain, C., Durand, C., Lindenbaum, P., Rieusset, J., Cariou, B., Moulin, P. and Di Filippo, M. APOB CRISPR-Cas9 Engineering in Hypobetalipoproteinemia: A Promising Tool for Functional Studies of Novel Variants Int J Mol Sci. 2022 Apr 13;23(8). doi: 10.3390/ijms23084281.

Publications 2021

Ahmed, S., Paramasivam, P., Kamath, M., Sharma, A., Rome, S. and Murugesan, R. Genetic Exchange of Lung-Derived Exosome to Brain Causing Neuronal Changes on COVID-19 Infection Mol Neurobiol. 2021 Oct;58(10). doi: 10.1007/s12035-021-02485-9.

Bassot, A., Prip-Buus, C., Alves, A., Berdeaux, O., Perrier, J., Lenoir, V., Ji-Cao, J., Berger, M. A., Loizon, E., Cabaret, S., Panthu, B., Rieusset, J. and Morio, B. Loss and gain of function of Grp75 or mitofusin 2 distinctly alter cholesterol metabolism, but all promote triglyceride accumulation in hepatocytes Biochim Biophys Acta Mol Cell Biol Lipids. 2021 Dec;1866(12). doi: 10.1016/j.bbalip.2021.159030.

Belhassen, M., Van Ganse, E., Nolin, M., Bérard, M., Bada, H., Bruckert, E., Krempf, M., Rebours, V., Valero, R. and Moulin, P. 10-Year Comparative Follow-up of Familial versus Multifactorial Chylomicronemia Syndromes J Clin Endocrinol Metab. 2021 Mar 8;106(3). doi: 10.1210/clinem/dgaa838.

Blanchard, C., Perennec, T., Smati, S., Tramunt, B., Guyomarch, B., Bigot-Corbel, E., Bordier, L., Borot, S., Bourron, O., Caussy, C., Coffin-Boutreux, C., Dutour, A., Germain, N., Gonfroy-Leymarie, C., Meyer, L., Prevost, G., Roussel, R., Seret-Bégué, D., Thivolet, C., Vergès, B., Pichelin, M., Gourdy, P., Hadjadj, S., Wargny, M., Pattou, F. and Cariou, B. History of bariatric surgery and COVID 19 outcomes in patients with type 2 diabetes: results from the CORONADO study Obesity (Silver Spring). 2021 Sep 29;doi: 10.1002/oby.23314.

Bosset, M., Bonjour, M., Castellnou, S., Hafdi-Nejjari, Z., Bournaud-Salinas, C., Decaussin-Petrucci, M., Lifante, J. C., Perrin, A., Peix, J. L., Moulin, P., Sassolas, G., Pugeat, M. and Borson-Chazot, F. Long-Term Outcome of Lobectomy for Thyroid Cancer Eur Thyroid J. 2021 Nov;10(6). doi: 10.1159/000510620.

Boursier, J., Anty, R., Carette, C., Cariou, B., Castera, L., Caussy, C., Fontaine, H., Garioud, A., Gourdy, P., Guerci, B., Guillaume, M., Michot, N., Minello, A., Ouizeman, D. J., Serfaty, L., Bonnet, F., Vergès, B. and Petit, J. M. Management of diabetes mellitus in patients with cirrhosis: An overview and joint statement Diabetes Metab. 2021 Sep;47(5). doi: 10.1016/j.diabet.2021.101272.

Bravard, A., Gérard, C., Defois, C., Benoit, B., Makki, K., Meugnier, E., Rainteau, D., Rieusset, J., Godet, M. and Vidal, H. Metformin treatment for 8 days impacts multiple intestinal parameters in high-fat high-sucrose fed mice Sci Rep. 2021 Aug 17;11(1). doi: 10.1038/s41598-021-95117-0.

Cariou, B., Goronflot, T., Rimbert, A., Boullu, S., Le May, C., Moulin, P., Pichelin, M., Potier, L., Smati, S., Sultan, A., Tramunt, B., Wargny, M., Gourdy, P. and Hadjadj, S. Routine use of statins and increased COVID-19 related mortality in inpatients with type 2 diabetes: Results from the CORONADO study Diabetes Metab. 2021 Mar;47(2). doi: 10.1016/j.diabet.2020.10.001.

Cariou, B., Pichelin, M., Goronflot, T., Gonfroy, C., Marre, M., Raffaitin-Cardin, C., Thivolet, C., Wargny, M., Hadjadj, S. and Gourdy, P. Phenotypic characteristics and prognosis of newly diagnosed diabetes in hospitalized patients with COVID-19: Results from the CORONADO study Diabetes Res Clin Pract. 2021 May;175(doi: 10.1016/j.diabres.2021.108695.

Castro-Sepúlveda, M., Morio, B., Tuñón-Suárez, M., Jannas-Vela, S., Díaz-Castro, F., Rieusset, J. and Zbinden-Foncea, H. The fasting-feeding metabolic transition regulates mitochondrial dynamics Faseb j. 2021 Oct;35(10). doi: 10.1096/fj.202100929R.

Caussy, C., Aubin, A. and Loomba, R. The Relationship Between Type 2 Diabetes, NAFLD, and Cardiovascular Risk Curr Diab Rep. 2021 Mar 19;21(5). doi: 10.1007/s11892-021-01383-7.

Chatel, B., Ducreux, S., Harhous, Z., Bendridi, N., Varlet, I., Ogier, A. C., Bernard, M., Gondin, J., Rieusset, J., Westerblad, H., Bendahan, D. and Gineste, C. Impaired aerobic capacity and premature fatigue preceding muscle weakness in the skeletal muscle Tfam-knockout mouse model Dis Model Mech. 2021 Sep 1;14(9). doi: 10.1242/dmm.048981.

Chetboun, M., Raverdy, V., Labreuche, J., Simonnet, A., Wallet, F., Caussy, C., Antonelli, M., Artigas, A., Goma, G., Meziani, F., Helms, J., Mylonakis, E., Levy, M. M., Kalligeros, M., Latronico, N., Piva, S., Cerf, C., Neuville, M., Klouche, K., Larcher, R., Tamion, F., Occhiali, E., Snacken, M., Preiser, J. C., Kontar, L., Riviere, A., Silva, S., Sarton, B., Krouchi, R., Dubar, V., Palaiodimos, L., Karamanis, D., Perche, J., L’Her, E., Busetto, L., Dicker, D., Lev, S., Duhamel, A., Jourdain, M. and Pattou, F. BMI and pneumonia outcomes in critically ill covid-19 patients: An international multicenter study Obesity (Silver Spring). 2021 Sep;29(9). doi: 10.1002/oby.23223.

Couchet, M., Breuillard, C., Corne, C., Rendu, J., Morio, B., Schlattner, U. and Moinard, C. Ornithine Transcarbamylase – From Structure to Metabolism: An Update Front Physiol. 2021 12(doi: 10.3389/fphys.2021.748249.

Doñate Puertas, R., Arora, R., Rome, S., Asatryan, B., Roderick, H. L. and Chevalier, P. Epigenetics in atrial fibrillation: A reappraisal Heart Rhythm. 2021 May;18(5). doi: 10.1016/j.hrthm.2021.01.007.

Durlach, V., Bonnefont-Rousselot, D., Boccara, F., Varret, M., Di-Filippo Charcosset, M., Cariou, B., Valero, R., Charriere, S., Farnier, M., Morange, P. E., Meilhac, O., Lambert, G., Moulin, P., Gillery, P., Beliard-Lasserre, S., Bruckert, E., Carrié, A., Ferrières, J., Collet, X., Chapman, M. J. and Anglés-Cano, E. Lipoprotein(a): Pathophysiology, measurement, indication and treatment in cardiovascular disease. A consensus statement from the Nouvelle Société Francophone d’Athérosclérose (NSFA) Arch Cardiovasc Dis. 2021 Dec;114(12). doi: 10.1016/j.acvd.2021.10.009.

Fragoso, J., Carvalho Jurema Santos, G., da Silva, H. T., Loizon, E., de Oliveira Nogueira Souza, V., Vidal, H., Guedes, R. C. A., Costa-Silva, J. H., da Silva Aragão, R., Pirola, L. and Leandro, C. G. Effects of maternal low-protein diet and spontaneous physical activity on the transcription of neurotrophic factors in the placenta and the brains of mothers and offspring rats J Dev Orig Health Dis. 2021 Jun;12(3). doi: 10.1017/s2040174420000756.

Franc, S., Benhamou, P. Y., Borot, S., Chaillous, L., Delemer, B., Doron, M., Guerci, B., Hanaire, H., Huneker, E., Jeandidier, N., Amadou, C., Renard, E., Reznik, Y., Schaepelynck, P., Simon, C., Thivolet, C., Thomas, C., Hannaert, P. and Charpentier, G. No more hypoglycaemia on days with physical activity and unrestricted diet when using a closed-loop system for 12 weeks: A post hoc secondary analysis of the multicentre, randomized controlled Diabeloop WP7 trial Diabetes Obes Metab. 2021 Sep;23(9). doi: 10.1111/dom.14442.

Gallo, A., Pérez de Isla, L., Charrière, S., Vimont, A., Alonso, R., Muñiz-Grijalvo, O., Díaz-Díaz, J. L., Zambón, D., Moulin, P., Bruckert, E., Mata, P. and Béliard, S. The Added Value of Coronary Calcium Score in Predicting Cardiovascular Events in Familial Hypercholesterolemia JACC Cardiovasc Imaging. 2021 Dec;14(12). doi: 10.1016/j.jcmg.2021.06.011.

Gaudillière, M., Marsot, C., Balaire, L., Groisne, L., Moret, M., Villar-Fimbel, S., Douek, P., Moulin, P. and Charrière, S. Higher prevalence of incidental findings identified upon coronary calcium score assessment in type 2 and type 3 diabetes versus type 1 diabetes PLoS One. 2021 16(5). doi: 10.1371/journal.pone.0251693.

Ginsberg, H. N., Packard, C. J., Chapman, M. J., Borén, J., Aguilar-Salinas, C. A., Averna, M., Ference, B. A., Gaudet, D., Hegele, R. A., Kersten, S., Lewis, G. F., Lichtenstein, A. H., Moulin, P., Nordestgaard, B. G., Remaley, A. T., Staels, B., Stroes, E. S. G., Taskinen, M. R., Tokgözoğlu, L. S., Tybjaerg-Hansen, A., Stock, J. K. and Catapano, A. L. Triglyceride-rich lipoproteins and their remnants: metabolic insights, role in atherosclerotic cardiovascular disease, and emerging therapeutic strategies-a consensus statement from the European Atherosclerosis Society Eur Heart J. 2021 Dec 14;42(47). doi: 10.1093/eurheartj/ehab551.

Jalabert, A., Reininger, L., Berger, E., Coute, Y., Meugnier, E., Forterre, A., Errazuriz-Cerda, E., Geloen, A., Aouadi, M., Bouzakri, K., Rieusset, J. and Rome, S. Profiling of ob/ob mice skeletal muscle exosome-like vesicles demonstrates combined action of miRNAs, proteins and lipids to modulate lipid homeostasis in recipient cells Sci Rep. 2021 Nov 3;11(1). doi: 10.1038/s41598-021-00983-3.

Jeremy, B., Bozec, E., Bounoure, F., Khettab, H., Malloizel-Delaunay, J., Skiba, M., Iacob, M., Donnadieu, N., Coquard, A., Morio, B., Laillet, B., Rigaudière, J. P., Chardigny, J. M., Monteil, C., Vendeville, C., Mercier, A., Cailleux, A. F., Blanchard, A., Amar, J., Fezeu, L. K., Pannier, B., Bura-Rivière, A., Boutouyrie, P. and Joannidès, R. The effect of camelina oil on vascular function in essential hypertensive patients with metabolic syndrome: A randomized, placebo-controlled, double-blind study Am J Clin Nutr. 2021 Nov 15;doi: 10.1093/ajcn/nqab374.

Lablanche, S., Borot, S., Wojtusciszyn, A., Skaare, K., Penfornis, A., Malvezzi, P., Badet, L., Thivolet, C., Morelon, E., Buron, F., Renard, E., Tauveron, I., Villard, O., Munch, M., Sommacal, S., Clouaire, L., Jacquet, M., Gonsaud, L., Camillo-Brault, C., Colin, C., Bosson, J. L., Bosco, D., Berney, T., Kessler, L. and Benhamou, P. Y. Ten-year outcomes of islet transplantation in patients with type 1 diabetes: Data from the Swiss-French GRAGIL network Am J Transplant. 2021 Nov;21(11). doi: 10.1111/ajt.16637.

Lalau, J. D., Al-Salameh, A., Hadjadj, S., Goronflot, T., Wiernsperger, N., Pichelin, M., Allix, I., Amadou, C., Bourron, O., Duriez, T., Gautier, J. F., Dutour, A., Gonfroy, C., Gouet, D., Joubert, M., Julier, I., Larger, E., Marchand, L., Marre, M., Meyer, L., Olivier, F., Prevost, G., Quiniou, P., Raffaitin-Cardin, C., Roussel, R., Saulnier, P. J., Seret-Begue, D., Thivolet, C., Vatier, C., Desailloud, R., Wargny, M., Gourdy, P. and Cariou, B. Metformin use is associated with a reduced risk of mortality in patients with diabetes hospitalised for COVID-19 Diabetes Metab. 2021 Sep;47(5). doi: 10.1016/j.diabet.2020.101216.

Le Lay, S., Rome, S., Loyer, X. and Nieto, L. Adipocyte-derived extracellular vesicles in health and diseases: Nano-packages with vast biological properties FASEB Bioadv. 2021 Jun;3(6). doi: 10.1096/fba.2020-00147.

Madec, A. M., Perrier, J., Panthu, B. and Dingreville, F. Role of mitochondria-associated endoplasmic reticulum membrane (MAMs) interactions and calcium exchange in the development of type 2 diabetes Int Rev Cell Mol Biol. 2021 363(doi: 10.1016/bs.ircmb.2021.06.001.

Morio, B., Panthu, B., Bassot, A. and Rieusset, J. Role of mitochondria in liver metabolic health and diseases Cell Calcium. 2021 Mar;94(doi: 10.1016/j.ceca.2020.102336.

Parini, P., Frikke-Schmidt, R., Tselepis, A. D., Moulin, P., von Eckardstein, A., Binder, C. J., Catapano, A. L., Ray, K. K. and Tokgözoğlu, L. Taking action: European Atherosclerosis Society targets the United Nations Sustainable Development Goals 2030 agenda to fight atherosclerotic cardiovascular disease in Europe Atherosclerosis. 2021 Apr;322(doi: 10.1016/j.atherosclerosis.2021.02.007.

Perrin-Cocon, L., Vidalain, P. O., Jacquemin, C., Aublin-Gex, A., Olmstead, K., Panthu, B., Rautureau, G. J. P., André, P., Nyczka, P., Hütt, M. T., Amoedo, N., Rossignol, R., Filipp, F. V., Lotteau, V. and Diaz, O. A hexokinase isoenzyme switch in human liver cancer cells promotes lipogenesis and enhances innate immunity Commun Biol. 2021 Feb 16;4(1). doi: 10.1038/s42003-021-01749-3.

Pinel, A., Rigaudière, J. P., Jouve, C., Montaurier, C., Jousse, C., M, L. H., Morio, B. and Capel, F. Transgenerational supplementation with eicosapentaenoic acid reduced the metabolic consequences on the whole body and skeletal muscle in mice receiving an obesogenic diet Eur J Nutr. 2021 Sep;60(6). doi: 10.1007/s00394-021-02502-6.

Pinel, A., Rigaudière, J. P., Morio, B. and Capel, F. Adipose Tissue Dysfunctions in Response to an Obesogenic Diet Are Reduced in Mice after Transgenerational Supplementation with Omega 3 Fatty Acids Metabolites. 2021 Dec 4;11(12). doi: 10.3390/metabo11120838.

Rautureau, G. J. P., Morio, B., Guibert, S., Lefevre, C., Perrier, J., Alves, A., Chauvin, M. A., Pinteur, C., Monet, M. A., Godet, M., Madec, A. M., Rieusset, J., Mey, A. and Panthu, B. Dietary obesity in mice is associated with lipid deposition and metabolic shifts in the lungs sharing features with the liver Sci Rep. 2021 Apr 22;11(1). doi: 10.1038/s41598-021-88097-8.

Rimbert, A., Vanhoye, X., Coulibaly, D., Marrec, M., Pichelin, M., Charrière, S., Peretti, N., Valéro, R., Wargny, M., Carrié, A., Lindenbaum, P., Deleuze, J. F., Genin, E., Redon, R., Rollat-Farnier, P. A., Goxe, D., Degraef, G., Marmontel, O., Divry, E., Bigot-Corbel, E., Moulin, P., Cariou, B. and Di Filippo, M. Phenotypic Differences Between Polygenic and Monogenic Hypobetalipoproteinemia Arterioscler Thromb Vasc Biol. 2021 Jan;41(1). doi: 10.1161/atvbaha.120.315491.

Rome, S., Blandin, A. and Le Lay, S. Adipocyte-Derived Extracellular Vesicles: State of the Art Int J Mol Sci. 2021 Feb 11;22(4). doi: 10.3390/ijms22041788.

Roussel, R., Darmon, P., Pichelin, M., Goronflot, T., Abouleka, Y., Ait Bachir, L., Allix, I., Ancelle, D., Barraud, S., Bordier, L., Carlier, A., Chevalier, N., Coffin-Boutreux, C., Cosson, E., Dorange, A., Dupuy, O., Fontaine, P., Fremy, B., Galtier, F., Germain, N., Guedj, A. M., Larger, E., Laugier-Robiolle, S., Laviolle, B., Ludwig, L., Monier, A., Montanier, N., Moulin, P., Moura, I., Prevost, G., Reznik, Y., Sabbah, N., Saulnier, P. J., Serusclat, P., Vatier, C., Wargny, M., Hadjadj, S., Gourdy, P. and Cariou, B. Use of dipeptidyl peptidase-4 inhibitors and prognosis of COVID-19 in hospitalized patients with type 2 diabetes: A propensity score analysis from the CORONADO study Diabetes Obes Metab. 2021 May;23(5). doi: 10.1111/dom.14324.

Sango Solanas, P., Tse Ve Koon, K., Ratiney, H., Millioz, F., Caussy, C. and Beuf, O. Harmonic wideband simultaneous dual-frequency MR Elastography NMR Biomed. 2021 Feb;34(2). doi: 10.1002/nbm.4442.

Schattenberg, J. M., Anstee, Q. M., Caussy, C., Bugianesi, E. and Popovic, B. Differences between current clinical guidelines for screening, diagnosis and management of nonalcoholic fatty liver disease and real-world practice: a targeted literature review Expert Rev Gastroenterol Hepatol. 2021 Nov;15(11). doi: 10.1080/17474124.2021.1974295.

Smati, S., Tramunt, B., Wargny, M., Caussy, C., Gaborit, B., Vatier, C., Vergès, B., Ancelle, D., Amadou, C., Bachir, L. A., Bourron, O., Coffin-Boutreux, C., Barraud, S., Dorange, A., Fremy, B., Gautier, J. F., Germain, N., Larger, E., Laugier-Robiolle, S., Meyer, L., Monier, A., Moura, I., Potier, L., Sabbah, N., Seret-Bégué, D., Winiszewski, P., Pichelin, M., Saulnier, P. J., Hadjadj, S., Cariou, B. and Gourdy, P. Relationship between obesity and severe COVID-19 outcomes in patients with type 2 diabetes: Results from the CORONADO study Diabetes Obes Metab. 2021 Feb;23(2). doi: 10.1111/dom.14228.

Thivolet, C. Insulin pump initiation in outpatient settings: When technology facilitates new healthcare organizations Diabetes Metab. 2021 Nov;47(6). doi: 10.1016/j.diabet.2021.101290.

Tramunt, B., Smati, S., Coudol, S., Wargny, M., Pichelin, M., Guyomarch, B., Al-Salameh, A., Amadou, C., Barraud, S., Bigot, E., Bordier, L., Borot, S., Bourgeon, M., Bourron, O., Charrière, S., Chevalier, N., Cosson, E., Fève, B., Flaus-Furmaniuk, A., Fontaine, P., Galioot, A., Gonfroy-Leymarie, C., Guerci, B., Lablanche, S., Lalau, J. D., Larger, E., Lasbleiz, A., Laviolle, B., Marre, M., Munch, M., Potier, L., Prevost, G., Renard, E., Reznik, Y., Seret-Bégué, D., Sibilia, P., Thuillier, P., Vergès, B., Gautier, J. F., Hadjadj, S., Cariou, B., Mauvais-Jarvis, F. and Gourdy, P. Sex disparities in COVID-19 outcomes of inpatients with diabetes: insights from the CORONADO study Eur J Endocrinol. 2021 Jul 5;185(2). doi: 10.1530/eje-21-0068.

Turnin, M. C., Gourdy, P., Martini, J., Buisson, J. C., Chauchard, M. C., Delaunay, J., Schirr-Bonnans, S., Taoui, S., Poncet, M. F., Cosma, V., Lablanche, S., Coustols-Valat, M., Chaillous, L., Thivolet, C., Sanz, C., Penfornis, A., Lepage, B., Colineaux, H., Mounié, M., Costa, N., Molinier, L. and Hanaire, H. Impact of a Remote Monitoring Programme Including Lifestyle Education Software in Type 2 Diabetes: Results of the Educ@dom Randomised Multicentre Study Diabetes Ther. 2021 Jul;12(7). doi: 10.1007/s13300-021-01095-x.

Wargny, M., Potier, L., Gourdy, P., Pichelin, M., Amadou, C., Benhamou, P. Y., Bonnet, J. B., Bordier, L., Bourron, O., Chaumeil, C., Chevalier, N., Darmon, P., Delenne, B., Demarsy, D., Dumas, M., Dupuy, O., Flaus-Furmaniuk, A., Gautier, J. F., Guedj, A. M., Jeandidier, N., Larger, E., Le Berre, J. P., Lungo, M., Montanier, N., Moulin, P., Plat, F., Rigalleau, V., Robert, R., Seret-Bégué, D., Sérusclat, P., Smati, S., Thébaut, J. F., Tramunt, B., Vatier, C., Velayoudom, F. L., Vergès, B., Winiszewski, P., Zabulon, A., Gourraud, P. A., Roussel, R., Cariou, B. and Hadjadj, S. Predictors of hospital discharge and mortality in patients with diabetes and COVID-19: updated results from the nationwide CORONADO study Diabetologia. 2021 Apr;64(4). doi: 10.1007/s00125-020-05351-w.

Witwer, K. W., Goberdhan, D. C., O’Driscoll, L., Théry, C., Welsh, J. A., Blenkiron, C., Buzás, E. I., Di Vizio, D., Erdbrügger, U., Falcón-Pérez, J. M., Fu, Q. L., Hill, A. F., Lenassi, M., Lötvall, J., Nieuwland, R., Ochiya, T., Rome, S., Sahoo, S. and Zheng, L. Updating MISEV: Evolving the minimal requirements for studies of extracellular vesicles J Extracell Vesicles. 2021 Dec;10(14). doi: 10.1002/jev2.12182.

Ziegler, D. V., Vindrieux, D., Goehrig, D., Jaber, S., Collin, G., Griveau, A., Wiel, C., Bendridi, N., Djebali, S., Farfariello, V., Prevarskaya, N., Payen, L., Marvel, J., Aubert, S., Flaman, J. M., Rieusset, J., Martin, N. and Bernard, D. Calcium channel ITPR2 and mitochondria-ER contacts promote cellular senescence and aging Nat Commun. 2021 Feb 1;12(1). doi: 10.1038/s41467-021-20993-z.

MERISM TEAM : « Mitochondria-ER Interactions and Signalling in Metabolic health and diseases »

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